Base de dados : MEDLINE
Pesquisa : F03.700.750 [Categoria DeCS]
Referências encontradas : 84610 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 8461 ir para página                         

  1 / 84610 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29410289
[Au] Autor:Xu Y; Ren J; Ye H
[Ad] Endereço:Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Beijing Institute for Brain Disorders, Center of Schizophrenia, Capital Medical University, Beijing 100069, China. Electronic address: xuyl@ccmu.edu.cn.
[Ti] Título:Association between variations in the disrupted in schizophrenia 1 gene and schizophrenia: A meta-analysis.
[So] Source:Gene;651:94-99, 2018 Apr 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Schizophrenia is a severe psychiatric disorder. Genetic and functional studies have strongly implicated the disrupted in schizophrenia 1 gene (DISC1) as a candidate susceptibility gene for schizophrenia. Moreover, recent association studies have indicated that several DISC1 single nucleotide polymorphisms (SNPs) are associated with schizophrenia. However, the association is hardly replicate in different ethnic group. Here, we performed a meta-analysis of the association between DISC1 SNPs and schizophrenia in which the samples were divided into subgroups according to ethnicity. Both rs3738401 and rs821616 showed not significantly association with schizophrenia in the Caucasian, Asian, Japanese or Han Chinese populations.
[Mh] Termos MeSH primário: Proteínas do Tecido Nervoso/genética
Polimorfismo de Nucleotídeo Único
Esquizofrenia/genética
[Mh] Termos MeSH secundário: Grupo com Ancestrais do Continente Asiático/genética
Grupo com Ancestrais do Continente Europeu/genética
Estudos de Associação Genética
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (DISC1 protein, human); 0 (Nerve Tissue Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


  2 / 84610 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29231006
[Au] Autor:Sun ZW; Shi TT; Fu PX
[Ad] Endereço:Beijing Ankang Hospital, Beijing 101300, China.
[Ti] Título:[Characteristics of Schizophrenia Patients' Homicide Behaviors and Their Correlations with Criminal Capacity].
[So] Source:Fa Yi Xue Za Zhi;33(1):32-35, 2017 Feb.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To explore the characteristics of schizophrenia patients' homicide behaviors and the influences of the assessments of criminal capacity. METHODS: Indicators such as demographic and clinical data, characteristics of criminal behaviors and criminal capacity from the suspects whom were diagnosed by forensic psychiatry as schizophrenia ( =110) and normal mental ( =70) with homicide behavior, were collected by self-made investigation form and compared. The influences of the assessments of criminal capacity on the suspects diagnosed as schizophrenia were also analyzed using logistic regression analysis. RESULTS: There were no significant statistical differences between the schizophrenic group and the normal mental group concerning age, gender, education and marital status ( >0.05). There were significant statistical differences between the two groups concerning thought disorder, emotion state and social function before crime ( <0.05) and there were significant statistical differences in some characteristics of the case such as aggressive history ( <0.05), cue, trigger, plan, criminal incentives, object of crime, circumstance cognition and self-protection ( <0.05). Multivariate logistic regression analysis suggested that thought disorder, emotion state, social function, criminal incentives, plan and self-protection before crime of the schizophrenic group were positively correlated with the criminal capacity ( <0.05). CONCLUSIONS: The relevant influences of psychopathology and crime characteristics should be considered comprehensively for improving the accuracy of the criminal capacity evaluation on the suspects diagnosed as schizophrenia with homicide behavior.
[Mh] Termos MeSH primário: Agressão/psicologia
Crime
Homicídio/psicologia
Esquizofrenia/diagnóstico
Psicologia do Esquizofrênico
[Mh] Termos MeSH secundário: Criminosos
Psiquiatria Legal
Seres Humanos
Motivação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.01.008


  3 / 84610 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28742291
[Au] Autor:Sultan RS; Olfson M; Correll CU; Duncan EJ
[Ad] Endereço:New York State Psychiatric Institute/Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, New York, NY 10032. rs3511@cumc.columbia.edu.
[Ti] Título:Evaluating the Effect of the Changes in FDA Guidelines for Clozapine Monitoring.
[So] Source:J Clin Psychiatry;78(8):e933-e939, 2017 Sep/Oct.
[Is] ISSN:1555-2101
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Concerns exist that clozapine is underutilized in the management of treatment-resistant schizophrenia. Although a 2015 change in the US Food and Drug Administration (FDA) monitoring recommendations lowered the threshold of the absolute neutrophil count for treatment interruption from 1,500/µL to 1,000/µL and removed white blood cell count thresholds from the monitoring algorithm, the implications of this policy change on clozapine interruptions remain unknown. METHODS: We analyzed outpatient prescribing records for antipsychotic medications in the Veterans Integrated Service Network 7 (VISN 7) database between 1999 and 2012 to assess the potential impact of the recent changes in FDA neutropenia monitoring recommendations on clozapine treatment discontinuation. We evaluated results of complete blood count monitoring to compare percentages of patients who developed or would have developed ≥ 1 hematologic event under the previous and current FDA guidelines in the first year following initiation of clozapine. RESULTS: From a cohort of 14,620 patients with schizophrenia (ICD-9-295.x), 246 patients received clozapine treatment (1.7%). No agranulocytosis was observed during the study period. Under the former recommendations, 5 patients in the clozapine initiation cohort (n = 160, 3.1%; 95% CI, 0.43-5.83) qualified for treatment interruption during the first year of clozapine treatment, while only 1 patient (0.6%) qualified under the current recommendations. Under the former recommendations, hematologic events occurred at a similar rate for individuals taking and not taking clozapine. CONCLUSIONS: While clozapine remains an underused medication, the new FDA monitoring guidelines are likely to substantially reduce the percentage of patients who meet criteria for clozapine-associated hematologic events requiring treatment interruption. This decrease may reduce the clinical burden of managing patients on clozapine and therefore increase the number of individuals treated with this uniquely effective medication. However, prospective studies of individuals treated under the new guidelines are needed to fully assess safety of the FDA's change.
[Mh] Termos MeSH primário: Clozapina
Monitoramento de Medicamentos
Neutropenia
Esquizofrenia/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Sistemas de Notificação de Reações Adversas a Medicamentos/estatística & dados numéricos
Antipsicóticos/administração & dosagem
Antipsicóticos/efeitos adversos
Clozapina/administração & dosagem
Clozapina/efeitos adversos
Monitoramento de Medicamentos/métodos
Monitoramento de Medicamentos/estatística & dados numéricos
Prescrições de Medicamentos/estatística & dados numéricos
Feminino
Seres Humanos
Contagem de Leucócitos
Masculino
Conduta do Tratamento Medicamentoso/organização & administração
Conduta do Tratamento Medicamentoso/normas
Meia-Idade
Neutropenia/induzido quimicamente
Neutropenia/diagnóstico
Neutropenia/epidemiologia
Neutropenia/prevenção & controle
Farmacovigilância
Guias de Prática Clínica como Assunto
Escalas de Graduação Psiquiátrica
Melhoria de Qualidade
Esquizofrenia/diagnóstico
Esquizofrenia/epidemiologia
Estados Unidos/epidemiologia
United States Food and Drug Administration
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents); J60AR2IKIC (Clozapine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  4 / 84610 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28470156
[Au] Autor:Joung J; Kim S
[Ad] Endereço:College of Nursing, Seoul National University, Seoul, Korea.
[Ti] Título:[Effects of a Relapse Prevention Program on Insight, Empowerment and Treatment Adherence in Patients with Schizophrenia].
[So] Source:J Korean Acad Nurs;47(2):188-198, 2017 Apr.
[Is] ISSN:2093-758X
[Cp] País de publicação:Korea (South)
[La] Idioma:kor
[Ab] Resumo:PURPOSE: The purpose of this study was to develop a relapse prevention program (RPP) and examine the effects of the RPP on insight, empowerment, and treatment adherence in patients with schizophrenia. METHODS: A non-equivalent control group pretest-posttest design was used. Participants were 54 inpatients who had a diagnosis of schizophrenia (experimental group: 26, control group: 28). The study was carried out from February 7, 2012 to February 6, 2013. Over a 10-day period prior to discharge each participant in the experimental group received three one-hour sessions of RPP a one-to-one patient-nurse interaction. Data were collected using Assess Unawareness of Mental Disorder (SUMD), Empowerment Scale, and Insight and Treatment Attitude Questionnaire (ITAQ) and analyzed using PASW 18.0 with chi-square test, independent t-test, Mann-Whitney U test, and ANCOVA. RESULTS: The experimental group had a significant increase in insight and treatment adherence compared to the control group. However, there was no significant difference in empowerment between the two groups. CONCLUSION: Findings indicate that the RPP for patients with schizophrenia was effective in improving insight and treatment adherence. A longitudinal study is needed to confirm the persistence of these effects of RPP in patients with schizophrenia.
[Mh] Termos MeSH primário: Poder (Psicologia)
Avaliação de Programas e Projetos de Saúde
Esquizofrenia/prevenção & controle
Cooperação e Adesão ao Tratamento
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Recidiva
Esquizofrenia/diagnóstico
Psicologia do Esquizofrênico
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4040/jkan.2017.47.2.188


  5 / 84610 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29267417
[Au] Autor:Yvon F; Prouteau A
[Ad] Endereço:Université de Bordeaux, France.
[Ti] Título:[Towards an Understanding of Stigma: What is the Stereotype Associated with Schizophrenia].
[Ti] Título:Vers une compréhension de la stigmatisation : quel est le stéréotype associé à la schizophrénie ?.
[So] Source:Sante Ment Que;42(2):125-131, 2017.
[Is] ISSN:0383-6320
[Cp] País de publicação:Canada
[La] Idioma:fre
[Ab] Resumo:Objectives Stigmatization of people suffering from schizophrenia spectrum disorder relies on the existence of a stereotype which is associated with a social category, here schizophrenia. The short report's aim is to briefly synthesize the recent literature about the content of the stereotype associated with schizophrenia, and to suggest some perspectives for future studies, on the basis of recent advances in the domain.Methods First, we present the theoretical concepts of stigma and stereotype. Second, we propose a brief synthesis of the recently published articles focusing on the content of schizophrenia stereotype in the general population, in English and in French.Results The stereotype associated with mental illness is clearly negative. The most common model in the literature assumes 4 factors in the content of stereotype: attribution of responsibility in the condition, dangerousness, poor prognosis, unpredictability and incompetence in social roles. If the stereotype could vary among countries, it is clearly associated with desire for social distance and discrimination. The stereotype also varies among mental illnesses. Compared with bipolar disorders and autism, schizophrenia focuses the most negative aspects of mental illness stereotype, especially in terms of dangerousness and social distance.Conclusion The study of stereotype, though rapidly growing, still raises questions about the validity of commonly used models in the psychiatric literature, and may benefit from further specific studies. Social psychology models and methods appear to be a promising perspective. The production of data, useful for users, families as well as for professionals may require multidisciplinarity for future projects.
[Mh] Termos MeSH primário: Esquizofrenia
Estigma Social
Estereotipagem
[Mh] Termos MeSH secundário: Seres Humanos
Transtornos Mentais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  6 / 84610 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29267414
[Au] Autor:Zanon D; Merceron K
[Ad] Endereço:Centre de Postcure Psychiatrique de l'association Psy'Activ, service Briords, Carquefou (44).
[Ti] Título:[Cognitive Functioning and Work Outcome Among People with Schizophrenia Spectrum Disorder: The Contribution of the International Classification of Functioning].
[Ti] Título:Le fonctionnement cognitif et le travail chez les personnes souffrant de troubles du spectre schizophrénique : l'apport de la Classification internationale du fonctionnement..
[So] Source:Sante Ment Que;42(2):71-85, 2017.
[Is] ISSN:0383-6320
[Cp] País de publicação:Canada
[La] Idioma:fre
[Ab] Resumo:Objectives Cognitive impairment can be a barrier to employment of people with a schizophrenia spectrum disorder (SSD). However, other factors have also been identified as potentially hindering work integration and job tenure. But the links between all these factors remain unknown. The objective of this article is to propound an integrative model, using the International Classification of Functioning (ICF), of how cognitive impairment associated with SSD is related to other factors involved in difficulties in work integration and job tenure.Methods The description of the theoretical framework of the ICF enables to organize these factors in a comprehensive model. Then, a review of recent literature allows us to identify factors associated with employment of people with SSD, and to see the link between cognitive functioning and other factors.Results Most of reviewed studies find moderate correlations or no correlation between cognitive impairments and work integration or job tenure. Stronger correlations were nevertheless found between cognitive factors and work behavior or performance. Considering other factors, like personal or environmental factors, and the framework of the ICF, a comprehensive view of the vocational rehabilitation for people with SSD is developed. Interactions between some personal (e.g. self-efficacy or self esteem) and environmental (e.g. job coach or layout of workstation) factors may influence the translation of cognitive difficulties into work participation restrictions.Conclusion Vocational rehabilitation programs should further consider the complexity of interactions between cognitive, personal and environmental factors, and how they impact work functioning. As defined in ICF, activity limitations may represent an interesting mediator between cognitive variables and work functioning. Future research should be conducted to bring a better understanding of these patterns of interactions.
[Mh] Termos MeSH primário: Cognição/classificação
Emprego
Reabilitação Vocacional
Esquizofrenia/classificação
Esquizofrenia/reabilitação
[Mh] Termos MeSH secundário: Seres Humanos
Classificação Internacional de Funcionalidade, Incapacidade e Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  7 / 84610 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29179828
[Au] Autor:Hjorth P; Juel A; Hansen MV; Madsen NJ; Viuff AG; Munk-Jørgensen P
[Ad] Endereço:Mental Health Center, Psychiatric Hospital, Randers, Denmark. Electronic address: Peter.Hjorth@rsyd.dk.
[Ti] Título:Reducing the Risk of Cardiovascular Diseases in Non-selected Outpatients With Schizophrenia: A 30-Month Program Conducted in a Real-life Setting.
[So] Source:Arch Psychiatr Nurs;31(6):602-609, 2017 12.
[Is] ISSN:1532-8228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The most common cause of premature death in people with schizophrenia is cardiovascular disease, partially explained by an unhealthy lifestyle, smoking, poor diet and sedentary behavior. We aimed to reduce cardiovascular risk factors. METHOD: Naturalistic follow-up study with 54 long-term-treated non-selected outpatients with schizophrenia. The 30-month program consisted of individual guidance, group sessions and normal treatment and care offered in our clinic. RESULTS: On average, the participating women reduced their waist circumference by 11.4cm (P=0.037), whereas the participating men increased their waist circumference by 3.3cm (P=0.590). Patients' consumption of fast food was reduced from 1.2 to 0.8 times/week (P=0.016), just as their consumption of soft drinks was reduced from 0.7 to 0.1l/day (P=0.006). Their consumption of coffee increased from 1.6 to 2.5 cups/day (P=0.086). The time women spent on light physical activity increased from 134 to 469min/week (P=0.055). The number of daily cigarettes smoked was reduced by 25.7% for all smokers. CONCLUSIONS: Our program showed that it is possible for women but not for men to reduce their risk factors for developing cardiovascular disease. The program is manageable in most outpatient clinics and can be performed by nursing staff interested in physical health with support from and in cooperation with medical doctors, psychiatrist and leaders/managers.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/prevenção & controle
Promoção da Saúde
Pacientes Ambulatoriais/psicologia
Esquizofrenia/terapia
[Mh] Termos MeSH secundário: Adulto
Doenças Cardiovasculares/mortalidade
Doenças Cardiovasculares/terapia
Exercício/fisiologia
Feminino
Seguimentos
Seres Humanos
Estilo de Vida
Masculino
Fatores de Risco
Esquizofrenia/complicações
Fumar/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


  8 / 84610 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29179826
[Au] Autor:Oh E; Song E; Shin J
[Ad] Endereço:Department of Nursing, Jeonbuk Science College, Republic of Korea.
[Ti] Título:Individual Factors Affecting Self-esteem, and Relationships Among Self-esteem, Body Mass Index, and Body Image in Patients With Schizophrenia.
[So] Source:Arch Psychiatr Nurs;31(6):588-595, 2017 12.
[Is] ISSN:1532-8228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purposes of this study were to identify correlations between body mass index, body image, and self-esteem in patients with schizophrenia and to analyse the specific factors affecting self-esteem. This study had a descriptive design, utilising a cross-sectional survey. Participants were patients with schizophrenia who were admitted to a mental health facility in South Korea. A total of 180 questionnaires were distributed, and an appropriate total sample size of 167 valid questionnaires was analysed. Self-esteem was significantly correlated with body image, the subscale of appearance orientation, and body areas satisfaction. However, body mass index exhibited no significant correlation with any variable. The variables found to have a significant explanatory power of 21.4% were appearance orientation and body areas satisfaction. The explanatory power of all factors was 33.6%. The self-esteem of patients with schizophrenia was influenced by body mass index and body image. The positive symptoms of schizophrenia can be controlled by medication, whereas negative symptoms can be improved through education and nursing care with medication. Thus, psychiatric nurses should develop education and care programs that contribute to the positive body image and self-esteem of patients with schizophrenia.
[Mh] Termos MeSH primário: Imagem Corporal
Índice de Massa Corporal
Esquizofrenia
Autoimagem
[Mh] Termos MeSH secundário: Adulto
Antipsicóticos/uso terapêutico
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Enfermagem Psiquiátrica/métodos
República da Coreia
Esquizofrenia/tratamento farmacológico
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antipsychotic Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


  9 / 84610 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28463847
[Au] Autor:Benítez-Burraco A; Di Pietro L; Barba M; Lattanzi W
[Ad] Endereço:Department of Philology, Faculty of Humanities, University of Huelva, Huelva, Spain.
[Ti] Título:Schizophrenia and Human Self-Domestication: An Evolutionary Linguistics Approach.
[So] Source:Brain Behav Evol;89(3):162-184, 2017.
[Is] ISSN:1421-9743
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Schizophrenia (SZ) is a pervasive neurodevelopmental disorder that entails social and cognitive deficits, including marked language problems. Its complex multifactorial etiopathogenesis, including genetic and environmental factors, is still widely uncertain. SZ incidence has always been high and quite stable in human populations, across time and regardless of cultural implications, for unclear reasons. It has been hypothesized that SZ pathophysiology may involve the biological components that changed during the recent human evolutionary history, and led to our distinctive mode of cognition, which includes language skills. In this paper we explore this hypothesis, focusing on the self-domestication of the human species. This has been claimed to account for many human-specific distinctive traits, including aspects of our behavior and cognition, and to favor the emergence of complex languages through cultural evolution. The "domestication syndrome" in mammals comprises the constellation of traits exhibited by domesticated strains, seemingly resulting from the hypofunction of the neural crest. It is our intention to show that people with SZ exhibit more marked domesticated traits at the morphological, physiological, and behavioral levels. We also show that genes involved in domestication and neural crest development and function comprise nearly 20% of SZ candidates, most of which exhibit altered expression profiles in the brain of SZ patients, specifically in areas involved in language processing. Based on these observations, we conclude that SZ may represent an abnormal ontogenetic itinerary for the human faculty of language, resulting, at least in part, from changes in genes important for the domestication syndrome and primarily involving the neural crest.
[Mh] Termos MeSH primário: Esquizofrenia/genética
Esquizofrenia/fisiopatologia
[Mh] Termos MeSH secundário: Evolução Biológica
Encéfalo/patologia
Cognição/fisiologia
Transtornos Cognitivos/fisiopatologia
Bases de Dados Genéticas
Regulação da Expressão Gênica no Desenvolvimento/genética
Seres Humanos
Linguagem
Linguística/métodos
Crista Neural/fisiologia
Psicologia do Esquizofrênico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1159/000468506


  10 / 84610 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28461252
[Au] Autor:Nedic Erjavec G; Uzun S; Nikolac Perkovic M; Kozumplik O; Svob Strac D; Mimica N; Hirasawa-Fujita M; Domino EF; Pivac N
[Ad] Endereço:Rudjer Boskovic Institute, Division of Molecular Medicine, Zagreb, Croatia.
[Ti] Título:Cortisol in schizophrenia: No association with tobacco smoking, clinical symptoms or antipsychotic medication.
[So] Source:Prog Neuropsychopharmacol Biol Psychiatry;77:228-235, 2017 Jul 03.
[Is] ISSN:1878-4216
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cigarette smoking is associated with higher cortisol levels in healthy subjects. In schizophrenia this relationship is not clear. There are divergent results on the association between cortisol with smoking, clinical symptoms and medication in schizophrenia. This study evaluated this association in 196 Caucasian inpatients with schizophrenia (51.30±26.68years old), subdivided into 123 smokers and 73 non-smokers. Basal salivary cortisol levels were measured twice, at 08.00 and 09.00AM, 90-120min after awakening. The effect of smoking on cortisol was evaluated according to current smoking status, the number of cigarettes/day and the nicotine addiction intensity. The influence of clinical symptoms and/or antipsychotic medication on cortisol was determined using the Positive and Negative Syndrome Scale (PANSS), and chlorpromazine equivalent doses. Non-smokers were older, received lower doses of antipsychotics, had higher PANSS scores, and had longer duration of illness than smokers. Salivary cortisol was similar in schizophrenic patients subdivided according to the smoking status, the number of cigarettes/day and nicotine addiction intensity. No significant correlation was found between salivary cortisol and PANSS scores, chlorpromazine equivalent doses, age of onset or the duration of illness. The findings revealed no association between salivary cortisol and smoking, nicotine addiction intensity, or clinical symptoms. Our preliminary data showed no correlation between salivary cortisol and chlorpromazine equivalent doses and/or antipsychotic medication. Our findings suggest that smoking does not affect the cortisol response in schizophrenic patients as it has been shown in healthy individuals. Future studies should investigate a possible desensitization of the stress system to smoking.
[Mh] Termos MeSH primário: Antipsicóticos/uso terapêutico
Hidrocortisona/metabolismo
Esquizofrenia/metabolismo
Fumar/metabolismo
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
Saliva/metabolismo
Esquizofrenia/diagnóstico
Esquizofrenia/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE



página 1 de 8461 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde