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[PMID]:29267500
[Au] Autor:Vieira E; Maia HS; Monteiro CB; Carvalho LM; Tonon T; Vanz AP; Schwartz IVD; Ribeiro MG
[Ad] Endereço:Agência Nacional de Saúde Suplementar, Rio de Janeiro, RJ, Brasil.
[Ti] Título:Quality of life and adherence to treatment in early-treated Brazilian phenylketonuria pediatric patients.
[So] Source:Braz J Med Biol Res;51(2):e6709, 2017 Dec 11.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Early dietary treatment of phenylketonuria (PKU), an inborn error of phenylalanine (Phe) metabolism, results in normal cognitive development. Although health-related quality of life (HRQoL) of PKU patients has been reported as unaffected in high-income countries, there are scarce data concerning HRQoL and adherence to treatment of PKU children and adolescents from Brazil. The present study compared HRQoL scores in core dimensions of Brazilian early-treated PKU pediatric patients with those of a reference population, and explored possible relationships between adherence to treatment and HRQoL. Early-treated PKU pediatric patient HRQoL was evaluated by self- and parent-proxy reports of the Pediatric Quality of Life Inventory (PedsQL) core scales. Adherence to treatment was evaluated by median Phe levels and percentage of results within the therapeutic target range in two periods. Means for total and core scales scores of PedsQL self- and parent proxy-reports of PKU patients were significantly lower than their respective means for controls. Adequacy of median Phe concentrations and the mean percentage of values in the target range fell substantially from the first year of life to the last year of this study. There was no significant difference in mean total and core scale scores for self- and parent proxy-reports between patients with adequate and those with inadequate median Phe concentrations. The harmful consequences for intellectual capacity caused by poor adherence to dietary treatment could explain the observed decrease in all HRQoL scales, especially in school functioning. Healthcare system and financial difficulties may also have influenced negatively all HRQoL dimensions.
[Mh] Termos MeSH primário: Fenilcetonúrias/dietoterapia
Qualidade de Vida
Cooperação e Adesão ao Tratamento/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Análise de Variância
Brasil
Criança
Feminino
Seres Humanos
Testes de Inteligência
Modelos Lineares
Masculino
Pais
Fenilalanina/sangue
Fenilcetonúrias/psicologia
Procurador
Qualidade de Vida/psicologia
Prevenção Secundária
Autorrelato
Fatores Socioeconômicos
Fatores de Tempo
Cooperação e Adesão ao Tratamento/psicologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
47E5O17Y3R (Phenylalanine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29231021
[Au] Autor:Wang JJ; Liu C; Liu L; Zhang SY; Li HZ; Cai WX
[Ad] Endereço:Wenzhou Medical University, Wenzhou 325035, China.
[Ti] Título:[Eye Movement Characteristics of Cooperation Degree during Image Completion Test in Psychiatric Impairment Assessment].
[So] Source:Fa Yi Xue Za Zhi;33(2):154-157, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To explore the difference of eye movement characteristics between uncooperative and cooperative subjects with mental disorder after cerebral trauma. METHODS: Thirty-nine subjects which needed psychiatric impairment assessment were selected. According to the binomial forced-choice digit memory test (BFDMT), all subjects were divided into cooperative and uncooperative groups. The subjects were asked to take the image completion test from Wechsler adult intelligence scale. Meanwhile, the data of eye movement track, fixation, saccade, pupil and blink were recorded by the track system of eye movement. RESULTS: There were significantly differences ( <0.05) in the data of saccade between cooperative (10 cases) and uncooperative groups (29 cases). The frequency, time, amplitude, acceleration of saccadic in uncooperative group were significantly higher than cooperation group. The saccade latencies of cooperation group increased more than uncooperative group. There was a significant difference ( <0.05) in total discrete distance, average distance and total time of fixation between two groups, while the average duration time, number and frequency of fixation had no significantly difference ( >0.05) between two groups. And the blink frequency of cooperation group was higher than uncooperative group. CONCLUSIONS: Eye movement can be an objective index for the primary judgment of cooperation level.
[Mh] Termos MeSH primário: Movimentos Oculares/fisiologia
Movimentos Sacádicos/fisiologia
[Mh] Termos MeSH secundário: Adulto
Medições dos Movimentos Oculares
Seres Humanos
Testes de Inteligência
Escalas de Wechsler
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.009


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[PMID]:28749089
[Au] Autor:Vijverberg EGB; Schouws S; Meesters PD; Verwijk E; Comijs H; Koene T; Schreuder C; Beekman A; Scheltens P; Stek M; Pijnenburg Y; Dols A
[Ad] Endereço:Alzheimer Center and Department of Neurology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands. e.vijverberg@vumc.nl.
[Ti] Título:Cognitive Deficits in Patients With Neuropsychiatric Symptoms: A Comparative Study Between Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders.
[So] Source:J Clin Psychiatry;78(8):e940-e946, 2017 Sep/Oct.
[Is] ISSN:1555-2101
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare neuropsychological profiles in behavioral variant frontotemporal dementia (bvFTD) with its most common primary psychiatric differential diagnoses, major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia, in older patients with active symptoms. METHODS: We included patients from different cohorts with MDD (DSM-IV-TR: 296.20-296.23, 296.30-296.33; n = 42; mean ± SD age, 72.0 ± 8.0 years; female = 57.1%) included from 2002 to 2007, noneuthymic BD (DSM-IV-TR: 296.00-296.06, 296.40-296.46, 296.50-296.56, 296.60-296.66, 296.7; DSM-IV-TR: 296.89; DSM-IV-TR: 296.80; n = 41; age, 71.7 ± 8.8 years; female = 53.7%) included from 2011 to 2015, nonremitted schizophrenia (DSM-IV-TR: 295.10, 295.20, 295.30, 295.60, 295.90; n = 47; age, 67.5 ± 7.1 years; female = 66%) included from 2006 to 2008, or probable/definite bvFTD (n = 173; age, 62.6 ± 8.0 years; female = 39.9%) (Frontotemporal Dementia Consensus criteria) included from 2000 to 2015 and healthy controls (n = 78; age, 71.9 ± 8.0 years; female = 71.8%) included from 2005 to 2007. Neuropsychological tests concerned the domains of attention and working memory, verbal memory, verbal fluency, and executive functioning. Analyses of variance were performed with age, gender, and education level as covariates. Post hoc Bonferroni tests were used to detail group differences. RESULTS: Compared to the healthy controls, both the bvFTD and primary psychiatric disorder groups showed significant impairment on all cognitive domains. Executive function was more disturbed in all primary psychiatric disorders compared to bvFTD (P < .001). Attention and working memory were significantly better in the bvFTD and schizophrenia groups compared to the MDD and BD groups (P < .001). For verbal memory, the bvFTD group scored significantly higher compared to patients with schizophrenia, BD, or MDD (P < .001). Patients with bvFTD had significantly lower scores on verbal fluency, especially due to Animal Naming, in comparison with the BD group (P < .001); however, these scores were not significantly different from those of MDD or schizophrenia patients. CONCLUSIONS: Cognitive deficits in bvFTD are less severe than in primary psychiatric disorders with active symptoms. This indicates that in the differential diagnosis of bvFTD, disturbances on tests for cognitive performance do not rule out primary psychiatric diagnoses.
[Mh] Termos MeSH primário: Disfunção Cognitiva
Demência Frontotemporal
Transtornos Mentais
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Análise de Variância
Disfunção Cognitiva/diagnóstico
Disfunção Cognitiva/epidemiologia
Disfunção Cognitiva/etiologia
Estudos de Coortes
Manual Diagnóstico e Estatístico de Transtornos Mentais
Função Executiva
Feminino
Demência Frontotemporal/complicações
Demência Frontotemporal/diagnóstico
Demência Frontotemporal/psicologia
Seres Humanos
Testes de Inteligência
Masculino
Memória
Transtornos Mentais/classificação
Transtornos Mentais/complicações
Transtornos Mentais/diagnóstico
Transtornos Mentais/psicologia
Países Baixos/epidemiologia
Testes Neuropsicológicos
Escalas de Graduação Psiquiátrica
Índice de Gravidade de Doença
Fatores Socioeconômicos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


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[PMID]:28743040
[Au] Autor:Furlong MA; Herring A; Buckley JP; Goldman BD; Daniels JL; Engel LS; Wolff MS; Chen J; Wetmur J; Barr DB; Engel SM
[Ad] Endereço:Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, United States. Electronic address: mfurlong@email.arizona.edu.
[Ti] Título:Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes.
[So] Source:Environ Res;158:737-747, 2017 10.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Prenatal exposure to organophosphorus pesticides (OPs) has been associated with different neurodevelopmental outcomes across different cohorts. A phenotypic approach may address some of these differences by incorporating information across scales and accounting for the complex correlational structure of neurodevelopmental outcomes. Additionally, Bayesian hierarchical modeling can account for confounding by collinear co-exposures. We use this framework to examine associations between prenatal exposure to OPs and behavior, executive functioning, and IQ assessed at age 6-9 years in a cohort of 404 mother/infant pairs recruited during pregnancy. We derived phenotypes of neurodevelopment with a factor analysis, and estimated associations between OP metabolites and these phenotypes in Bayesian hierarchical models for exposure mixtures. We report seven factors: 1) Impulsivity and Externalizing, 2) Executive Functioning, 3) Internalizing, 4) Perceptual Reasoning, 5) Adaptability, 6) Processing Speed, and 7) Verbal Intelligence. These, along with the Working Memory Index, were standardized and scaled so that positive values reflected positive attributes and negative values represented adverse outcomes. Standardized dimethylphosphate metabolites were negatively associated with Internalizing factor scores (ß^ - 0.13, 95% CI - 0.26, 0.00) but positively associated with Executive Functioning factor scores (ß^ 0.18, 95% CI 0.04, 0.31). Standardized diethylphosphate metabolites were negatively associated with the Working Memory Index (ß^ - 0.17, 95% CI - 0.33, - 0.03). Associations with factor scores were generally stronger and more precise than associations with individual instrument-specific items. Factor analysis of outcomes may provide some advantages in etiological studies of childhood neurodevelopment by incorporating information across scales to reduce dimensionality and improve precision.
[Mh] Termos MeSH primário: Comportamento Infantil/efeitos dos fármacos
Desenvolvimento Infantil/efeitos dos fármacos
Poluentes Ambientais/toxicidade
Função Executiva/efeitos dos fármacos
Inteligência/efeitos dos fármacos
Compostos Organofosforados/toxicidade
Efeitos Tardios da Exposição Pré-Natal/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Feminino
Seres Humanos
Testes de Inteligência
Estudos Longitudinais
Masculino
Exposição Materna
Cidade de Nova Iorque/epidemiologia
Praguicidas/toxicidade
Gravidez
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Organophosphorus Compounds); 0 (Pesticides)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180303
[Lr] Data última revisão:
180303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


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[PMID]:28453778
[Au] Autor:Caramaschi D; Sharp GC; Nohr EA; Berryman K; Lewis SJ; Davey Smith G; Relton CL
[Ad] Endereço:Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine.
[Ti] Título:Exploring a causal role of DNA methylation in the relationship between maternal vitamin B12 during pregnancy and child's IQ at age 8, cognitive performance and educational attainment: a two-step Mendelian randomization study.
[So] Source:Hum Mol Genet;26(15):3001-3013, 2017 08 01.
[Is] ISSN:1460-2083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An adequate intake of vitamin B12 during pregnancy plays an important role in offspring neurodevelopment, potentially via epigenetic processes. We used a two-step Mendelian randomization approach to assess whether DNA methylation plays a mediating and causal role in associations between maternal vitamin B12 status and offspring's cognition. Firstly, we estimated the causal effect of maternal vitamin B12 levels on cord blood DNA methylation using the maternal FUT2 genotypes rs492602:A > G and rs1047781:A > T as proxies for circulating vitamin B12 levels in the Avon Longitudinal Study of Parents and Children (ALSPAC) and we tested the observed associations in a replication cohort. Secondly, we estimated the causal effect of DNA methylation on IQ using the offspring genotype at sites close to the methylated CpG site as a proxy for DNA methylation in ALSPAC and in a replication sample. The first step Mendelian randomization estimated that maternal vitamin B12 had a small causal effect on DNA methylation in offspring at three CpG sites, which was replicated for one of the sites. The second step Mendelian randomization found weak evidence of a causal effect of DNA methylation at two of these sites on childhood performance IQ which was replicated for one of the sites. The findings support a causal effect of maternal vitamin B12 levels on cord blood DNA methylation, and a causal effect of vitamin B12-responsive DNA methylation changes on children's cognition. Some limitations were identified and future studies using a similar approach should aim to overcome such issues.
[Mh] Termos MeSH primário: Inteligência/efeitos dos fármacos
Efeitos Tardios da Exposição Pré-Natal/genética
Vitamina B 12/metabolismo
[Mh] Termos MeSH secundário: Adulto
Criança
Cognição/efeitos dos fármacos
Metilação de DNA/genética
Metilação de DNA/fisiologia
Epigênese Genética/genética
Família
Feminino
Sangue Fetal/metabolismo
Genótipo
Seres Humanos
Testes de Inteligência
Estudos Longitudinais
Masculino
Análise da Randomização Mendeliana
Gravidez
Efeitos Tardios da Exposição Pré-Natal/metabolismo
Distribuição Aleatória
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180225
[Lr] Data última revisão:
180225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/hmg/ddx164


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[PMID]:28455721
[Au] Autor:Rosa M; Puig O; Lázaro L; Vallés V; Lera S; Sánchez-Gistau V; Calvo R
[Ad] Endereço:Department of Child and Adolescent Psychiatry and Psychology, Clínic Institute of Neurosciences, Hospital Clínic de Barcelona, Barcelona, Spain.
[Ti] Título:Broad Cognitive Profile in Children and Adolescents with HF-ASD and in Their Siblings: Widespread Underperformance and its Clinical and Adaptive Correlates.
[So] Source:J Autism Dev Disord;47(7):2153-2162, 2017 Jul.
[Is] ISSN:1573-3432
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite evidence supporting the presence of cognitive deficits in children and adolescents with high-functioning autism spectrum disorder (HF-ASD), the nature of these deficits and their clinical and adaptive correlates remain unclear. Moreover, there are few cognitive studies of ASD siblings as a high risk population. We compared 50 children and adolescents with HF-ASD, 22 unaffected siblings of the HF-ASD sample and 34 community controls using an extensive neuropsychological battery. Planning, cognitive flexibility, verbal and working memory, visual local-global processing and emotion recognition are impaired in HF-ASD. Worse cognitive performance, especially in verbal and working memory, was significantly correlated with more severe symptoms and poorer adaptive functioning, also when controlling for intelligence quotient. Results in siblings may suggest an intermediate profile.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/fisiopatologia
Cognição
Testes de Inteligência/normas
Irmãos
[Mh] Termos MeSH secundário: Adolescente
Transtorno do Espectro Autista/diagnóstico
Criança
Emoções
Feminino
Seres Humanos
Masculino
Memória de Curto Prazo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s10803-017-3137-x


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[PMID]:27777716
[Au] Autor:Shah P; Catmur C; Bird G
[Ad] Endereço:Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, University of London, London, SE5 8AF UK.
[Ti] Título:Emotional decision-making in autism spectrum disorder: the roles of interoception and alexithymia.
[So] Source:Mol Autism;7:43, 2016.
[Is] ISSN:2040-2392
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The way choices are framed influences decision-making. These "framing effects" emerge through the integration of emotional responses into decision-making under uncertainty. It was previously reported that susceptibility to the framing effect was reduced in individuals with autism spectrum disorder (ASD) due to a reduced tendency to incorporate emotional information into the decision-making process. However, recent research indicates that, where observed, emotional processing impairments in ASD may be due to co-occurring alexithymia. Alexithymia is thought to arise due to impaired interoception (the ability to perceive the internal state of one's body), raising the possibility that emotional signals are not perceived and thus not integrated into decision-making in those with alexithymia and that therefore reduced framing effects in ASD are a product of co-occurring alexithymia rather than ASD per se. Accordingly, the present study compared framing effects in autistic individuals with neurotypical controls matched for alexithymia. Results showed a marked deviation between groups. The framing effect was, in line with previous data, significantly smaller in autistic individuals, and there was no relationship between alexithymia or interoception and decision-making in the ASD group. In the neurotypical group, however, the size of the framing effect was associated with alexithymia and interoception, even after controlling for autistic traits. These results demonstrate that although framing effects are associated with interoception and alexithymia in the neurotypical population, emotional and interoceptive signals have less impact upon the decision-making process in ASD.
[Mh] Termos MeSH primário: Sintomas Afetivos/psicologia
Transtorno do Espectro Autista/psicologia
Tomada de Decisões
Interocepção/fisiologia
[Mh] Termos MeSH secundário: Adulto
Sintomas Afetivos/fisiopatologia
Transtorno do Espectro Autista/fisiopatologia
Estudos de Casos e Controles
Feminino
Frustração
Felicidade
Seres Humanos
Testes de Inteligência
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29066580
[Au] Autor:Lopez AS; Lanzieri TM; Claussen AH; Vinson SS; Turcich MR; Iovino IR; Voigt RG; Caviness AC; Miller JA; Williamson WD; Hales CM; Bialek SR; Demmler-Harrison G; Congenital Cytomegalovirus Longitudinal Study Group
[Ad] Endereço:National Center for Immunization and Respiratory Diseases, and.
[Ti] Título:Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection.
[So] Source:Pediatrics;140(5), 2017 Nov.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To examine intelligence, language, and academic achievement through 18 years of age among children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected infants. METHODS: We used growth curve modeling to analyze trends in IQ (full-scale, verbal, and nonverbal intelligence), receptive and expressive vocabulary, and academic achievement in math and reading. Separate models were fit for each outcome, modeling the change in overall scores with increasing age for patients with normal hearing ( = 78) or with sensorineural hearing loss (SNHL) diagnosed by 2 years of age ( = 11) and controls ( = 40). RESULTS: Patients with SNHL had full-scale intelligence and receptive vocabulary scores that were 7.0 and 13.1 points lower, respectively, compared with controls, but no significant differences were noted in these scores among patients with normal hearing and controls. No significant differences were noted in scores for verbal and nonverbal intelligence, expressive vocabulary, and academic achievement in math and reading among patients with normal hearing or with SNHL and controls. CONCLUSIONS: Infants with asymptomatic congenital cytomegalovirus infection identified through newborn screening with normal hearing by age 2 years do not appear to have differences in IQ, vocabulary or academic achievement scores during childhood, or adolescence compared with uninfected children.
[Mh] Termos MeSH primário: Doenças Assintomáticas/epidemiologia
Infecções por Citomegalovirus/epidemiologia
Escolaridade
Testes de Inteligência
Inteligência
[Mh] Termos MeSH secundário: Adolescente
Adulto
Doenças Assintomáticas/psicologia
Criança
Pré-Escolar
Infecções por Citomegalovirus/diagnóstico
Infecções por Citomegalovirus/psicologia
Feminino
Seres Humanos
Lactente
Recém-Nascido
Estudos Longitudinais
Masculino
Meia-Idade
Triagem Neonatal/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE


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[PMID]:28987057
[Au] Autor:Karakula-Juchnowicz H; Stecka M
[Ad] Endereço:I Klinika Psychiatrii, Psychoterapii i Wczesnej Interwencji UM w Lublinie.
[Ti] Título:Polish Adult Reading Test (PART) - construction of Polish test for estimating the level of premorbid intelligence in schizophrenia.
[Ti] Título:Polski Test Czytania Slów dla Doroslych (PART) ­ konstrukcja polskiego testu do pomiaru poziomu inteligencji przedchorobowej w schizofrenii..
[So] Source:Psychiatr Pol;51(4):673-685, 2017 Aug 29.
[Is] ISSN:2391-5854
[Cp] País de publicação:Poland
[La] Idioma:eng; pol
[Ab] Resumo:OBJECTIVES: In view of unavailability in Poland of the standardized methods to measure PIQ, the aim of the work was to develop a Polish test to assess the premorbid level of intelligence - PART(Polish AdultReading Test) and to measureits psychometric properties, such as validity, reliability as well as standardization in the group of schizophrenia patients. METHODS: The principles of PART construction were based on the idea of popular worldwide National Adult Reading Test by Hazel Nelson. The research comprised a group of 122 subjects (65 schizophrenia patients and 57 healthy people), aged 18-60 years, matched for age and gender. RESULTS: PART appears to be a method with high internal consistency and reliability measured by test-retest, inter-rater reliability, and the method with acceptable diagnostic and prognostic validity. The standardized procedures of PART have been investigated and described. CONCLUSIONS: Considering the psychometric values of PART and a short time of its performance, the test may be a useful diagnostic instrument in the assessment of premorbid level of intelligence in a group of schizophrenic patients.
[Mh] Termos MeSH primário: Testes de Inteligência/normas
Inteligência
Leitura
[Mh] Termos MeSH secundário: Adulto
Transtornos Cognitivos/diagnóstico
Feminino
Seres Humanos
Masculino
Psicometria
Transtornos Psicóticos/diagnóstico
Reprodutibilidade dos Testes
Psicologia do Esquizofrênico
Transtorno da Personalidade Esquizotípica/diagnóstico
Transtorno da Personalidade Esquizotípica/psicologia
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE


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Wajngarten, Mauricio
Lotufo, Paulo A
Texto completo SciELO Brasil
[PMID]:28954006
[Au] Autor:Squarzoni P; Tamashiro-Duran JH; Duran FLS; Leite CC; Wajngarten M; Scazufca M; Menezes PR; Lotufo PA; Alves TCTF; Busatto GF
[Ad] Endereço:Departamento de Psiquiatria, Instituto de Psiquiatria (IPQ), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
[Ti] Título:High frequency of silent brain infarcts associated with cognitive deficits in an economically disadvantaged population.
[So] Source:Clinics (Sao Paulo);72(8):474-480, 2017 Aug.
[Is] ISSN:1980-5322
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE:: Using magnetic resonance imaging, we aimed to assess the presence of silent brain vascular lesions in a sample of apparently healthy elderly individuals who were recruited from an economically disadvantaged urban region (São Paulo, Brazil). We also wished to investigate whether the findings were associated with worse cognitive performance. METHODS:: A sample of 250 elderly subjects (66-75 years) without dementia or neuropsychiatric disorders were recruited from predefined census sectors of an economically disadvantaged area of Sao Paulo and received structural magnetic resonance imaging scans and cognitive testing. A high proportion of individuals had very low levels of education (4 years or less, n=185; 21 with no formal education). RESULTS:: The prevalence of at least one silent vascular-related cortical or subcortical lesion was 22.8% (95% confidence interval, 17.7-28.5), and the basal ganglia was the most frequently affected site (63.14% of cases). The subgroup with brain infarcts presented significantly lower levels of education than the subgroup with no brain lesions as well as significantly worse current performance in cognitive test domains, including memory and attention (p<0.002). CONCLUSIONS:: Silent brain infarcts were present at a substantially high frequency in our elderly sample from an economically disadvantaged urban region and were significantly more prevalent in subjects with lower levels of education. Covert cerebrovascular disease significantly contributes to cognitive deficits, and in the absence of magnetic resonance imaging data, this cognitive impairment may be considered simply related to ageing. Emphatic attention should be paid to potentially deleterious effects of vascular brain lesions in poorly educated elderly individuals from economically disadvantaged environments.
[Mh] Termos MeSH primário: Doenças Assintomáticas/epidemiologia
Infarto Encefálico/complicações
Infarto Encefálico/epidemiologia
Disfunção Cognitiva/epidemiologia
Disfunção Cognitiva/etiologia
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Análise de Variância
Infarto Encefálico/fisiopatologia
Brasil/epidemiologia
Disfunção Cognitiva/fisiopatologia
Feminino
Seres Humanos
Testes de Inteligência
Imagem por Ressonância Magnética
Masculino
Testes Neuropsicológicos
Prevalência
Escalas de Graduação Psiquiátrica
Valores de Referência
Medição de Risco
Fatores de Risco
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE



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