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[PMID]:28449599
[Au] Autor:Weikum D; Shrestha R; Ferro EG; Vagenas P; Copenhaver M; Spudich S; Alpert MD; Cabello R; Lama JR; Sanchez J; Altice FL
[Ad] Endereço:a Section of Infectious Diseases, AIDS Program , Yale School of Medicine , New Haven , CT , USA.
[Ti] Título:An explanatory factor analysis of a brief self-report scale to detect neurocognitive impairment among HIV-positive men who have sex with men and transgender women in Peru.
[So] Source:AIDS Care;29(10):1297-1301, 2017 Oct.
[Is] ISSN:1360-0451
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neurocognitive impairment (NCI) has been associated with poor clinical outcomes in various patient populations. This study used exploratory factor analysis (EFA) to examine the factor structure of the existing 95-item Neuropsychological Impairment Scale (NIS) to create a suitable NCI screening instrument for people living with HIV (PLH). In Lima, Peru, 313 HIV-positive men who have sex with men (MSM) and transgender women (TGW) prescribed antiretroviral therapy (ART) completed the NIS using computer-assisted self-interviews (CASI). The EFA used principal axis factoring and orthogonal varimax rotation, which resulted in 42 items with an 8-factor solution that explained 51.8% of the overall variance. The revised, 8-factor, Brief Inventory of Neurocognitive Impairment for Peru (BINI-P) showed a diverse set of factors with excellent to good reliability (i.e., F α = 0.92 to F α = 0.78). This EFA supports the use of the BINI-P to screen for NCI among Spanish-speaking, HIV-positive MSM and TGW. Future research should examine the effectiveness of the BINI-P in detecting NCI in clinical care settings and the impact of NCI on HIV health-related outcomes, including linkage and retention in care, ART adherence and HIV risk behaviors.
[Mh] Termos MeSH primário: Infecções por HIV/psicologia
Homossexualidade Masculina/psicologia
Transtornos Neurocognitivos/diagnóstico
Testes Neuropsicológicos
Pessoas Transgênero/psicologia
[Mh] Termos MeSH secundário: Adulto
Análise Fatorial
Feminino
Infecções por HIV/tratamento farmacológico
Seres Humanos
Masculino
Transtornos Neurocognitivos/psicologia
Peru
Reprodutibilidade dos Testes
Autorrelato
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/09540121.2017.1322681


  2 / 81958 MEDLINE  
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[PMID]:28749089
[Au] Autor:Vijverberg EGB; Schouws S; Meesters PD; Verwijk E; Comijs H; Koene T; Schreuder C; Beekman A; Scheltens P; Stek M; Pijnenburg Y; Dols A
[Ad] Endereço:Alzheimer Center and Department of Neurology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands. e.vijverberg@vumc.nl.
[Ti] Título:Cognitive Deficits in Patients With Neuropsychiatric Symptoms: A Comparative Study Between Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders.
[So] Source:J Clin Psychiatry;78(8):e940-e946, 2017 Sep/Oct.
[Is] ISSN:1555-2101
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare neuropsychological profiles in behavioral variant frontotemporal dementia (bvFTD) with its most common primary psychiatric differential diagnoses, major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia, in older patients with active symptoms. METHODS: We included patients from different cohorts with MDD (DSM-IV-TR: 296.20-296.23, 296.30-296.33; n = 42; mean ± SD age, 72.0 ± 8.0 years; female = 57.1%) included from 2002 to 2007, noneuthymic BD (DSM-IV-TR: 296.00-296.06, 296.40-296.46, 296.50-296.56, 296.60-296.66, 296.7; DSM-IV-TR: 296.89; DSM-IV-TR: 296.80; n = 41; age, 71.7 ± 8.8 years; female = 53.7%) included from 2011 to 2015, nonremitted schizophrenia (DSM-IV-TR: 295.10, 295.20, 295.30, 295.60, 295.90; n = 47; age, 67.5 ± 7.1 years; female = 66%) included from 2006 to 2008, or probable/definite bvFTD (n = 173; age, 62.6 ± 8.0 years; female = 39.9%) (Frontotemporal Dementia Consensus criteria) included from 2000 to 2015 and healthy controls (n = 78; age, 71.9 ± 8.0 years; female = 71.8%) included from 2005 to 2007. Neuropsychological tests concerned the domains of attention and working memory, verbal memory, verbal fluency, and executive functioning. Analyses of variance were performed with age, gender, and education level as covariates. Post hoc Bonferroni tests were used to detail group differences. RESULTS: Compared to the healthy controls, both the bvFTD and primary psychiatric disorder groups showed significant impairment on all cognitive domains. Executive function was more disturbed in all primary psychiatric disorders compared to bvFTD (P < .001). Attention and working memory were significantly better in the bvFTD and schizophrenia groups compared to the MDD and BD groups (P < .001). For verbal memory, the bvFTD group scored significantly higher compared to patients with schizophrenia, BD, or MDD (P < .001). Patients with bvFTD had significantly lower scores on verbal fluency, especially due to Animal Naming, in comparison with the BD group (P < .001); however, these scores were not significantly different from those of MDD or schizophrenia patients. CONCLUSIONS: Cognitive deficits in bvFTD are less severe than in primary psychiatric disorders with active symptoms. This indicates that in the differential diagnosis of bvFTD, disturbances on tests for cognitive performance do not rule out primary psychiatric diagnoses.
[Mh] Termos MeSH primário: Disfunção Cognitiva
Demência Frontotemporal
Transtornos Mentais
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Análise de Variância
Disfunção Cognitiva/diagnóstico
Disfunção Cognitiva/epidemiologia
Disfunção Cognitiva/etiologia
Estudos de Coortes
Manual Diagnóstico e Estatístico de Transtornos Mentais
Função Executiva
Feminino
Demência Frontotemporal/complicações
Demência Frontotemporal/diagnóstico
Demência Frontotemporal/psicologia
Seres Humanos
Testes de Inteligência
Masculino
Memória
Transtornos Mentais/classificação
Transtornos Mentais/complicações
Transtornos Mentais/diagnóstico
Transtornos Mentais/psicologia
Países Baixos/epidemiologia
Testes Neuropsicológicos
Escalas de Graduação Psiquiátrica
Índice de Gravidade de Doença
Fatores Socioeconômicos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


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[PMID]:28469563
[Au] Autor:Kerr MSD; Sacré P; Kahn K; Park HJ; Johnson M; Lee J; Thompson S; Bulacio J; Jones J; González-Martínez J; Liégeois-Chauvel C; Sarma SV; Gale JT
[Ad] Endereço:Department of Biomedical Engineering, Johns Hopkins UniversityBaltimore, MD, USA.
[Ti] Título:The Role of Associative Cortices and Hippocampus during Movement Perturbations.
[So] Source:Front Neural Circuits;11:26, 2017.
[Is] ISSN:1662-5110
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Although motor control has been extensively studied, most research involving neural recordings has focused on primary motor cortex, pre-motor cortex, supplementary motor area, and cerebellum. These regions are involved during normal movements, however, associative cortices and hippocampus are also likely involved during perturbed movements as one must detect the unexpected disturbance, inhibit the previous motor plan, and create a new plan to compensate. Minimal data is available on these brain regions during such "robust" movements. Here, epileptic patients implanted with intracerebral electrodes performed reaching movements while experiencing occasional unexpected force perturbations allowing study of the fronto-parietal, limbic and hippocampal network at unprecedented high spatial, and temporal scales. Areas including orbitofrontal cortex (OFC) and hippocampus showed increased activation during perturbed trials. These results, coupled with a visual novelty control task, suggest the hippocampal MTL-P300 novelty response is modality independent, and that the OFC is involved in modifying motor plans during robust movement.
[Mh] Termos MeSH primário: Mapeamento Encefálico
Córtex Cerebral/fisiopatologia
Potenciais Evocados Visuais/fisiologia
Hipocampo/fisiopatologia
Transtornos dos Movimentos/patologia
[Mh] Termos MeSH secundário: Adulto
Eletroencefalografia
Epilepsia/complicações
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Transtornos dos Movimentos/etiologia
Vias Neurais/fisiopatologia
Testes Neuropsicológicos
Estimulação Luminosa
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.3389/fncir.2017.00026


  4 / 81958 MEDLINE  
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[PMID]:28448827
[Au] Autor:Broyd A; Balzan RP; Woodward TS; Allen P
[Ad] Endereço:Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College, London, UK.
[Ti] Título:Dopamine, cognitive biases and assessment of certainty: A neurocognitive model of delusions.
[So] Source:Clin Psychol Rev;54:96-106, 2017 Jun.
[Is] ISSN:1873-7811
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper examines the evidence that delusions can be explained within the framework of a neurocognitive model of how the brain assesses certainty. Here, 'certainty' refers to both low-level interpretations of one's environment and high-level (conscious) appraisals of one's beliefs and experiences. A model is proposed explaining how the brain systems responsible for assigning certainty might dysfunction, contributing to the cause and maintenance of delusional beliefs. It is suggested that delusions arise through a combination of perturbed striatal dopamine and aberrant salience as well as cognitive biases such as the tendency to jump to conclusions (JTC) and hypersalience of evidence-hypothesis matches. The role of emotion, stress, trauma and sociocultural factors in forming and modifying delusions is also considered. Understanding the mechanisms involved in forming and maintaining delusions has important clinical implications, as interventions that improve cognitive flexibility (e.g. cognitive remediation therapy and mindfulness training) could potentially attenuate neurocognitive processes.
[Mh] Termos MeSH primário: Cognição/fisiologia
Delusões/psicologia
Dopamina/metabolismo
Modelos Psicológicos
Psicologia do Esquizofrênico
[Mh] Termos MeSH secundário: Delusões/metabolismo
Seres Humanos
Testes Neuropsicológicos
Incerteza
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


  5 / 81958 MEDLINE  
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[PMID]:29415316
[Au] Autor:Labenz C; Schattenberg JM
[Ti] Título:[Animal Naming Test - Animals as diagnostic solution?]
[Ti] Título:Animal-Naming-Test ­ Tiere als diagnostischer Ausweg?.
[So] Source:Z Gastroenterol;56(2):168-169, 2018 02.
[Is] ISSN:1439-7803
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Testes Neuropsicológicos
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-117268


  6 / 81958 MEDLINE  
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[PMID]:29304167
[Au] Autor:Caine D; Nihat A; Crabb P; Rudge P; Cipolotti L; Collinge J; Mead S
[Ad] Endereço:NHS National Prion Clinic, National Hospital for Neurology and Neurosurgery (NHNN), University College London Hospitals NHS Foundation Trust, London, United Kingdom.
[Ti] Título:The language disorder of prion disease is characteristic of a dynamic aphasia and is rarely an isolated clinical feature.
[So] Source:PLoS One;13(1):e0190818, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Akinetic mutism is a key diagnostic feature of prion diseases, however, their rapidly progressive nature makes detailed investigation of the language disorder in a large cohort extremely challenging. This study aims to position prion diseases in the nosology of language disorders and improve early clinical recognition. METHODS: A systematic, prospective investigation of language disorders in a large cohort of patients diagnosed with prion diseases. 568 patients were included as a sub-study of the National Prion Monitoring Cohort. All patients had at least one assessment with the MRC Scale, a milestone-based functional scale with language and non-language components. Forty patients, with early symptoms and able to travel to the study site, were also administered a comprehensive battery of language tests (spontaneous speech, semantics, syntax, repetition, naming, comprehension and lexical retrieval under different conditions). RESULTS: 5/568 (0.9%) patients presented with leading language symptoms. Those with repeated measurements deteriorated at a slower rate in language compared to non-language milestones. Amongst the subgroup of 40 patients who underwent detailed language testing, only three tasks-semantic and phonemic fluency and sentence comprehension-were particularly vulnerable early in the disease. These tasks were highly correlated with performance on non-verbal executive tests. Patients were also impaired on a test of dynamic aphasia. CONCLUSION: These results provide evidence that the language disorder in prion disease is rarely an isolated clinical or cognitive feature. The language abnormality is indicative of a dynamic aphasia in the context of a prominent dysexecutive syndrome, similar to that seen in patients with the degenerative movement disorder progressive supranuclear palsy (PSP).
[Mh] Termos MeSH primário: Afasia/complicações
Doenças Priônicas/complicações
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Feminino
Seres Humanos
Testes de Linguagem
Masculino
Meia-Idade
Testes Neuropsicológicos
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190818


  7 / 81958 MEDLINE  
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[PMID]:28463345
[Au] Autor:Upadhyaya MA; Nasrallah HA
[Ad] Endereço:The Everest Foundation, Los Angeles, CA USA E-mail: mupadhya@bronxleb.org
[Ti] Título:The intense desire for healthy limb amputation: A dis-proprioceptive neuropsychiatric disorder.
[So] Source:Ann Clin Psychiatry;29(2):125-132, 2017 05.
[Is] ISSN:1547-3325
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The first mention of a condition in which apparently nonpsychotic individuals have a strong, unrelenting desire to amputate ≥1 of their healthy limbs was published nearly 4 decades ago. Once dismissed as a paraphilia, the condition in recent years has been re-investigated with neurologic testing and imaging, yielding evidence suggesting it may be attributable to a neuroanatomical anomaly. METHODS: A literature review of data was conducted of recently published studies with pinprick testing, magnetic resonance imaging (MRI)/functional MRI imaging, magnetoencephalography, and interviews of individuals with a desire for limb amputation. RESULTS: Published literature on this condition features studies with a limited number of participants. However, the results indicate that affected individuals predominantly desire amputation of the left lower limb, and correspondingly, usually have changes in cortical thickness in the right parietal lobe. CONCLUSIONS: Further investigation of this condition is warranted, particularly, more research into the precise nature of the anomalous neuroanatomy, biopsychosocial background of those with the condition, and longitudinal perspective of the childhood onset and evolution of symptoms. Large sample studies involving a collaborative effort across multiple sites are required.
[Mh] Termos MeSH primário: Amputação/psicologia
Transtornos Dismórficos Corporais
Técnicas de Rastreamento Neuroanatômico/métodos
Distúrbios Somatossensoriais
[Mh] Termos MeSH secundário: Transtornos Dismórficos Corporais/patologia
Transtornos Dismórficos Corporais/psicologia
Lateralidade Funcional
Seres Humanos
Imagem por Ressonância Magnética/métodos
Testes Neuropsicológicos
Distúrbios Somatossensoriais/patologia
Distúrbios Somatossensoriais/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  8 / 81958 MEDLINE  
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[PMID]:28054495
[Au] Autor:Ré AHN; Logan SW; Cattuzzo MT; Henrique RS; Tudela MC; Stodden DF
[Ad] Endereço:a Physical Education and Health , University of São Paulo , Sao Paulo , Brazil.
[Ti] Título:Comparison of motor competence levels on two assessments across childhood.
[So] Source:J Sports Sci;36(1):1-6, 2018 Jan.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study compared performances and motor delay classifications for the Test of Gross Motor Development-2nd edition (TGMD-2) and the Körperkoordinationstest Für Kinder (KTK) in a sample of 424 healthy children (47% girls) between 5 and 10 years of age. Low-to-moderate correlations (r range = 0.34-0.52) were found between assessments across age. In general, both boys and girls demonstrated higher raw scores across age groups. However, percentile scores indicated younger children outperformed older children, denoting a normative percentile-based decrease in motor competence (MC) in the older age groups. In total, the TGMD-2 and KTK classified 39.4% and 18.4% children, respectively, as demonstrating very low MC (percentile ≤5). In conclusion, the TGMD-2 classified significantly more children with motor delays than the KTK and the differences between children's motor skill classification levels by these assessments became greater as the age groups increased. Therefore, the TGMD-2 may demonstrate more susceptibility to sociocultural influences and be more influenced by cumulative motor experiences throughout childhood. Low-to-moderate correlations between assessments also suggest the TGMD-2 and KTK may measure different aspects of MC. As such, it may be important to use multiple assessments to comprehensively assess motor competence.
[Mh] Termos MeSH primário: Desenvolvimento Infantil/fisiologia
Deficiências do Desenvolvimento/classificação
Destreza Motora/fisiologia
Testes Neuropsicológicos
[Mh] Termos MeSH secundário: Fatores Etários
Brasil
Criança
Pré-Escolar
Estudos Transversais
Cultura
Deficiências do Desenvolvimento/diagnóstico
Feminino
Seres Humanos
Masculino
Fatores Sexuais
Fatores Socioeconômicos
Análise e Desempenho de Tarefas
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2016.1276294


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[PMID]:27778334
[Au] Autor:Gouveia A; Dias SP; Santos T; Rocha H; Coelho CR; Ruano L; Galego O; Diogo MC; Seixas D; Sá MJ; Batista S
[Ad] Endereço:Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
[Ti] Título:Cognitive impairment and magnetic resonance imaging correlates in primary progressive multiple sclerosis.
[So] Source:Acta Neurol Scand;136(2):109-115, 2017 Aug.
[Is] ISSN:1600-0404
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To characterize cognitive impairment in primary progressive multiple sclerosis (PPMS) and to correlate the pattern of cognitive deficits with brain magnetic resonance imaging (MRI) volumetric data. MATERIALS AND METHODS: In a multicenter cross-sectional study, we recruited consecutive patients with PPMS as well as age, sex, and education level-matched healthy controls (HC). All participants underwent neuropsychological (NP) assessment, and brain MRI was performed in patients with PPMS for analysis of lesion load, subcortical GM volumes, and regional cortical volumes. RESULTS: We recruited 55 patients with PPMS and 36 HC. Thirty-six patients were included in the MRI analysis. Patients with PPMS performed significantly worse than HC in all NP tests. Subcortical GM volume was significantly correlated with all NP tests, except for Stroop Test, with the largest effect for the thalamus (r=-.516 [BVMT-R DR, P=.016 FDR-corrected] to r=.664 [SDMT, P<.001 FDR-corrected]). In the stepwise linear regression model, thalamic volume was the only predictor of performance in all NP tests. CONCLUSION: Cognitive impairment is common in PPMS and affects all evaluated cognitive domains. Subcortical GM volume, particularly of the thalamus, is a strong predictor of cognitive performance, suggesting it has a central role in the pathophysiology of PPMS-related cognitive dysfunction.
[Mh] Termos MeSH primário: Disfunção Cognitiva/diagnóstico por imagem
Disfunção Cognitiva/psicologia
Imagem por Ressonância Magnética
Esclerose Múltipla Crônica Progressiva/diagnóstico por imagem
Esclerose Múltipla Crônica Progressiva/psicologia
[Mh] Termos MeSH secundário: Adulto
Disfunção Cognitiva/epidemiologia
Estudos Transversais
Feminino
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Esclerose Múltipla Crônica Progressiva/epidemiologia
Testes Neuropsicológicos
Tálamo/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1111/ane.12702


  10 / 81958 MEDLINE  
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[PMID]:28449889
[Au] Autor:Terzaghi M; Spelta L; Minafra B; Rustioni V; Zangaglia R; Pacchetti C; Manni R
[Ad] Endereço:Unit of Sleep Medicine and Epilepsy, C. Mondino National Neurological Institute, Pavia, Italy. Electronic address: michele.terzaghi@mondino.it.
[Ti] Título:Treating sleep apnea in Parkinson's disease with C-PAP: feasibility concerns and effects on cognition and alertness.
[So] Source:Sleep Med;33:114-118, 2017 May.
[Is] ISSN:1878-5506
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Obstructive sleep apnea (OSA) is highly prevalent in Parkinson disease (PD) and is known to contribute to cognitive impairment and daytime sleepiness. We investigated feasibility of continuous positive airway pressure treatment (CPAP) and its effects on subjective daytime sleepiness and cognitive profile in PD plus OSA subjects in a longitudinal three months follow up study. METHODS: Seventy (age 71.7 ± 7.6, disease duration 9.9 ± 12.3, UPDRS-III 33.7 ± 12.5, MMSE 25.3 ± 3.6; years of education 7.7 ± 3.2) out of 228 consecutive PD patients undergoing in-lab video-polysomnography were found to have obstructive sleep apnea. Thirty-six subjects accepted to titrate therapeutic CPAP. Video-polysomnography, neuropsychological battery evaluating different cognitive domains and subjective scales for daytime sleepiness were scheduled at baseline and after three months. All the patients were given educational informations relative to diagnosis of OSA and benefits of OSA treatment, and an individualized training with CPAP. RESULTS: Twenty-seven (75%) subjects dropped out of the study due to CPAP intolerance. No demographic or disease-related variables (in particular, severity of OSA), could be found between subjects who completed the study versus those who dropped out. Nine subjects completed the three-month follow up, and there were no significant changes in subjective sleepiness, neuropsychological scores and sleep structure (except for reduction in apnea/hypopnea index and a trend toward increase in stage N3 sleep). CONCLUSION: Our data show that feasibility of CPAP treatment can be significantly threatened by overall attrition rates. Further studies should consider well-structured adherence promoting interventions. The actual role of OSA as a determinant of the profile of subjective daytime sleepiness and cognition in PD, and the effects of CPAP in PD need to be further studied.
[Mh] Termos MeSH primário: Atenção/fisiologia
Cognição/fisiologia
Disfunção Cognitiva/complicações
Pressão Positiva Contínua nas Vias Aéreas/métodos
Estudos de Viabilidade
Doença de Parkinson/complicações
Síndromes da Apneia do Sono/terapia
Apneia Obstrutiva do Sono/terapia
[Mh] Termos MeSH secundário: Idoso
Disfunção Cognitiva/epidemiologia
Disfunção Cognitiva/fisiopatologia
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Testes Neuropsicológicos/normas
Doença de Parkinson/epidemiologia
Doença de Parkinson/terapia
Cooperação do Paciente
Polissonografia/métodos
Síndromes da Apneia do Sono/complicações
Síndromes da Apneia do Sono/fisiopatologia
Apneia Obstrutiva do Sono/complicações
Apneia Obstrutiva do Sono/epidemiologia
Apneia Obstrutiva do Sono/fisiopatologia
Fases do Sono/fisiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde