Base de dados : MEDLINE
Pesquisa : G01.060.350.369.300 [Categoria DeCS]
Referências encontradas : 1193 [refinar]
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[PMID]:28953959
[Au] Autor:Kim J; Montagne K; Nemoto H; Ushida T; Furukawa KS
[Ad] Endereço:Department of Mechanical Engineering, Graduate School of Engineering, University of Tokyo, Tokyo, Japan.
[Ti] Título:Hypergravity down-regulates c-fos gene expression via ROCK/Rho-GTP and the PI3K signaling pathway in murine ATDC5 chondroprogenitor cells.
[So] Source:PLoS One;12(9):e0185394, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chondrocytes are known to be physiologically loaded with diverse physical factors such as compressive stress, shear stress and hydrostatic pressure. Although the effects of those mechanical stimuli onto various cell models have been widely studied, those of hypergravity have not yet been revealed clearly. Hereby, we hypothesized that the hypergravity affects relative positions of intracellular elements including nucleus and cytoskeletons due to their density differences, triggering mechanotransduction in the cell. The aim of this study was to investigate the effect of hypergravity on c-fos expression in the murine ATDC5 chondroprogenitor cells, as c-fos is a well known key regulator of cell proliferation and differentiation, including in chondrocytes. We first found that hypergravity down-regulated c-fos expression transiently via ROCK/Rho-GTP and PI3K signaling, and the down-regulation was suppressed by inhibition of actin polymerization.
[Mh] Termos MeSH primário: Condrócitos/citologia
Regulação para Baixo
Guanosina Trifosfato/metabolismo
Hipergravidade
Fosfatidilinositol 3-Quinases/metabolismo
Proteínas Proto-Oncogênicas c-fos/genética
Proteínas rho de Ligação ao GTP/metabolismo
Quinases Associadas a rho/metabolismo
[Mh] Termos MeSH secundário: Citoesqueleto de Actina/metabolismo
Androstadienos/farmacologia
Animais
Linhagem Celular
Condrócitos/efeitos dos fármacos
Condrócitos/metabolismo
Regulação para Baixo/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Camundongos
Modelos Biológicos
Proteínas Proto-Oncogênicas c-fos/metabolismo
Transdução de Sinais/efeitos dos fármacos
Células-Tronco/citologia
Células-Tronco/efeitos dos fármacos
Células-Tronco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androstadienes); 0 (Proto-Oncogene Proteins c-fos); 86-01-1 (Guanosine Triphosphate); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (rho-Associated Kinases); EC 3.6.5.2 (rho GTP-Binding Proteins); XVA4O219QW (wortmannin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185394


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[PMID]:28869123
[Au] Autor:Katsimpouras C; Zacharopoulou M; Matsakas L; Rova U; Christakopoulos P; Topakas E
[Ad] Endereço:Industrial Biotechnology & Biocatalysis Group, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str., Zografou Campus, Athens 15780, Greece.
[Ti] Título:Sequential high gravity ethanol fermentation and anaerobic digestion of steam explosion and organosolv pretreated corn stover.
[So] Source:Bioresour Technol;244(Pt 1):1129-1136, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present work investigates the suitability of pretreated corn stover (CS) to serve as feedstock for high gravity (HG) ethanol production at solids-content of 24wt%. Steam explosion, with and without the addition of H SO , and organosolv pretreated CS samples underwent a liquefaction/saccharification step followed by simultaneous saccharification and fermentation (SSF). Maximum ethanol concentration of ca. 76g/L (78.3% ethanol yield) was obtained from steam exploded CS (SECS) with 0.2% H SO . Organosolv pretreated CS (OCS) also resulted in high ethanol concentration of ca. 65g/L (62.3% ethanol yield). Moreover, methane production through anaerobic digestion (AD) was conducted from fermentation residues and resulted in maximum methane yields of ca. 120 and 69mL/g volatile solids (VS) for SECS and OCS samples, respectively. The results indicated that the implementation of a liquefaction/saccharification step before SSF employing a liquefaction reactor seemed to handle HG conditions adequately.
[Mh] Termos MeSH primário: Etanol
Fermentação
[Mh] Termos MeSH secundário: Explosões
Hipergravidade
Vapor
Zea mays
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Steam); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


  3 / 1193 MEDLINE  
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[PMID]:28779676
[Au] Autor:Soares J; Demeke MM; Van de Velde M; Foulquié-Moreno MR; Kerstens D; Sels BF; Verplaetse A; Fernandes AAR; Thevelein JM; Fernandes PMB
[Ad] Endereço:Núcleo de Biotecnologia, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, 29040-090 Vitória, Espírito Santo, Brazil.
[Ti] Título:Fed-batch production of green coconut hydrolysates for high-gravity second-generation bioethanol fermentation with cellulosic yeast.
[So] Source:Bioresour Technol;244(Pt 1):234-242, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The residual biomass obtained from the production of Cocos nucifera L. (coconut) is a potential source of feedstock for bioethanol production. Even though coconut hydrolysates for ethanol production have previously been obtained, high-solid loads to obtain high sugar and ethanol levels remain a challenge. We investigated the use of a fed-batch regime in the production of sugar-rich hydrolysates from the green coconut fruit and its mesocarp. Fermentation of the hydrolysates obtained from green coconut or its mesocarp, containing 8.4 and 9.7% (w/v) sugar, resulted in 3.8 and 4.3% (v/v) ethanol, respectively. However, green coconut hydrolysate showed a prolonged fermentation lag phase. The inhibitor profile suggested that fatty acids and acetic acid were the main fermentation inhibitors. Therefore, a fed-batch regime with mild alkaline pretreatment followed by saccharification, is presented as a strategy for fermentation of such challenging biomass hydrolysates, even though further improvement of yeast inhibitor tolerance is also needed.
[Mh] Termos MeSH primário: Biocombustíveis
Cocos
Etanol
[Mh] Termos MeSH secundário: Fermentação
Hipergravidade
Saccharomyces cerevisiae
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biofuels); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE


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[PMID]:28720191
[Au] Autor:Suresh R; Blue RS; Mathers C; Castleberry TL; Vanderploeg JM
[Ti] Título:Sustained Accelerated Idioventricular Rhythm in a Centrifuge-Simulated Suborbital Spaceflight.
[So] Source:Aerosp Med Hum Perform;88(8):789-793, 2017 Aug 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Hypergravitational exposures during human centrifugation are known to provoke dysrhythmias, including sinus dysrhythmias/tachycardias, premature atrial/ventricular contractions, and even atrial fibrillations or flutter patterns. However, events are generally short-lived and resolve rapidly after cessation of acceleration. This case report describes a prolonged ectopic ventricular rhythm in response to high G exposure. CASE REPORT: A previously healthy 30-yr-old man voluntarily participated in centrifuge trials as a part of a larger study, experiencing a total of 7 centrifuge runs over 48 h. Day 1 consisted of two +Gz runs (peak +3.5 Gz, run 2) and two +Gx runs (peak +6.0 Gx, run 4). Day 2 consisted of three runs approximating suborbital spaceflight profiles (combined +Gx and +Gz). Hemodynamic data collected included blood pressure, heart rate, and continuous three-lead electrocardiogram. Following the final acceleration exposure of the last Day 2 run (peak +4.5 Gx and +4.0 Gz combined, resultant +6.0 G), during a period of idle resting centrifuge activity (resultant vector +1.4 G), the subject demonstrated a marked change in his three-lead electrocardiogram from normal sinus rhythm to a wide-complex ectopic ventricular rhythm at a rate of 91-95 bpm, consistent with an accelerated idioventricular rhythm (AIVR). This rhythm was sustained for 2 m, 24 s before reversion to normal sinus. The subject reported no adverse symptoms during this time. DISCUSSION: While prolonged, the dysrhythmia was asymptomatic and self-limited. AIVR is likely a physiological response to acceleration and can be managed conservatively. Vigilance is needed to ensure that AIVR is correctly distinguished from other, malignant rhythms to avoid inappropriate treatment and negative operational impacts.Suresh R, Blue RS, Mathers C, Castleberry TL, Vanderploeg JM. Sustained accelerated idioventricular rhythm in a centrifuge-simulated suborbital spaceflight. Aerosp Med Hum Perform. 2017; 88(8):789-793.
[Mh] Termos MeSH primário: Ritmo Idioventricular Acelerado/etiologia
Hipergravidade/efeitos adversos
Simulação de Ambiente Espacial
[Mh] Termos MeSH secundário: Ritmo Idioventricular Acelerado/fisiopatologia
Adulto
Medicina Aeroespacial
Doenças Assintomáticas
Centrifugação
Eletrocardiografia
Seres Humanos
Masculino
Remissão Espontânea
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4896.2017


  5 / 1193 MEDLINE  
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[PMID]:28720183
[Au] Autor:Kim S; Cho T; Lee Y; Koo H; Choi B; Kim D
[Ti] Título:G-LOC Warning Algorithms Based on EMG Features of the Gastrocnemius Muscle.
[So] Source:Aerosp Med Hum Perform;88(8):737-742, 2017 Aug 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: G-induced loss of consciousness (G-LOC) is mainly caused by failure to sustain an oxygenated blood supply to the pilot's brain because of the sudden acceleration in the direction of the +Gz axis, and is considered a critical safety issue. The purpose of this study was to develop G-LOC warning algorithms based on monitoring electromyograms (EMG) of the gastrocnemius muscle on the calf. METHODS: EMG data was retrieved from a total of 67 pilots and pilot trainees of the Korean Air Force during high-G training on a human centrifugal simulator. Seven EMG features were obtained from root mean square (RMS), integrated absolute value (IAV), and mean absolute value (MAV) for muscle contraction, slope sign changes (SSC), waveform length (WL), zero crossing (ZC), and median frequency (MF) for muscle contraction and fatigue. RESULTS: Out of seven EMG features, IAV and WL showed a rapid decay before G-LOC. Based on these findings, this study developed two algorithms which can detect G-LOC during flight and provide warning signals to the pilots. The probability of G-LOC occurrence was detected through monitoring the decay trend for representing muscle endurance and climb rate of the IAV and WL value during sudden acceleration above 6 G, representing muscle power. The sensitivity of the algorithms using IAV and WL features was 100% and the specificity was 66.7%. DISCUSSION: This study suggests that a G-LOC detecting and warning system may be a customized, real-time countermeasure by improving the accuracy of detecting G-LOC.Kim S, Cho T, Lee Y, Koo H, Choi B, Kim D. G-LOC warning algorithms based on EMG features of the gastrocnemius muscle. Aerosp Med Hum Perform. 2017; 88(8):737-742.
[Mh] Termos MeSH primário: Aceleração/efeitos adversos
Algoritmos
Gravitação
Hipergravidade/efeitos adversos
Militares
Músculo Esquelético/fisiopatologia
Pilotos
Inconsciência/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Medicina Aeroespacial
Eletromiografia
Seres Humanos
Treinamento por Simulação
Inconsciência/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4781.2017


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[PMID]:28629106
[Au] Autor:Chao B; Liu R; Zhang X; Zhang X; Tan T
[Ad] Endereço:National Energy R&D Center for Biorefinery, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
[Ti] Título:Tannin extraction pretreatment and very high gravity fermentation of acorn starch for bioethanol production.
[So] Source:Bioresour Technol;241:900-907, 2017 Oct.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The bioethanol production from a novel non-grain feedstock, acorn starch, was studied in this work. The inhibition of tannin in strain growth was investigated, and the effect of tannin was negligible when the tannin concentration was lower than 1g/L in medium. Therefore, the extraction of tannin was performed using 40% (v/v) ethanol-water solution as the solvent for three times under the conditions of solid/liquid ratio 1:20, 60°C, 3h, by which more than 80% of tannin in acorn was extracted and the content of tannin in acorn decreased from 7.4% (w/w) to 1.5% (w/w). Very high gravity (VHG) fermentation technology was subsequently carried out to achieve a high ethanol concentration at 86.4g/L. A comprehensive process for bioethanol production from acorn starch was designed and a preliminary economic assessment was then performed revealing that this process appeared technically and economically justified.
[Mh] Termos MeSH primário: Biocombustíveis
Taninos/metabolismo
[Mh] Termos MeSH secundário: Etanol
Fermentação
Hipergravidade
Amido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biofuels); 0 (Tannins); 3K9958V90M (Ethanol); 9005-25-8 (Starch)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE


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[PMID]:28539156
[Au] Autor:Hall L
[Ti] Título:Early Human Factors Studies for Spaceflight at the Aeromedical Field Laboratory at Holloman Air Force Base.
[So] Source:Aerosp Med Hum Perform;88(6):608-609, 2017 Jun 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Pesquisa/história
Voo Espacial/história
[Mh] Termos MeSH secundário: Animais
História do Século XX
Seres Humanos
Hipergravidade
Instalações Militares
Estados Unidos
Simulação de Ausência de Peso
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4766.2017


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[PMID]:28539143
[Au] Autor:Slungaard E; McLeod J; Green NDC; Kiran A; Newham DJ; Harridge SDR
[Ti] Título:Incidence of G-Induced Loss of Consciousness and Almost Loss of Consciousness in the Royal Air Force.
[So] Source:Aerosp Med Hum Perform;88(6):550-555, 2017 Jun 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Exposure to sustained +Gz acceleration with inadequate G protection can result in G-induced loss of consciousness (G-LOC) or almost loss of consciousness (A-LOC). The UK Royal Air Force (RAF) last conducted a survey of G-LOC within their military aircrew in 2005 with interventions subsequently introduced. The aim of this study was to repeat the 2005 survey in order to evaluate the impact of those interventions. METHODS: An anonymous questionnaire requesting details of G-LOC and A-LOC events was mailed to all RAF pilots (N = 1878) and weapons systems operators (WSOs) (N = 473), irrespective of aircraft currently flown. RESULTS: The questionnaire was returned by 809 aircrew (34.4% response rate). There were 120 (14.8%) aircrew who reported at least one episode of G-LOC and 260 (32.2%) reported at least one episode of A-LOC. The reported prevalence of G-LOC in the previous 2005 survey was 20.1% (N = 454). There was an increased reporting of G-LOC in the Hawk, Tucano, and Grob Tutor aircraft, with 5 G-LOC and 19 A-LOC events reported in the Grob Tutor compared to none in 2005. DISCUSSION: The prevalence of reported G-LOC has decreased in the surveyed populations, which may be due to the introduction of centrifuge training, but also may be influenced by patterns of G exposure and other factors. Scope for further reduction remains through correct execution of the anti-G straining maneuver (AGSM) with centrifuge training early in flying training and use of a structured conditioning program to increase the general strength of muscles involved in the AGSM.Slungaard E, McLeod J, Green NDC, Kiran A, Newham DJ, Harridge SDR. Incidence of G-induced loss of consciousness and almost loss of consciousness in the Royal Air Force. Aerosp Med Hum Perform. 2017; 88(6):550-555.
[Mh] Termos MeSH primário: Hipergravidade/efeitos adversos
Militares/estatística & dados numéricos
Pilotos/estatística & dados numéricos
Inconsciência/etiologia
[Mh] Termos MeSH secundário: Adulto
Medicina Aeroespacial
Aeronaves
Centrifugação
Gravitação
Seres Humanos
Incidência
Prevalência
Treinamento por Simulação
Inquéritos e Questionários
Inconsciência/epidemiologia
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4752.2017


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[PMID]:28095952
[Au] Autor:Honkanen T; Oksa J; Mäntysaari MJ; Kyröläinen H; Avela J
[Ti] Título:Neck and Shoulder Muscle Activation Among Experienced and Inexperienced Pilots in +Gz Exposure.
[So] Source:Aerosp Med Hum Perform;88(2):90-95, 2017 Feb 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of the present study was to compare differences in electromyography (EMG) activation of the neck and shoulder muscles between groups of inexperienced and experienced pilots during controlled +Gz exposure in a centrifuge. METHODS: The subjects were volunteer cadets (inexperienced group) and lieutenants (experienced group) undergoing their first centrifuge training. The first group did not have any high performance aircraft (HPA) experience, while the latter one had a 1-yr experience of intense flying of HPA. During the centrifuge run, EMG activity was recorded from the left and right shoulder, neck flexor, and neck extensor muscles. RESULTS: The pilots without HPA experience had significantly higher muscle activity in the neck flexor and extensor muscles during the last 5 s of the recorded period at G levels exceeding +7.4. DISCUSSION: Muscle activity in the neck and shoulder muscles was gradually higher among the whole study group with increasing +Gz forces. Because pilots without any HPA experience had significantly higher muscle activity than their counterparts with experience of HPA, we suppose that the experience of high +Gz forces might lead to lower muscle activation in the same flight mission.Honkanen T, Oksa J, Mäntysaari MJ, Kyröläinen H, Avela J. Neck and shoulder muscle activation among experienced and inexperienced pilots in +Gz exposure. Aerosp Med Hum Perform. 2017; 88(2):90-95.
[Mh] Termos MeSH primário: Gravitação
Hipergravidade
Militares
Músculos do Pescoço/fisiologia
Pilotos
[Mh] Termos MeSH secundário: Medicina Aeroespacial
Centrifugação
Eletromiografia
Finlândia
Seres Humanos
Músculo Esquelético/fisiologia
Ombro
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4659.2017


  10 / 1193 MEDLINE  
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[PMID]:27988216
[Au] Autor:Phukoetphim N; Salakkam A; Laopaiboon P; Laopaiboon L
[Ad] Endereço:Graduate School, Khon Kaen University, Khon Kaen, 40002, Thailand.
[Ti] Título:Kinetic models for batch ethanol production from sweet sorghum juice under normal and high gravity fermentations: Logistic and modified Gompertz models.
[So] Source:J Biotechnol;243:69-75, 2017 Feb 10.
[Is] ISSN:1873-4863
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to model batch ethanol production from sweet sorghum juice (SSJ), under normal gravity (NG, 160g/L of total sugar) and high gravity (HG, 240g/L of total sugar) conditions with and without nutrient supplementation (9g/L of yeast extract), by Saccharomyces cerevisiae NP 01. Growth and ethanol production increased with increasing initial sugar concentration, and the addition of yeast extract enhanced both cell growth and ethanol production. From the results, either logistic or a modified Gompertz equation could be used to describe yeast growth, depending on information required. Furthermore, the modified Gompertz model was suitable for modeling ethanol production. Both the models fitted the data very well with coefficients of determination exceeding 0.98. The results clearly showed that these models can be employed in the development of ethanol production processes using SSJ under both NG and HG conditions. The models were also shown to be applicable to other ethanol fermentation systems employing pure and mixed sugars as carbon sources.
[Mh] Termos MeSH primário: Técnicas de Cultura Celular por Lotes/métodos
Etanol/metabolismo
Modelos Químicos
Extratos Vegetais/metabolismo
Sorghum/metabolismo
[Mh] Termos MeSH secundário: Metabolismo dos Carboidratos
Carboidratos/administração & dosagem
Carbono/administração & dosagem
Carbono/metabolismo
Fermentação
Sucos de Frutas e Vegetais/microbiologia
Hipergravidade
Cinética
Extratos Vegetais/química
Saccharomyces cerevisiae/crescimento & desenvolvimento
Saccharomyces cerevisiae/metabolismo
Sorghum/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates); 0 (Plant Extracts); 3K9958V90M (Ethanol); 7440-44-0 (Carbon)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE



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