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[PMID]:28847318
[Au] Autor:Towers S
[Ad] Endereço:Simon A. Levin Mathematical,Computational and Modelling Sciences Center,Arizona State University,Tempe,AZ,USA.
[Ti] Título:Sunspot activity and influenza pandemics: a statistical assessment of the purported association.
[So] Source:Epidemiol Infect;145(13):2640-2655, 2017 10.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Since 1978, a series of papers in the literature have claimed to find a significant association between sunspot activity and the timing of influenza pandemics. This paper examines these analyses, and attempts to recreate the three most recent statistical analyses by Ertel (1994), Tapping et al. (2001), and Yeung (2006), which all have purported to find a significant relationship between sunspot numbers and pandemic influenza. As will be discussed, each analysis had errors in the data. In addition, in each analysis arbitrary selections or assumptions were also made, and the authors did not assess the robustness of their analyses to changes in those arbitrary assumptions. Varying the arbitrary assumptions to other, equally valid, assumptions negates the claims of significance. Indeed, an arbitrary selection made in one of the analyses appears to have resulted in almost maximal apparent significance; changing it only slightly yields a null result. This analysis applies statistically rigorous methodology to examine the purported sunspot/pandemic link, using more statistically powerful un-binned analysis methods, rather than relying on arbitrarily binned data. The analyses are repeated using both the Wolf and Group sunspot numbers. In all cases, no statistically significant evidence of any association was found. However, while the focus in this particular analysis was on the purported relationship of influenza pandemics to sunspot activity, the faults found in the past analyses are common pitfalls; inattention to analysis reproducibility and robustness assessment are common problems in the sciences, that are unfortunately not noted often enough in review.
[Mh] Termos MeSH primário: Influenza Humana/epidemiologia
Pandemias/estatística & dados numéricos
Atividade Solar
[Mh] Termos MeSH secundário: Seres Humanos
Influenza Humana/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1017/S095026881700173X


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[PMID]:28820918
[Au] Autor:Arévalo JF; Kong J; Bressler NM
[Ti] Título:Safely Viewing Solar Eclipses.
[So] Source:JAMA;318(11):1080, 2017 09 19.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Queimaduras Oculares/prevenção & controle
Lesões por Radiação/prevenção & controle
Retina/efeitos da radiação
Atividade Solar
Luz Solar/efeitos adversos
[Mh] Termos MeSH secundário: Seres Humanos
Retina/lesões
Segurança
[Pt] Tipo de publicação:PATIENT EDUCATION HANDOUT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.9495


  3 / 714 MEDLINE  
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[PMID]:28767703
[Au] Autor:Krause AR; Speacht TL; Zhang Y; Lang CH; Donahue HJ
[Ad] Endereço:Department of Orthopaedics, Penn State College of Medicine, Hershey, Pennsylvania, United States of America.
[Ti] Título:Simulated space radiation sensitizes bone but not muscle to the catabolic effects of mechanical unloading.
[So] Source:PLoS One;12(8):e0182403, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Deep space travel exposes astronauts to extended periods of space radiation and mechanical unloading, both of which may induce significant muscle and bone loss. Astronauts are exposed to space radiation from solar particle events (SPE) and background radiation referred to as galactic cosmic radiation (GCR). To explore interactions between skeletal muscle and bone under these conditions, we hypothesized that decreased mechanical load, as in the microgravity of space, would lead to increased susceptibility to space radiation-induced bone and muscle loss. We evaluated changes in bone and muscle of mice exposed to hind limb suspension (HLS) unloading alone or in addition to proton and high (H) atomic number (Z) and energy (E) (HZE) (16O) radiation. Adult male C57Bl/6J mice were randomly assigned to six groups: No radiation ± HLS, 50 cGy proton radiation ± HLS, and 50 cGy proton radiation + 10 cGy 16O radiation ± HLS. Radiation alone did not induce bone or muscle loss, whereas HLS alone resulted in both bone and muscle loss. Absolute trabecular and cortical bone volume fraction (BV/TV) was decreased 24% and 6% in HLS-no radiation vs the normally loaded no-radiation group. Trabecular thickness and mineral density also decreased with HLS. For some outcomes, such as BV/TV, trabecular number and tissue mineral density, additional bone loss was observed in the HLS+proton+HZE radiation group compared to HLS alone. In contrast, whereas HLS alone decreased muscle mass (19% gastrocnemius, 35% quadriceps), protein synthesis, and increased proteasome activity, radiation did not exacerbate these catabolic outcomes. Our results suggest that combining simulated space radiation with HLS results in additional bone loss that may not be experienced by muscle.
[Mh] Termos MeSH primário: Osso Esponjoso/efeitos da radiação
Osso Cortical/efeitos da radiação
Elevação dos Membros Posteriores/métodos
Músculo Esquelético/efeitos da radiação
[Mh] Termos MeSH secundário: Animais
Osso Esponjoso/diagnóstico por imagem
Osso Cortical/diagnóstico por imagem
Radiação Cósmica
Masculino
Camundongos
Músculo Esquelético/diagnóstico por imagem
Distribuição Aleatória
Atividade Solar
Simulação de Ambiente Espacial
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182403


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[PMID]:27717941
[Au] Autor:Samsonov SN; Manykina VI; Kleimenova NG; Parshina SS; Strekalovskaya AA; Petrova PG
[Ad] Endereço:Institute of Cosmophysic Researches and Aeronomy named after Yu.G. Shafer, Siberian Branch of the Russian Academy of Sciences, Yakutsk, Russia.
[Ti] Título:The HELIO-geophysical storminess health effects in the cardio-vascular system of a human in the middle and high latitudes.
[So] Source:Wiad Lek;69(3 pt 2):537-541, 2016.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: cardiovascular impairment remains one of the most current problems of today's life and the definition of the connection between its development and the state of heliogeophysical storminess is currently important. The results of long-term researches of communication between cardiovascular catastrophes (myocardial infarction) and heliogeophysical storminess in the middle and high latitudes are shown in this work. AIM: to study the influence of space weather parameters on human cardio-vascular system in the high and middle latitudes. To define the particular space weather parameters and the mechanisms of their influence on human myocardial infarction progressing. MATERIAL AND METHODS: for the statistical processing of medical records data we use a spectral-time analysis, a correlation method and a method of overlapping of epochs. We have studied about 145 thousand medical records of ambulance medical services for the period of 1992 -2001. In order to define the reasons influencing the development of a myocardial infarction, we have made a comparison of myocardial infarction progress cases with Kp-index characterizing the level of geomagnetic storminess. RESULTS: the coincidence of geomagnetic storminess maximum with the cases of myocardial infarction, as well as the number of heart attacks excess in 1.5 times per a year near the maximum heliogeophysical activity (1992) compared to the year near the minimum of activity (1998) indicate possible influence of geomagnetic storminess on the myocardial infarction development of people living in subauroral latitudes. CONCLUSIONS: it was concluded that the appearance of heliogeophysical storminess in the myocardial infarction development in the mid-latitudes is largely due to the presence of Pc1 geomagnetic pulsations, and in the high latitudes, especially in maximum years of heliogeophysical storminess, it is due to the geomagnetic storminess caused by the parameters of the solar wind and the interplanetary magnetic field.
[Mh] Termos MeSH primário: Campos Magnéticos/efeitos adversos
Infarto do Miocárdio/etiologia
Atividade Solar
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE


  5 / 714 MEDLINE  
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[PMID]:27453947
[Au] Autor:Birch AC; Schunker H; Braun DC; Cameron R; Gizon L; Löptien B; Rempel M
[Ad] Endereço:Max-Planck-Institut für Sonnensystemforschung, Justus-von-Liebig-Weg 3, 37077 Göttingen, Germany.
[Ti] Título:A low upper limit on the subsurface rise speed of solar active regions.
[So] Source:Sci Adv;2(7):e1600557, 2016 07.
[Is] ISSN:2375-2548
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Magnetic field emerges at the surface of the Sun as sunspots and active regions. This process generates a poloidal magnetic field from a rising toroidal flux tube; it is a crucial but poorly understood aspect of the solar dynamo. The emergence of magnetic field is also important because it is a key driver of solar activity. We show that measurements of horizontal flows at the solar surface around emerging active regions, in combination with numerical simulations of solar magnetoconvection, can constrain the subsurface rise speed of emerging magnetic flux. The observed flows imply that the rise speed of the magnetic field is no larger than 150 m/s at a depth of 20 Mm, that is, well below the prediction of the (standard) thin flux tube model but in the range expected for convective velocities at this depth. We conclude that convective flows control the dynamics of rising flux tubes in the upper layers of the Sun and cannot be neglected in models of flux emergence.
[Mh] Termos MeSH primário: Modelos Teóricos
[Mh] Termos MeSH secundário: Campos Magnéticos
Atividade Solar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE
[do] DOI:10.1126/sciadv.1600557


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[PMID]:27310145
[Au] Autor:Spiga R; Batton-Hubert M; Sarazin M
[Ad] Endereço:Service de Santé publique et d'information médicale, Centre Hospitalo-Universitaire, Saint-Etienne, France.
[Ti] Título:Predicting Fluctuating Rates of Hospitalizations in Relation to Influenza Epidemics and Meteorological Factors.
[So] Source:PLoS One;11(6):e0157492, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: In France, rates of hospital admissions increase at the peaks of influenza epidemics. Predicting influenza-associated hospitalizations could help to anticipate increased hospital activity. The purpose of this study is to identify predictors of influenza epidemics through the analysis of meteorological data, and medical data provided by general practitioners. METHODS: Historical data were collected from Meteo France, the Sentinelles network and hospitals' information systems for a period of 8 years (2007-2015). First, connections between meteorological and medical data were estimated with the Pearson correlation coefficient, Principal component analysis and classification methods (Ward and k-means). Epidemic states of tested weeks were then predicted for each week during a one-year period using linear discriminant analysis. Finally, transition probabilities between epidemic states were calculated with the Markov Chain method. RESULTS: High correlations were found between influenza-associated hospitalizations and the variables: Sentinelles and emergency department admissions, and anti-correlations were found between hospitalizations and each of meteorological factors applying a time lag of: -13, -12 and -32 days respectively for temperature, absolute humidity and solar radiation. Epidemic weeks were predicted accurately with the linear discriminant analysis method; however there were many misclassifications about intermediate and non-epidemic weeks. Transition probability to an epidemic state was 100% when meteorological variables were below: 2°C, 4 g/m3 and 32 W/m2, respectively for temperature, absolute humidity and solar radiation. This probability was 0% when meteorological variables were above: 6°C, 5.8g/m3 and 74W/m2. CONCLUSION: These results confirm a good correlation between influenza-associated hospitalizations, meteorological factors and general practitioner's activity, the latter being the strongest predictor of hospital activity.
[Mh] Termos MeSH primário: Epidemias/estatística & dados numéricos
Hospitalização/estatística & dados numéricos
Influenza Humana/epidemiologia
Modelos Estatísticos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
França/epidemiologia
Seres Humanos
Umidade
Lactente
Recém-Nascido
Influenza Humana/virologia
Masculino
Cadeias de Markov
Meia-Idade
Análise de Componente Principal
Estações do Ano
Atividade Solar
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0157492


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[PMID]:27306208
[Au] Autor:Vaiciulis V; Radisauskas R; Ustinaviciene R; Kaliniene G; Tamosiunas A
[Ad] Endereço:Department of Environmental and Occupational Medicine, Lithuanian University of Health Sciences, Tilzes str. 18, LT-50009, Kaunas, Lithuania. vidmantas.vaiciulis@lsmuni.lt.
[Ti] Título:Associations of morbidity and mortality from coronary heart disease with heliogeophysical factors.
[So] Source:Environ Sci Pollut Res Int;23(18):18630-8, 2016 Sep.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the associations among morbidity of acute myocardial infarction (AMI) and mortality from ischemic heart disease (IHD) with heliogeophysical factors among the Kaunas population. The study population was stratified into three age categories: 25-54, 55-64, and ≥65 years. In this study, solar flares (SF), solar proton fluences (SPF), and geomagnetic activity (GMA) were employed as heliogeophysical factors and used Poisson regression and two methods of time series modeling (lag and lead). Influence of GMA in different age and sex category is uneven. The mean number of AMI events per day was greatest (23 %) among men aged 25-54 years on the third day and the same sex aged 55-64 years-increased 10 % 2 days before when the GMA intensity was A+S. Both for men and women aged ≥65 years, the highest increase in the mean number of deaths from IHD events per day was observed on the second day when the GMA intensity was A+S-51 and 34 %, respectively. Evaluating the impact of SF of 10(-5) ≤ SF < 10(-4) W/m(2) (M+X) intensity, the mean number of AMI events per day was greatest for 55-64-year-old women and men on the same and second days. Such SF were associated with a 13 and 20 % increase, respectively. Evaluating the impact of large fluence SPF, it was determined that the increase in the mean number of AMI events per day among 25-54-year-old men was greatest (30 %) 1 day, and death from IHD (54 %) was observed among women aged ≥65 years 2 days before the energy of the SPF has increased.
[Mh] Termos MeSH primário: Doença das Coronárias/mortalidade
Morbidade
Atividade Solar
[Mh] Termos MeSH secundário: Adulto
Idoso
Doença das Coronárias/epidemiologia
Morte
Feminino
Seres Humanos
Lituânia/epidemiologia
Masculino
Meia-Idade
Infarto do Miocárdio/epidemiologia
Isquemia Miocárdica
Prótons
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protons)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-7056-8


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[PMID]:27180339
[Au] Autor:Stoupel EG
[Ti] Título:Cosmic ray (neutron) activity and air pollution nanoparticles - cardiovascular disease risk factors - separate or together?
[So] Source:J Basic Clin Physiol Pharmacol;27(5):493-6, 2016 Sep 01.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In the last decade, a number of studies were published showing links between cardiovascular events such as stroke (CVA), acute myocardial infarction (AMI), sudden cardiac death (SCD) and cosmic ray activity (CRA) marker neutron activity on the Earth's surface (imp/min). A number of concomitant studies described air pollution fine particles as a similar risk factor. It is not clear which way each of the mentioned factors acts on the way of affecting the human body. The aim of this study is to present separate data of these two factors as risk factors and to discuss the possibility of seeing the nanoparticles polluting our air as carriers of neutrons on their way to the human cardiovascular system. METHODS: Many studies of our groups and groups studying air pollution effects were revised, and the possibility of combined action of both factors was considered. RESULTS: It is known that neutrons on the Earth surface are the markers of CRA. CRA is inversely related to space weather parameters such as solar (SA) and geomagnetic activity. The presumed way of biological action of neutrons is connection with H+ and, as protons, attack on our cells and tissues. The way of action of nanoparticles is explained by specific physical and chemical action of the materials they represent. It is a strong possibility that one way to connect H radicals in the human body is that particles are neutron carriers and can be absorbed in different parts of the body and then affect the systems of human body. CONCLUSIONS: The combined action of CRA (neutron) activity is a possible way of affecting the environment. The precise mechanism of this cooperative action demands additional studies.
[Mh] Termos MeSH primário: Poluição do Ar/efeitos adversos
Doenças Cardiovasculares/etiologia
Radiação Cósmica/efeitos adversos
Nanopartículas/efeitos adversos
Nêutrons/efeitos adversos
[Mh] Termos MeSH secundário: Terra (Planeta)
Seres Humanos
Fatores de Risco
Atividade Solar
Tempo (Meteorologia)
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160516
[St] Status:MEDLINE


  9 / 714 MEDLINE  
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[PMID]:27161905
[Au] Autor:Papathanasopoulos P; Preka-Papadema P; Gkotsinas A; Dimisianos N; Hillaris A; Katsavrias C; Antonakopoulos G; Moussas X; Andreadou E; Georgiou V; Papachristou P; Kargiotis O
[Ad] Endereço:Department of Neurology, Medical School, University of Patras, Greece. Electronic address: takis25@yahoo.com.
[Ti] Título:The possible effects of the solar and geomagnetic activity on multiple sclerosis.
[So] Source:Clin Neurol Neurosurg;146:82-9, 2016 Jul.
[Is] ISSN:1872-6968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Increasing observational evidence on the biological effects of Space Weather suggests that geomagnetic disturbances may be an environmental risk factor for multiple sclerosis (MS) relapses. In the present study, we aim to investigate the possible effect of geomagnetic disturbances on MS activity. PATIENTS AND METHODS: MS patient admittance rates were correlated with the solar and geophysical data covering an eleven-year period (1996-2006, 23rd solar cycle). We also examined the relationship of patterns of the solar flares, the coronal mass ejections (CMEs) and the solar wind with the recorded MS admission numbers. RESULTS: The rate of MS patient admittance due to acute relapses was found to be associated with the solar and geomagnetic events. There was a "primary" peak in MS admittance rates shortly after intense geomagnetic storms followed by a "secondary" peak 7-8 months later. CONCLUSION: We conclude that the geomagnetic and solar activity may represent an environmental health risk factor for multiple sclerosis and we discuss the possible mechanisms underlying this association. More data from larger case series are needed to confirm these preliminary results and to explore the possible influence of Space Weather on the biological and radiological markers of the disease.
[Mh] Termos MeSH primário: Exposição Ambiental/efeitos adversos
Fenômenos Magnéticos
Esclerose Múltipla/epidemiologia
Admissão do Paciente/estatística & dados numéricos
Atividade Solar
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Esclerose Múltipla/etiologia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160511
[St] Status:MEDLINE


  10 / 714 MEDLINE  
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[PMID]:27136236
[Au] Autor:Qu J
[Ad] Endereço:Department of Infectious Disease Control, Tianjin Center for Disease Control and Prevention, Tianjin, China. qujiangwen1122@126.com.
[Ti] Título:Is sunspot activity a factor in influenza pandemics?
[So] Source:Rev Med Virol;26(5):309-13, 2016 Sep.
[Is] ISSN:1099-1654
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The 2009 AH1N1 pandemic became a global health concern, although fortunately, its worst anticipated effects were not realised. While the origins of such outbreaks remain poorly understood, it is very important to identify the precipitating factors in their emergence so that future pandemics can be detected as quickly as possible. Methords: Descriptive epidemiology was used to analyse the association between influenza pandemics and possible pandemics and relative number of sunspots. Non-conditional logistic regression was performed to analyse the statistical association between sunspot extremes and influenza pandemics to within plus or minus 1 year. RESULTS: Almost all recorded influenza/possible pandemics have occurred in time frames corresponding to sunspot extremes, or +/- 1 year within such extremes. These periods were identified as important risk factors in both possible and confirmed influenza pandemics (odds ratio: 3.87; 95% confidence interval: 1.08 to 13.85). CONCLUSIONS: Extremes of sunspot activity to within plus or minus 1 year may precipitate influenza pandemics. Mechanisms of epidemic initiation and early spread are discussed including primary causation by externally derived viral variants (from space via cometary dust). Efforts to construct a comprehensive early warning system for potential influenza and other viral pandemics that include analysis of sunspot activity and stratospheric sampling for viral variants should be supported. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Influenza Humana/epidemiologia
Pandemias
Atividade Solar
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160503
[St] Status:MEDLINE
[do] DOI:10.1002/rmv.1887



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