Base de dados : MEDLINE
Pesquisa : G01.249 [Categoria DeCS]
Referências encontradas : 1051 [refinar]
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  1 / 1051 MEDLINE  
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[PMID]:28912232
[Au] Autor:Link JM
[Ad] Endereço:Center for Neutrino Physics and Department of Physics, Virginia Tech, Blacksburg, VA 24061, USA. jonathan.link@vt.edu.
[Ti] Título:Scattering neutrinos caught in the act.
[So] Source:Science;357(6356):1098-1099, 2017 09 15.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Partículas Elementares
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1126/science.aao4050


  2 / 1051 MEDLINE  
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[PMID]:28593976
[Ti] Título:Rare particle decays offer hope of new physics.
[So] Source:Nature;546(7657):185-186, 2017 06 07.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Partículas Elementares
Física
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1038/546185b


  3 / 1051 MEDLINE  
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[PMID]:28382992
[Au] Autor:Barbeau PS
[Ad] Endereço:Department of Physics, Duke University, North Carolina 27708-0305, USA.
[Ti] Título:Particle physics: The search for no neutrinos.
[So] Source:Nature;544(7648):38-39, 2017 04 05.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Partículas Elementares
Física
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:NEWS; COMMENT
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1038/544038a


  4 / 1051 MEDLINE  
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[PMID]:28290489
[Au] Autor:Durante M; Orecchia R; Loeffler JS
[Ad] Endereço:Trento Institute for Fundamental Physics and Applications (TIFPA), National Institute of Nuclear Physics (INFN), University of Trento, Via Sommarive 14, 38123 Povo, Trento, Italy.
[Ti] Título:Charged-particle therapy in cancer: clinical uses and future perspectives.
[So] Source:Nat Rev Clin Oncol;14(8):483-495, 2017 Aug.
[Is] ISSN:1759-4782
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Radiotherapy with high-energy charged particles has become an attractive therapeutic option for patients with several tumour types because this approach better spares healthy tissue from radiation than conventional photon therapy. The cost associated with the delivery of charged particles, however, is higher than that of even the most elaborate photon-delivery technologies. Reliable evidence of the relative cost-effectiveness of both modalities can only come from the results of randomized clinical trials. Thus, the hurdles that currently limit direct comparisons of these two approaches in clinical trials, especially those related to insurance coverage, should be removed. Herein, we review several randomized trials of charged-particle therapies that are ongoing, with results that will enable selective delivery to patients who are most likely to benefit from them. We also discuss aspects related to radiobiology, including the immune response and hypoxia, which will need to be taken into consideration in future randomized trials to fully exploit the potential of charged particles.
[Mh] Termos MeSH primário: Partículas Elementares/uso terapêutico
Neoplasias/radioterapia
Ensaios Clínicos Controlados Aleatórios como Assunto
[Mh] Termos MeSH secundário: Seres Humanos
Radioterapia (Especialidade)/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.1038/nrclinonc.2017.30


  5 / 1051 MEDLINE  
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[PMID]:27995904
[Au] Autor:Cunha M; Monini C; Testa E; Beuve M
[Ad] Endereço:Université de Lyon, F-69622, Lyon, France. Université de Lyon 1, Villeurbanne, France. CNRS/IN2P3, Institut de Physique Nucléaire de Lyon, France.
[Ti] Título:NanOx, a new model to predict cell survival in the context of particle therapy.
[So] Source:Phys Med Biol;62(4):1248-1268, 2017 Feb 21.
[Is] ISSN:1361-6560
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Particle therapy is increasingly attractive for the treatment of tumors and the number of facilities offering it is rising worldwide. Due to the well-known enhanced effectiveness of ions, it is of utmost importance to plan treatments with great care to ensure tumor killing and healthy tissues sparing. Hence, the accurate quantification of the relative biological effectiveness (RBE) of ions, used in the calculation of the biological dose, is critical. Nevertheless, the RBE is a complex function of many parameters and its determination requires modeling. The approaches currently used have allowed particle therapy to thrive, but still show some shortcomings. We present herein a short description of a new theoretical framework, NanOx, to calculate cell survival in the context of particle therapy. It gathers principles from existing approaches, while addressing some of their weaknesses. NanOx is a multiscale model that takes the stochastic nature of radiation at nanometric and micrometric scales fully into account, integrating also the chemical aspects of radiation-matter interaction. The latter are included in the model by means of a chemical specific energy, determined from the production of reactive chemical species induced by irradiation. Such a production represents the accumulation of oxidative stress and sublethal damage in the cell, potentially generating non-local lethal events in NanOx. The complementary local lethal events occur in a very localized region and can, alone, lead to cell death. Both these classes of events contribute to cell death. The comparison between experimental data and model predictions for the V79 cell line show a good agreement. In particular, the dependence of the typical shoulders of cell survival curves on linear energy transfer are well described, but also the effectiveness of different ions, including the overkill effect. These results required the adjustment of a number of parameters compatible with the application of the model in a clinical scenario thereby showing the potential of NanOx. Said parameters are discussed in detail in this paper.
[Mh] Termos MeSH primário: Sobrevivência Celular/efeitos da radiação
Partículas Elementares/uso terapêutico
Fibroblastos/efeitos da radiação
Pulmão/efeitos da radiação
Modelos Teóricos
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Cricetinae
Cricetulus
Fibroblastos/citologia
Transferência Linear de Energia
Pulmão/citologia
Eficiência Biológica Relativa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1088/1361-6560/aa54c9


  6 / 1051 MEDLINE  
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[PMID]:27988058
[Au] Autor:Holzscheiter MH; Alsner J; Bassler N; Boll R; Caccia M; Knudsen H; Maggiore C; Petersen JB; Sellner S; Straße T; Singers Sørensen B; Overgaard J
[Ad] Endereço:Department of Physics and Astronomy, University of New Mexico, Albuquerque, USA; Max Planck Institute for Nuclear Physics, Heidelberg, Germany. Electronic address: michael.holzscheiter@gmail.com.
[Ti] Título:The relative biological effectiveness of antiprotons.
[So] Source:Radiother Oncol;121(3):453-458, 2016 Dec.
[Is] ISSN:1879-0887
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Aside from the enhancement of physical dose deposited by antiprotons annihilating in tissue-like material compared to protons of the same range a further increase of biological effective dose has been demonstrated. This enhancement can be expressed in an increase of the relative biological effectiveness (RBE) of antiprotons near the end of range. We have performed the first-ever direct measurement of the RBE of antiprotons both at rest and in flight. MATERIALS AND METHODS: Experimental data were generated on the RBE of an antiproton beam entering a tissue-like target consisting of V79 cells embedded in gelatin with an energy providing a range of approximately 10cm. RESULTS: The RBE in the entrance channel (the "plateau") is only slightly above the value for a comparable proton beam, and remains low until the proximal edge of the spread-out Bragg peak (SOBP). A steep increase of RBE is seen starting from the onset of the SOBP. CONCLUSIONS: This paper reports the final results of the experiment AD-4/ACE at CERN on the first-ever direct measurement of RBE of antiprotons and constitutes the first step toward developing treatment plans.
[Mh] Termos MeSH primário: Partículas Elementares/uso terapêutico
Radioterapia de Alta Energia/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Método de Monte Carlo
Neoplasias/radioterapia
Prótons/uso terapêutico
Radiometria/métodos
Dosagem Radioterapêutica
Eficiência Biológica Relativa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protons)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE


  7 / 1051 MEDLINE  
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[PMID]:27808202
[Au] Autor:Lombardo MP
[Ad] Endereço:Laboratori Nazionali di Frascati, Istituto Nazionale di Fisica Nucleare, I-00044 Frascati, Italy.
[Ti] Título:Particle physics: Axions exposed.
[So] Source:Nature;539(7627):40-41, 2016 11 03.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Partículas Elementares
Física
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170603
[Lr] Data última revisão:
170603
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE
[do] DOI:10.1038/539040a


  8 / 1051 MEDLINE  
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[PMID]:27742257
[Au] Autor:Simpson EC
[Ad] Endereço:Department of Nuclear Physics, The Australian National University, Research School of Physics and Engineering, Canberra, ACT 2601, Australia. Electronic address: edward.simpson@anu.edu.au.
[Ti] Título:Production of the PET isotope C in hadron therapy via neutron knockout.
[So] Source:Phys Med;32(12):1813-1818, 2016 Dec.
[Is] ISSN:1724-191X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Positron emitting isotopes such as C and C can be used for vital dose verification in hadron therapy. These isotopes are produced when the high energy C primary beam particles undergo nuclear reactions within the patient. METHODS: We discuss a model for calculating cross sections for the production C in C+ C collisions, applicable at hadron therapy energies. RESULTS: Good agreement with the available cross section measurements is found for C(-1n), though more detailed, systematic measurements would be very valuable. CONCLUSIONS: Nuclear structure plays a crucial role in the reactions of light nuclei, particularly when those reactions are peripheral and involve only a few nucleons. For such reactions, nuclear structure has a strong influence on the energy and angular distribution of the cross section, and is an important consideration for reliable dose verification using C in hadron therapy.
[Mh] Termos MeSH primário: Radioisótopos de Carbono
Partículas Elementares/uso terapêutico
Nêutrons
Tomografia por Emissão de Pósitrons
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Radioisotopes)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170331
[Lr] Data última revisão:
170331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161016
[St] Status:MEDLINE


  9 / 1051 MEDLINE  
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[PMID]:27104699
[Au] Autor:Bauer M; Neubert M
[Ad] Endereço:Institut für Theoretische Physik, Universität Heidelberg, Philosophenweg 16, 69120 Heidelberg, Germany.
[Ti] Título:Minimal Leptoquark Explanation for the R_{D
[So] Source:Phys Rev Lett;116(14):141802, 2016 04 08.
[Is] ISSN:1079-7114
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We show that by adding a single new scalar particle to the standard model, a TeV-scale leptoquark with the quantum numbers of a right-handed down quark, one can explain in a natural way three of the most striking anomalies of particle physics: the violation of lepton universality in B[over ¯]→K[over ¯]â„“^{+}â„“^{-} decays, the enhanced B[over ¯]→D^{(*)}τν[over ¯] decay rates, and the anomalous magnetic moment of the muon. Constraints from other precision measurements in the flavor sector can be satisfied without fine-tuning. Our model predicts enhanced B[over ¯]→K[over ¯]^{(*)}νν[over ¯] decay rates and a new-physics contribution to B_{s}-B[over ¯]_{s} mixing close to the current central fit value.
[Mh] Termos MeSH primário: Partículas Elementares
Modelos Teóricos
[Mh] Termos MeSH secundário: Física Nuclear/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160423
[St] Status:MEDLINE
[do] DOI:10.1103/PhysRevLett.116.141802


  10 / 1051 MEDLINE  
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[PMID]:26930077
[Au] Autor:Zarmi Y
[Ad] Endereço:The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion, 8499000, Israel.
[Ti] Título:Spatially Extended Relativistic Particles Out of Traveling Front Solutions of Sine-Gordon Equation in (1+2) Dimensions.
[So] Source:PLoS One;11(3):e0148993, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Slower-than-light multi-front solutions of the Sine-Gordon in (1+2) dimensions, constructed through the Hirota algorithm, are mapped onto spatially localized structures, which emulate free, spatially extended, massive relativistic particles. A localized structure is an image of the junctions at which the fronts intersect. It propagates together with the multi-front solution at the velocity of the latter. The profile of the localized structure obeys the linear wave equation in (1+2) dimensions, to which a term that represents interaction with a slower-than-light, Sine-Gordon-multi-front solution has been added. This result can be also formulated in terms of a (1+2)-dimensional Lagrangian system, in which the Sine-Gordon and wave equations are coupled. Expanding the Euler-Lagrange equations in powers of the coupling constant, the zero-order part of the solution reproduces the (1+2)-dimensional Sine-Gordon fronts. The first-order part is the spatially localized structure. PACS: 02.30.Ik, 03.65.Pm, 05.45.Yv, 02.30.Ik.
[Mh] Termos MeSH primário: Partículas Elementares
Modelos Teóricos
[Mh] Termos MeSH secundário: Algoritmos
Dinâmica não Linear
Teoria Quântica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0148993



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