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[PMID]:28470533
[Au] Autor:Öz S; Breiling A; Maercker C
[Ad] Endereço:German Cancer Research Center (DKFZ), Epigenomics and Cancer Risk Factors, Heidelberg, Germany.
[Ti] Título:Measurement of Cellular Behavior by Electrochemical Impedance Sensing.
[So] Source:Methods Mol Biol;1601:267-273, 2017.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is a great demand for label-free in vitro assays in a high-throughput context, in order to measure cell viability and analyze cellular functions like cell migration or cell differentiation under noninvasive conditions. Here, we describe impedance measurement to quantify dynamic changes on cell morphology in real time. In order to monitor physiological changes, cells are grown in tissue culture vessels where gold electrodes are incorporated at the bottom. An alternating current signal of several kHz is applied to the electrodes and the resulting voltage is measured to calculate the cellular impedance. Since impedance is closely related to the area of the electrodes covered by the growing cells, parameters such as cell number, size of the cells attached to the electrodes, and cell-cell and cell-substrate/extracellular matrix interactions contribute to the overall impedance values.
[Mh] Termos MeSH primário: Diferenciação Celular/fisiologia
Movimento Celular/fisiologia
Sobrevivência Celular/fisiologia
Impedância Elétrica
[Mh] Termos MeSH secundário: Adesão Celular/fisiologia
Comunicação Celular/fisiologia
Contagem de Células
Tamanho Celular
Eletrodos
Células-Tronco de Carcinoma Embrionário/química
Matriz Extracelular/química
Ouro/química
Ensaios de Triagem em Larga Escala
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7440-57-5 (Gold)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-6960-9_21


  2 / 14394 MEDLINE  
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[PMID]:28456219
[Au] Autor:Jotta B; Coutinho ABB; Pino AV; Souza MN
[Ad] Endereço:Biomedical Engineering Program, Universidade Federal do Rio de Janeiro/COPPE, Rio de Janeiro 21941-914, Brazil.
[Ti] Título:Lactate threshold by muscle electrical impedance in professional rowers.
[So] Source:Rev Sci Instrum;88(4):045105, 2017 Apr.
[Is] ISSN:1089-7623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lactate threshold (LT) is one of the physiological parameters usually used in rowing sport training prescription because it indicates the transitions from aerobic to anaerobic metabolism. Assessment of LT is classically based on a series of values of blood lactate concentrations obtained during progressive exercise tests and thus has an invasive aspect. The feasibility of noninvasive LT estimative through bioelectrical impedance spectroscopy (BIS) data collected in thigh muscles during rowing ergometer exercise tests was investigated. Nineteen professional rowers, age 19 (mean) ± 4.8 (standard deviation) yr, height 187.3 ± 6.6 cm, body mass 83 ± 7.7 kg, and training experience of 7 ± 4 yr, were evaluated in a rowing ergometer progressive test with paired measures of blood lactate concentration and BIS in thigh muscles. Bioelectrical impedance data were obtained by using a bipolar method of spectroscopy based on the current response to a voltage step. An electrical model was used to interpret BIS data and to derive parameters that were investigated to estimate LT noninvasively. From the serial blood lactate measurements, LT was also determined through Dmax method (LT ). The zero crossing of the second derivative of kinetic of the capacitance electrode (Ce), one of the BIS parameters, was used to estimate LT. The agreement between the LT estimates through BIS (LT ) and through Dmax method (LT ) was evaluated using Bland-Altman plots, leading to a mean difference between the estimates of just 0.07 W and a Pearson correlation coefficient r = 0.85. This result supports the utilization of the proposed method based on BIS parameters for estimating noninvasively the lactate threshold in rowing.
[Mh] Termos MeSH primário: Impedância Elétrica
Ácido Láctico/metabolismo
Músculo Esquelético/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Seres Humanos
Masculino
Análise de Regressão
Esportes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
33X04XA5AT (Lactic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE
[do] DOI:10.1063/1.4979072


  3 / 14394 MEDLINE  
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[PMID]:28457836
[Au] Autor:Kasinadhuni AK; Indahlastari A; Chauhan M; Schär M; Mareci TH; Sadleir RJ
[Ad] Endereço:J. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville FL, USA.
[Ti] Título:Imaging of current flow in the human head during transcranial electrical therapy.
[So] Source:Brain Stimul;10(4):764-772, 2017 Jul - Aug.
[Is] ISSN:1876-4754
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It has been assumed that effects caused by tDCS or tACS neuromodulation are due to electric current flow within brain structures. However, to date, direct current density distributions in the brains of human subjects have not been measured. Instead computational models of tDCS or tACS have been used to predict electric current and field distributions for dosimetry and mechanism analysis purposes. OBJECTIVE/HYPOTHESIS: We present the first in vivo images of electric current density distributions within the brain in four subjects undergoing transcranial electrical stimulation. METHODS: Magnetic resonance electrical impedance tomography (MREIT) techniques encode current flow in phase images. In four human subjects, we used MREIT to measure magnetic flux density distributions caused by tACS currents, and then calculated current density distributions from these data. Computational models of magnetic flux and current distribution, constructed using contemporaneously collected T -weighted structural MRI images, were co-registered to compare predicted and experimental results. RESULTS: We found consistency between experimental and simulated magnetic flux and current density distributions using transtemporal (T7-T8) and anterior-posterior (Fpz-Oz) electrode montages, and also differences that may indicate a need to improve models to better interpret experimental results. While human subject data agreed with computational model predictions in overall scale, differences may result from factors such as effective electrode surface area and conductivities assumed in models. CONCLUSIONS: We believe this method may be useful in improving reproducibility, assessing safety, and ultimately aiding understanding of mechanisms of action in electrical and magnetic neuromodulation modalities.
[Mh] Termos MeSH primário: Encéfalo/fisiologia
Potenciais Evocados
Imagem por Ressonância Magnética/métodos
Modelos Neurológicos
Estimulação Transcraniana por Corrente Contínua/métodos
[Mh] Termos MeSH secundário: Encéfalo/diagnóstico por imagem
Impedância Elétrica
Eletrodos
Análise de Elementos Finitos
Seres Humanos
Imagem por Ressonância Magnética/normas
Masculino
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  4 / 14394 MEDLINE  
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[PMID]:28465219
[Au] Autor:Sung KH; Chung CY; Lee KM; Cho BC; Moon SJ; Kim J; Park MS
[Ad] Endereço:Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Sungnam, Korea.
[Ti] Título:Differences in Body Composition According to Gross Motor Function in Children With Cerebral Palsy.
[So] Source:Arch Phys Med Rehabil;98(11):2295-2300, 2017 11.
[Is] ISSN:1532-821X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess differences in body composition according to gross motor function in children with cerebral palsy (CP) compared with healthy controls. DESIGN: Retrospective case-control study. SETTING: Tertiary referral center for CP. PARTICIPANTS: Participants (N=146) comprised consecutive patients with CP (n=100; mean age, 11.5±4.2y) who were admitted for orthopedic surgery between May 2014 and March 2016 and typically developing children (TDC, n=46; control group). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Bioelectrical impedance analysis (BIA) was used to assess body composition, including body fat, soft lean mass (SLM), fat-free mass (FFM), skeletal muscle mass (SMM), body cell mass (BCM), bone mineral content (BMC), and basal metabolic rate. Body composition measures were compared according to Gross Motor Function Classification System (GMFCS) level, as well as between children with CP and TDC. RESULTS: Children with CP with GMFCS levels IV and V had a lower height, weight, and body mass index than those with GMFCS levels I to III. Children with CP with GMFCS levels IV and V had a significantly lower SLM, SLM index, FFM, FFM index, SMM, SMM index, BCM, BCM index, BMC, and BMC index than those with GMFCS levels I to III and TDC. GMFCS level significantly affected SLM and BMC. CONCLUSIONS: Body composition analysis using BIA showed that nonambulatory children with CP had significantly lower FFM, SLM, SMM, BCM, and BMC than ambulatory children with CP and TDC. However, further study is required to allow the use of BIA as a valid nutritional assessment tool in patients with CP.
[Mh] Termos MeSH primário: Composição Corporal/fisiologia
Paralisia Cerebral/fisiopatologia
Destreza Motora/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Metabolismo Basal
Densidade Óssea
Criança
Impedância Elétrica
Feminino
Seres Humanos
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  5 / 14394 MEDLINE  
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[PMID]:28452241
[Au] Autor:Theerawit P; Sutherasan Y; Ball L; Pelosi P
[Ad] Endereço:a Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital , Mahidol University , Bangkok , Thailand.
[Ti] Título:Respiratory monitoring in adult intensive care unit.
[So] Source:Expert Rev Respir Med;11(6):453-468, 2017 Jun.
[Is] ISSN:1747-6356
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The mortality of patients with respiratory failure has steadily decreased with the advancements in protective ventilation and treatment options. Although respiratory monitoring per se has not been proven to affect the mortality of critically ill patients, it plays a crucial role in patients' care, as it helps to titrate the ventilatory support. Several new monitoring techniques have recently been made available at the bedside. The goals of monitoring comprise alerting physicians to detect the change in the patients' conditions, to improve the understanding of pathophysiology to guide the diagnosis and provide cost-effective clinical management. Areas covered: We performed a review of the recent scientific literature to provide an overview of the different methods used for respiratory monitoring in adult intensive care units, including bedside imaging techniques such as ultrasound and electrical impedance tomography. Expert commentary: Appropriate respiratory monitoring plays an important role in patients with and without respiratory failure as a guiding tool for the optimization of ventilation support, avoiding further complications and decreasing morbidity and mortality. The physician should tailor the monitoring strategy for each individual patient and know how to correctly interpret the data.
[Mh] Termos MeSH primário: Unidades de Terapia Intensiva
Pulmão/fisiopatologia
Monitorização Fisiológica/métodos
Respiração Artificial
Insuficiência Respiratória/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Estado Terminal
Impedância Elétrica
Seres Humanos
Insuficiência Respiratória/mortalidade
Insuficiência Respiratória/fisiopatologia
Tomografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/17476348.2017.1325324


  6 / 14394 MEDLINE  
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[PMID]:28459695
[Au] Autor:Barman U; Mukhopadhyay G; Goswami N; Ghosh SS; Paily RP
[Ti] Título:Detection of Glutathione by Glutathione-S-Transferase-Nanoconjugate Ensemble Electrochemical Device.
[So] Source:IEEE Trans Nanobioscience;16(4):271-279, 2017 06.
[Is] ISSN:1558-2639
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper reports a novel electrochemical method for detection of Glutathione (GSH) using Glutathione-S-Transferase (GST) - ZnO composite nanoparticles to investigate the prospects of the method for detection of cancer at an early stage. The purified GST enzyme was bound with ZnO nanoparticles by electrostatic interactions and the nanocomposite was dropcast on a silicon dioxide wafer. The GST functionalized deposited layer was then used as a chemiresistive channel to detect conjugation reaction between GSH and 1-Chloro-2, 4-Dinitrobenzene (CDNB). The zeta potential values of the ZnO nanoparticles and the GST were found to be 13.4 mV and-6.21 mV, respectively. Around 73.8% binding was observed between the enzyme and ZnO nanoparticles. I - V analysis of the chemiresistive channel showed an increase in conductivity of the channel due to conjugation reaction between GSH and CDNB as compared with that of GSH or CDNB alone. I - V characterization of the GST functionalized layer was performed at various concentrations of GSH and a sensitivity and limit of detection of 5.68 nA/ [Formula: see text] and 41.9 nM were obtained, respectively. Thus from I - V analysis of the chemiresistivechannel, the detectionand quantification of GSH could be obtained. The kinetic parameters of both GST and nanoconjugate of ZnO nanoparticles andGSTwere determinedwith respect to its substrates, GSH and CDNB, using Michaelis-Mentenmodel. This novel approach of detection of GSH bymeans of ZnO nanoparticle and GST enzyme composite can be further analyzed for in vitro experiments, which will lead us to a new and efficient way of detecting certain types of cancers at an early stage.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/instrumentação
Técnicas Eletroquímicas/instrumentação
Enzimas Imobilizadas/metabolismo
Glutationa Transferase/metabolismo
Glutationa/análise
Nanoconjugados/química
[Mh] Termos MeSH secundário: Técnicas Biossensoriais/métodos
Impedância Elétrica
Enzimas Imobilizadas/química
Glutationa Transferase/química
Limite de Detecção
Reprodutibilidade dos Testes
Óxido de Zinco/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzymes, Immobilized); 0 (Nanoconjugates); EC 2.5.1.18 (Glutathione Transferase); GAN16C9B8O (Glutathione); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1109/TNB.2017.2698241


  7 / 14394 MEDLINE  
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[PMID]:28836872
[Au] Autor:Dettmar PW; Gil-Gonzalez D; Fisher J; Flint L; Rainforth D; Moreno-Herrera A; Potts M
[Ad] Endereço:a Research Department , Technostics Limited, Castle Hill Hospital , Cottingham , UK.
[Ti] Título:A comparative study on the raft chemical properties of various alginate antacid raft-forming products.
[So] Source:Drug Dev Ind Pharm;44(1):30-39, 2018 Jan.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Research to measure the chemical characterization of alginate rafts for good raft performance and ascertain how formulation can affect chemical parameters. SIGNIFICANCE: A selection of alginate formulations was investigated all claiming to be proficient raft formers with significance between products established and ranked. METHODS: Procedures were selected which demonstrated the chemical characterization allowing rafts to effectively impede the reflux into the esophagus or in severe cases to be refluxed preferentially into the esophagus and exert a demulcent effect, with focus of current research on methods which complement previous studies centered on physical properties. The alginate content was analyzed by a newly developed HPLC method. Methods were used to determine the neutralization profile and the acid neutralization within the raft determined along with how raft structure affects neutralization. RESULTS: Alginate content of Gaviscon Double Action (GDA) within the raft was significantly superior (p < .0001) to all competitor products. The two products with the highest raft acid neutralization capacity were GDA and Rennie Duo, the latter product not being a raft former. Raft structure was key and GDA had the right level of porosity to allow for longer duration of neutralization. CONCLUSION: Alginate formulations require three chemical reactions to take place simultaneously: transformation to alginic acid, sodium carbonate reacting to form carbon dioxide, calcium releasing free calcium ions to bind with alginic acid providing strength to raft formation. GDA was significantly superior (p <.0001) to all other comparators.
[Mh] Termos MeSH primário: Alginatos/química
Hidróxido de Alumínio/química
Antiácidos/química
Carbonato de Cálcio/química
Carbonatos/química
Esôfago/química
Refluxo Gastroesofágico/tratamento farmacológico
Magnésio/química
Ácido Silícico/química
Bicarbonato de Sódio/química
[Mh] Termos MeSH secundário: Alginatos/farmacologia
Alginatos/uso terapêutico
Antiácidos/metabolismo
Antiácidos/uso terapêutico
Combinação de Medicamentos
Impedância Elétrica
Refluxo Gastroesofágico/metabolismo
Ácido Glucurônico/química
Ácido Glucurônico/farmacologia
Ácido Glucurônico/uso terapêutico
Ácidos Hexurônicos/química
Ácidos Hexurônicos/farmacologia
Ácidos Hexurônicos/uso terapêutico
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (Antacids); 0 (Carbonates); 0 (Drug Combinations); 0 (Hexuronic Acids); 1343-98-2 (Silicic Acid); 45P3261C7T (sodium carbonate); 5QB0T2IUN0 (Aluminum Hydroxide); 66220-44-8 (alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination); 82351-35-7 (Rennie); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); 8MDF5V39QO (Sodium Bicarbonate); H0G9379FGK (Calcium Carbonate); I38ZP9992A (Magnesium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1371737


  8 / 14394 MEDLINE  
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[PMID]:29252987
[Au] Autor:Kim S; Kim GH
[Ad] Endereço:Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Korea.
[Ti] Título:Roles of claudin-2, ZO-1 and occludin in leaky HK-2 cells.
[So] Source:PLoS One;12(12):e0189221, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Claudin-2, ZO-1, and occludin are major components of tight junctions (TJs) in the proximal tubule. However, their roles in maintaining paracellular permeability as leaky epithelia have yet to be defined. METHODS: To investigate the contributory role of TJ proteins in the leaky proximal tubule, we xamined the effect of inhibiting claudin-2, occludin, and ZO-1 expression on transepithelial electrical resistance (TER) and paracellular permeability using the immortalized human proximal tubule epithelial cell line HK-2. For this, small-interfering RNAs (siRNAs) against claudin-2, occludin and ZO-1 were transfected into HK-2 cells. TER and transepithelial flux rates of dextrans (4 and 70 kDa) were determined after 24 h. RESULTS: Transfection of siRNAs (25 nM) knocked down TJ protein expression. Control HK-2 monolayers achieved a steady-state TER of 6-8 Ω·cm2 when grown in 12-well Transwell filters, which are compatible with leaky epithelia. Knockdown of claudin-2 decreased in TER and increased occludin expression. Transfection with siRNA against either occludin or ZO-1 increased TER and decreased claudin-2 expression. TER was decreased by co-inhibition of claudin-2 and ZO-1 but increased by co-inhibition of claudin-2 and occludin. TER was suppressed when claudin-2, occludin, and ZO-1 were all inhibited. Dextran flux rate was increased by claudin-2, occludin, or ZO-1 siRNA transfection. Increased dextran flux was enhanced by co-transfection of claudin-2, ZO-1, and occludin siRNA. CONCLUSIONS: The depletion of claudin-2, occludin and ZO-1 in HK-2 cells had differential effects on TER and macromolecule flux. We demonstrated that integration of claudin-2, occludin and ZO-1 is necessary for maintaining the function of the proximal tubular epithelium.
[Mh] Termos MeSH primário: Claudina-2/metabolismo
Células Epiteliais/metabolismo
Ocludina/metabolismo
Proteína da Zônula de Oclusão-1/metabolismo
[Mh] Termos MeSH secundário: Linhagem Celular
Permeabilidade da Membrana Celular
Dextranos/metabolismo
Impedância Elétrica
Técnicas de Silenciamento de Genes
Seres Humanos
RNA Interferente Pequeno/metabolismo
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Claudin-2); 0 (Dextrans); 0 (Occludin); 0 (RNA, Small Interfering); 0 (Zonula Occludens-1 Protein)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189221


  9 / 14394 MEDLINE  
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[PMID]:29190055
[Au] Autor:Punkkinen J; Haak R; Kaartinen M; Walamies M
[Ti] Título:Help from habit reversal for supragastric belching.
[So] Source:Duodecim;132(22):2073-9, 2016.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:Supragastric belching differs from common gastric belching. It can be detected by 24-hour intra-esophageal impedance monitoring. Belching is seldom the only symptom: reflux symptom is present in 95% and dysphagia in 65% of the patients. In supragastric belching, the air does not come from the stomach but instead from the esophagus. Belching is caused by the patient him/herself swallowing air into the esophagus. This voluntary but unconscious symptom is treated by therapy in which explaining the mechanism of belching for the patient and learning of correct diaphragmatic breathing technique play a central role. Habit reversal is utilized for teaching the patient to react correctly to preemptive symptoms.
[Mh] Termos MeSH primário: Aerofagia/prevenção & controle
Eructação/prevenção & controle
Hábitos
[Mh] Termos MeSH secundário: Aerofagia/complicações
Aerofagia/fisiopatologia
Impedância Elétrica
Eructação/etiologia
Eructação/fisiopatologia
Esôfago/fisiopatologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  10 / 14394 MEDLINE  
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[PMID]:28742775
[Au] Autor:da Silva Ramos FJ; Hovnanian A; Souza R; Azevedo LCP; Amato MBP; Costa ELV
[Ti] Título:Estimation of Stroke Volume and Stroke Volume Changes by Electrical Impedance Tomography.
[So] Source:Anesth Analg;126(1):102-110, 2018 01.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Electrical impedance tomography (EIT) is a noninvasive imaging method that identifies changes in air and blood volume based on thoracic impedance changes. Recently, there has been growing interest in EIT to measure stroke volume (SV). The objectives of this study are as follows: (1) to evaluate the ability of systolic impedance variations (ΔZsys) to track changes in SV in relation to a baseline condition; (2) to assess the relationship of ΔZsys and SV in experimental subjects; and (3) to identify the influence of body dimensions on the relationship between ΔZsys and SV. METHODS: Twelve Agroceres pigs were instrumented with transpulmonary thermodilution catheter and EIT and were mechanically ventilated in a random order using different settings of tidal volume (VT) and positive end-expiratory pressure (PEEP): VT 10 mL·kg and PEEP 10 cm H2O, VT 10 mL·kg and PEEP 5 cm H2O, VT 6 mL·kg and PEEP 10 cm H2O, and VT 6 mL·kg and PEEP 5 cm H2O. After baseline data collection, subjects were submitted to hemorrhagic shock and successive fluid challenges. RESULTS: A total of 204 paired measurements of SV and ΔZsys were obtained. The 4-quadrant plot showed acceptable trending ability with a concordance rate of 91.2%. Changes in ΔZsys after fluid challenges presented an area under the curve of 0.83 (95% confidence interval, 0.74-0.92) to evaluate SV changes. Conversely, the linear association between ΔZsys and SV was poor, with R from linear mixed model of 0.35. Adding information on body dimensions improved the linear association between ΔZsys and SV up to R from linear mixed model of 0.85. CONCLUSIONS: EIT showed good trending ability and is a promising hemodynamic monitoring tool. Measurements of absolute SV require that body dimensions be taken into account.
[Mh] Termos MeSH primário: Impedância Elétrica
Volume Sistólico/fisiologia
Tomografia/métodos
[Mh] Termos MeSH secundário: Animais
Estudos Cross-Over
Feminino
Respiração com Pressão Positiva/métodos
Distribuição Aleatória
Choque Hemorrágico/diagnóstico por imagem
Choque Hemorrágico/fisiopatologia
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002271



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