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[PMID]:29385211
[Au] Autor:Hiwaki O; Miyaguchi H
[Ad] Endereço:Graduate School of Information Sciences, Hiroshima City University, Hiroshima, Japan.
[Ti] Título:Noninvasive measurement of dynamic brain signals using light penetrating the brain.
[So] Source:PLoS One;13(1):e0192095, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Conventional techniques for the noninvasive measurement of brain activity involve critical limitations in spatial or temporal resolution. Here, we propose the method for noninvasive brain function measurement with high spatiotemporal resolution using optical signals. We verified that diffused near-infrared light penetrating through the upper jaw and into the skull, which we term as optoencephalography (OEG), leads to the detection of dynamic brain signals that vary concurrently with the electrophysiological neural activity. We measured the OEG signals following the stimulation of the median nerve in common marmosets. The OEG signal response was tightly coupled with the electrophysiological response represented by the somatosensory evoked potential (SSEP). The OEG measurement is also shown to offer rather clear discrimination of brain signals.
[Mh] Termos MeSH primário: Encéfalo/fisiopatologia
Raios Infravermelhos
[Mh] Termos MeSH secundário: Animais
Callithrix
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0192095


  2 / 10753 MEDLINE  
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[PMID]:29200855
[Au] Autor:Gerstenhaber JA; Barone FC; Marcinkiewicz C; Li J; Shiloh AO; Sternberg M; Lelkes PI; Feuerstein G
[Ad] Endereço:Department of Bioengineering, College of Engineering, Temple University, Philadelphia, PA.
[Ti] Título:Vascular thrombus imaging in vivo via near-infrared fluorescent nanodiamond particles bioengineered with the disintegrin bitistatin (Part II).
[So] Source:Int J Nanomedicine;12:8471-8482, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:The aim of this feasibility study was to test the ability of fluorescent nanodiamond particles (F-NDP) covalently conjugated with bitistatin (F-NDP-Bit) to detect vascular blood clots in vivo using extracorporeal near-infrared (NIR) imaging. Specifically, we compared NIR fluorescence properties of F-NDP with N-V (F-NDP ) and N-V-N color centers and sizes (100-10,000 nm). Optimal NIR fluorescence and tissue penetration across biological tissues (rat skin, porcine axillary veins, and skin) was obtained for F-NDP with a mean diameter of 700 nm. Intravital imaging (using in vivo imaging system [IVIS]) in vitro revealed that F-NDP -loaded glass capillaries could be detected across 6 mm of rat red-muscle barrier and 12 mm of porcine skin, which equals the average vertical distance of a human carotid artery bifurcation from the surface of the adjacent skin (14 mm). In vivo, feasibility was demonstrated in a rat model of occlusive blood clots generated using FeCl in the carotid artery bifurcation. Following systemic infusions of F-NDP -Bit (3 or 15 mg/kg) via the external carotid artery or femoral vein (N=3), presence of the particles in the thrombi was confirmed both in situ via IVIS, and ex vivo via confocal imaging. The presence of F-NDP in the vascular clots was further confirmed by direct counting of fluorescent particles extracted from clots following tissue solubilization. Our data suggest that F-NDP -Bit associate with vascular blood clots, presumably by binding of F-NDP -Bit to activated platelets within the blood clot. We posit that F-NDP -Bit could serve as a noninvasive platform for identification of vascular thrombi using NIR energy monitored by an extracorporeal device.
[Mh] Termos MeSH primário: Bioengenharia/métodos
Diagnóstico por Imagem
Desintegrinas/química
Raios Infravermelhos
Nanodiamantes/química
Peptídeos/química
Trombose/diagnóstico
[Mh] Termos MeSH secundário: Animais
Artérias Carótidas/patologia
Modelos Animais de Doenças
Desintegrinas/administração & dosagem
Fluorescência
Seres Humanos
Infusões Intravenosas
Masculino
Peptídeos/administração & dosagem
Ratos Sprague-Dawley
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disintegrins); 0 (Nanodiamonds); 0 (Peptides); 124123-27-9 (bitistatin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S146946


  3 / 10753 MEDLINE  
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[PMID]:29340524
[Au] Autor:Baraba A; Kqiku L; Gabric D; Verzak Z; Hanscho K; Miletic I
[Ad] Endereço:Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
[Ti] Título:Efficacy of removal of cariogenic bacteria and carious dentin by ablation using different modes of Er:YAG lasers.
[So] Source:Braz J Med Biol Res;51(3):e6872, 2018 Jan 11.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The primary objective of this in vitro study was to evaluate the efficiency of removal of cariogenic bacteria and carious dentin by ablation using two lasers: fluorescence-feedback controlled (FFC) Er:YAG laser and different pulses of Er:YAG laser based on variable square pulse technology (VSPt). The secondary objective was to measure the temperature during laser ablation of carious tissue. Seventy-two extracted human molars were used in this study. Sixty teeth with carious dentin were randomly divided into four experimental groups according to the treatment for caries removal: group 1: 400 µs (FFC group); group 2: super short pulse (SSP group, 50 µs pulse); group 3: medium short pulse (MSP group, 100 µs pulse); group 4: short pulse (SP group, 300 µs pulse) and one positive control group with no treatment. Twelve teeth without carious lesion were used as a negative control group. After caries removal, swabs were taken with cotton pellets and real-time PCR analysis was performed. During caries ablation, a thermal infrared camera was used to measure the temperature changes. In all experimental groups, specimens were free of bacterial contamination after the treatment. In the SSP, MSP and SP groups, temperatures measured during caries ablation were significantly higher compared to temperatures in the FFC group (P<0.001). In this in vitro study, laser treatment for removal of carious dentin and cariogenic bacteria was an efficient treatment modality without causing excessive temperatures that might adversely affect pulp vitality.
[Mh] Termos MeSH primário: Bactérias/isolamento & purificação
Cárie Dentária/terapia
Preparo da Cavidade Dentária/métodos
Dentina/microbiologia
Lasers de Estado Sólido/uso terapêutico
[Mh] Termos MeSH secundário: Cárie Dentária/diagnóstico
Polpa Dentária/fisiologia
Bactérias Gram-Negativas/isolamento & purificação
Bactérias Gram-Positivas/isolamento & purificação
Seres Humanos
Raios Infravermelhos
Reação em Cadeia da Polimerase em Tempo Real
Temperatura Ambiente
Termografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE


  4 / 10753 MEDLINE  
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[PMID]:29353699
[Au] Autor:Abdel-Magied N; Ahmed AG; Shedid SM
[Ad] Endereço:Radiation Biology Research, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, 3st Ahmed Elzomer, Nasr city, Cairo, Egypt. Electronic address: nanyabdelmagid@yahoo.com.
[Ti] Título:Near-infrared heat lamp therapeutic effect on paraoxonase 1 and myeloperoxidase as potential biomarkers of redox state changes induced by γ-irradiation in albino rats.
[So] Source:J Photochem Photobiol B;179:105-112, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Infrared radiation has a potential therapeutic effect in some diseases. The aim of this study was to estimate the therapeutic role of near infrared heat lamp (NIRHL) on the variations of the activity of paraoxonase 1 (PON1) and myeloperoxidase (MPO), in relation to lipid disorders, associated with oxidative stress in rats gamma-irradiated. In addition, study the effect of the duration of NIRHL treatment. Animals were divided into six groups. The results revealed that irradiated rats treated with NIRHL 20 min/once/day showed positive modulation of PON1 and MPO linked to significant improvement of lipid disorders evidenced by lower triglycerides, low density lipoprotein cholesterol (LDL-C), oxidized low density lipoprotein cholesterol (oxLDL-C) and higher density lipoprotein cholesterol (HDL-C) as well as significant amelioration of redox state, manifested by markedly increase of glutathione (GSH) content, total antioxidant capacity (TAC) associated with a noticeable decrease of pro-inflammatory cytokines. (TNF-α, IL-1 beta and IL-6), nitric oxide (NO), nitric oxide synthase (NOs), malondialdehyde (MDA), compared to irradiated rats. The results showed also that the NIRHL treatment for 20 min/twice/day had negative effects on the previous parameters and on the behavior of rats such as itching, irritability, dyspnea and death in normal as well as, irradiated rats. In conclusion, the results in this study show that NIRHL therapy for a short time can effectively prevent the lipid disorders induced by radiation through the positive modulation mechanism of PON1 and MPO enzymes and improvement of oxidative stress.
[Mh] Termos MeSH primário: Arildialquilfosfatase/metabolismo
Biomarcadores/metabolismo
Raios Infravermelhos
Peroxidase/metabolismo
[Mh] Termos MeSH secundário: Animais
Cálcio/análise
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Citocinas/metabolismo
Raios gama
Glutationa/sangue
Masculino
Malondialdeído/sangue
Óxido Nítrico/sangue
Oxirredução
Ratos
Ratos Sprague-Dawley
Temperatura Ambiente
Irradiação Corporal Total
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (Cytokines); 31C4KY9ESH (Nitric Oxide); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.7 (Peroxidase); EC 3.1.8.1 (Aryldialkylphosphatase); GAN16C9B8O (Glutathione); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE


  5 / 10753 MEDLINE  
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[PMID]:29339160
[Au] Autor:Raudsepp A; Kent LM; Hall SB; Williams MAK
[Ad] Endereço:Institute of Fundamental Sciences, Massey University, Palmerston North 4442, New Zealand.
[Ti] Título:Overstretching partially alkyne functionalized dsDNA using near infrared optical tweezers.
[So] Source:Biochem Biophys Res Commun;496(3):975-980, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The force-extension behaviour of synthesized double-stranded DNAs (dsDNAs) designed to have 2.1% or 6.6% of the thymine bases alkyne functionalized was studied using near infrared (NIR) optical tweezers. Measurements were carried out on substrates with and without flurophores covalently attached to the alkyne moiety over an extended force range (F=0-70 pN) and results were compared to those obtained from an unmodified control. In accordance with earlier work [1] (measured over a force range F=0-5 pN), the force-extension of the dsDNA containing 2.1% modified-bases agreed well with that of the control. By contrast, the force-extension of the dsDNA containing 6.6% modified-bases showed an increasing deviation from that of the control as the dsDNA extension approached the molecule's contour length. These results indicate that incorporating alkyne functionalized bases can modify the mechanical properties of the dsDNA and that degree of functionalization should be carefully considered if a fluorescent mechanical analogue is required. A discrepancy between 1) the control dsDNA force-extension measured in Ref. [1] and that measured here and 2) dsDNA extensions carried out on the same duplex at different laser powers was noted; this was attributed to beam heating by the NIR trapping laser which was estimated to raise the local temperature at the optical traps by ΔT≈10-15°C.
[Mh] Termos MeSH primário: Alquinos/química
DNA/química
Pinças Ópticas
[Mh] Termos MeSH secundário: Módulo de Elasticidade
Raios Infravermelhos
Conformação de Ácido Nucleico
Estresse Mecânico
Resistência à Tração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkynes); 9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE


  6 / 10753 MEDLINE  
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[PMID]:29384856
[Au] Autor:Atas Berksoy E; Bag Ö; Yazici S; Çelik T
[Ad] Endereço:University of Health Sciences, Tepecik Education and Research Hospital, Pediatric Emergency Clinic, Izmir.
[Ti] Título:Use of noncontact infrared thermography to measure temperature in children in a triage room.
[So] Source:Medicine (Baltimore);97(5):e9737, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We compared the accuracy and utility of 3 infrared (IFR) thermographs fitted with axillary digital thermometers used to measure temperature in febrile and afebrile children admitted to an emergency triage room.A total of 184 febrile and 135 afebrile children presenting to a triage room were consecutively evaluated. Axillary temperature was recorded using a digital electronic thermometer. Simultaneously, IFR skin scans were performed on the forehead, the neck (over the carotid artery), and the nape by the same nurse. Fever was defined as an axillary temperature ≥37.5°C. The temperature readings at the 4 sites were compared.For all subjects, the median axillary temperature was 37.7 ±â€Š1.5°C, the IFR forehead temperature was 37 ±â€Š1.1°C, the IFR neck temperature was 37.6 ±â€Š1.5°C, and the IFR nape temperature was 37 ±â€Š1.2°C. A Bland-Altman plot of the differences suggested that all agreements between IFR and axillary measures were poor (the latter measure was considered the standard). The forehead measurements had a sensitivity of 88.6% and a specificity of 60% in patients with temperatures ≥36.75°C. The sensitivities of the neck measurement at cut-offs of ≥37.35°C and ≥36.95 were 95.5% and 78.8% for those aged 2 to 6 years. Thus, 11.4% of febrile subjects were missed when forehead measurements were performed.An IFR scan over the lateral side of neck is a reliable, comfortable, rapid, and noninvasive method for fever screening, particularly in children aged 2 to 6 years, in busy settings such as pediatric triage rooms.
[Mh] Termos MeSH primário: Termografia
Triagem
[Mh] Termos MeSH secundário: Adolescente
Temperatura Corporal
Criança
Pré-Escolar
Feminino
Febre/diagnóstico
Febre/fisiopatologia
Testa
Seres Humanos
Lactente
Raios Infravermelhos
Masculino
Pescoço
Enfermeiras e Enfermeiros
Estudos Prospectivos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Pele/fisiopatologia
Termômetros
Triagem/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009737


  7 / 10753 MEDLINE  
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[PMID]:29290016
[Au] Autor:Moramarco A; Giustini S; Nofroni I; Mallone F; Miraglia E; Iacovino C; Calvieri S; Lambiase A
[Ad] Endereço:Department of Sense Organs, 'Sapienza' University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
[Ti] Título:Near-infrared imaging: an in vivo, non-invasive diagnostic tool in neurofibromatosis type 1.
[So] Source:Graefes Arch Clin Exp Ophthalmol;256(2):307-311, 2018 Feb.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Only a few reports in the literature have investigated the presence of ocular abnormalities in neurofibromatosis type 1 (NF-1) patients. The aim of this study was to evaluate the prevalence of ocular abnormalities in a large population of NF1 patients, focusing on the choroidal changes. METHODS: This study was conducted on 160 consecutive patients with NF1 and 106 sex- and age-matched healthy subjects (control). Each patient underwent a complete ophthalmological examination inclusive of best-corrected visual acuity, intraocular pressure measurement, slit-lamp biomicroscopy, indirect fundus biomicroscopy, and near-infrared reflectance (NIR) retinography by using the spectral domain OCT. Moreover, all patients underwent complete dermatological exam and 1.5-Tesla MRI scan of the brain to assess the presence of optic nerve gliomas. RESULTS: Choroidal abnormalities were detected in 97% of patients, with a positive predictive value of 100% and a negative predictive value of 96.4%. Interestingly, a small number of patients (4/160; 2.5%) showed Lisch nodules without choroidal abnormalities, whereas a larger number of patents (22/160; 13.75%) presented choroidal lesions in absence of Lisch nodules. None of the patients showed the absence of both choroidal lesions and Lisch nodules. The number of choroidal lesions increased with age (r = 0.364, p = 0.0001) and with the severity of pathology (r = 0.23, p = 0.003). Any statistically significant correlation between choroidal lesions, visual acuity, and intraocular pressure was observed. CONCLUSIONS: NIR imaging represents an in vivo, non-invasive, sensitive and reproducible exam to detect choroidal nodules in NF-1 patients, suggesting that choroidal changes may represent an additional diagnostic criteria for NF1.
[Mh] Termos MeSH primário: Doenças da Coroide/diagnóstico
Corioide/patologia
Raios Infravermelhos
Neurofibromatose 1/diagnóstico
Oftalmoscopia/métodos
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Adulto
Doenças da Coroide/etiologia
Estudos Transversais
Diagnóstico Diferencial
Feminino
Seguimentos
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Neurofibromatose 1/complicações
Curva ROC
Reprodutibilidade dos Testes
Pele/patologia
Fatores de Tempo
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3870-z


  8 / 10753 MEDLINE  
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[PMID]:29205502
[Au] Autor:Rao P; Keenan JB; Rajab TK; Ferng A; Kim S; Khalpey Z
[Ad] Endereço:Sarver Heart Center, University of Arizona, Tucson, Arizona.
[Ti] Título:Intraoperative thermographic imaging to assess myocardial distribution of Del Nido cardioplegia.
[So] Source:J Card Surg;32(12):812-815, 2017 Dec.
[Is] ISSN:1540-8191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We describe the intraoperative non-invasive use of an infrared (IR) camera to monitor Del Nido cardioplegia delivery in patients undergoing cardiac surgery. Thermal pictures were taken pre- and post-cardioplegia and at timed points after arrest, and compared to readings from a transseptal temperature probe. There was good concordance between the transseptal probe and the IR camera temperature readings. This non-invasive technique, which assesses cardioplegic distribution, may help to determine when additional doses of Del Nido cardioplegia are required during periods of cardioplegic arrest.
[Mh] Termos MeSH primário: Parada Cardíaca Induzida
Raios Infravermelhos
Monitorização Intraoperatória/métodos
Termografia/métodos
[Mh] Termos MeSH secundário: Idoso
Soluções Cardioplégicas
Tomada de Decisão Clínica
Sistemas de Computação
Ponte de Artéria Coronária
Parada Cardíaca Induzida/métodos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardioplegic Solutions)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1111/jocs.13258


  9 / 10753 MEDLINE  
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[PMID]:29203372
[Au] Autor:Lohan SB; Vitt K; Scholz P; Keck CM; Meinke MC
[Ad] Endereço:Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Berlin, Germany. Electronic address: sil
[Ti] Título:ROS production and glutathione response in keratinocytes after application of ß-carotene and VIS/NIR irradiation.
[So] Source:Chem Biol Interact;280:1-7, 2018 Jan 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The skin is exposed to many stress factors which, in turn, can promote a shift of the antioxidant (AO) network towards the prooxidative side, supporting the development of various skin disorders. A balanced diet, in combination with a healthy lifestyle could reduce oxidative stress. Carotenoids are essential nonenzymatic AOs and main components of the exogenous AO system. To examine the interdependence between endogenous and exogenous AOs, secondary keratinocytes (HaCaT) were treated with various Beta (ß-)-carotene concentrations with subsequent stress treatment by moderate irradiation (700-2000 nm). To facilitate the uptake of ß-carotene, an innovative nanocrystal solution was used. Cell viability assay was applied to HaCaT cells to evaluate suitable concentration of ß-carotene, whereby the uptake was measured by resonant Raman spectroscopy. The redox status was determined before and after supplementation with two selected ß-carotene concentrations (0.02 and 0.1 µg/ml) and irradiation. Reactive oxygen species (ROS) were measured by electron paramagnetic resonance spectroscopy and the AO glutathione (GSH) by a fluorescent-based assay for evaluating the endogenous redox status. An increase of ROS and a reduction of GSH after irradiation was observed. Interestingly, the applied ß-carotene, already induce oxidative stress. Nevertheless, an effective protection against irradiation could be observed for the lower dose. The high dose turned pro-oxidative.
[Mh] Termos MeSH primário: Glutationa/metabolismo
Raios Infravermelhos
Luz
Estresse Oxidativo/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
beta Caroteno/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Espectroscopia de Ressonância de Spin Eletrônica
Seres Humanos
Queratinócitos/efeitos dos fármacos
Queratinócitos/metabolismo
Queratinócitos/efeitos da radiação
Oxirredução
Estresse Oxidativo/efeitos da radiação
Análise Espectral Raman
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 01YAE03M7J (beta Carotene); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  10 / 10753 MEDLINE  
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[PMID]:29220150
[Au] Autor:Jia J; Zhang Y; Zheng M; Shan C; Yan H; Wu W; Gao X; Cheng B; Liu W; Tang Y
[Ad] Endereço:State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, and ‡Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, La
[Ti] Título:Functionalized Eu(III)-Based Nanoscale Metal-Organic Framework To Achieve Near-IR-Triggered and -Targeted Two-Photon Absorption Photodynamic Therapy.
[So] Source:Inorg Chem;57(1):300-310, 2018 Jan 02.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The postsynthetic-modified nanoscale metal-organic framework (NMOF) probes selected as potential drug delivery platforms and photodynamic therapy agents to fulfill the effective and safe treatment of neoplastic diseases have attracted increasing attention recently. Herein, a Eu(III)-based NMOF probe elaborately postsynthetically modified with a ß-diketonate two-photon-absorbing (TPA) ligand is rationally designed and further functionalized by assembling the photosensitizer molecule (methylene blue, MB) in the pores and a cyclic peptide targeting motif on the surface of the NMOF, which could achieve highly efficient near-infrared (NIR)-triggered and -targeted photodynamic therapy (PDT). On the basis of the luminescence resonance energy transfer process between the NMOF donor and the photosensitizer MB acceptor, the probe can achieve a high tissue-penetrable TPA-PDT effect. Thus, the NMOFs in this study play the role of not only the nanocontainer for the photosensitizer but also the energy-transfer donor. Studies in vitro show enhanced cellular uptake and satisfactory PDT effectiveness toward cancer cells compared to the free photosensitizer MB. It is highly expected that this study contributes to the development of smart luminescent diagnostic and therapeutic probes.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Európio/farmacologia
Sondas Moleculares/farmacologia
Compostos Organometálicos/farmacologia
Fotoquimioterapia
Fótons
Fármacos Fotossensibilizantes/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Morte Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Európio/química
Seres Humanos
Raios Infravermelhos
Sondas Moleculares/síntese química
Sondas Moleculares/química
Nanopartículas/química
Compostos Organometálicos/síntese química
Compostos Organometálicos/química
Tamanho da Partícula
Fármacos Fotossensibilizantes/síntese química
Fármacos Fotossensibilizantes/química
Propriedades de Superfície
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Molecular Probes); 0 (Organometallic Compounds); 0 (Photosensitizing Agents); 444W947O8O (Europium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1021/acs.inorgchem.7b02475



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