Base de dados : MEDLINE
Pesquisa : G01.374.715.578 [Categoria DeCS]
Referências encontradas : 11474 [refinar]
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  1 / 11474 MEDLINE  
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[PMID]:28748670
[Au] Autor:Taye M; Lee W; Caetano-Anolles K; Dessie T; Hanotte O; Mwai OA; Kemp S; Cho S; Oh SJ; Lee HK; Kim H
[Ad] Endereço:Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea.
[Ti] Título:Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance.
[So] Source:Anim Sci J;88(12):1889-1901, 2017 Dec.
[Is] ISSN:1740-0929
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:As African indigenous cattle evolved in a hot tropical climate, they have developed an inherent thermotolerance; survival mechanisms include a light-colored and shiny coat, increased sweating, and cellular and molecular mechanisms to cope with high environmental temperature. Here, we report the positive selection signature of genes in African cattle breeds which contribute for their heat tolerance mechanisms. We compared the genomes of five indigenous African cattle breeds with the genomes of four commercial cattle breeds using cross-population composite likelihood ratio (XP-CLR) and cross-population extended haplotype homozygosity (XP-EHH) statistical methods. We identified 296 (XP-EHH) and 327 (XP-CLR) positively selected genes. Gene ontology analysis resulted in 41 biological process terms and six Kyoto Encyclopedia of Genes and Genomes pathways. Several genes and pathways were found to be involved in oxidative stress response, osmotic stress response, heat shock response, hair and skin properties, sweat gland development and sweating, feed intake and metabolism, and reproduction functions. The genes and pathways identified directly or indirectly contribute to the superior heat tolerance mechanisms in African cattle populations. The result will improve our understanding of the biological mechanisms of heat tolerance in African cattle breeds and opens an avenue for further study.
[Mh] Termos MeSH primário: Bovinos/genética
Bovinos/fisiologia
Estudos de Associação Genética/veterinária
Genoma/genética
Seleção Genética/genética
Termotolerância/genética
[Mh] Termos MeSH secundário: Animais
Ingestão de Alimentos/genética
Ontologia Genética
Cor de Cabelo/genética
Haplótipos/genética
Resposta ao Choque Térmico/genética
Homozigoto
Temperatura Alta
Pressão Osmótica
Estresse Oxidativo/genética
Glândulas Sudoríparas
Sudorese/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1111/asj.12851


  2 / 11474 MEDLINE  
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[PMID]:28451641
[Au] Autor:Yu J; Yang W; Liu H; Hao Y; Zhang Y
[Ad] Endereço:Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138.
[Ti] Título:An Aversive Response to Osmotic Upshift in .
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Environmental osmolarity presents a common type of sensory stimulus to animals. While behavioral responses to osmotic changes are important for maintaining a stable intracellular osmolarity, the underlying mechanisms are not fully understood. In the natural habitat of , changes in environmental osmolarity are commonplace. It is known that the nematode acutely avoids shocks of extremely high osmolarity. Here, we show that also generates gradually increased aversion of mild upshifts in environmental osmolarity. Different from an acute avoidance of osmotic shocks that depends on the function of a transient receptor potential vanilloid channel, the slow aversion to osmotic upshifts requires the cGMP-gated sensory channel subunit TAX-2. TAX-2 acts in several sensory neurons that are exposed to body fluid to generate the aversive response through a motor network that underlies navigation. Osmotic upshifts activate the body cavity sensory neuron URX, which is known to induce aversion upon activation. Together, our results characterize the molecular and cellular mechanisms underlying a novel sensorimotor response to osmotic stimuli and reveal that engages different behaviors and the underlying mechanisms to regulate responses to extracellular osmolarity.
[Mh] Termos MeSH primário: Proteínas de Caenorhabditis elegans/metabolismo
Canais Iônicos/metabolismo
Osmorregulação
Células Receptoras Sensoriais/metabolismo
[Mh] Termos MeSH secundário: Animais
Caenorhabditis elegans
Locomoção
Pressão Osmótica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); 0 (Ion Channels); 0 (tax-2 protein, C elegans)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  3 / 11474 MEDLINE  
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[PMID]:29262714
[Au] Autor:Karadag B; Yücel NC
[Ad] Endereço:Department of Chemistry, Faculty of Science, Dokuz Eylul University , Buca, 35390, Izmir , Turkey.
[Ti] Título:Cinnamic acid and fish flour affect wheat phenolic acids and flavonoid compounds, lipid peroxidation, proline levels under salt stress.
[So] Source:Acta Biol Hung;68(4):388-397, 2017 Dec.
[Is] ISSN:0236-5383
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:To elucidate the physiological mechanism of salt stress mitigated by cinnamic acid (CA) and fish flour (FF) pretreatment, wheat was pretreated with 20, 50 and 100 ppm CA and 1 g/10 mL FF for 2 d and was then cultivated. We investigated whether exogenous CA + FF could protect wheat from salt stress and examined whether the protective effect was associated with the regulation of seed vigor, antioxidant defense systems, phenolic biosynthesis and lipid peroxidation. At 2 days exogenous CA did not influence seed vigor. Salt stress increased the phenolic biosynthesis, but the CA + FF-combined pretreatment enhanced the phenolic biosynthesis even more under salt stress and decreased lipid peroxidation to some extent, enhancing the tolerance of wheat to salt stress.
[Mh] Termos MeSH primário: Cinamatos/metabolismo
Farinha de Peixe
Flavonoides/metabolismo
Hidroxibenzoatos/metabolismo
Peroxidação de Lipídeos
Pressão Osmótica
Triticum/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Flavonoids); 0 (Hydroxybenzoates); 29656-58-4 (phenolic acid); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1556/018.68.2017.4.5


  4 / 11474 MEDLINE  
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[PMID]:29371596
[Au] Autor:Duch A; Canal B; Barroso SI; García-Rubio M; Seisenbacher G; Aguilera A; de Nadal E; Posas F
[Ad] Endereço:Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), E-08003, Barcelona, Spain.
[Ti] Título:Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.
[So] Source:Nat Commun;9(1):379, 2018 01 25.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have evolved strategies to prevent such conflicts. However, little is known regarding how cells cope with sudden increases of transcription while replicating. Here, we report the existence of a general mechanism for the protection of genomic integrity upon transcriptional outbursts in S phase that is mediated by Mrc1. The N-terminal phosphorylation of Mrc1 blocked replication and prevented transcription-associated recombination (TAR) and genomic instability during stress-induced gene expression in S phase. An unbiased kinome screening identified several kinases that phosphorylate Mrc1 at the N terminus upon different environmental stresses. Mrc1 function was not restricted to environmental cues but was also required when unscheduled transcription was triggered by low fitness states such as genomic instability or slow growth. Our data indicate that Mrc1 integrates multiple signals, thereby defining a general safeguard mechanism to protect genomic integrity upon transcriptional outbursts.
[Mh] Termos MeSH primário: Proteínas de Ciclo Celular/genética
Replicação do DNA
Regulação Fúngica da Expressão Gênica
Instabilidade Genômica
Proteínas Serina-Treonina Quinases/genética
Proteínas de Saccharomyces cerevisiae/genética
Saccharomyces cerevisiae/genética
Transcrição Genética
[Mh] Termos MeSH secundário: Proteínas de Ciclo Celular/metabolismo
Escherichia coli/genética
Escherichia coli/metabolismo
Glucose/deficiência
Temperatura Alta
Peróxido de Hidrogênio/farmacologia
Pressão Osmótica
Estresse Oxidativo/genética
Fosforilação
Proteínas Serina-Treonina Quinases/metabolismo
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Fase S
Saccharomyces cerevisiae/efeitos dos fármacos
Saccharomyces cerevisiae/metabolismo
Proteínas de Saccharomyces cerevisiae/metabolismo
Transdução de Sinais
Cloreto de Sódio/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cell Cycle Proteins); 0 (MRC1 protein, S cerevisiae); 0 (Recombinant Proteins); 0 (Saccharomyces cerevisiae Proteins); 451W47IQ8X (Sodium Chloride); BBX060AN9V (Hydrogen Peroxide); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02756-x


  5 / 11474 MEDLINE  
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[PMID]:28749490
[Au] Autor:Dmitrieva OA; Fedotova MV; Buchner R
[Ad] Endereço:G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Akademicheskaya st. 1, 153045 Ivanovo, Russian Federation. hebrus@mail.ru.
[Ti] Título:Evidence for cooperative Na and Cl binding by strongly hydrated l-proline.
[So] Source:Phys Chem Chem Phys;19(31):20474-20483, 2017 Aug 09.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In nature the amino acid l-proline (Pro) is a ubiquitous and highly effective osmolyte protecting cells against osmotic stress. To understand this effect knowledge of the hydration of Pro and its interactions with dissolved salts is essential. We studied these properties by combining statistical mechanics and broadband dielectric spectroscopy and found that Pro remains strongly hydrated up to high amino-acid concentrations. This is also the case upon NaCl addition to a 0.6 M Pro solution. Here, additionally a Pro·NaCl aggregate is formed with a stability constant of K° ≈ 0.95…1.25 M , where Na and Cl cooperatively bind to adjacent carboxylate-oxygen and ammonium-hydrogen atoms, respectively.
[Mh] Termos MeSH primário: Cloretos/química
Prolina/química
Sódio/química
[Mh] Termos MeSH secundário: Espectroscopia Dielétrica
Íons/química
Conformação Molecular
Pressão Osmótica
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Ions); 059QF0KO0R (Water); 9DLQ4CIU6V (Proline); 9NEZ333N27 (Sodium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp04335j


  6 / 11474 MEDLINE  
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[PMID]:28744670
[Au] Autor:Lema I; Amazit L; Lamribet K; Fagart J; Blanchard A; Lombès M; Cherradi N; Viengchareun S
[Ad] Endereço:Inserm U1185, Faculté de Médecine Paris-Sud, Université Paris-Saclay, 63 rue Gabriel Peri, 94276, Le Kremlin-Bicêtre, France.
[Ti] Título:RNA-binding protein HuR enhances mineralocorticoid signaling in renal KC3AC1 cells under hypotonicity.
[So] Source:Cell Mol Life Sci;74(24):4587-4597, 2017 12.
[Is] ISSN:1420-9071
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Mineralocorticoid receptor (MR) mediates the sodium-retaining action of aldosterone in the distal nephron. Herein, we decipher mechanisms by which hypotonicity increases MR expression in renal principal cells. We identify HuR (human antigen R), an mRNA-stabilizing protein, as an important posttranscriptional regulator of MR expression. Hypotonicity triggers a rapid and reversible nuclear export of HuR in renal KC3AC1 cells, as quantified by high-throughput microscopy. We also identify a key hairpin motif in the 3'-untranslated region of MR transcript, pivotal for the interaction with HuR and its stabilizing function. Next, we show that hypotonicity increases MR recruitment onto Sgk1 promoter, a well-known MR target gene, thereby enhancing aldosterone responsiveness. Our data shed new light on the crucial role of HuR as a stabilizing factor for the MR transcript and provide evidence for a short autoregulatory loop in which expression of a nuclear receptor transcriptionally regulating water and sodium balance is controlled by osmotic tone.
[Mh] Termos MeSH primário: Proteína Semelhante a ELAV 1/metabolismo
Rim/metabolismo
Mineralocorticoides/metabolismo
Pressão Osmótica/fisiologia
Proteínas de Ligação a RNA/metabolismo
Receptores de Mineralocorticoides/metabolismo
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Regiões 3' não Traduzidas/genética
Transporte Ativo do Núcleo Celular/genética
Aldosterona/metabolismo
Regulação da Expressão Gênica/genética
Células HEK293
Seres Humanos
Proteínas Imediatamente Precoces/metabolismo
Rim/fisiologia
Osmose/fisiologia
Regiões Promotoras Genéticas/genética
Proteínas Serina-Treonina Quinases/metabolismo
Processamento Pós-Transcricional do RNA/genética
RNA Mensageiro/metabolismo
Transcrição Genética/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (3' Untranslated Regions); 0 (ELAV-Like Protein 1); 0 (ELAVL1 protein, human); 0 (Immediate-Early Proteins); 0 (Mineralocorticoids); 0 (RNA, Messenger); 0 (RNA-Binding Proteins); 0 (Receptors, Mineralocorticoid); 4964P6T9RB (Aldosterone); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 2.7.11.1 (serum-glucocorticoid regulated kinase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1007/s00018-017-2594-x


  7 / 11474 MEDLINE  
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[PMID]:28449392
[Au] Autor:Saraiva GFR; Ferreira AS; Souza GM
[Ad] Endereço:Graduate Program in Agronomy, Western São Paulo University, (PPGA/UNOESTE), Presidente Prudente, Brazil.
[Ti] Título:Osmotic stress decreases complexity underlying the electrophysiological dynamic in soybean.
[So] Source:Plant Biol (Stuttg);19(5):702-708, 2017 Sep.
[Is] ISSN:1438-8677
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Studies on plant electrophysiology are mostly focused on specific traits of single cells. Inspired by the complexity of the signalling network in plants, and by analogy with neurons in human brains, we sought evidence of high complexity in the electrical dynamics of plant signalling and a likely relationship with environmental cues. An EEG-like standard protocol was adopted for high-resolution measurements of the electrical signal in Glycine max seedlings. The signals were continuously recorded in the same plants before and after osmotic stimuli with a -2 MPa mannitol solution. Non-linear time series analyses methods were used as follows: auto-correlation and cross-correlation function, power spectra density function, and complexity of the time series estimated as Approximate Entropy (ApEn). Using Approximate Entropy analysis we found that the level of temporal complexity of the electrical signals was affected by the environmental conditions, decreasing when the plant was subjected to a low osmotic potential. Electrical spikes observed only after stimuli followed a power law distribution, which is indicative of scale invariance. Our results suggest that changes in complexity of the electrical signals could be associated with water stress conditions in plants. We hypothesised that the power law distribution of the spikes could be explained by a self-organised critical state (SOC) after osmotic stress.
[Mh] Termos MeSH primário: Eletrofisiologia/métodos
Pressão Osmótica/fisiologia
Feijão de Soja/metabolismo
[Mh] Termos MeSH secundário: Feijão de Soja/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1111/plb.12576


  8 / 11474 MEDLINE  
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[PMID]:29232718
[Au] Autor:Zhu Y; Wang B; Tang K; Hsu CC; Xie S; Du H; Yang Y; Tao WA; Zhu JK
[Ad] Endereço:Shanghai Center for Plant Stress Biology and CAS Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China.
[Ti] Título:An Arabidopsis Nucleoporin NUP85 modulates plant responses to ABA and salt stress.
[So] Source:PLoS Genet;13(12):e1007124, 2017 12.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several nucleoporins in the nuclear pore complex (NPC) have been reported to be involved in abiotic stress responses in plants. However, the molecular mechanism of how NPC regulates abiotic stress responses, especially the expression of stress responsive genes remains poorly understood. From a forward genetics screen using an abiotic stress-responsive luciferase reporter (RD29A-LUC) in the sickle-1 (sic-1) mutant background, we identified a suppressor caused by a mutation in NUCLEOPORIN 85 (NUP85), which exhibited reduced expression of RD29A-LUC in response to ABA and salt stress. Consistently, the ABA and salinity induced expression of several stress responsive genes such as RD29A, COR15A and COR47 was significantly compromised in nup85 mutants and other nucleoporin mutants such as nup160 and hos1. Subsequently, Immunoprecipitation and mass spectrometry analysis revealed that NUP85 is potentially associated with HOS1 and other nucleoporins within the nup107-160 complex, along with several mediator subunits. We further showed that there is a direct physical interaction between MED18 and NUP85. Similar to NUP85 mutations, MED18 mutation was also found to attenuate expression of stress responsive genes. Taken together, we not only revealed the involvement of NUP85 and other nucleoporins in regulating ABA and salt stress responses, but also uncovered a potential relation between NPC and mediator complex in modulating the gene expression in plants.
[Mh] Termos MeSH primário: Proteínas de Arabidopsis/genética
Arabidopsis/genética
Complexo de Proteínas Formadoras de Poros Nucleares/genética
Plantas Geneticamente Modificadas/genética
Estresse Fisiológico/genética
[Mh] Termos MeSH secundário: Ácido Abscísico/toxicidade
Arabidopsis/fisiologia
Regulação da Expressão Gênica de Plantas
Peptídeos e Proteínas de Sinalização Intracelular/genética
Complexo Mediador/genética
Mutação
Complexo de Proteínas Formadoras de Poros Nucleares/biossíntese
Proteínas Nucleares/genética
Pressão Osmótica
Salinidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (COR15 protein, Arabidopsis); 0 (HOS1 protein, Arabidopsis); 0 (Intracellular Signaling Peptides and Proteins); 0 (MED18 protein, Arabidopsis); 0 (Mediator Complex); 0 (NUP85 protein, Arabidopsis); 0 (Nuclear Pore Complex Proteins); 0 (Nuclear Proteins); 0 (RD29a protein, Arabidopsis); 144906-14-9 (COR47 protein, Arabidopsis); 72S9A8J5GW (Abscisic Acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1007124


  9 / 11474 MEDLINE  
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[PMID]:29228055
[Au] Autor:Pereira-Santana A; Alvarado-Robledo EJ; Zamora-Briseño JA; Ayala-Sumuano JT; Gonzalez-Mendoza VM; Espadas-Gil F; Alcaraz LD; Castaño E; Keb-Llanes MA; Sanchez-Teyer F; Rodriguez-Zapata LC
[Ad] Endereço:Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Mérida, Yucatán, México.
[Ti] Título:Transcriptional profiling of sugarcane leaves and roots under progressive osmotic stress reveals a regulated coordination of gene expression in a spatiotemporal manner.
[So] Source:PLoS One;12(12):e0189271, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sugarcane is one of the most important crops worldwide and is a key plant for the global production of sucrose. Sugarcane cultivation is severely affected by drought stress and it is considered as the major limiting factor for their productivity. In recent years, this plant has been subjected to intensive research focused on improving its resilience against water scarcity; particularly the molecular mechanisms in response to drought stress have become an underlying issue for its improvement. To better understand water stress and the molecular mechanisms we performed a de novo transcriptomic assembly of sugarcane (var. Mex 69-290). A total of 16 libraries were sequenced in a 2x100 bp configuration on a HiSeq-Illumina platform. A total of 536 and 750 genes were differentially up-regulated along with the stress treatments for leave and root tissues respectively, while 1093 and 531 genes were differentially down-regulated in leaves and roots respectively. Gene Ontology functional analysis showed that genes related to response of water deprivation, heat, abscisic acid, and flavonoid biosynthesis were enriched during stress treatment in our study. The reliability of the observed expression patterns was confirmed by RT-qPCR. Additionally, several physiological parameters of sugarcane were significantly affected due to stress imposition. The results of this study may help identify useful target genes and provide tissue-specific data set of genes that are differentially expressed in response to osmotic stress, as well as a complete analysis of the main groups is significantly enriched under this condition. This study provides a useful benchmark for improving drought tolerance in sugarcane and other economically important grass species.
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica
Saccharum/genética
Transcrição Genética
[Mh] Termos MeSH secundário: Pressão Osmótica
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189271


  10 / 11474 MEDLINE  
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[PMID]:29212002
[Au] Autor:Li Y; He L; Gonzalez NAP; Graham J; Wolgemuth C; Wirtz D; Sun SX
[Ad] Endereço:Departments of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland.
[Ti] Título:Going with the Flow: Water Flux and Cell Shape during Cytokinesis.
[So] Source:Biophys J;113(11):2487-2495, 2017 Dec 05.
[Is] ISSN:1542-0086
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cell shape changes during cytokinesis in eukaryotic cells have been attributed to contractile forces from the actomyosin ring and the actomyosin cortex. Here we propose an additional mechanism where active pumping of ions and water at the cell poles and the division furrow can also achieve the same type of shape change during cytokinesis without myosin contraction. We develop a general mathematical model to examine shape changes in a permeable object subject to boundary fluxes. We find that hydrodynamic flows in the cytoplasm and the relative drag between the cytoskeleton network phase and the water phase also play a role in determining the cell shape during cytokinesis. Forces from the actomyosin contractile ring and cortex do contribute to the cell shape, and can work together with water permeation to facilitate cytokinesis. To influence water flow, we osmotically shock the cell during cell division, and find that the cell can actively adapt to osmotic changes and complete division. Depolymerizing the actin cytoskeleton during cytokinesis also does not affect the contraction speed. We also explore the role of membrane ion channels and pumps in setting up the spatially varying water flux.
[Mh] Termos MeSH primário: Forma Celular
Citocinese
Modelos Biológicos
Movimento
Água/metabolismo
[Mh] Termos MeSH secundário: Actomiosina/metabolismo
Divisão Celular
Replicação do DNA
Pressão Osmótica
Permeabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 9013-26-7 (Actomyosin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde