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[PMID]:29369175
[Au] Autor:Wen XH; Li Y; Han D; Sun L; Ren PX; Ren D
[Ad] Endereço:The Second Department of Respiratory, Shaanxi Provincial People's Hospital.
[Ti] Título:The relationship between cognitive function and arterial partial pressure O2 in patients with COPD: A meta-analysis.
[So] Source:Medicine (Baltimore);97(4):e9599, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The high incidence of cognition disorders in chronic obstructive pulmonary disease (COPD) patients represents a main focus in public health field recently. Thus, we tried to explore relationship between cognitive function and arterial partial pressure O2 (PaO2) in patients with COPD as assessed by Mini-mental State Examination (MMSE) and/or Montreal Cognitive Assessment (MoCA). MATERIALS AND METHODS: Medical and scientific literature databases, such as Web of Science, PubMed, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database, were searched independently by 2 reviewers until February 2016. Correlation coefficient (r or rs) values were obtained from each study, and 95% confidence intervals (CIs) were calculated using STATA12.0 software. RESULTS: A total of 2049 studies were produced, and 9 of which were analyzed (714 participants) in the meta-analysis. The pooled r observed medium relationship for all selected studies (r = 0.405, 95% CI 0.31-0.55), and notable heterogeneity was also tested between studies (χ = 17.72, P = .023; I = 54.9%). After the sensitivity and subgroup analysis, the heterogeneity significantly decreased. Subgroup analysis showed that MMSE score was stronger correlation between PaO2 and cognitive function than MoCA score in the COPD patients. Begg test did not indicate potential risk of publication bias. CONCLUSIONS: There was a negative correlation between cognitive function and anoxia in patients with COPD, so it may be extremely essential to predict and improve the status of hypoxia in COPD patients.
[Mh] Termos MeSH primário: Pressão Arterial/fisiologia
Cognição/fisiologia
Oxigênio/análise
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Doença Pulmonar Obstrutiva Crônica/psicologia
[Mh] Termos MeSH secundário: Gasometria
Transtornos Cognitivos/etiologia
Estudos Transversais
Seres Humanos
Hipóxia/etiologia
Hipóxia/psicologia
Pressão Parcial
Doença Pulmonar Obstrutiva Crônica/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009599


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[PMID]:29040312
[Au] Autor:Lin HJ; Huang CT; Hsiao HF; Chiang MC; Jeng MJ
[Ad] Endereço:Department of Respiratory Therapy, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
[Ti] Título:End-tidal carbon dioxide measurement in preterm infants with low birth weight.
[So] Source:PLoS One;12(10):e0186408, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: There are conflicting data regarding the use of end-tidal carbon dioxide (PetCO2) measurement in preterm infants. The aim of this study was to evaluate the effects of different dead space to tidal volume ratios (VD/VT) on the correlation between PetCO2 and arterial carbon dioxide pressure (PaCO2) in ventilated preterm infants with respiratory distress syndrome (RDS). METHODS: We enrolled ventilated preterm infants (with assist control mode or synchronous intermittent mandatory mode) with RDS who were treated with surfactant in this prospective study. Simultaneous PetCO2 and PaCO2 data pairs were obtained from ventilated neonates monitored using mainstream capnography. Data obtained before and after surfactant treatment were also analyzed. RESULTS: One-hundred and one PetCO2 and PaCO2 pairs from 34 neonates were analyzed. There was a moderate correlation between PetCO2 and PaCO2 values (r = 0.603, P < 0.01). The correlation was higher in the post-surfactant treatment group (r = 0.786, P < 0.01) than the pre-surfactant treatment group (r = 0.235). The values of PaCO2 and PetCO2 obtained based on the treatment stage of surfactant therapy were 42.4 ± 8.6 mmHg and 32.6 ± 7.2 mmHg, respectively, in pre-surfactant treatment group, and 37.8 ± 10.3 mmHg and 33.7 ± 9.3 mmHg, respectively, in the post-surfactant treatment group. Furthermore, we found a significant decrease in VD/VT in the post-surfactant treatment group when compared to the pre-surfactant treatment group (P = 0.003). CONCLUSIONS: VD/VT decreased significantly after surfactant therapy and the correlation between PetCO2 and PaCO2 was higher after surfactant therapy in preterm infants with RDS.
[Mh] Termos MeSH primário: Dióxido de Carbono/análise
Surfactantes Pulmonares/uso terapêutico
Síndrome do Desconforto Respiratório do Recém-Nascido/diagnóstico
Síndrome do Desconforto Respiratório do Recém-Nascido/terapia
[Mh] Termos MeSH secundário: Gasometria
Dióxido de Carbono/metabolismo
Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido de Baixo Peso
Recém-Nascido
Recém-Nascido Prematuro
Masculino
Monitorização Fisiológica
Pressão Parcial
Estudos Prospectivos
Respiração Artificial
Espaço Morto Respiratório/fisiologia
Síndrome do Desconforto Respiratório do Recém-Nascido/fisiopatologia
Volume de Ventilação Pulmonar/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pulmonary Surfactants); 142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186408


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[PMID]:29020036
[Au] Autor:Belcher DA; Banerjee U; Baehr CM; Richardson KE; Cabrales P; Berthiaume F; Palmer AF
[Ad] Endereço:William G. Lowrie Department of Chemical and Biomolecular Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, United States of America.
[Ti] Título:Mixtures of tense and relaxed state polymerized human hemoglobin regulate oxygen affinity and tissue construct oxygenation.
[So] Source:PLoS One;12(10):e0185988, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pure tense (T) and relaxed (R) quaternary state polymerized human hemoglobins (PolyhHbs) were synthesized and their biophysical properties characterized, along with mixtures of T- and R-state PolyhHbs. It was observed that the oxygen affinity of PolyhHb mixtures varied linearly with T-state mole fraction. Computational analysis of PolyhHb facilitated oxygenation of a single fiber in a hepatic hollow fiber (HF) bioreactor was performed to evaluate the oxygenation potential of T- and R-state PolyhHb mixtures. PolyhHb mixtures with T-state mole fractions greater than 50% resulted in hypoxic and hyperoxic zones occupying less than 5% of the total extra capillary space (ECS). Under these conditions, the ratio of the pericentral volume to the perivenous volume in the ECS doubled as the T-state mole fraction increased from 50 to 100%. These results show the effect of varying the T/R-state PolyhHb mole fraction on oxygenation of tissue-engineered constructs and their potential to oxygenate tissues.
[Mh] Termos MeSH primário: Hemoglobinas/química
Hemoglobinas/isolamento & purificação
Oxigênio/metabolismo
Polimerização
Tecidos Suporte/química
[Mh] Termos MeSH secundário: Fenômenos Biofísicos
Reatores Biológicos
Monóxido de Carbono/metabolismo
Filtração
Hemoglobinas/síntese química
Seres Humanos
Hidrodinâmica
Cinética
Metemoglobina/metabolismo
Óxido Nítrico/metabolismo
Pressão Parcial
Conformação Proteica
Soluções
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins); 0 (Solutions); 31C4KY9ESH (Nitric Oxide); 7U1EE4V452 (Carbon Monoxide); 9008-37-1 (Methemoglobin); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185988


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[PMID]:28957378
[Au] Autor:Watson SA; Fabricius KE; Munday PL
[Ad] Endereço:Australian Research Council Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, Queensland, Australia.
[Ti] Título:Quantifying pCO2 in biological ocean acidification experiments: A comparison of four methods.
[So] Source:PLoS One;12(9):e0185469, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Quantifying the amount of carbon dioxide (CO2) in seawater is an essential component of ocean acidification research; however, equipment for measuring CO2 directly can be costly and involve complex, bulky apparatus. Consequently, other parameters of the carbonate system, such as pH and total alkalinity (AT), are often measured and used to calculate the partial pressure of CO2 (pCO2) in seawater, especially in biological CO2-manipulation studies, including large ecological experiments and those conducted at field sites. Here we compare four methods of pCO2 determination that have been used in biological ocean acidification experiments: 1) Versatile INstrument for the Determination of Total inorganic carbon and titration Alkalinity (VINDTA) measurement of dissolved inorganic carbon (CT) and AT, 2) spectrophotometric measurement of pHT and AT, 3) electrode measurement of pHNBS and AT, and 4) the direct measurement of CO2 using a portable CO2 equilibrator with a non-dispersive infrared (NDIR) gas analyser. In this study, we found these four methods can produce very similar pCO2 estimates, and the three methods often suited to field-based application (spectrophotometric pHT, electrode pHNBS and CO2 equilibrator) produced estimated measurement uncertainties of 3.5-4.6% for pCO2. Importantly, we are not advocating the replacement of established methods to measure seawater carbonate chemistry, particularly for high-accuracy quantification of carbonate parameters in seawater such as open ocean chemistry, for real-time measures of ocean change, nor for the measurement of small changes in seawater pCO2. However, for biological CO2-manipulation experiments measuring differences of over 100 µatm pCO2 among treatments, we find the four methods described here can produce similar results with careful use.
[Mh] Termos MeSH primário: Ácidos/química
Dióxido de Carbono/análise
Biologia Marinha/métodos
Oceanos e Mares
Pressão Parcial
[Mh] Termos MeSH secundário: Álcalis/química
Eletrodos
Raios Infravermelhos
Padrões de Referência
Água do Mar/química
Espectrofotometria
Incerteza
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids); 0 (Alkalies); 142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185469


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[PMID]:28753621
[Au] Autor:Belhaj A; Dewachter L; Rorive S; Remmelink M; Weynand B; Melot C; Hupkens E; Dewachter C; Creteur J; Mc Entee K; Naeije R; Rondelet B
[Ad] Endereço:Department of Cardio-Vascular, Thoracic Surgery and Lung Transplantation, CHU UcL Namur, Université Catholique de Louvain, Yvoir, Belgium.
[Ti] Título:Mechanical versus humoral determinants of brain death-induced lung injury.
[So] Source:PLoS One;12(7):e0181899, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The mechanisms of brain death (BD)-induced lung injury remain incompletely understood, as uncertainties persist about time-course and relative importance of mechanical and humoral perturbations. METHODS: Brain death was induced by slow intracranial blood infusion in anesthetized pigs after randomization to placebo (n = 11) or to methylprednisolone (n = 8) to inhibit the expression of pro-inflammatory mediators. Pulmonary artery pressure (PAP), wedged PAP (PAWP), pulmonary vascular resistance (PVR) and effective pulmonary capillary pressure (PCP) were measured 1 and 5 hours after Cushing reflex. Lung tissue was sampled to determine gene expressions of cytokines and oxidative stress molecules, and pathologically score lung injury. RESULTS: Intracranial hypertension caused a transient increase in blood pressure followed, after brain death was diagnosed, by persistent increases in PAP, PCP and the venous component of PVR, while PAWP did not change. Arterial PO2/fraction of inspired O2 (PaO2/FiO2) decreased. Brain death was associated with an accumulation of neutrophils and an increased apoptotic rate in lung tissue together with increased pro-inflammatory interleukin (IL)-6/IL-10 ratio and increased heme oxygenase(HO)-1 and hypoxia inducible factor(HIF)-1 alpha expression. Blood expressions of IL-6 and IL-1ß were also increased. Methylprednisolone pre-treatment was associated with a blunting of increased PCP and PVR venous component, which returned to baseline 5 hours after BD, and partially corrected lung tissue biological perturbations. PaO2/FiO2 was inversely correlated to PCP and lung injury score. CONCLUSIONS: Brain death-induced lung injury may be best explained by an initial excessive increase in pulmonary capillary pressure with increased pulmonary venous resistance, and was associated with lung activation of inflammatory apoptotic processes which were partially prevented by methylprednisolone.
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda/etiologia
Lesão Pulmonar Aguda/fisiopatologia
Morte Encefálica/patologia
Morte Encefálica/fisiopatologia
Imunidade Humoral
Mecânica Respiratória
[Mh] Termos MeSH secundário: Lesão Pulmonar Aguda/sangue
Animais
Apoptose
Morte Encefálica/sangue
Moléculas de Adesão Celular/genética
Moléculas de Adesão Celular/metabolismo
Feminino
Regulação da Expressão Gênica
Hemodinâmica
Interleucinas/metabolismo
Pulmão/patologia
Pulmão/fisiopatologia
Análise Multivariada
Neutrófilos/patologia
Estresse Oxidativo
Oxigênio/metabolismo
Pressão Parcial
Peroxidase/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Sus scrofa
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Adhesion Molecules); 0 (Interleukins); 0 (RNA, Messenger); 0 (Tumor Necrosis Factor-alpha); EC 1.11.1.7 (Peroxidase); S88TT14065 (Oxygen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181899


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[PMID]:28705306
[Au] Autor:Yamamoto K; Tanabe N; Suda R; Sasaki A; Matsumura A; Ema R; Kasai H; Kato F; Sekine A; Nishimura R; Jujo T; Sugiura T; Shigeta A; Sakao S; Tatsumi K
[Ad] Endereço:Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. Electronic address: shiitake@mx7.ttcn.ne.jp.
[Ti] Título:Riociguat for patients with chronic thromboembolic pulmonary hypertension: Usefulness of transitioning from phosphodiesterase type 5 inhibitor.
[So] Source:Respir Investig;55(4):270-275, 2017 Jul.
[Is] ISSN:2212-5353
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Riociguat, the first approved drug for patients with chronic thromboembolic pulmonary hypertension (CTEPH), is a soluble guanylate cyclase (sGC) Stimulator. It directly stimulates sGC independently of nitric oxide (NO) and increases sGC sensitivity for NO. The safety and efficacy of transitioning from a phosphodiesterase 5 inhibitor (PDE5i) to riociguat is unknown. METHODS AND RESULTS: Twenty-three patients were prospectively enrolled: 8 symptomatic patients with inadequate clinical responses to PDE5i were changed to riociguat (transitioned group); 15 started riociguat anew (new or add-on group). We analyzed the change from baseline to 6-12 months of riociguat treatment for the 6-minute walk distance (6MWD), mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR), cardiac index (CI), partial pressure of oxygen in arterial blood (PaO2), brain natriuretic peptide (BNP), World Health Organization (WHO) functional class, safety and adverse events. The mPAP, BNP and WHO functional class significantly improved in total. In the transitioned group, BNP significantly decreased by -116.5±188.6pg/ml (P=0.0156). The 6MWD, mPAP, PVR, CI, and PaO2 improved but not significantly. The baseline condition was significantly more severe in the transitioned than in the new or add-on group. No patients discontinued riociguat. Relatively rapid transitioning from PDE5i to riociguat was safe under careful observation. CONCLUSIONS: Transitioning to riociguat may be safe and effective in CTEPH patients with inadequate clinical responses to PDE5i.
[Mh] Termos MeSH primário: Substituição de Medicamentos
Hipertensão Pulmonar/tratamento farmacológico
Inibidores da Fosfodiesterase 5/uso terapêutico
Embolia Pulmonar/tratamento farmacológico
Pirazóis/uso terapêutico
Pirimidinas/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Pressão Arterial
Doença Crônica
Feminino
Seres Humanos
Hipertensão Pulmonar/metabolismo
Hipertensão Pulmonar/fisiopatologia
Masculino
Meia-Idade
Peptídeo Natriurético Encefálico/metabolismo
Consumo de Oxigênio
Pressão Parcial
Artéria Pulmonar/fisiopatologia
Embolia Pulmonar/metabolismo
Embolia Pulmonar/fisiopatologia
Fatores de Tempo
Resistência Vascular
Teste de Caminhada
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphodiesterase 5 Inhibitors); 0 (Pyrazoles); 0 (Pyrimidines); 114471-18-0 (Natriuretic Peptide, Brain); RU3FE2Y4XI (riociguat)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE


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[PMID]:28631764
[Au] Autor:Marini M; Caretta G; Vagnarelli F; Lucà F; Biscottini E; Lavorgna A; Procaccini V; Riva L; Vianello G; Aspromonte N; Mortara A; De Maria R; Capasso P; Valente S; Gulizia MM
[Ad] Endereço:S.O.D. Cardiologia-Emodinamica-UTIC, Dipartimento di Scienze Cardiovascolari, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona - Area Giovani ANMCO.
[Ti] Título:[Hemodynamic effects of positive end-expiratory pressure].
[Ti] Título:Gli effetti emodinamici della pressione positiva di fine espirazione..
[So] Source:G Ital Cardiol (Rome);18(6):505-512, 2017 Jun.
[Is] ISSN:1827-6806
[Cp] País de publicação:Italy
[La] Idioma:ita
[Ab] Resumo:The application of a positive end-expiratory pressure (PEEP), the cornerstone of noninvasive ventilation (NIV), causes hemodynamic changes in the cardiovascular system. To understand the benefits of NIV it is necessary to resume concepts of cardiovascular physiology and pathophysiology about cardiac function determinants, venous return, ventricular interdependence and heart-lung interaction, and to understand how PEEP interacts with them. The hemodynamic effects of PEEP are mediated by the increase in transpulmonary pressure, which results in increased pulmonary vascular resistance and in an attending small reduction of venous return in conditions of euvolemia, in a substantial reduction of left ventricular afterload and a potential positive effect on left ventricular stroke volume.The aim of this review is to describe how the application of PEEP does not necessarily induce detrimental hemodynamic effects, but may decrease oxygen consumption and improve cardiac performance. These effects can justify the use of NIV in hemodynamically unstable patients.
[Mh] Termos MeSH primário: Hemodinâmica
Respiração com Pressão Positiva
[Mh] Termos MeSH secundário: Coração/fisiologia
Seres Humanos
Oxigênio/sangue
Consumo de Oxigênio
Pressão Parcial
Fenômenos Fisiológicos Respiratórios
Resistência Vascular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1714/2700.27611


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[PMID]:28614129
[Au] Autor:Dunham AM; Grega MA; Brown CH; McKhann GM; Baumgartner WA; Gottesman RF
[Ad] Endereço:From the Departments of *Surgery, †Neurology, ‡Anesthesiology, and §Cardiac Surgery, the Johns Hopkins University School of Medicine, Baltimore, Maryland.
[Ti] Título:Perioperative Low Arterial Oxygenation Is Associated With Increased Stroke Risk in Cardiac Surgery.
[So] Source:Anesth Analg;125(1):38-43, 2017 Jul.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Both patient characteristics and intraoperative factors have been associated with a higher risk of stroke after cardiac surgery. We hypothesized that poor systemic oxygenation in the perioperative period is associated with increased risk of stroke following cardiopulmonary bypass. METHODS: In this study of 251 adult patients who underwent cardiopulmonary bypass procedures at a single center from 2003 to 2006, cases (patients with a postoperative stroke at least 24 hours after surgery) were matched 1:2 to controls without stroke. Minimum and average partial pressure of oxygen in arterial blood (PaO2) values, from arterial blood gas values during and up to 24 hours after surgery, were evaluated as continuous and categorical predictors. Conditional logistic regression models adjusted for potential confounders (demographics, comorbidities, and intraoperative variables) were used to evaluate associations between PaO2 variables and stroke status. RESULTS: Lower nadir PaO2 values were associated with postoperative stroke, with estimated odds of stroke increasing over 20% (adjusted odds ratio [OR], 1.23; 95% confidence interval [CI], 1.07-1.41) per 10 mm Hg lower nadir PaO2, and similarly increased odds of stroke per lower quartile of nadir PaO2 (OR, 1.60; 95% CI, 1.19-2.16). When average PaO2 was considered, odds of stroke was also increased (adjusted OR, 1.39 per lower quartile of mean PaO2; 95% CI, 1.05-1.83). Having a nadir PaO2 value in the lowest versus any other quartile was associated with an estimated 2.41-fold increased odds of stroke (95% CI, 1.22-4.78). Quartile of nadir but not average PaO2 results remained significant after adjustment for multiple comparisons. CONCLUSIONS: Odds of stroke after cardiac surgery are increased in patients with a low minimum PaO2 within 24 hours of surgery. Results should be validated in an independent cohort. Further characterizing the underlying etiology of hypoxic episodes will be important to improve patient outcomes.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Cardíacos/efeitos adversos
Hipóxia/sangue
Oxigênio/sangue
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Idoso
Baltimore
Biomarcadores/sangue
Gasometria
Ponte Cardiopulmonar/efeitos adversos
Distribuição de Qui-Quadrado
Bases de Dados Factuais
Feminino
Seres Humanos
Hipóxia/diagnóstico
Hipóxia/etiologia
Modelos Lineares
Modelos Logísticos
Masculino
Meia-Idade
Monitorização Intraoperatória/métodos
Dinâmica não Linear
Razão de Chances
Pressão Parcial
Período Perioperatório
Estudos Retrospectivos
Medição de Risco
Fatores de Risco
Acidente Vascular Cerebral/sangue
Acidente Vascular Cerebral/diagnóstico
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002157


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[PMID]:28539140
[Au] Autor:Conkin J; Wessel JH; Norcross JR; Bekdash OS; Abercromby AFJ; Koslovsky MD; Gernhardt ML
[Ti] Título:Hemoglobin Oxygen Saturation with Mild Hypoxia and Microgravity.
[So] Source:Aerosp Med Hum Perform;88(6):527-534, 2017 Jun 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Microgravity (µG) exposure and even early recovery from µG in combination with mild hypoxia may increase the alveolar-arterial oxygen (O2) partial pressure gradient. METHODS: Four male astronauts on STS-69 (1995) and four on STS-72 (1996) were exposed on Earth to an acute sequential hypoxic challenge by breathing for 4 min 18.0%, 14.9%, 13.5%, 12.9%, and 12.2% oxygen-balance nitrogen. The 18.0% O2 mixture at sea level resulted in an inspired O2 partial pressure (PIo2) of 127 mmHg. The equivalent PIO2 was also achieved by breathing 26.5% O2 at 527 mmHg that occurred for several days in µG on the Space Shuttle. A Novametrix CO2SMO Model 7100 recorded hemoglobin (Hb) oxygen saturation through finger pulse oximetry (Spo2, %). There were 12 in-flight measurements collected. Measurements were also taken the day of (R+0) and 2 d after (R+2) return to Earth. Linear mixed effects models assessed changes in Spo2 during and after exposure to µG. RESULTS: Astronaut Spo2 levels at baseline, R+0, and R+2 were not significantly different from in flight, about 97% given a PIo2 of 127 mmHg. There was also no difference in astronaut Spo2 levels between baseline and R+0 or R+2 over the hypoxic challenge. CONCLUSIONS: The multitude of physiological changes associated with µG and during recovery from µG did not affect astronaut Spo2 under hypoxic challenge.Conkin J, Wessel JH III, Norcross JR, Bekdash OS, Abercromby AFJ, Koslovsky MD, Gernhardt ML. Hemoglobin oxygen saturation with mild hypoxia and microgravity. Aerosp Med Hum Perform. 2017; 88(6):527-534.
[Mh] Termos MeSH primário: Hemoglobinas/metabolismo
Hipóxia/metabolismo
Oxigênio/metabolismo
Voo Espacial
Ausência de Peso
[Mh] Termos MeSH secundário: Adulto
Astronautas
Seres Humanos
Masculino
Oximetria
Pressão Parcial
Troca Gasosa Pulmonar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins); S88TT14065 (Oxygen)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4804.2017


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[PMID]:28482381
[Au] Autor:Liu J; Wang Q; Qian SY; Xu WM; Li LL; Ning LM; Ren XX; Lyu F; Cheng YB; Gao LJ; Liu CF; Xu W; Pei L; Lu GP; Chen WM
[Ad] Endereço:Pediatric Intensive Care Unit, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
[Ti] Título:[Nasal continuous positive airway pressure ventilation in children with community-acquired pneumonia under five years of age: a prospective, multi-center clinical study].
[So] Source:Zhonghua Er Ke Za Zhi;55(5):329-333, 2017 May 04.
[Is] ISSN:0578-1310
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To analyze the clinical characteristics of community-acquired pneumonia (CAP) in children under five years of age and analyze the safety and efficiency of nasal continuous positive airway pressure (NCPAP) ventilation for CAP in this population. This was a prospective multicenter study. Children who were admitted to these six centers with CAP and met the NCPAP ventilation indications, aged from 29 d to 5 years, were continuously included during November 2013 to October 2015. The baseline data were collected and NCPAP ventilation were then followed up by operation standards, and the vital signs and arterial blood gas change at special time points were observed and recorded. Any side effect associated with NCPAP were recorded. For categorical variables, comparisons were performed using Fisher test. Rank-sum test and test were performed respectively for abnormal and normal distribution continuous variables. The variables pre-NCPAP and post-NCPAP were analyzed by repeated measures ANOVA analysis. Totally 145 children were included, and 13 children were excluded due to incomplete data. One hundred and two children(77.3%)were ≤12 months; 91 children (68.9%) were from rural area. NCPAP ventilation was effective in 123 children, with a response rate of 93.2%, were all discharged with a better condition; it was ineffective in 9 children(6.8%), and they were all intubated and went on mechanical ventilation, 5 were discharged with a better condition, and 4 died after gaving up treatment. The gender, age, body weight, residence, main symptoms, main signs, imaging diagnosis, medications, partial pressure of oxygen(PaO(2)), breath and heart rate before NCPAP treatment of two groups had no significant differences(all >0.05). The rates of combining underlying diseases, trouble with feeding and cyanosis, and the partial pressure of carbon dioxide(PaCO(2) ) before NCPAP ventilation were higher in NCPAP ineffective group ((59±11 ) .( 49±11) mmHg, 1 mmHg=0.133 kPa, =-2.597, =0.028); while the PaO(2)/fraction of inspiration O(2) (FiO(2) ) before NCPAP was lower((150±37) . (207±63) mmHg, =2.697, =0.008). The breathing, heart rate and PaCO(2) of NCPAP effective group decreased significantly, while the PaO(2) and PaO(2)/FiO(2) increased significantly after 2, 8, 24 h of NCPAP ventilation(all =0.000). PaCO(2) in children with hypercapnia before NCPAP ventilation in NCPAP effective group decreased significantly ((48±9), (47±12), (45±11) .(58±7)mmHg, all =0.000). All children tolerated well to NCPAP ventilation, and there were no severe side effects or complications associated with NCPAP ventilation. NCPAP ventilation is safe and effectively improved the oxygenation and hypercapnia in infants with CAP. But it may not work well in children with underlying diseases, manifest as difficulty in feeding/cyanosis and extremely high PaCO(2) or low PaO(2)/FiO(2), and they may need early intubation.
[Mh] Termos MeSH primário: Pressão Positiva Contínua nas Vias Aéreas
Pneumonia/terapia
[Mh] Termos MeSH secundário: Gasometria
Dióxido de Carbono
Pré-Escolar
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Oxigênio
Pressão Parcial
Estudos Prospectivos
Respiração Artificial
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide); S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1310.2017.05.004



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