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[PMID]:29261703
[Au] Autor:Drew AJ; Izykowski MT; Bachus KN; Henninger HB; Foreman KB
[Ad] Endereço:Department of Orthopaedics, University of Utah, Salt Lake City, Utah, United States of America.
[Ti] Título:Transhumeral loading during advanced upper extremity activities of daily living.
[So] Source:PLoS One;12(12):e0189418, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Percutaneous osseointegrated (OI) implants for direct skeletal attachment of upper extremity prosthetics represent an alternative to traditional socket suspension that may yield improved patient function and satisfaction. This is especially true in high-level, transhumeral amputees where prosthetic fitting is challenging and abandonment rates remain high. However, maintaining mechanical integrity of the bone-implant interface is crucial for safe clinical introduction of this technology. The collection of population data on the transhumeral loading environment will aid in the design of compliance and overload protection devices that mitigate the risk of periprosthetic fracture. We collected marker-based upper extremity kinematic data from non-amputee volunteers during advanced activities of daily living (AADLs) that applied dynamic loading to the humerus. Inverse dynamic analysis was applied to calculate the axial force, bending and torsional moments at three virtual amputation levels representing 25, 50, and 75% residual humeral length. The influences of amputation level, elbow flexion constraint, gender and anthropometric scaling were assessed. Results indicate that the proximal (25%) amputation level experienced significantly higher axial forces and bending moments across all subjects when compared to distal amputation levels (p≤0.030). Constraining elbow flexion had a limited influence on peak transhumeral loads. Male subjects experienced higher axial forces during all evaluated activities (p≤0.023). Peak axial force for all activities occurred during jumping jacks (174.5N). Peak bending (57.6Nm) and torsional (57.2Nm) moments occurred during jumping jacks and rapid internal humeral rotation, respectively. Calculated loads fall within the range of implant fixation failure loads reported in cadaveric investigations of humeral stem fixation; indicating that periprosthetic fracture may occur during non-contact AADLs. These kinematic data, collected over a range of AADLs, will aid in the development of overload protection devices and appropriate post-operative rehabilitation protocols that balance return to an active lifestyle with patient safety.
[Mh] Termos MeSH primário: Atividades Cotidianas
Mãos/fisiologia
Úmero/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Amputação
Antropometria
Fenômenos Biomecânicos
Demografia
Cotovelo/fisiologia
Feminino
Seres Humanos
Úmero/cirurgia
Locomoção
Masculino
Meia-Idade
Amplitude de Movimento Articular
Torção Mecânica
Suporte de Carga
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189418


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[PMID]:28609782
[Au] Autor:Wang Q; Irobalieva RN; Chiu W; Schmid MF; Fogg JM; Zechiedrich L; Pettitt BM
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
[Ti] Título:Influence of DNA sequence on the structure of minicircles under torsional stress.
[So] Source:Nucleic Acids Res;45(13):7633-7642, 2017 Jul 27.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The sequence dependence of the conformational distribution of DNA under various levels of torsional stress is an important unsolved problem. Combining theory and coarse-grained simulations shows that the DNA sequence and a structural correlation due to topology constraints of a circle are the main factors that dictate the 3D structure of a 336 bp DNA minicircle under torsional stress. We found that DNA minicircle topoisomers can have multiple bend locations under high torsional stress and that the positions of these sharp bends are determined by the sequence, and by a positive mechanical correlation along the sequence. We showed that simulations and theory are able to provide sequence-specific information about individual DNA minicircles observed by cryo-electron tomography (cryo-ET). We provided a sequence-specific cryo-ET tomogram fitting of DNA minicircles, registering the sequence within the geometric features. Our results indicate that the conformational distribution of minicircles under torsional stress can be designed, which has important implications for using minicircle DNA for gene therapy.
[Mh] Termos MeSH primário: DNA Circular/química
DNA Circular/genética
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Fenômenos Biofísicos
Simulação por Computador
Microscopia Crioeletrônica
DNA Circular/ultraestrutura
Seres Humanos
Modelos Moleculares
Conformação de Ácido Nucleico
Eletricidade Estática
Torção Mecânica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Circular)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkx516


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[PMID]:28570094
[Au] Autor:Morvan G; Guerini H; Carré G; Vuillemin V
[Ad] Endereço:1 Centre d'Imagerie Médicale Léonard de Vinci, 43 rue Cortambert, 75116 Paris, France.
[Ti] Título:Femoral Torsion: Impact of Femur Position on CT and Stereoradiography Measurements.
[So] Source:AJR Am J Roentgenol;209(2):W93-W99, 2017 Aug.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study is to evaluate stereoradiographic measurements of femoral torsion with different femoral positions, in comparison with CT measurements, with use of the current standard axial-slice technique. We hypothesize that CT measurements vary with femoral spatial positioning because of the resulting projection onto the CT plane, whereas stereoradiographic measurements, which are derived from a 3D reconstruction of the femur, remain constant. MATERIALS AND METHODS: Both in vitro and in vivo studies were conducted. CT and stereoradiographic examinations were performed using 30 dry femurs in the following six femoral positions: neutral position (with the femoral mechanical axis aligned with the longitudinal axis of the CT scanner or stereoradiography system), 10° of abduction, 10° of adduction, 5° of flexion, 10° of flexion, and 5° of extension. The impact of femoral position on torsion measurement was assessed using paired t tests. In addition, 18 patients (mean [± SD] age, 42.3 ± 19.9 years) who underwent both CT and stereoradiography examinations were retrospectively assessed. The correlation between femoral positioning and torsion measurement was determined using the Pearson correlation coefficient. RESULTS: Flexion and extension statistically significantly affected CT measurement of femoral torsion (p < 0.01) but not stereoradiography measurement (p > 0.21). A strong correlation existed between hip flexion and the difference between femoral torsion measured by CT and stereoradiography (r = -0.80). CONCLUSION: The accuracy of femoral torsion determined by axial CT depends on the position of the femur. Hip flexion significantly reduced the femoral torsion angle measured by CT. Conversely, the accuracy of stereoradiography was independent of femur positioning. Thus, stereoradiography is preferable to CT for accurate measurement of femoral torsion, while it also substantially reduces the radiation dose.
[Mh] Termos MeSH primário: Fêmur/diagnóstico por imagem
Tomografia Computadorizada por Raios X
Anormalidade Torcional/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Cadáver
Feminino
Fêmur/fisiopatologia
Articulação do Quadril/diagnóstico por imagem
Articulação do Quadril/fisiopatologia
Seres Humanos
Imagem Tridimensional
Masculino
Meia-Idade
Posicionamento do Paciente
Interpretação de Imagem Radiográfica Assistida por Computador/métodos
Amplitude de Movimento Articular
Estudos Retrospectivos
Software
Anormalidade Torcional/fisiopatologia
Torção Mecânica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.16.16638


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[PMID]:28412438
[Au] Autor:Simard O; Niavarani SR; Gaudreault V; Boissonneault G
[Ad] Endereço:Department of Biochemistry, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada.
[Ti] Título:Torsional stress promotes trinucleotidic expansion in spermatids.
[So] Source:Mutat Res;800-802:1-7, 2017 Aug.
[Is] ISSN:1873-135X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Trinucleotide repeats are involved in various neurodegenerative diseases and are highly unstable both in dividing or non-dividing cells. In Huntington disease (HD), the age of onset of symptoms is inversely correlated to the number of CAG repeats within exon 1 of the HTT gene. HD shows paternal anticipation as CAG repeats are increased during spermatogenesis. CAG expansion were indeed found to be generated during the chromatin remodeling in spermatids where most histones are evicted and replaced by protamines. This process involves striking change in DNA topology since free supercoils must be eliminated. Using an in vitro CAG repeat reporter assay and a highly active nuclear extracts from spermatids, we demonstrate that free negative supercoils result in CAG TNR expansion at a stabilized hairpin. We also suggest a possible role for protamines in promoting localized torsional stress and consequently TNR expansion. The transient increase in torsional stress during spermiogenesis may therefore provide an ideal context for the generation of such secondary DNA structures leading to the paternal anticipation of trinucleotidic diseases.
[Mh] Termos MeSH primário: DNA Super-Helicoidal/genética
Espermátides/metabolismo
Torção Mecânica
Repetições de Trinucleotídeos
[Mh] Termos MeSH secundário: Animais
Canabidiol/análogos & derivados
Canabidiol/farmacologia
Montagem e Desmontagem da Cromatina/genética
DNA Topoisomerases Tipo II/metabolismo
Éxons
Histonas/genética
Histonas/metabolismo
Proteína Huntingtina/genética
Proteína Huntingtina/metabolismo
Doença de Huntington/genética
Masculino
Camundongos
Protaminas/metabolismo
Reprodutibilidade dos Testes
Espermatogênese/genética
Inibidores da Topoisomerase II/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Superhelical); 0 (HTT protein, human); 0 (Histones); 0 (Huntingtin Protein); 0 (Protamines); 0 (Topoisomerase II Inhibitors); 137252-25-6 (cannabidiol hydroxyquinone); 19GBJ60SN5 (Cannabidiol); EC 5.99.1.3 (DNA Topoisomerases, Type II)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE


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[PMID]:28123150
[Au] Autor:Sveric KM; Ulbrich S; Rady M; Ruf T; Kvakan H; Strasser RH; Jellinghaus S
[Ad] Endereço:Department of Cardiology, University of Technology Dresden.
[Ti] Título:Three-Dimensional Left Ventricular Torsion in Patients With Dilated Cardiomyopathy - A Marker of Disease Severity.
[So] Source:Circ J;81(4):529-536, 2017 Mar 24.
[Is] ISSN:1347-4820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: LV twist has a key role in maintaining left ventricular (LV) contractility during exercise. The purpose of this study was to investigate LV torsion instead of twist as a surrogate marker of peak oxygen uptake (peak V̇O ) assessed by cardiopulmonary exercise testing (CPET) in patients with non-ischemic dilated cardiomyopathy (DCM).Methods and Results:We evaluated 45 outpatients with DCM (50±12 years, 24% females) with 3D speckle-tracking electrocardiography prior to CPET. LV torsion, LV ejection fraction (EF), LV diastolic function, LV global longitudinal (GLS) and circumferential (GCS) strain were quantified. A reduced functional capacity (FC) was defined as a peak V̇O <20 mL/kg/min. LV torsion correlated most strongly with peak V̇O (r=0.76, P<0.001). LV torsion instead of twist was an independent predictor of peak V̇O (B: 0.59 to 0.71, P<0.001) in multivariable analyses. Impaired LV torsion <0.61 degrees/cm was able to predict a reduced FC with higher sensitivity and specificity (0.91 and 0.81; area under the curve (AUC): 0.88, P<0.001) than LV EF, GLS or GCS (AUC 0.64, 0.63 and 0.66; P<0.05 for differences in AUC). CONCLUSIONS: Peak V̇O correlated more strongly with LV torsion than with LV diastolic function, LV EF, GLS or GCS. LV torsion had high accuracy in identifying patients with a reduced FC.
[Mh] Termos MeSH primário: Cardiomiopatia Dilatada/fisiopatologia
Disfunção Ventricular Esquerda/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Área Sob a Curva
Teste de Esforço/métodos
Feminino
Seres Humanos
Imagem Tridimensional
Masculino
Meia-Idade
Consumo de Oxigênio/fisiologia
Sensibilidade e Especificidade
Índice de Gravidade de Doença
Torção Mecânica
Disfunção Ventricular Esquerda/diagnóstico por imagem
Função Ventricular Esquerda/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1253/circj.CJ-16-0965


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[PMID]:28094424
[Au] Autor:Macedo AS; Moens NM; Runciman J; Gibson TW; Minto BW
[Ti] Título:Ex vivo torsional properties of a 2.5 mm veterinary interlocking nail system in canine femurs. Comparison with a 2.4 mm limited contact bone plate.
[So] Source:Vet Comp Orthop Traumatol;30(2):118-124, 2017 Mar 20.
[Is] ISSN:0932-0814
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the torsional properties of the Targon Vet Nail System (TVS) in small canine femurs and to compare these properties to those of the 2.4 mm LC-DCP plates. METHODS: Thirty-six cadaveric femurs were allocated to three groups (n = 12). In all bones, points just distal to the lesser trochanter and just proximal to the fabellae were marked and a midshaft transverse osteotomy was performed. Group 1: bones were fixed with the 2.5 mm TVS with the bolts applied at the pre-identified marks. Group 2: A TVS system with 25% shorter inter-bolt distance was used. Group 3: A 7-hole 2.4 mm LC-DCP plates were applied. All constructs were tested non-destructively for 10 cycles, followed by an acute torsion to failure. RESULTS: Torque at yield was 0.806 ± 0.183 and 0.805 ± 0.093 Nm for groups 1 and 2 and 1.737 ± 0.461 Nm for group 3. Stiffness was 0.05 ± 0.01, 0.05 ± 0.007, and 0.14 ± 0.015 Nm/° for groups 1 to 3 respectively. Maximal angular displacement under cyclic loading was 16.6° ± 2.5°, 15.6° ± 2.1°, and 7.8° ± 1.06° respectively. There was no significant difference for any of the parameters between groups 1 and 2. Both torque at yield and stiffness were significantly greater between group 3 and groups 1 and 2. CLINICAL SIGNIFICANCE: The TVS had approximately half the torsional strength and approximately 1/3 of the stiffness of the 2.4 mm bone plate. Slippage of the locking mechanism was probably the cause of the early failure. The system should be considered as a low-strength and low-stiffness system when compared to bone plates.
[Mh] Termos MeSH primário: Pinos Ortopédicos/veterinária
Placas Ósseas/veterinária
Cães/cirurgia
Fêmur/cirurgia
[Mh] Termos MeSH secundário: Animais
Torção Mecânica
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.3415/VCOT-16-05-0083


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[PMID]:28093411
[Au] Autor:Hung CL; Gonçalves A; Shah AM; Cheng S; Kitzman D; Solomon SD
[Ad] Endereço:From the Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan (C.-L.H.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (C.-L.H., A.G., A.M.S., S.C., S.D.S.); Division of Cardiology, Departments of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
[Ti] Título:Age- and Sex-Related Influences on Left Ventricular Mechanics in Elderly Individuals Free of Prevalent Heart Failure: The ARIC Study (Atherosclerosis Risk in Communities).
[So] Source:Circ Cardiovasc Imaging;10(1), 2017 Jan.
[Is] ISSN:1942-0080
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Advanced age is related to left ventricular (LV) remodeling. We sought to investigate the relationships between aging, elevated hemodynamic load, cardiac mechanics, and LV remodeling in an elderly community-based population. METHODS AND RESULTS: We studied 1105 subjects (76±5 years, 61% women) without prevalent heart failure, who attended the visit 5 of the ARIC study (Atherosclerosis Risk in Communities). LV global longitudinal strain, global circumferential strain, and torsion indices were analyzed using 3-dimensional echocardiography. Advanced age was associated with greater LV concentricity, lower myocardial diastolic relaxation, reduced global longitudinal strain (adjusted estimate, 0.39±0.19% (SE)/decade; P=0.038), borderline greater global circumferential strain (adjusted estimate, -0.59±0.36% (SE)/decade; P=0.08), and higher torsion indices (adjusted estimate for torsion, 0.33±0.04° (SE)/decade; P<0.001). In addition, greater concentricity was associated with decreased global longitudinal strain and greater torsion in multivariable models (all P<0.001). Women showed smaller LV cavity size, greater concentricity, lower myocardial relaxation velocity E', though demonstrated greater global longitudinal strain, global circumferential strain, and torsion than men (all P<0.05). Overall, subjects with hypertension and increasing age were more likely to have higher torsion, though the association between advanced age and greater torsion was more pronounced in women than in men (both interaction P<0.05). CONCLUSIONS: In an asymptomatic, senescent community-dwelling population, we observed a distinct, sex-specific pattern of cardiac remodeling. Although we observed worse diastolic and longitudinal function with advanced age or elevated load in both sexes, a significant increase of torsion was more pronounced in women.
[Mh] Termos MeSH primário: Aterosclerose/epidemiologia
Insuficiência Cardíaca/epidemiologia
Disfunção Ventricular Esquerda/epidemiologia
Função Ventricular Esquerda
Remodelação Ventricular
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Aterosclerose/diagnóstico por imagem
Aterosclerose/fisiopatologia
Fenômenos Biomecânicos
Estudos Transversais
Diástole
Ecocardiografia Tridimensional
Feminino
Insuficiência Cardíaca/diagnóstico por imagem
Insuficiência Cardíaca/fisiopatologia
Hemodinâmica
Seres Humanos
Hipertensão/complicações
Hipertensão/fisiopatologia
Masculino
Prevalência
Estudos Prospectivos
Fatores de Risco
Fatores Sexuais
Fatores de Tempo
Torção Mecânica
Estados Unidos/epidemiologia
Disfunção Ventricular Esquerda/diagnóstico por imagem
Disfunção Ventricular Esquerda/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE


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[PMID]:28081051
[Ti] Título:Procedure Oriented Torsional Anatomy of the Forearm for Spasticity Injection: Erratum.
[So] Source:J Comput Assist Tomogr;41(1):172, 2017 Jan.
[Is] ISSN:1532-3145
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antebraço/diagnóstico por imagem
Antebraço/patologia
Espasticidade Muscular/diagnóstico por imagem
Espasticidade Muscular/terapia
Músculo Esquelético/diagnóstico por imagem
Posicionamento do Paciente/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Injeções
Músculo Esquelético/patologia
Torção Mecânica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1097/RCT.0000000000000596


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[PMID]:27878699
[Au] Autor:Zhang L; Zhou X; Wang J; Mu Y; Liu B; Lv W; Wang Y; Liu H; Liu H; Zhi G
[Ad] Endereço:Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
[Ti] Título:Differentiation of light-chain cardiac amyloidosis from hypertrophic cardiomyopathy using myocardial mechanical parameters by velocity vector imaging echocardiography.
[So] Source:Int J Cardiovasc Imaging;33(4):499-507, 2017 Apr.
[Is] ISSN:1875-8312
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We aimed to evaluate the diagnostic efficacy of layered velocity vector imaging (VVI)-derived left ventricular (LV) mechanical parameters in the differential diagnosis of primary light-chain cardiac amyloidosis (AL-CA) and hypertrophic cardiomyopathy (HCM). We recruited 35 subjects with histologically-diagnosed AL-CA, 35 subjects with HCM, and 30 age-matched healthy controls. We used conventional echocardiography and electrocardiogram to evaluate general heart function and electrophysiology properties. Furthermore, we applied two-dimensional VVI echocardiography to assess the layered mechanical parameters during systole, including endocardial and epicardial longitudinal strain (ENDO and EPI LSsys), circumferential strain (CSsys), radial strain (RSsys), rotation (ROT) and twist (TWI), in different LV walls and levels. Two groups of patients had similarly elevated LV wall thickness and mild diastolic dysfunction, but normal ejection fraction. ENDO LSsys of three circular LV levels and six LV walls was markedly decreased in AL-CA patients, with the most prominent reduction in the basal level. The reduction of ENDO and EPI LSsys in HCM subjects was less profound, and was restricted to certain LV wall and levels. AL-CA patients had significantly reduced RSsys in the LV basal level compared with control or HCM patients. Two groups of patients exhibited similar reduction in layered regional CSsys, ROT and TWI. ROC analysis revealed that the sensitivity and specificity of basal ENDO LSsys for predicting AL-CA was 86 and 89%. Assessment of layered LSsys of LV walls and levels by VVI appeared to provide a more sensitive and specific diagnostic index for the differential diagnosis of AL-CA from HCM than conventional echocardiography. Future studies are warranted to evaluate its diagnostic efficacy for AL-CA diagnosis in the large population.
[Mh] Termos MeSH primário: Amiloidose/diagnóstico por imagem
Cardiomiopatias/diagnóstico por imagem
Cardiomiopatia Hipertrófica/diagnóstico por imagem
Ecocardiografia Doppler/métodos
Ecocardiografia Quadridimensional/métodos
Cadeias Leves de Imunoglobulina/imunologia
Contração Miocárdica
Função Ventricular Esquerda
[Mh] Termos MeSH secundário: Adulto
Idoso
Amiloidose/imunologia
Amiloidose/fisiopatologia
Área Sob a Curva
Fenômenos Biomecânicos
Cardiomiopatias/imunologia
Cardiomiopatias/fisiopatologia
Cardiomiopatia Hipertrófica/fisiopatologia
Estudos de Casos e Controles
Diagnóstico Diferencial
Feminino
Seres Humanos
Interpretação de Imagem Assistida por Computador
Masculino
Meia-Idade
Valor Preditivo dos Testes
Curva ROC
Reprodutibilidade dos Testes
Estresse Mecânico
Torção Mecânica
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin Light Chains)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE
[do] DOI:10.1007/s10554-016-1027-5


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[PMID]:27787699
[Au] Autor:Ikonomidis I; Tzortzis S; Tsantes A; Ntai K; Triantafyllidi H; Trivilou P; Katsimaglis G; Dima K; Parissis J; Lekakis J
[Ad] Endereço:2nd Cardiology Department, Attikon Hospital, University of Athens, Rimini 1, Chaidari, 12462, Athens, Greece. ignoik@otenet.gr.
[Ti] Título:The interplay between renin-angiotensin system activation, abnormal myocardial deformation and neurohumoral activation in hypertensive heart disease: a speckle tracking echocardiography study.
[So] Source:Int J Cardiovasc Imaging;33(3):323-329, 2017 Mar.
[Is] ISSN:1875-8312
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Angiotensin converting enzyme (ACE) promotes cardiac fibrosis. LV myocardial deformation and torsion are markers of subclinical myocardial dysfunction. We investigated the association of serum ACE levels with LV deformation markers in untreated hypertensives. In 120 untreated patients (age: 53.5 ± 11.2 years) with essential hypertension and 60 healthy controls, we measured (a) LV longitudinal, circumferential and radial strain (S), peak torsion and the percentage changes between peak twisting and untwisting at the end of early diastolic filling (%dpTw-Utw ) using speckle tracking echocardiography and (b) serum levels of ACE and NTproBNP. Compared to controls, patients had decreased longitudinal strain (-19.1 ± 2.9 vs. -21.7 ± 1.8%), increased peak twisting (19.1 ± 4.6 vs.14.0 ± 3.7 deg) but decreased %dpTw-Utw (78 ± 8 vs. 86 ± 8%) and higher serum ACE levels (27.6 ± 8.0 vs 20.9 ± 7.1 U/ml) (p < 0.05 for all comparisons). Increasing serum ACE levels were related to impaired radial strain and longitudinal systolic SR (b = -0.41 and b = 0.31 respectively, p < 0.01), as well as to reduced %dpTw-Utw (b = -0.37, p < 0.05). Furthermore, increasing serum ACE levels were related to increasing NTproBNP levels (b = 0.41, p < 0.01). In multivariate analysis, the above relations of serum ACE levels and LV function parameters remained significant after adjustment for other confounding factors (p < 0.01). The close link between serum ACE levels and impaired LV deformation suggests that activation of renin-angiotensin system is involved in the impairment of LV function resulting in elevated LV filling pressures causing the concomitant elevation of BNP levels in untreated hypertensive patients.
[Mh] Termos MeSH primário: Ecocardiografia Doppler/métodos
Hipertensão/diagnóstico por imagem
Contração Miocárdica
Peptidil Dipeptidase A/sangue
Sistema Renina-Angiotensina
Disfunção Ventricular Esquerda/diagnóstico por imagem
Função Ventricular Esquerda
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores/sangue
Fenômenos Biomecânicos
Distribuição de Qui-Quadrado
Feminino
Fibrose
Seres Humanos
Hipertensão/complicações
Hipertensão/fisiopatologia
Modelos Lineares
Masculino
Meia-Idade
Análise Multivariada
Peptídeo Natriurético Encefálico/sangue
Fragmentos de Peptídeos/sangue
Valor Preditivo dos Testes
Prognóstico
Fatores de Risco
Estresse Mecânico
Torção Mecânica
Regulação para Cima
Disfunção Ventricular Esquerda/etiologia
Disfunção Ventricular Esquerda/fisiopatologia
Pressão Ventricular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Peptide Fragments); 0 (pro-brain natriuretic peptide (1-76)); 114471-18-0 (Natriuretic Peptide, Brain); EC 3.4.15.1 (ACE protein, human); EC 3.4.15.1 (Peptidyl-Dipeptidase A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.1007/s10554-016-1010-1



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