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[PMID]:28658055
[Au] Autor:Fisher DR; Fahey FH
[Ad] Endereço:*Versant Medical Physics and Radiation Safety, 229 Saint St., Richland, WA 99354 USA; †Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA 02115 USA.
[Ti] Título:Appropriate Use of Effective Dose in Radiation Protection and Risk Assessment.
[So] Source:Health Phys;113(2):102-109, 2017 Aug.
[Is] ISSN:1538-5159
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Effective dose was introduced by the ICRP for the single, over-arching purpose of setting limits for radiation protection. Effective dose is a derived quantity or mathematical construct and not a physical, measurable quantity. The formula for calculating effective dose to a reference model incorporates terms to account for all radiation types, organ and tissue radiosensitivities, population groups, and multiple biological endpoints. The properties and appropriate applications of effective dose are not well understood by many within and outside the health physics profession; no other quantity in radiation protection has been more confusing or misunderstood. According to ICRP Publication 103, effective dose is to be used for "prospective dose assessment for planning and optimization in radiological protection, and retrospective demonstration of compliance for regulatory purposes." In practice, effective dose has been applied incorrectly to predict cancer risk among exposed persons. The concept of effective dose applies generally to reference models only and not to individual subjects. While conceived to represent a measure of cancer risk or heritable detrimental effects, effective dose is not predictive of future cancer risk. The formula for calculating effective dose incorporates committee-selected weighting factors for radiation quality and organ sensitivity; however, the organ weighting factors are averaged across all ages and both genders and thus do not apply to any specific individual or radiosensitive subpopulations such as children and young women. Further, it is not appropriate to apply effective dose to individual medical patients because patient-specific parameters may vary substantially from the assumptions used in generalized models. Also, effective dose is not applicable to therapeutic uses of radiation, as its mathematical underpinnings pertain only to observed late (stochastic) effects of radiation exposure and do not account for short-term adverse tissue reactions. The weighting factors incorporate substantial uncertainties, and linearity of the dose-response function at low dose is uncertain and highly disputed. Since effective dose is not predictive of future cancer incidence, it follows that effective dose should never be used to estimate future cancer risk from specific sources of radiation exposure. Instead, individual assessments of potential detriment should only be based on organ or tissue radiation absorbed dose, together with best scientific understanding of the corresponding dose-response relationships.
[Mh] Termos MeSH primário: Neoplasias Induzidas por Radiação/epidemiologia
Modelos de Riscos Proporcionais
Exposição à Radiação/estatística & dados numéricos
Proteção Radiológica/normas
Eficiência Biológica Relativa
Medição de Risco/normas
Contagem Corporal Total/normas
[Mh] Termos MeSH secundário: Bioensaio/normas
Seres Humanos
Incidência
Internacionalidade
Guias de Prática Clínica como Assunto
Prevalência
Radiação
Dose de Radiação
Monitoramento de Radiação/normas
Taxa de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1097/HP.0000000000000674


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[PMID]:28499490
[Au] Autor:Patel H; Yadav N; Parmar R; Patel S; Singh AP; Shrivastava N; Dalai SK
[Ad] Endereço:Institute of Science, Nirma University, Ahmedabad 382481, India.
[Ti] Título:Frequent inoculations with radiation attenuated sporozoite is essential for inducing sterile protection that correlates with a threshold level of Plasmodia liver-stage specific CD8 T cells.
[So] Source:Cell Immunol;317:48-54, 2017 Jul.
[Is] ISSN:1090-2163
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Whole sporozoite vaccine (WSV) is shown to induce sterile protection that targets Plasmodium liver-stage infection. There are many underlying issues associated with induction of effective sterile protracted protection. In this study, we have addressed how the alterations in successive vaccine regimen could possibly affect the induction of sterile protection. We have demonstrated that the pattern of vaccination with RAS (radiation attenuated sporozoites) induces varying degrees of protection among B6 mice. Animals receiving four successive doses generated 100% sterile protection. However, three successive doses, though with the same parasite inoculum as four doses, could induce sterile protection in ∼50% mice. Interestingly, mice immunized with the same 3 doses, but with longer gap, could not survive the challenge. We demonstrate that degree of protection correlates with the frequencies of IFN-γ and multifunctional (IFN-γ CD107a ) CD8 T cells present in liver. The failure to achieve protective threshold frequency of these cells in liver might make the host more vulnerable to parasite infection during infectious sporozoite challenge.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/imunologia
Interferon gama/metabolismo
Hepatopatias/imunologia
Fígado/imunologia
Vacinas Antimaláricas/imunologia
Malária/imunologia
Plasmodium/imunologia
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD8-Positivos/parasitologia
Células Cultivadas
Interações Hospedeiro-Parasita
Seres Humanos
Memória Imunológica
Fígado/parasitologia
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos C57BL
Radiação
Esporozoítos/imunologia
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Malaria Vaccines); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE


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[PMID]:28284934
[Au] Autor:Singh B; Singh B
[Ad] Endereço:Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India. Electronic address: baljitsinghhpu@yahoo.com.
[Ti] Título:Influence of graphene-oxide nanosheets impregnation on properties of sterculia gum-polyacrylamide hydrogel formed by radiation induced polymerization.
[So] Source:Int J Biol Macromol;99:699-712, 2017 Jun.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Present work is an attempt, to explore the potential of graphene oxide nanoplates impregnation, on the mechanical and drug delivery properties of sterculia gum-polyacrylamide composite hydrogel formed by radiation induced polymerization. These polymers were characterized by SEM, cryo-SEM, AFM, FTIR's, C NMR and swelling studies. Release profile of an anticancer drug 'gemcitabine' was studied to determine the drug release mechanism and best fit kinetic model. Furthermore, some important biomedical properties of the polymers such as blood compatibility, mucoadhesion, antioxidant properties and gel strength were also studied. Impregnation of GO into sterculia gum-poly(AAm) hydrogels decreased the swelling of hydrogels but improved the mechanical, drug loading and drug release properties of the hydrogels. Release of gemcitabine from drug loaded hydrogels occurred through non-Fickian diffusion mechanism and release profile was best fitted in first order kinetic model. These hydrogels have been found as haemocompatible, mucoadhesive, and antioxidant in nature.
[Mh] Termos MeSH primário: Resinas Acrílicas/química
Grafite/química
Hidrogéis/química
Goma de Karaya/química
Óxidos/química
Polimerização
Radiação
[Mh] Termos MeSH secundário: Adesividade
Antioxidantes/química
Antioxidantes/farmacologia
Antioxidantes/toxicidade
Materiais Biocompatíveis/química
Materiais Biocompatíveis/farmacologia
Materiais Biocompatíveis/toxicidade
Portadores de Fármacos/química
Portadores de Fármacos/farmacologia
Portadores de Fármacos/toxicidade
Liberação Controlada de Fármacos
Fluoroquinolonas/química
Mucosa Intestinal/química
Cinética
Modelos Moleculares
Conformação Molecular
Nanoestruturas/química
Naftiridinas/química
Sterculia/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Antioxidants); 0 (Biocompatible Materials); 0 (Drug Carriers); 0 (Fluoroquinolones); 0 (Hydrogels); 0 (Naphthyridines); 0 (Oxides); 7782-42-5 (Graphite); 9000-36-6 (Karaya Gum); 9003-05-8 (polyacrylamide); OKR68Y0E4T (gemifloxacin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


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[PMID]:28260074
[Au] Autor:Yu H; Sun SQ; Gu XB; Wang W; Gao XS
[Ad] Endereço:Department of Radiation Oncology, Peking University First Hospital, Peking University, Beijing 100034, P.R. China.
[Ti] Título:Atorvastatin prolongs the lifespan of radiation­induced reactive oxygen species in PC-3 prostate cancer cells to enhance the cell killing effect.
[So] Source:Oncol Rep;37(4):2049-2056, 2017 Apr.
[Is] ISSN:1791-2431
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Studies have reported that atorvastatin (ATO) may increase the radiosensitivity of malignant cells. However, the influence of ATO on reactive oxygen species (ROS) levels before and after irradiation has not been fully illustrated. In the present study, radiosensitivity was evaluated by a clonogenic assay and a cell survival curve and cell apoptosis was measured by flow cytometry. ROS were detected by a laser scanning confocal microscope and flow cytometry with a DCFH-DA probe. NADPH oxidases (NOXs) and superoxide dismutase (SOD) proteins were detected by immunoblotting, and total SOD activity was measured using an SOD kit. We also conducted transient transfection of NOX2 and NOX4 genes to increase intracellular ROS generation and applied SOD mimetic tempol to enhance ROS elimination ability. Our results demonstrated that, with ATO-alone treatment, the survival fractions of irradiated PC-3 cells were significantly decreased. Meanwhile, the apoptosis rate of the irradiated cells increased significantly (P<0.05). The ROS levels of the study group decreased obviously before irradiation (P<0.01), however, the radiation-induced ROS of the study group was at a high level even when irradiation had been terminated for 2 h (P<0.01). Moreover, NOX2 and NOX4 levels and total SOD activity decreased (P<0.01), while the levels of SOD1 were stably maintained (P>0.05). On the other hand, the decreased survival fractions and high radiation-induced ROS levels were abrogated by increasing the level of NOXs by gene transfection or by enhancing the ability of SOD utilizing the addition of tempol. In conclusion, ATO enhanced the cell killing effect of irradiation by reducing endogenous ROS levels and prolonging the lifespan of radiation­induced ROS via a decrease in the level of NOXs and SOD activity.
[Mh] Termos MeSH primário: Atorvastatina Cálcica/administração & dosagem
Glicoproteínas de Membrana/genética
NADPH Oxidases/genética
Neoplasias da Próstata/tratamento farmacológico
Protetores contra Radiação/administração & dosagem
Superóxido Dismutase/biossíntese
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Antioxidantes/efeitos da radiação
Apoptose/efeitos dos fármacos
Apoptose/efeitos da radiação
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos da radiação
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Masculino
Glicoproteínas de Membrana/biossíntese
NADPH Oxidase 2
NADPH Oxidase 4
NADPH Oxidases/biossíntese
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/efeitos da radiação
Neoplasias da Próstata/genética
Neoplasias da Próstata/patologia
Neoplasias da Próstata/radioterapia
Radiação
Tolerância a Radiação/efeitos dos fármacos
Tolerância a Radiação/genética
Espécies Reativas de Oxigênio/metabolismo
Espécies Reativas de Oxigênio/efeitos da radiação
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Membrane Glycoproteins); 0 (Radiation-Protective Agents); 0 (Reactive Oxygen Species); 48A5M73Z4Q (Atorvastatin Calcium); EC 1.15.1.1 (Superoxide Dismutase); EC 1.6.3.- (CYBB protein, human); EC 1.6.3.- (NADPH Oxidase 2); EC 1.6.3.- (NADPH Oxidase 4); EC 1.6.3.- (NADPH Oxidases); EC 1.6.3.- (NOX4 protein, human)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.3892/or.2017.5447


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[PMID]:28256187
[Au] Autor:Casadevall A; Cordero RJB; Bryan R; Nosanchuk J; Dadachova E
[Ad] Endereço:Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.
[Ti] Título:Melanin, Radiation, and Energy Transduction in Fungi.
[So] Source:Microbiol Spectr;5(2), 2017 Mar.
[Is] ISSN:2165-0497
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Melanin pigments are found in many diverse fungal species, where they serve a variety of functions that promote fitness and cell survival. Melanotic fungi inhabit some of the most extreme habitats on earth such as the damaged nuclear reactor at Chernobyl and the highlands of Antarctica, both of which are high-radiation environments. Melanotic fungi migrate toward radioactive sources, which appear to enhance their growth. This phenomenon, combined with the known capacities of melanin to absorb a broad spectrum of electromagnetic radiation and transduce this radiation into other forms of energy, raises the possibility that melanin also functions in harvesting such energy for biological usage. The ability of melanotic fungi to harness electromagnetic radiation for physiological processes has enormous implications for biological energy flows in the biosphere and for exobiology, since it provides new mechanisms for survival in extraterrestrial conditions. Whereas some features of the way melanin-related energy transduction works can be discerned by linking various observations and circumstantial data, the mechanistic details remain to be discovered.
[Mh] Termos MeSH primário: Metabolismo Energético
Fungos/metabolismo
Fungos/efeitos da radiação
Melaninas/metabolismo
Radiação
[Mh] Termos MeSH secundário: Fungos/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Melanins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1128/microbiolspec.FUNK-0037-2016


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[PMID]:28230805
[Au] Autor:Fan H; Wang J; Meng Q; Xu X; Fan T; Jin Z
[Ad] Endereço:The State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China. fanhaoran0622@163.com.
[Ti] Título:Preparation of Photoirradiation Molecular Imprinting Polymer for Selective Separation of Branched Cyclodextrins.
[So] Source:Molecules;22(2), 2017 Feb 21.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In the present study, photoirradiation molecularly imprinted polymer (MIP) with azobenzene was used as a functional monomer for the selective separation of the branched cyclodextrins. The functional monomer 4-methacryloyloxy azobenzene (MAA) and the molecular template 6- -α-d-maltosyl-ß-cyclodextrin (G2-ß-CD) were implemented for the molecular imprinting. The core-shell structure of photoirradiation MIP was visualized by the transmission electron microscopy (TEM). With Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), we identified that G2-ß-CD was imprinted into the polymer and removed from the MIP. The binding association constant ( ) and the maximum number of the binding site ( ) were 1.72 × 104 M and 7.93 µmol·g MIP, respectively. With alternate irradiation at 365 and 440 nm light, the prepared MIP reversibly released and rebound to the G2-ß-CD, which resulted in the nearly zero amount of G2-ß-CD in the solution. The HPLC results indicated that the purity of G2-ß-CD could reach 90.8% after going through MIP. The main finding of our study was that the photoirradiation of MIP was an easy and effective method for the selective separation of the branched cyclodextrins.
[Mh] Termos MeSH primário: Ciclodextrinas/química
Luz
Impressão Molecular
Polímeros/química
Radiação
[Mh] Termos MeSH secundário: Isomerismo
Microscopia Eletrônica
Impressão Molecular/métodos
Polímeros/síntese química
Espectroscopia de Prótons por Ressonância Magnética
Espectroscopia de Infravermelho com Transformada de Fourier
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclodextrins); 0 (Polymers)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


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[PMID]:28166286
[Au] Autor:Seong KM; Kwon T; Seo S; Lee D; Park S; Jin YW; Lee SS
[Ad] Endereço:Laboratory of Low Dose Risk Assessment, National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
[Ti] Título:Perception of low dose radiation risks among radiation researchers in Korea.
[So] Source:PLoS One;12(2):e0171777, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Expert's risk evaluation of radiation exposure strongly influences the public's risk perception. Experts can inform laypersons of significant radiation information including health knowledge based on experimental data. However, some experts' radiation risk perception is often based on non-conclusive scientific evidence (i.e., radiation levels below 100 millisievert), which is currently under debate. Examining perception levels among experts is important for communication with the public since these individual's opinions have often exacerbated the public's confusion. We conducted a survey of Korean radiation researchers to investigate their perceptions of the risks associated with radiation exposure below 100 millisievert. A linear regression analysis revealed that having ≥ 11 years' research experience was a critical factor associated with radiation risk perception, which was inversely correlated with each other. Increased opportunities to understand radiation effects at < 100 millisievert could alter the public's risk perception of radiation exposure. In addition, radiation researchers conceived that more scientific evidence reducing the uncertainty for radiation effects < 100 millisievert is necessary for successful public communication. We concluded that sustained education addressing scientific findings is a critical attribute that will affect the risk perception of radiation exposure.
[Mh] Termos MeSH primário: Exposição Ocupacional
Percepção
Vigilância em Saúde Pública
Dose de Radiação
Radiação
Pesquisadores/psicologia
[Mh] Termos MeSH secundário: Análise Fatorial
Seres Humanos
Exposição Ocupacional/efeitos adversos
República da Coreia/epidemiologia
Medição de Risco
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171777


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[PMID]:28133985
[Au] Autor:Qin J; Li S; Zhang C; Gao DW; Li Q; Zhang H; Jin XD; Liu Y
[Ad] Endereço:1 Department of Radiotherapy, Lanzhou General Hospital of PLA, Lanzhou 730050, China.
[Ti] Título:Apoptosis and injuries of heavy ion beam and x-ray radiation on malignant melanoma cell.
[So] Source:Exp Biol Med (Maywood);242(9):953-960, 2017 May.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aims to investigate the influence of high linear energy transfer (LET) heavy ion ( C ) and low LET X-ray radiation on apoptosis and related proteins of malignant melanoma on tumor-bearing mice under the same physical dosage. C57BL/6 J mice were burdened by tumors and randomized into three groups. These mice received heavy ion ( C ) and X-ray radiation under the same physical dosage, respectively; their weight and tumor volumes were measured every three days post-radiation. After 30 days, these mice were sacrificed. Then, median survival time was calculated and tumors on mice were proliferated. In addition, immunohistochemistry was carried out for apoptosis-related proteins to reflect the expression level. After tumor-bearing mice were radiated to heavy ion, median survival time improved and tumor volume significantly decreased in conjunction with the upregulated expression of pro-apoptosis factors, Bax and cytochrome C, and the downregulated expression of apoptosis-profilin (Bcl-2, Survivin) and proliferation-related proteins (proliferating cell nuclear antigen). The results indicated that radiation can promote the apoptosis of malignant melanoma cells and inhibit their proliferation. This case was more suitable for heavy ion ( C ). High LET heavy ion ( C ) radiation could significantly improve the killing ability for malignant melanoma cells by inducing apoptosis in tumor cells and inhibiting their proliferation. These results demonstrated that heavy ion ( C ) presented special advantages in terms of treating malignant melanoma. Impact statement Malignant melanoma is a malignant skin tumor derived from melanin cells, which has a high malignant degree and high fatality rate. In this study, proliferating cell nuclear antigen (PCNA) can induce the apoptosis of malignant melanoma cells and inhibit its proliferation, and its induction effect on apoptosis is significantly higher than low LET X-ray; hence, it is expected to overcome its lower sensitivity to radiation. This study can provide theoretical basis for clinical trials, in which malignant melanoma is treated by heavy ion ( C ), in order to accurately determine the clinical efficacy of heavy ion therapy. Clinical applications has revealed that local tumor control rate is high when heavy ion is used to treat malignant melanoma, indicating that heavy ion is an important direction in treating melanoma in the future.
[Mh] Termos MeSH primário: Apoptose/efeitos da radiação
Íons Pesados
Melanoma/patologia
Melanoma/radioterapia
Radiação
Radioterapia/métodos
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/radioterapia
Raios X
[Mh] Termos MeSH secundário: Animais
Proteínas Reguladoras de Apoptose/análise
Imuno-Histoquímica
Camundongos Endogâmicos C57BL
Análise de Sobrevida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apoptosis Regulatory Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE
[do] DOI:10.1177/1535370216689827


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[PMID]:28091341
[Au] Autor:Inaida S; Tsuda T; Matsuno S
[Ad] Endereço:Department of Epidemiology,Graduate School of Medicine,Dentistry and Pharmaceutical Sciences,Okayama University,Okayama,Japan.
[Ti] Título:Correlation between infectious disease and soil radiation in Japan: an exploratory study using national sentinel surveillance data.
[So] Source:Epidemiol Infect;145(6):1183-1192, 2017 04.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We investigated the relationship between epidemics and soil radiation through an exploratory study using sentinel surveillance data (individuals aged <20 years) during the last three epidemic seasons of influenza and norovirus in Japan. We used a spatial analysis method of a geographical information system (GIS). We mapped the epidemic spreading patterns from sentinel incidence rates. We calculated the average soil radiation [dm (µGy/h)] for each sentinel site using data on uranium, thorium, and potassium oxide in the soil and examined the incidence rate in units of 0·01 µGy/h. The correlations between the incidence rate and the average soil radiation were assessed. Epidemic clusters of influenza and norovirus infections were observed in areas with relatively high radiation exposure. A positive correlation was detected between the average incidence rate and radiation dose, at r = 0·61-0·84 (P < 0·01) for influenza infections and r = 0·61-0·72 (P < 0·01) for norovirus infections. An increase in the incidence rate was found between areas with radiation exposure of 0 < dm < 0·01 and 0·15 ⩽ dm < 0·16, at 1·80 [95% confidence interval (CI) 1·47-2·12] times higher for influenza infection and 2·07 (95% CI 1·53-2·61) times higher for norovirus infection. Our results suggest a potential association between decreased immunity and irradiation because of soil radiation. Further studies on immunity in these epidemic-prone areas are desirable.
[Mh] Termos MeSH primário: Infecções por Caliciviridae/epidemiologia
Influenza Humana/epidemiologia
Radiação
Vigilância de Evento Sentinela
Solo/química
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Seres Humanos
Incidência
Lactente
Recém-Nascido
Japão/epidemiologia
Masculino
Norovirus/isolamento & purificação
Orthomyxoviridae/isolamento & purificação
Óxidos/análise
Compostos de Potássio/análise
Tório/análise
Topografia Médica
Urânio/análise
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxides); 0 (Potassium Compounds); 0 (Soil); 4OC371KSTK (Uranium); 58D606078H (potassium oxide); 60YU5MIG9W (Thorium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268816003034


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[PMID]:28081144
[Au] Autor:Li X; Dunn J; Salins D; Zhou G; Zhou W; Schüssler-Fiorenza Rose SM; Perelman D; Colbert E; Runge R; Rego S; Sonecha R; Datta S; McLaughlin T; Snyder MP
[Ad] Endereço:Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America.
[Ti] Título:Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information.
[So] Source:PLoS Biol;15(1):e2001402, 2017 Jan.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO2] and increased radiation exposure). These events are associated with physiological macro-phenotypes such as fatigue, providing a strong association between reduced pressure/oxygen and fatigue on high-altitude flights. Importantly, we combined biosensor information with frequent medical measurements and made two important observations: First, wearable devices were useful in identification of early signs of Lyme disease and inflammatory responses; we used this information to develop a personalized, activity-based normalization framework to identify abnormal physiological signals from longitudinal data for facile disease detection. Second, wearables distinguish physiological differences between insulin-sensitive and -resistant individuals. Overall, these results indicate that portable biosensors provide useful information for monitoring personal activities and physiology and are likely to play an important role in managing health and enabling affordable health care access to groups traditionally limited by socioeconomic class or remote geography.
[Mh] Termos MeSH primário: Técnicas Biossensoriais
Eletrônica Médica
Saúde
Modelagem Computacional Específica para o Paciente
[Mh] Termos MeSH secundário: Ritmo Circadiano/fisiologia
Eletrônica Médica/instrumentação
Seres Humanos
Inflamação/diagnóstico
Insulina/metabolismo
Resistência à Insulina
Oxigênio/metabolismo
Pressão Parcial
Medicina de Precisão
Radiação
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insulin); S88TT14065 (Oxygen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170711
[Lr] Data última revisão:
170711
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2001402



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