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[PMID]:29328944
[Au] Autor:Sáez-Muñoz M; Bas MDC; Ortiz J; Martorell S
[Ad] Endereço:Laboratorio de Radiactividad Ambiental, MEDASEGI Research Group, Universitat Politècnica de València, Spain. Electronic address: masaemuo@etsii.upv.es.
[Ti] Título:Analysis of the evolution of gross alpha and gross beta activities in airborne samples in Valencia (Spain).
[So] Source:J Environ Radioact;183:94-101, 2018 Mar.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Gross alpha (A ) and gross beta activities (A ) were measured weekly in the airborne of the Universitat Politècnica de Valencia campus (in the east of Spain) during the period 2009-2015 (7 years). The geometric mean values of weekly A and A were 0.53·10 Bq m and 5.77·10 Bq m , respectively; with an average ratio A /A of 0.097. This study highlights the heterogeneity of gross alpha and gross beta activities depending on the different periods of the year. Data show seasonal variations with the highest activity in summer months and the lowest one in winter months. Several atmospheric factors were considered in order to explain this intra-annual variation (wind speed, temperature, relative humidity, precipitations, dust content and prevailing wind directions). Multiple Linear Regression Analysis were performed in order to obtain information on significant atmospheric factors that affect gross α and gross ß variability, which could be useful in identifying meteorological or atmospheric changes that could cause deviations in gross α and gross ß activity depending on the seasons considered. Models obtained explain more than 60% of variability for global data, and also for winter and spring-autumn months. However, more research is needed to explain gross α and gross ß variability in summer months, because the atmospheric factors considered in the MLR explain less than 35% of variability.
[Mh] Termos MeSH primário: Poluentes Radioativos do Ar/análise
Partículas alfa
Partículas beta
Monitoramento de Radiação
[Mh] Termos MeSH secundário: Umidade
Espanha
Temperatura Ambiente
Vento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Radioactive)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE


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[PMID]:29063838
[Au] Autor:Gholami YH; Wilson N; James D; Kuncic Z
[Ad] Endereço:Institute of Medical Physics, School of Physics, The University of Sydney, Sydney, New South Wales, Australia.
[Ti] Título:Toward Personalized Dosimetry with P Microparticle Therapy for Advanced Pancreatic Cancer.
[So] Source:Int J Radiat Oncol Biol Phys;99(4):1029-1038, 2017 Nov 15.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To develop a Monte Carlo model for patient-specific dosimetry of P microparticle localized internal radionuclide therapy for advanced pancreatic cancer. METHODS AND MATERIALS: Spherical tumor geometries and a pancreatic phantom were modeled, as well as different 3-dimensional non-uniform clinical pancreatic geometries based on patient-specific ultrasound images. The dosimetry simulations modeled the dose distribution due to the energy spectrum of emitted beta particles. RESULTS: The average dose for small (3-cm diameter) and large (6-cm diameter) spherical tumors was 111 Gy (for 7.6 MBq administered activity) and 128 Gy (for 58 MBq), respectively. For the clinical 3-dimensional geometries, on the basis of patient data, the mean doses delivered to the tumor were calculated to be in the range 102 to 113 Gy, with negligible dose to the pancreas for the smallest tumor volumes. The calculated dose distributions are highly non-uniform. For the largest tumor studied, the pancreas received approximately 6% of the tumor dose (5.7 Gy). Importantly, we found that because the smallest tumor studied exhibited the most dynamic changes in volume in response to the treatment, the dose to tumor and pancreas is significantly underestimated if a static tumor volume is assumed. CONCLUSIONS: These results demonstrate the dosimetry of P microparticle localized internal radionuclide therapy for pancreatic cancer and the possibility of developing personalized treatment strategies. The results also highlight the importance of considering the effects of non-uniform dose distributions and dynamic change of tumor mass during treatment on the dosimetry of the tumor and critical organs.
[Mh] Termos MeSH primário: Método de Monte Carlo
Neoplasias Pancreáticas/radioterapia
Radioisótopos de Fósforo/uso terapêutico
Medicina de Precisão/métodos
Dosagem Radioterapêutica
[Mh] Termos MeSH secundário: Partículas beta/uso terapêutico
Seres Humanos
Pâncreas/diagnóstico por imagem
Pâncreas/efeitos da radiação
Neoplasias Pancreáticas/diagnóstico por imagem
Neoplasias Pancreáticas/patologia
Esferoides Celulares
Carga Tumoral/efeitos da radiação
Células Tumorais Cultivadas
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphorus Radioisotopes)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE


  3 / 1347 MEDLINE  
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[PMID]:28864619
[Au] Autor:Müller C; van der Meulen NP; Benesová M; Schibli R
[Ad] Endereço:Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institut, Villigen-PSA, Switzerland.
[Ti] Título:Therapeutic Radiometals Beyond Lu and Y: Production and Application of Promising α-Particle, ß -Particle, and Auger Electron Emitters.
[So] Source:J Nucl Med;58(Suppl 2):91S-96S, 2017 Sep.
[Is] ISSN:1535-5667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In recent years, new α-particle-, ß -particle-, and Auger electron-emitting radiometals-such as Cu, Sc, Ho, Tb, Tb, Pb/ Bi, Ac, and Bi-have been produced and evaluated (pre)clinically for therapeutic purposes. In this short review article, the most important routes of production of these radiometals are critically discussed, as are examples of their application in preclinical and clinical studies.
[Mh] Termos MeSH primário: Partículas alfa/uso terapêutico
Partículas beta/uso terapêutico
Elétrons
Metais/química
Radioquímica/métodos
Radioisótopos/química
Radioisótopos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Metals); 0 (Radioisotopes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE
[do] DOI:10.2967/jnumed.116.186825


  4 / 1347 MEDLINE  
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[PMID]:28797482
[Au] Autor:Bertolaso P; Leroy L; Gross-Goupil M; Aupee O; Ravaud A; Roubaud G; Cazeau AL; Le Moulec S
[Ad] Endereço:CHU Saint-André, 1, rue Jean-Burguet, 33075 Bordeaux cedex, France.
[Ti] Título:[Principles, modalities and indications of the administration of Radium in cancers, focus on metastatic prostate cancer: State of arts].
[Ti] Título:Principes, modalités et indication de l'administration du Radium dans les cancers, focus sur le cancer de la prostate métastatique : état des lieux..
[So] Source:Bull Cancer;104(9):762-770, 2017 Sep.
[Is] ISSN:1769-6917
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Prostate cancer is the first cancer in men and has a specific tropism to bones. This tropism provided the rationale to develop bone targeting radiopharmaceutical agents, such as strontium, samarium and more recently the Radium-223, an alpha-emitter. In a phase III trial, ALSYMPCA, Radium-223 not only improved pain relief, but also impacted on overall survival. Despite an approval by both FDA and EMA, prescription of this agent remains limited by the lack of refund, especially in France. Radium-223 is currently evaluated in several clinical trials (combination with chemotherapy, radiotherapy or hormone therapy) in order to optimize the therapeutic sequences in metastatic bone prostate cancer and argues for being incorporated into the current therapeutic arsenal.
[Mh] Termos MeSH primário: Neoplasias Ósseas/radioterapia
Neoplasias Ósseas/secundário
Dor do Câncer/radioterapia
Neoplasias da Próstata
Compostos Radiofarmacêuticos/uso terapêutico
Rádio (Elemento)/uso terapêutico
[Mh] Termos MeSH secundário: Partículas alfa/uso terapêutico
Partículas beta/uso terapêutico
Neoplasias Ósseas/mortalidade
Dor do Câncer/etiologia
Ensaios Clínicos como Assunto
Raios gama/uso terapêutico
Seres Humanos
Masculino
Proteção Radiológica
Compostos Radiofarmacêuticos/efeitos adversos
Rádio (Elemento)/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Radiopharmaceuticals); W90AYD6R3Q (Radium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE


  5 / 1347 MEDLINE  
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[PMID]:28728127
[Au] Autor:Rozhko TV; Guseynov OA; Guseynova VE; Bondar AA; Devyatlovskaya AN; Kudryasheva NS
[Ad] Endereço:Krasnoyarsk State Medical Academy, 1 P.Zheleznyaka, Krasnoyarsk, 660022, Russia.
[Ti] Título:Is bacterial luminescence response to low-dose radiation associated with mutagenicity?
[So] Source:J Environ Radioact;177:261-265, 2017 Oct.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Luminous marine bacteria are widely used in bioassays with luminescence intensity being a physiological parameter tested. The purpose of the study was to determine whether bacterial genetic alteration is responsible for bioluminescence kinetics change under low-dose radiation exposure. The alpha-emitting radionuclide Am and beta-emitting radionuclide H were used as the sources of low-dose ionizing radiation. Changes of bioluminescence kinetics of Photobacterium phosphoreum in solutions of Am(NO ) , 7 kBq/L, and tritiated water, 100 MBq/L, were studied; bioluminescence kinetics stages (absence of effect, activation, and inhibition) were determined. Bacterial suspension was sampled at different stages of the bioluminescent kinetics; the doses accumulated by the samples were close or a little higher than a tentative limit of a low-dose interval: 0.10 and 0.85 Gy for Am, or 0.11 and 0.18 Gy for H. Sequence analysis of the 16S ribosomal RNA gene did not reveal a mutagenic effect of low-dose alpha and beta radiation in the bacterial samples. Previous results on bacterial DNA exposed to low-dose gamma radiation (0.25 Gy) were analyzed and compared to those for alpha and beta irradiation. It is concluded that bioluminescence activation and/or inhibition under the applied conditions of low-dose alpha, beta and gamma radioactive exposure is not associated with DNA mutations in the gene sequences tested.
[Mh] Termos MeSH primário: Relação Dose-Resposta à Radiação
Testes de Mutagenicidade
Photobacterium/efeitos da radiação
Dose de Radiação
[Mh] Termos MeSH secundário: Partículas beta
Luminescência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE


  6 / 1347 MEDLINE  
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[PMID]:28521153
[Au] Autor:Park HM; Park KH; Kang SW; Joo KS
[Ad] Endereço:Department of Physics, University of Myongji, Yongin-Si, Gyeonggi-Do, Republic of Korea.
[Ti] Título:Feasibility of in situ beta ray measurements in underwater environment.
[So] Source:J Environ Radioact;175-176:120-125, 2017 Sep.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We describe an attempt at the development of an in situ detector for beta ray measurements in underwater environment. The prototype of the in situ detector is based on a CaF2: Eu scintillator using crystal light guide and Si photomultiplier. Tests were conducted using various reference sources for evaluating the linearity and stability of the detector in underwater environment. The system is simple and stable for long-term monitoring, and consumes low power. We show here an effective detection distance of 7 mm and a 2.273 MeV end-point energy spectrum of Sr/ Y when using the system underwater. The results demonstrate the feasibility of in situ beta ray measurements in underwater environment and can be applied for designing an in situ detector for radioactivity measurement in underwater environment. The in situ detector can also have other applications such as installation on the marine monitoring platform and quantitative analysis of radionuclides.
[Mh] Termos MeSH primário: Monitoramento de Radiação/métodos
Poluentes Radioativos da Água/análise
[Mh] Termos MeSH secundário: Partículas beta
Meio Ambiente
Radioisótopos
Silício
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radioisotopes); 0 (Water Pollutants, Radioactive); Z4152N8IUI (Silicon)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE


  7 / 1347 MEDLINE  
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[PMID]:28480860
[Au] Autor:Kairkhanova Y; Chaizhunusоva N; Urazalin M; Stepanenko V; Hоshi M
[Ad] Endereço:Semey State Medical University, Republic of Kazakhstan; A. Tsyb Medical Radiological Research Center - National Medical Research Radiological Center, Ministry of Health of Russian Federation, Obninsk, Russia; Hiroshima University, Hiroshima, Japan.
[Ti] Título:[RESEARCH OF INTESTINAL MICROFLORA IN THE RATS FOLLOWING THE INTERNAL AND EXTERNAL IRRADIATION].
[So] Source:Georgian Med News;(264):103-109, 2017 Mar.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:rus
[Ab] Resumo:The aim of the research was comparative investigation of the quantitative and qualitative composition of large intestinal microflora following internal (by dispersed powdered 56Mn) and internal exposure of Wistar rats. Ten weeks-old male Wistar rats were used. Rats were divided into four groups: L-56Mn group with 12 rats, H-56Mn with ten rats, 60Co group with nine rats and control group with nine rats. L-56Mn and H-56Mn groups were exposed to two different doses of 56MnO2 powder. 60Co group received 2 Gy of external 60Co γ-ray whole body irradiation. Totally 40 rats. Three rats from each group were sacrificed throw 6 hours and on days 3, 14, and 60 after the exposure. Animals were examined throw 6 hours and on days 3, 14 and 60 after exposure. Although the absorbed doses in large intestine were only 0.69 and 1.90 Gy in 56Mn exposed groups, respectively, changes in large intestinal microflora were evident. After 6 hours and on day 3 after 56Mn exposure amount of main representatives of large intestinal microflora (Bifidobacterium and lactobacilli) was decreased in the dose dependent manner. On the other hand, the amount of conditionally pathogenic bacteria was increased. These changes were persistent even on day 14. External 60Co γ-irradiation at a dose of 2 Gy also changed the intestinal microflora, but these changes were not persistent and on day 14 after irradiation returned to the control level. Our data suggest that internal exposure to dispersed powdered 56Mn has a significant biological impact on the intestinal microflora for a prolonged period of time, when it is compared with the effects of external radiation.
[Mh] Termos MeSH primário: Intestino Grosso/efeitos da radiação
[Mh] Termos MeSH secundário: Animais
Bactérias/isolamento & purificação
Partículas beta
Candida/isolamento & purificação
Radioisótopos de Cobalto
Relação Dose-Resposta à Radiação
Raios gama
Intestino Grosso/microbiologia
Masculino
Manganês
Radioisótopos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cobalt Radioisotopes); 0 (Radioisotopes); 42Z2K6ZL8P (Manganese)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE


  8 / 1347 MEDLINE  
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[PMID]:28415482
[Au] Autor:Pellegata AF; Bottagisio M; Boschetti F; Ferroni M; Bortolin M; Drago L; Lovati AB
[Ad] Endereço:Department of Chemistry, Materials and Chemical Engineering Giulio Natta, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
[Ti] Título:Terminal sterilization of equine-derived decellularized tendons for clinical use.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:43-49, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the last few years, the demand for tissue substitutes has increased and decellularized matrices has been widely proposed in the medical field to restore severe damages thanks to high biocompatibility and biomechanical properties similar to the native tissues. However, biological grafts represent a potential source of contamination and disease transmission; thus, there is the need to achieve acceptable levels of sterility. Several sterilization methods have been investigated with no consensus on the outcomes in terms of minimizing structural damages and preserving functional features of the decellularized matrix for transplantation in humans. With the aim of making decellularized tendons safe for clinical use, we evaluated the cytocompatibility, and biochemical, structural and biomechanical variations of decellularized equine tendons sterilized with peracetic acid or ß-irradiation and differently wet- or dry- stored at 4°C or -80°C, respectively. Considering that both sterilization and long-term storage are crucial steps that could not be avoided, our results pointed at ionizing ß-rays as terminal sterilization method for decellularized grafts followed by frozen dry storage. Indeed, this approach can maintain the integrity of collagen-based structures and can avoid biomechanical changes, thus making xenogeneic decellularized tendons a promising candidate for clinical use.
[Mh] Termos MeSH primário: Ácido Peracético/química
Esterilização/métodos
Tendões/química
[Mh] Termos MeSH secundário: Animais
Partículas beta
Cavalos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
I6KPI2E1HD (Peracetic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


  9 / 1347 MEDLINE  
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[PMID]:28234702
[Au] Autor:Smith DL
[Ad] Endereço:*141 Belvedere Road, Beacon, NY 12508.
[Ti] Título:Further Developments in Beta-Gamma to Alpha Ratios.
[So] Source:Health Phys;112(4):409-413, 2017 Apr.
[Is] ISSN:1538-5159
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An emphasis on alpha-emitting nuclides at nuclear power plants has produced methods for assessing the relative hazard of alpha versus other species. From the relative hazards, or ratios, decisions on the level of effort for worker protection and monitoring are made. The Electric Power Research Institute (EPRI) has issued technical guidance on relative alpha hazard and action level beta-gamma to alpha ratios. This paper shows the development of the ratio concept from first principles and brings hard-to-detect species into consideration. Outcomes from the exercise of computational forms of the ratios are compared to the EPRI results and the differences are noted. Some discussion of the implications and advantages of the developed forms then follows.
[Mh] Termos MeSH primário: Partículas alfa
Partículas beta
Guias como Assunto
Exposição Ocupacional/análise
Exposição à Radiação/análise
Monitoramento de Radiação/normas
[Mh] Termos MeSH secundário: Algoritmos
Simulação por Computador
Modelos Estatísticos
Proteção Radiológica/normas
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Estados Unidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1097/HP.0000000000000652


  10 / 1347 MEDLINE  
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[PMID]:28232604
[Au] Autor:Heskamp S; Hernandez R; Molkenboer-Kuenen JDM; Essler M; Bruchertseifer F; Morgenstern A; Steenbergen EJ; Cai W; Seidl C; McBride WJ; Goldenberg DM; Boerman OC
[Ad] Endereço:Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands sandra.heskamp@radboudumc.nl.
[Ti] Título:α- Versus ß-Emitting Radionuclides for Pretargeted Radioimmunotherapy of Carcinoembryonic Antigen-Expressing Human Colon Cancer Xenografts.
[So] Source:J Nucl Med;58(6):926-933, 2017 Jun.
[Is] ISSN:1535-5667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pretargeted radioimmunotherapy (PRIT) with the ß-emitting radionuclide Lu is an attractive approach to treat carcinoembryonic antigen (CEA)-expressing tumors. The therapeutic efficacy of PRIT might be improved using α-emitting radionuclides such as Bi. Herein, we report and compare the tumor-targeting properties and therapeutic efficacy of Bi and Lu for PRIT of CEA-expressing xenografts, using the bispecific monoclonal antibody TF2 (anti-CEA × anti-histamine-succinyl-glycine [HSG]) and the di-HSG-DOTA peptide IMP288. The in vitro binding characteristics of Bi-IMP288 were compared with those of Lu-IMP288. Tumor targeting of Bi-IMP288 and Lu-IMP288 was studied in mice bearing subcutaneous LS174T tumors that were pretargeted with TF2. Finally, the effect of Bi-IMP288 (6, 12, or 17 MBq) and Lu-IMP288 (60 MBq) on tumor growth and survival was assessed. Toxicity was determined by monitoring body weight, analyzing blood samples for hematologic and renal toxicity (hemoglobin, leukocytes, platelets, creatinine), and immunohistochemical analysis of the kidneys. The in vitro binding characteristics of Bi-IMP288 (dissociation constant, 0.45 ± 0.20 nM) to TF2-pretargeted LS174T cells were similar to those of Lu-IMP288 (dissociation constant, 0.53 ± 0.12 nM). In vivo accumulation of Bi-IMP288 in LS174T tumors was observed as early as 15 min after injection (9.2 ± 2.0 percentage injected dose [%ID]/g). Bi-IMP288 cleared rapidly from the circulation; at 30 min after injection, the blood levels were 0.44 ± 0.28 %ID/g. Uptake in normal tissues was low, except for the kidneys, where uptake was 1.8 ± 1.1 %ID/g at 30 min after injection. The biodistribution of Bi-IMP288 was comparable to that of Lu-IMP288. Mice treated with a single dose of Bi-IMP288 or Lu-IMP288 showed significant inhibition of tumor growth. Median survival for the groups treated with phosphate-buffered saline, 6 MBq Bi-IMP288, 12 MBq Bi-IMP288, and 60 MBq Lu-IMP288 was 22, 31, 45, and 42 d, respectively. Mice receiving 17 MBq Bi-IMP288 showed significant weight loss, resulting in a median survival of only 24 d. No changes in hemoglobin, platelets, or leukocytes were observed in the treatment groups. However, immunohistochemical analysis of the kidneys of mice treated with 17 or 12 MBq Bi-IMP288 showed signs of tubular damage, indicating nephrotoxicity. To our knowledge, this study shows for the first time that PRIT with TF2 and Bi-IMP288 is feasible and at least as effective as Lu-IMP288. However, at higher doses, kidney toxicity was observed. Future studies are warranted to determine the optimal dosing schedule to improve therapeutic efficacy while reducing renal toxicity.
[Mh] Termos MeSH primário: Antígeno Carcinoembrionário/imunologia
Neoplasias do Colo/imunologia
Neoplasias do Colo/radioterapia
Terapia de Alvo Molecular/métodos
Radioimunoterapia/métodos
Radioisótopos/uso terapêutico
[Mh] Termos MeSH secundário: Partículas alfa/uso terapêutico
Animais
Partículas beta/uso terapêutico
Linhagem Celular Tumoral
Neoplasias do Colo/patologia
Feminino
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinoembryonic Antigen); 0 (Radioisotopes)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.2967/jnumed.116.187021



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