Base de dados : MEDLINE
Pesquisa : G01.750.770.776.891.500 [Categoria DeCS]
Referências encontradas : 1447 [refinar]
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[PMID]:29360450
[Au] Autor:Song Z; Ye Y; Zhang Z; Shen J; Hu Z; Wang Z; Zheng J
[Ad] Endereço:Department of Orthopaedics, Suining Central Hospital, Sichuan, People's Republic of China.
[Ti] Título:Noninvasive, targeted gene therapy for acute spinal cord injury using LIFU-mediated BDNF-loaded cationic nanobubble destruction.
[So] Source:Biochem Biophys Res Commun;496(3):911-920, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Various gene delivery systems have been widely studied for the acute spinal cord injury (SCI) treatment. In the present study, a novel type of brain-derived neurotrophic factor (BDNF)-loaded cationic nanobubbles (CNBs) conjugated with MAP-2 antibody (mAb /BDNF/CNBs) was prepared to provide low-intensity focused ultrasound (LIFU)-targeted gene therapy. In vitro experiments, the ultrasound-targeted tranfection to BDNF overexpressioin in neurons and efficiently inhibition neuronal apoptosis have been demonstrated, and the elaborately designed mAb /BDNF/CNBs can specifically target to the neurons. Furthermore, in a acute SCI rat model, LIFU-mediated mAb /BDNF/CNBs transfection significantly increased BDNF expression, attenuated histological injury, decreased neurons loss, inhibited neuronal apoptosis in injured spinal cords, and increased BBB scores in SCI rats. LIFU-mediated mAb /BDNF/CNBs destruction significantly increase transfection efficiency of BDNF gene both in vitro and in vivo, and has a significant neuroprotective effect on the injured spinal cord. Therefore, the combination of LIFU irradiation and gene therapy through mAb /BDNF/CNBs can be considered as a novel non-invasive and targeted treatment for gene therapy of SCI.
[Mh] Termos MeSH primário: Fator Neurotrófico Derivado do Encéfalo/administração & dosagem
Preparações de Ação Retardada/administração & dosagem
Terapia Genética/métodos
Nanocápsulas/efeitos da radiação
Sonicação/métodos
Traumatismos da Medula Espinal/genética
Traumatismos da Medula Espinal/terapia
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Fator Neurotrófico Derivado do Encéfalo/genética
Cátions
Fluorcarbonetos/efeitos da radiação
Marcação de Genes/métodos
Ondas de Choque de Alta Energia
Masculino
Terapia de Alvo Molecular/métodos
Nanocápsulas/química
Nanosferas/química
Nanosferas/efeitos da radiação
Ratos
Ratos Sprague-Dawley
Traumatismos da Medula Espinal/patologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (Cations); 0 (Delayed-Action Preparations); 0 (Fluorocarbons); 0 (Nanocapsules); 0 (brain-derived neurotrophic factor, human); CK0N3WH0SR (perflutren)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE


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[PMID]:28778552
[Au] Autor:Nowacka M; Fijalkowska A; Wiktor A; Dadan M; Tylewicz U; Dalla Rosa M; Witrowa-Rajchert D
[Ad] Endereço:Department of Food Engineering and Process Management, Faculty of Food Sciences, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland. Electronic address: malgorzata_nowacka@sggw.pl.
[Ti] Título:Influence of power ultrasound on the main quality properties and cell viability of osmotic dehydrated cranberries.
[So] Source:Ultrasonics;83:33-41, 2018 Feb.
[Is] ISSN:1874-9968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to investigate the effect of ultrasound treatment in two osmotic solutions, carried out at different time, on some physical properties, antioxidant activity and cell survival of cranberries. Ultrasound treatment was conducted at 21kHz for 30 and 60min in liquid medium: 61.5% sucrose solution and 30% sucrose solution with 0.1% steviol glycosides addition. Some samples before the ultrasound treatment were subjected to cutting or blanching. The results showed that dry matter content and concentration of the dissolved substances increased during ultrasound treatment in osmotic solution, however higher value was observed for treatment in 61.5% sucrose solution and for longer time. Water activity and volume of cranberries did not change after the ultrasonic treatment. Combined treatment led to colour and antioxidant activity alterations as well. A cell viability of whole and cut samples decreased after 60min of osmotic treatment and completely lost in the blanched samples.
[Mh] Termos MeSH primário: Sobrevivência Celular/efeitos da radiação
Dessecação/métodos
Conservação de Alimentos/métodos
Qualidade dos Alimentos
Ondas de Choque de Alta Energia
Osmose/efeitos da radiação
Vaccinium macrocarpon/efeitos da radiação
[Mh] Termos MeSH secundário: Sobrevivência Celular/fisiologia
Diterpenos Caurânicos/química
Relação Dose-Resposta à Radiação
Análise de Alimentos
Glucosídeos/química
Dose de Radiação
Sacarose/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes, Kaurane); 0 (Glucosides); 0YON5MXJ9P (stevioside); 57-50-1 (Sucrose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE


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[PMID]:28404320
[Au] Autor:Inguglia ES; Zhang Z; Burgess C; Kerry JP; Tiwari BK
[Ad] Endereço:Department of Food Chemistry & Technology, Teagasc Food Research Centre, Ashtown, Dublin 15, Ireland; Food Packaging Group, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.
[Ti] Título:Influence of extrinsic operational parameters on salt diffusion during ultrasound assisted meat curing.
[So] Source:Ultrasonics;83:164-170, 2018 Feb.
[Is] ISSN:1874-9968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study investigated the effect of geometric parameters of the ultrasound instrument during meat salting in order to enhance salt diffusion and salt distribution in pork meat on a lab scale. The effects of probe size (∅2.5 and 1.3cm) and of different distances between the transducer and the meat sample (0.3, 0.5, and 0.8cm) on NaCl diffusion were investigated. Changes in the moisture content and NaCl gain were used to evaluate salt distribution and diffusion in the samples, parallel and perpendicular to ultrasound propagation direction. Results showed that 0.3cm was the most efficient distance between the probe and the sample to ensure a higher salt diffusion rate. A distance of 0.5cm was however considered as a trade-off distance to ensure salt diffusion and maintenance of meat quality parameters. The enhancement of salt diffusion by ultrasound was observed to decrease with increased horizontal distance from the probe. This study is of valuable importance for meat processing industries willing to apply new technologies on a larger scale and with defined operational standards. The data suggest that the geometric parameters of ultrasound systems can have strong influence on the efficiency of ultrasonic enhancement of NaCl uptake in meat and can be a crucial element in determining salt uptake during meat processing.
[Mh] Termos MeSH primário: Conservação de Alimentos/métodos
Ondas de Choque de Alta Energia
Carne/efeitos da radiação
Cloreto de Sódio/química
Cloreto de Sódio/efeitos da radiação
Água/química
[Mh] Termos MeSH secundário: Dessecação/métodos
Difusão/efeitos da radiação
Relação Dose-Resposta à Radiação
Análise de Alimentos
Dose de Radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


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[PMID]:28242037
[Au] Autor:Rezek Jambrak A; Simunek M; Evacic S; Markov K; Smoljanic G; Frece J
[Ad] Endereço:Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia. Electronic address: arezek@pbf.hr.
[Ti] Título:Influence of high power ultrasound on selected moulds, yeasts and Alicyclobacillus acidoterrestris in apple, cranberry and blueberry juice and nectar.
[So] Source:Ultrasonics;83:3-17, 2018 Feb.
[Is] ISSN:1874-9968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to investigate the effect of non-thermal technology, high power ultrasound (HPU) on inactivation of Aspergillus ochraceus 318, Penicillium expansum 565, Rhodotorula sp. 74, Saccharomyces cerevisiae 5 and Alicyclobacillus acidoterrestris DSM 3922 in clear juices and nectars from apple, blueberry and cranberry juice concentrate. Inoculated juice and nectars were treated by high power ultrasound (20kHz) according to procedure set by central composite design (CCD). Three operational parameters, amplitude (60, 90 and 120µm), temperature (20, 40 and 60°C), and treatment time (3, 6 or 9min) were varied in order to observe the influence of ultrasound and combination of ultrasound and slight heating (thermosonication) on growth and inactivation of selected microorganisms. Number of vegetative cells of A. acidoterrestris DSM 3922 were not significantly reduced by high power ultrasound (p>0.05), except in apple juice, where statistical significant (p<0.05) influence of quadratic interaction of amplitude on bacteria reduction were observed. In all samples of fruit juices and nectars in terms of ultrasonic treatment at 60°C and times of 3, 6 and 9min, regardless of the value of the amplitude, complete inactivation of the growth of yeasts and moulds were achieved, while at 20 and 40°C it is not observed. The value of reduction of cells of selected yeasts and moulds for ultrasound treatments at 60°C and the duration of the 3, 6 and 9min ranged from 3.556 to 5.934 log units, depending on the initial number of selected yeasts and moulds before treatment.
[Mh] Termos MeSH primário: Bactérias/efeitos da radiação
Contaminação de Alimentos/prevenção & controle
Sucos de Frutas e Vegetais/microbiologia
Sucos de Frutas e Vegetais/efeitos da radiação
Fungos/efeitos da radiação
Ondas de Choque de Alta Energia
Esterilização/métodos
[Mh] Termos MeSH secundário: Bactérias/citologia
Relação Dose-Resposta à Radiação
Manipulação de Alimentos/métodos
Microbiologia de Alimentos
Fungos/citologia
Dose de Radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE


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[PMID]:29095274
[Au] Autor:Qi T; Ye L; Wang B; Zhang B; Chen J
[Ad] Endereço:Department of Infertility and Sexual Medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
[Ti] Título:Comparison of the effects of extracorporeal shock wave therapy and a vacuum erectile device on penile erectile dysfunction: a randomized clinical trial.
[So] Source:Medicine (Baltimore);96(44):e8414, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This randomized clinical trial (October 2012-December 2013) compared extracorporeal shock wave therapy (ESWT) and a vacuum erectile device (VED) for management of erectile dysfunction (ED). METHODS: Consecutive Chinese patients (20-55 years) with ED, abnormal nocturnal penile tumescence and rigidity (NPTR), and international index of erectile function-5 items (IIEF-5) score <22 were randomized to receive ESWT or VED (twice weekly, 4 weeks). Primary outcomes were treatment efficacy and success rate 4 weeks after completion of therapy. Secondary outcomes included changes in IIEF-5 score, sex encounter profile (SEP) score, erection hardness score (EHS) and NPTR assessments 4 weeks post-therapy. All enrolled patients (n = 30 per group) completed the study. At baseline, age, IIEF-5 score, SEP score, EHS, and NPTR assessments were similar between groups. RESULTS: Four weeks post-therapy, IIEF-5 score increased in the ESWT (15.03 ±â€Š3.00 vs. 11.60 ±â€Š2.28) and VED (15.10 ±â€Š3.06 vs. 11.53 ±â€Š2.27) groups, as did SEP score, EHS, and NPTR measures (all P < .05). Efficacy in the ESWT and VED groups was excellent in 10% and 13.3%, respectively, and moderate in 63.3% and 53.3%, respectively. Treatment success rate in the ESWT and VED groups was 73.3% and 67.7%, respectively. CONCLUSION: VED use and ESWT have comparable efficacies in the treatment of ED in Chinese patients.
[Mh] Termos MeSH primário: Disfunção Erétil/terapia
Ondas de Choque de Alta Energia/uso terapêutico
Vácuo
[Mh] Termos MeSH secundário: Adulto
China
Disfunção Erétil/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Ereção Peniana
Estudos Prospectivos
Índice de Gravidade de Doença
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008414


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[PMID]:28860045
[Au] Autor:Wright AJ; Bohner AD; Bernhisel AA; Zaugg B; Barlow WR; Pettey JH; Olson RJ
[Ad] Endereço:Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
[Ti] Título:The Effect of Pulsing on Transverse Ultrasound Efficiency and Chatter.
[So] Source:Am J Ophthalmol;183:107-110, 2017 Nov.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the effects of micropulse, long pulse, and continuous ultrasound on transverse ultrasound using Abbott Medical Optics' (AMO) WhiteStar Signature Pro with the Ellips FX handpiece. DESIGN: In vitro laboratory study. METHODS: This study was conducted at the John A. Moran Eye Center Laboratory, University of Utah, Salt Lake City, Utah, USA. Porcine lenses were hardened in formalin for 2 hours and equilibrated in basic salt solution (BSS) over a 24-hour period. The lenses were then cubed in 2.0 × 2.0-mm pieces. These pieces were stored in BSS until the time of experimentation. The AMO WhiteStar Signature Pro machine (Abbott Medical Optics) with the Ellips FX handpiece and a 0.9-mm bent Dewey tip with a 30-degree bevel (Microsurgical Technology Inc) were used for phacoemulsification. Three runs of 20 lenses each were performed, measuring efficiency and chatter. Transverse ultrasound varied in the 3 runs and included continuous, 6 ms on/off micropulse, and 50 ms on/off long pulse. RESULTS: Micropulse was more efficient than long pulse by 43% (P = .00003) and continuous by 42% (P = .000387). There were also less chatter events with micropulse than with long-pulse and continuous ultrasound. However, this difference did not reach significance. CONCLUSION: The 6 ms on and 6 ms off micropulse transverse 3-dimensional ultrasound is more efficient and produces fewer chatter events than both long-pulse and continuous ultrasound.
[Mh] Termos MeSH primário: Catarata/terapia
Ondas de Choque de Alta Energia/uso terapêutico
Cristalino
Facoemulsificação/métodos
Terapia por Ultrassom/métodos
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE


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[PMID]:28618416
[Au] Autor:Du L; Shen T; Liu B; Zhang Y; Zhao C; Jia N; Wang Q; He Q
[Ad] Endereço:Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
[Ti] Título:Shock Wave Therapy Promotes Cardiomyocyte Autophagy and Survival during Hypoxia.
[So] Source:Cell Physiol Biochem;42(2):673-684, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Autophagy plays an important role in cardiovascular disease. Controversy still exists regarding the effect of autophagy on ischemic/hypoxic myocardium. Cardiac shock wave therapy (CSWT) is an effective alternative treatment for refractory ischemic heart disease. Whether CSWT can regulate cardiomyocyte autophagy under hypoxic conditions is not clear. We established a myocardial hypoxia model using the H9c2 cell line and performed shock waves (SWs) treatment to evaluate the effect of SW on autophagy. METHODS: The H9c2 cells were incubated under hypoxic conditions, and SW treatment was then performed at energies of 0.02, 0.05, or 0.10 mJ/mm2. The cell viability and intracellular ATP level were examined. Western blot analysis was used to assess the expression of LC3B, AMPK, mTOR, Beclin-1, Sirt1, and HIF-1α. Autophagic vacuoles were visualized by monodansylcadaverine staining. RESULTS: After the 24-hour hypoxic period, cardiomyocyte viability and ATP levels were decreased and autophagy was significantly increased in H9c2 cells. SW treatment with an energy of 0.05 mJ/mm2 significantly increased the cellular viability, ATP level, LC3B-II/I, and number of autophagic vacuoles. In addition, phosphorylated AMPK and Sirt1 were increased and phosphorylated mTOR and HIF-1α were decreased after SW treatment. CONCLUSION: SW treatment can potentially promote cardiomyocyte autophagy during hypoxia and protect cardiomyocyte function by regulating the AMPK/mTOR pathway.
[Mh] Termos MeSH primário: Autofagia/efeitos da radiação
Ondas de Choque de Alta Energia/uso terapêutico
Isquemia Miocárdica/terapia
Miócitos Cardíacos/efeitos da radiação
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos da radiação
Hipóxia Celular/genética
Linhagem Celular
Sobrevivência Celular/efeitos da radiação
Modelos Animais de Doenças
Seres Humanos
Isquemia Miocárdica/fisiopatologia
Miócitos Cardíacos/patologia
Fagossomos/metabolismo
Fagossomos/efeitos da radiação
Fosforilação
Ratos
Transdução de Sinais/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1159/000477885


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[PMID]:28606756
[Au] Autor:Mammadova N; Ghaisas S; Zenitsky G; Sakaguchi DS; Kanthasamy AG; Greenlee JJ; West Greenlee MH
[Ad] Endereço:Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa; Immunobiology Graduate Program, Iowa State University, Ames, Iowa; Neuroscience Graduate Program, Iowa State University, Ames, Iowa.
[Ti] Título:Lasting Retinal Injury in a Mouse Model of Blast-Induced Trauma.
[So] Source:Am J Pathol;187(7):1459-1472, 2017 Jul.
[Is] ISSN:1525-2191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Traumatic brain injury due to blast exposure is currently the most prevalent of war injuries. Although secondary ocular blast injuries due to flying debris are more common, primary ocular blast exposure resulting from blast wave pressure has been reported among survivors of explosions, but with limited understanding of the resulting retinal pathologies. Using a compressed air-driven shock tube system, adult male and female C57BL/6 mice were exposed to blast wave pressure of 300 kPa (43.5 psi) per day for 3 successive days, and euthanized 30 days after injury. We assessed retinal tissues using immunofluorescence for glial fibrillary acidic protein, microglia-specific proteins Iba1 and CD68, and phosphorylated tau (AT-270 pThr181 and AT-180 pThr231). Primary blast wave pressure resulted in activation of Müller glia, loss of photoreceptor cells, and an increase in phosphorylated tau in retinal neurons and glia. We found that 300-kPa blasts yielded no detectable cognitive or motor deficits, and no neurochemical or biochemical evidence of injury in the striatum or prefrontal cortex, respectively. These changes were detected 30 days after blast exposure, suggesting the possibility of long-lasting retinal injury and neuronal inflammation after primary blast exposure.
[Mh] Termos MeSH primário: Traumatismos por Explosões/fisiopatologia
Proteínas de Ligação ao Cálcio/metabolismo
Ondas de Choque de Alta Energia/efeitos adversos
Proteínas dos Microfilamentos/metabolismo
Doenças Retinianas/fisiopatologia
Ferimentos e Lesões/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Antígenos CD/metabolismo
Antígenos de Diferenciação Mielomonocítica/metabolismo
Traumatismos por Explosões/metabolismo
Modelos Animais de Doenças
Feminino
Proteína Glial Fibrilar Ácida/metabolismo
Seres Humanos
Inflamação
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Microglia/metabolismo
Microglia/patologia
Células Fotorreceptoras/metabolismo
Células Fotorreceptoras/patologia
Retina/lesões
Doenças Retinianas/metabolismo
Fatores de Tempo
Ferimentos e Lesões/metabolismo
Proteínas tau/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aif1 protein, mouse); 0 (Antigens, CD); 0 (Antigens, Differentiation, Myelomonocytic); 0 (CD68 protein, mouse); 0 (Calcium-Binding Proteins); 0 (Glial Fibrillary Acidic Protein); 0 (Mapt protein, mouse); 0 (Microfilament Proteins); 0 (tau Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE


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[PMID]:28403111
[Au] Autor:Sun J; Gao F; Wang Y; Sun W; Jiang B; Li Z
[Ad] Endereço:aThe Graduate School of Peking Union Medical College bCentre for Osteonecrosis and Joint-Preserving & Reconstruction, Department of Orthopedic Surgery, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China cDepartment of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
[Ti] Título:Extracorporeal shock wave therapy is effective in treating chronic plantar fasciitis: A meta-analysis of RCTs.
[So] Source:Medicine (Baltimore);96(15):e6621, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plantar fasciitis (PF) is the most common reason for heel pain. The efficacy of extracorporeal shock wave therapy (ESWT) as an ideal alternative to conservative treatments and surgery is controversial, and almost all previous articles compared general ESWT with placebo without indicating the kind of shock wave. We undertook a meta-analysis to compare the efficacy of general ESWT, focused shock wave (FSW), and radial shock wave (RSW) with placebo, to assess their effectiveness in chronic PF. METHODS: The PubMed, Medline, EmBase, Web of Science, and Cochrane library databases were searched for studies comparing FSW or RSW therapy with placebo in chronic PF. Clinical outcomes included the odds ratios (ORs) of pain relief, pain reduction, and complications. Relevant data were analyzed using RevMan v5.3. RESULTS: Nine studies involving 935 patients were included. ESWT had higher improvement rates than the placebo group (OR 2.58, 95% confidence interval [CI] 1.97-3.39, P < .00001). ESWT had markedly lower standardized mean difference than placebo, with heterogeneity observed (standardized mean difference 1.01, 95% CI -0.01 to 2.03, P = .05, I = 96%, P < .00001). FSW and RSW therapies had greater therapeutic success in pain relief than the placebo group (OR 2.17, 95% CI 1.49-3.16, P < .0001; OR 4.63, 95% CI 1.30-16.46, P = .02), but significant heterogeneity was observed in RSW therapy versus placebo (I = 81%, P = .005). CONCLUSION: This meta-analysis suggested that FSW therapy can relieve pain in chronic PF as an ideal alternative option; meanwhile, no firm conclusions of general ESWT and RSW effectiveness can be drawn. Due to variations in the included studies, additional trials are needed to validate these conclusions.
[Mh] Termos MeSH primário: Fasciíte Plantar/terapia
Ondas de Choque de Alta Energia/uso terapêutico
Manejo da Dor/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Fasciíte Plantar/complicações
Feminino
Calcanhar/patologia
Seres Humanos
Masculino
Meia-Idade
Dor/etiologia
Dor/patologia
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170430
[Lr] Data última revisão:
170430
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006621


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[PMID]:28400182
[Au] Autor:Wu YC; Tsai WC; Tu YK; Yu TY
[Ad] Endereço:Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
[Ti] Título:Comparative Effectiveness of Nonoperative Treatments for Chronic Calcific Tendinitis of the Shoulder: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
[So] Source:Arch Phys Med Rehabil;98(8):1678-1692.e6, 2017 Aug.
[Is] ISSN:1532-821X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the effectiveness of various nonoperative treatments for chronic calcific tendinitis of the shoulder, a systematic review and network meta-analysis of randomized trials was performed to evaluate changes in pain reduction, functional improvements in patients with calcific tendinitis, and the ratio of complete resolution of calcific deposition. DATA SOURCES: Studies were comprehensively searched, without language restrictions, on PubMed, Embase, Cochrane Controlled Trials Register, the Cochrane, and other databases. The reference lists of articles and reviews were cross-checked for possible studies. STUDY SELECTION: Randomized controlled trials from before August 2016 were included. Study selection was conducted by 2 reviewers independently. DATA EXTRACTION: The quality of studies was assessed and data extracted by 2 independent reviewers. Disagreements were settled by consulting a third reviewer to reach a consensus. DATA SYNTHESIS: Fourteen studies with 1105 participants were included in the network meta-analysis that used a random-effect model to investigate the mean difference of pooled effect sizes of the visual analog scale, Constant-Murley score, and the ratio of complete resolution of calcific deposition on native radiographs. CONCLUSIONS: The present network meta-analysis demonstrates that ultrasound-guided needling (UGN), radial extracorporeal shockwave therapy (RSW), and high-energy focused extracorporeal shockwave therapy (H-FSW) alleviate pain and achieve complete resolution of calcium deposition. Compared with low-energy focused extracorporeal shockwave therapy, transcutaneous electrical nerve stimulation, and ultrasound therapy, H-FSW is the best therapy for providing functional recovery. Physicians should consider UGN, RSW, and H-FSW as alternative effective therapies for chronic calcific tendinitis of the shoulder when initial conservative treatment fails.
[Mh] Termos MeSH primário: Calcinose/reabilitação
Modalidades de Fisioterapia
Dor de Ombro/reabilitação
Tendinopatia/reabilitação
[Mh] Termos MeSH secundário: Ondas de Choque de Alta Energia/uso terapêutico
Seres Humanos
Agulhas
Metanálise em Rede
Ensaios Clínicos Controlados Aleatórios como Assunto
Estimulação Elétrica Nervosa Transcutânea/métodos
Terapia por Ultrassom/métodos
Ultrassonografia de Intervenção
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE



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