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  1 / 19755 MEDLINE  
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[PMID]:27770624
[Au] Autor:Rocchi F; Dylla ME; Bohlen PA; Ramachandran R
[Ad] Endereço:Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
[Ti] Título:Spatial and temporal disparity in signals and maskers affects signal detection in non-human primates.
[So] Source:Hear Res;344:1-12, 2017 Feb.
[Is] ISSN:1878-5891
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Detection thresholds for auditory stimuli (signals) increase in the presence of maskers. Natural environments contain maskers/distractors that can have a wide range of spatiotemporal properties relative to the signal. While these parameters have been well explored psychophysically in humans, they have not been well explored in animal models, and their neuronal underpinnings are not well understood. As a precursor to the neuronal measurements, we report the effects of systematically varying the spatial and temporal relationship between signals and noise in macaque monkeys (Macaca mulatta and Macaca radiata). Macaques detected tones masked by noise in a Go/No-Go task in which the spatiotemporal relationships between the tone and noise were systematically varied. Masked thresholds were higher when the masker was continuous or gated on and off simultaneously with the signal, and lower when the continuous masker was turned off during the signal. A burst of noise caused higher masked thresholds if it completely temporally overlapped with the signal, whereas partial overlap resulted in lower thresholds. Noise durations needed to be at least 100 ms before significant masking could be observed. Thresholds for short duration tones were significantly higher when the onsets of signal and masker coincided compared to when the signal was presented during the steady state portion of the noise (overshoot). When signal and masker were separated in space, masked signal detection thresholds decreased relative to when the masker and signal were co-located (spatial release from masking). Masking release was larger for azimuthal separations than for elevation separations. These results in macaques are similar to those observed in humans, suggesting that the specific spatiotemporal relationship between signal and masker determine threshold in natural environments for macaques in a manner similar to humans. These results form the basis for future investigations of neuronal correlates and mechanisms of masking.
[Mh] Termos MeSH primário: Comportamento Animal
Sinais (Psicologia)
Ruído/efeitos adversos
Mascaramento Perceptivo
Nível de Percepção Sonora
Detecção de Sinal Psicológico
Localização de Som
[Mh] Termos MeSH secundário: Estimulação Acústica
Animais
Audiometria
Vias Auditivas/fisiologia
Limiar Auditivo
Macaca mulatta
Macaca radiata
Masculino
Modelos Animais
Periodicidade
Psicoacústica
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


  2 / 19755 MEDLINE  
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[PMID]:28462486
[Au] Autor:Diatroptov MЕ; Diatroptova MA
[Ad] Endereço:Research Institute of Human Morphology, Moscow, Russia.
[Ti] Título:Infradian Biorhythm of Thyroid Hormone Concentrations in Mammals and Birds.
[So] Source:Bull Exp Biol Med;162(6):815-819, 2017 Apr.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies of the dynamics of thyroid hormone concentrations in the blood revealed a 3-day rhythm that significantly manifested in male Wistar rats and Chinchilla rabbits during intensive growth and in common starlings (Sturnus vulgaris) during moult. Synphasic 3-day biorhythms of thyroid hormonal activities were found in these animals, which attested to an external synchronizer of this biorhythm common for mammals and birds. The maximum level of thyroid hormones coincided with the extrema of daily fluctuations of the Earth rotation velocity, as a result of which this external factor or another factor closely related to it seemed to be involved in synchronization of the 3-day infradian biorhythm of thyroid hormones in mammals and birds.
[Mh] Termos MeSH primário: Corticosterona/sangue
Passeriformes/fisiologia
Periodicidade
Glândula Tireoide/fisiologia
Tiroxina/sangue
Tri-Iodotironina/sangue
[Mh] Termos MeSH secundário: Animais
Geografia
Masculino
Muda/fisiologia
Coelhos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
06LU7C9H1V (Triiodothyronine); Q51BO43MG4 (Thyroxine); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-017-3720-3


  3 / 19755 MEDLINE  
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[PMID]:29371650
[Au] Autor:Sheikhbahaei S; Turovsky EA; Hosford PS; Hadjihambi A; Theparambil SM; Liu B; Marina N; Teschemacher AG; Kasparov S; Smith JC; Gourine AV
[Ad] Endereço:Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK.
[Ti] Título:Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity.
[So] Source:Nat Commun;9(1):370, 2018 01 25.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Astrocytes are implicated in modulation of neuronal excitability and synaptic function, but it remains unknown if these glial cells can directly control activities of motor circuits to influence complex behaviors in vivo. This study focused on the vital respiratory rhythm-generating circuits of the preBötzinger complex (preBötC) and determined how compromised function of local astrocytes affects breathing in conscious experimental animals (rats). Vesicular release mechanisms in astrocytes were disrupted by virally driven expression of either the dominant-negative SNARE protein or light chain of tetanus toxin. We show that blockade of vesicular release in preBötC astrocytes reduces the resting breathing rate and frequency of periodic sighs, decreases rhythm variability, impairs respiratory responses to hypoxia and hypercapnia, and dramatically reduces the exercise capacity. These findings indicate that astrocytes modulate the activity of CNS circuits generating the respiratory rhythm, critically contribute to adaptive respiratory responses in conditions of increased metabolic demand and determine the exercise capacity.
[Mh] Termos MeSH primário: Astrócitos/fisiologia
Tronco Encefálico/fisiologia
Periodicidade
Condicionamento Físico Animal/fisiologia
Respiração
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Adenoviridae/genética
Adenoviridae/metabolismo
Animais
Animais Recém-Nascidos
Astrócitos/citologia
Tronco Encefálico/citologia
Cálcio/metabolismo
Feminino
Regulação da Expressão Gênica
Vetores Genéticos/química
Vetores Genéticos/metabolismo
Hipercapnia/metabolismo
Hipercapnia/fisiopatologia
Hipóxia/metabolismo
Hipóxia/fisiopatologia
Masculino
Bulbo/citologia
Bulbo/fisiologia
Cultura Primária de Células
Ratos
Ratos Sprague-Dawley
Proteínas SNARE/antagonistas & inibidores
Proteínas SNARE/genética
Proteínas SNARE/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (SNARE Proteins); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02723-6


  4 / 19755 MEDLINE  
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[PMID]:29324793
[Au] Autor:Poljak S; Ferreiro AM; Chiappero MB; Sánchez J; Gabrielli M; Lizarralde MS
[Ad] Endereço:Laboratorio de Ecología Molecular, Centro Austral de Investigaciones Científicas, Consejo Nacional de Investigaciones Científicas y Tecnológicas, Ushuaia, Tierra del Fuego, Argentina.
[Ti] Título:Phylogeography of screaming hairy armadillo Chaetophractus vellerosus: Successive disjunctions and extinctions due to cyclical climatic changes in southern South America.
[So] Source:PLoS One;13(1):e0190944, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Little is known about phylogeography of armadillo species native to southern South America. In this study we describe the phylogeography of the screaming hairy armadillo Chaetophractus vellerosus, discuss previous hypothesis about the origin of its disjunct distribution and propose an alternative one, based on novel information on genetic variability. Variation of partial sequences of mitochondrial DNA Control Region (CR) from 73 individuals from 23 localities were analyzed to carry out a phylogeographic analysis using neutrality tests, mismatch distribution, median-joining (MJ) network and paleontological records. We found 17 polymorphic sites resulting in 15 haplotypes. Two new geographic records that expand known distribution of the species are presented; one of them links the distributions of recently synonimized species C. nationi and C. vellerosus. Screaming hairy armadillo phylogeographic pattern can be addressed as category V of Avise: common widespread linages plus closely related lineages confined to one or a few nearby locales each. The older linages are distributed in the north-central area of the species distribution range in Argentina (i.e. ancestral area of distribution). C. vellerosus seems to be a low vagility species that expanded, and probably is expanding, its distribution range while presents signs of genetic structuring in central areas. To explain the disjunct distribution, a hypothesis of extinction of the species in intermediate areas due to quaternary climatic shift to more humid conditions was proposed. We offer an alternative explanation: long distance colonization, based on null genetic variability, paleontological record and evidence of alternance of cold/arid and temperate/humid climatic periods during the last million years in southern South America.
[Mh] Termos MeSH primário: Tatus/genética
Clima
[Mh] Termos MeSH secundário: Animais
DNA Mitocondrial
Extinção Biológica
Haplótipos
Umidade
Periodicidade
Filogeografia
América do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190944


  5 / 19755 MEDLINE  
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[PMID]:28467676
[Au] Autor:Crowder CM; Meyer E; Fan TY; Weis VM
[Ad] Endereço:Department of Integrative Biology, Oregon State University, Corvallis, OR, USA.
[Ti] Título:Impacts of temperature and lunar day on gene expression profiles during a monthly reproductive cycle in the brooding coral Pocillopora damicornis.
[So] Source:Mol Ecol;26(15):3913-3925, 2017 Aug.
[Is] ISSN:1365-294X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Reproductive timing in brooding corals has been correlated to temperature and lunar irradiance, but the mechanisms by which corals transduce these environmental variables into molecular signals are unknown. To gain insight into these processes, global gene expression profiles in the coral Pocillopora damicornis were examined (via RNA-Seq) across lunar phases and between temperature treatments, during a monthly planulation cycle. The interaction of temperature and lunar day together had the largest influence on gene expression. Mean timing of planulation, which occurred at lunar days 7.4 and 12.5 for 28- and 23°C-treated corals, respectively, was associated with an upregulation of transcripts in individual temperature treatments. Expression profiles of planulation-associated genes were compared between temperature treatments, revealing that elevated temperatures disrupted expression profiles associated with planulation. Gene functions inferred from homologous matches to online databases suggest complex neuropeptide signalling, with calcium as a central mediator, acting through tyrosine kinase and G protein-coupled receptor pathways. This work contributes to our understanding of coral reproductive physiology and the impacts of environmental variables on coral reproductive pathways.
[Mh] Termos MeSH primário: Antozoários/genética
Periodicidade
Temperatura Ambiente
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Antozoários/fisiologia
Lua
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/mec.14162


  6 / 19755 MEDLINE  
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[PMID]:29283229
[Au] Autor:Sukmansky OI; Reutov VP
[Ti] Título:Gasotransmitters: Physiological Role and Involvement in the Pathogenesis of the Diseases.
[So] Source:Usp Fiziol Nauk;47(3):30-58, 2016 Jul-Sep.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In recent decades, it has been found the existence of a new class of biologically active substances - gaseous mediators (gasotransmitters), performing in the cells the signaling function and with high specificity involved in the intercellular and intracellular communication. This review characterizes the main gasotransmitters: nitric oxide, carbon monoxide, hydrogen sulfide, sulfur dioxide and polysulfides. Their physiological role and involvement in the pathogenesis of diseases is described. Basic information about main gasotransmitters is generalized in the original table. Nitrate-Nitrite background, which is a chemical background of the existence of modern man, affects the intra- and intercellular signaling system, alters the ultrastructure of neurons, neuron-neuron and neuron-glia interaction, eliminates the effects of endogenous gasotransmitters and affects the average life expectancy. In accordance with the principle of cyclicity is proposed and substantiated the hypothesis of the existence of "hydrogen sulfide cycle", combining three sulfur-containing gasotransmitters. It is suggested that the cyclic organization of gasotransmitters in the cells and the whole body can be due to the existence of a global principle of cyclicity, which can spread its influence on almost all the structural and functional levels in the animate and inanimate nature.
[Mh] Termos MeSH primário: Monóxido de Carbono/metabolismo
Gasotransmissores/fisiologia
Sulfeto de Hidrogênio/metabolismo
Expectativa de Vida/tendências
Óxido Nítrico/fisiologia
Sulfetos/metabolismo
Dióxido de Enxofre/metabolismo
[Mh] Termos MeSH secundário: Doenças Cardiovasculares/metabolismo
Doenças Cardiovasculares/patologia
Comunicação Celular
Seres Humanos
Neoplasias/metabolismo
Neoplasias/patologia
Neuroglia/citologia
Neuroglia/fisiologia
Neurônios/citologia
Neurônios/fisiologia
Periodicidade
Transdução de Sinais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Gasotransmitters); 0 (Sulfides); 0UZA3422Q4 (Sulfur Dioxide); 31C4KY9ESH (Nitric Oxide); 7U1EE4V452 (Carbon Monoxide); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


  7 / 19755 MEDLINE  
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[PMID]:28972130
[Au] Autor:Ronconi L; Melcher D
[Ad] Endereço:Center for Mind/Brain Sciences, University of Trento, 38068 Rovereto, Italy luca.ronconi@unitn.it.
[Ti] Título:The Role of Oscillatory Phase in Determining the Temporal Organization of Perception: Evidence from Sensory Entrainment.
[So] Source:J Neurosci;37(44):10636-10644, 2017 Nov 01.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent behavioral, neuroimaging, and neurophysiological studies have renewed the idea that the information processing within different temporal windows is linked to the phase and/or frequency of the ongoing oscillations, predominantly in the theta/alpha band (∼4-7 and 8-12 Hz, respectively). However, being correlational in nature, this evidence might reflect a nonfunctional byproduct rather than having a causal role. A more direct link can be shown with methods that manipulate oscillatory activity. Here, we used audiovisual entrainment at different frequencies in the prestimulus period of a temporal integration/segregation task. We hypothesized that entrainment would align ongoing oscillations and drive them toward the stimulation frequency. To reveal behavioral oscillations in temporal perception after the entrainment, we sampled the segregation/integration performance densely in time. In Experiment 1, two groups of human participants (both males and females) received stimulation either at the lower or the upper boundary of the alpha band (∼8.5 vs 11.5 Hz). For both entrainment frequencies, we found a phase alignment of the perceptual oscillation across subjects, but with two different power spectra that peaked near the entrainment frequency. These results were confirmed when perceptual oscillations were characterized in the time domain with sinusoidal fittings. In Experiment 2, we replicated the findings in a within-subject design, extending the results for frequencies in the theta (∼6.5 Hz), but not in the beta (∼15 Hz), range. Overall, these findings show that temporal segregation can be modified by sensory entrainment, providing evidence for a critical role of ongoing oscillations in the temporal organization of perception. The continuous flow of sensory input is not processed in an analog fashion, but rather is grouped by the perceptual system over time. Recent studies pinpointed the phase and/or frequency of the neural oscillations in the theta/alpha band (∼4-12 Hz) as possible mechanisms underlying temporal windows in perception. Here, we combined two innovative methodologies to provide more direct support for this evidence. We used sensory entrainment to align neural oscillations to different frequencies and then characterized the resultant perceptual oscillation with a temporal dense sampling of the integration/segregation performance. Our results provide the first evidence that the frequency of temporal segregation can be modified by sensory entrainment, supporting a critical role of ongoing oscillations in the integration/segregation of information over time.
[Mh] Termos MeSH primário: Estimulação Acústica/métodos
Ritmo alfa/fisiologia
Percepção Auditiva/fisiologia
Estimulação Luminosa/métodos
Percepção do Tempo/fisiologia
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Adulto
Eletroencefalografia/métodos
Feminino
Seres Humanos
Masculino
Periodicidade
Distribuição Aleatória
Córtex Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.1704-17.2017


  8 / 19755 MEDLINE  
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[PMID]:28842417
[Au] Autor:Guzulaitis R; Hounsgaard J
[Ad] Endereço:Department of Neuroscience, University of Copenhagen, Panum Institute, Copenhagen, DK 2200, Denmark r.guzulaitis@gmail.com.
[Ti] Título:Synaptic Excitation in Spinal Motoneurons Alternates with Synaptic Inhibition and Is Balanced by Outward Rectification during Rhythmic Motor Network Activity.
[So] Source:J Neurosci;37(38):9239-9248, 2017 Sep 20.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Regular firing in spinal motoneurons of red-eared turtles ( , either sex) evoked by steady depolarization at rest is replaced by irregular firing during functional network activity. The transition caused by increased input conductance and synaptic fluctuations in membrane potential was suggested to originate from intense concurrent inhibition and excitation. We show that the conductance increase in motoneurons during functional network activity is mainly caused by intrinsic outward rectification near threshold for action potentials by activation of voltage and Ca gated K channels. Intrinsic outward rectification facilitates spiking by focusing synaptic depolarization near threshold for action potentials. By direct recording of synaptic currents, we also show that motoneurons are activated by out-of-phase peaks in excitation and inhibition during network activity, whereas continuous low-level concurrent inhibition and excitation may contribute to irregular firing. Neurons embedded in active neural networks can enter a high-conductance state. High-conductance states were observed in spinal motoneurons during rhythmic motor behavior. Assuming no change in intrinsic conductance, it was suggested that the high-conductance state in motoneurons originated from balanced inhibition and excitation. In this study, we demonstrate that intrinsic outward rectification significantly contributes to the high-conductance state. Outward rectification balances synaptic excitation and maintains membrane potential near spike threshold. In addition, direct synaptic current recordings show out-of-phase excitation and inhibition in motoneurons during rhythmic network activity.
[Mh] Termos MeSH primário: Potenciais de Ação/fisiologia
Geradores de Padrão Central/fisiologia
Neurônios Motores/fisiologia
Inibição Neural/fisiologia
Periodicidade
Medula Espinal/fisiologia
Transmissão Sináptica/fisiologia
[Mh] Termos MeSH secundário: Animais
Potenciais Pós-Sinápticos Excitadores/fisiologia
Potenciais da Membrana/fisiologia
Neurônios Motores/citologia
Rede Nervosa/fisiologia
Medula Espinal/citologia
Tartarugas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170827
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0800-17.2017


  9 / 19755 MEDLINE  
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[PMID]:28821650
[Au] Autor:Rotstein HG; Schneider E; Szczupak L
[Ad] Endereço:Department of Mathematical Sciences, New Jersey Institute of Technology, University Heights, Newark, New Jersey 07102.
[Ti] Título:Feedback Signal from Motoneurons Influences a Rhythmic Pattern Generator.
[So] Source:J Neurosci;37(38):9149-9159, 2017 Sep 20.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Motoneurons are not mere output units of neuronal circuits that control motor behavior but participate in pattern generation. Research on the circuit that controls the crawling motor behavior in leeches indicated that motoneurons participate as modulators of this rhythmic motor pattern. Crawling results from successive bouts of elongation and contraction of the whole leech body. In the isolated segmental ganglia, dopamine can induce a rhythmic antiphasic activity of the motoneurons that control contraction (DE-3 motoneurons) and elongation (CV motoneurons). The study was performed in isolated ganglia where manipulation of the activity of specific motoneurons was performed in the course of fictive crawling ( ). In this study, the membrane potential of CV was manipulated while was monitored through the rhythmic activity of DE-3. Matching behavioral observations that show that elongation dominates the rhythmic pattern, the electrophysiological activity of CV motoneurons dominates the cycle. Brief excitation of CV motoneurons during episodes resets the rhythmic activity of DE-3, indicating that CV feeds back to the rhythmic pattern generator. CV hyperpolarization accelerated the rhythm to an extent that depended on the magnitude of the cycle period, suggesting that CV exerted a positive feedback on the unit(s) of the pattern generator that controls the elongation phase. A simple computational model was implemented to test the consequences of such feedback. The simulations indicate that the duty cycle of CV depended on the strength of the positive feedback between CV and the pattern generator circuit. Rhythmic movements of animals are controlled by neuronal networks that have been conceived as hierarchical structures. At the basis of this hierarchy, we find the motoneurons, few neurons at the top control global aspects of the behavior (e.g., onset, duration); and within these two ends, specific neuronal circuits control the actual rhythmic pattern of movements. We have investigated whether motoneurons are limited to function as output units. Analysis of the network that controls crawling behavior in the leech has clearly indicated that motoneurons, in addition to controlling muscle activity, send signals to the pattern generator. Physiological and modeling studies on the role of specific motoneurons suggest that these feedback signals modulate the phase relationship of the rhythmic activity.
[Mh] Termos MeSH primário: Geradores de Padrão Central/fisiologia
Retroalimentação Fisiológica/fisiologia
Sanguessugas/fisiologia
Locomoção/fisiologia
Neurônios Motores/fisiologia
Rede Nervosa/fisiologia
Periodicidade
[Mh] Termos MeSH secundário: Adaptação Fisiológica/fisiologia
Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0756-17.2017


  10 / 19755 MEDLINE  
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[PMID]:28791941
[Au] Autor:Zeman P
[Ad] Endereço:Medical Laboratories,Prague,Czech Republic.
[Ti] Título:Predictability of tick-borne encephalitis fluctuations.
[So] Source:Epidemiol Infect;145(13):2781-2786, 2017 10.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tick-borne encephalitis is a serious arboviral infection with unstable dynamics and profound inter-annual fluctuations in case numbers. A dependable predictive model has been sought since the discovery of the disease. The present study demonstrates that four superimposed cycles, approximately 2·4, 3, 5·4, and 10·4 years long, can account for three-fifths of the variation in the disease fluctuations over central Europe. Using harmonic regression, these cycles can be projected into the future, yielding forecasts of sufficient accuracy for up to 4 years ahead. For the years 2016-2018, this model predicts elevated incidence levels in most parts of the region.
[Mh] Termos MeSH primário: Encefalite Transmitida por Carrapatos/epidemiologia
[Mh] Termos MeSH secundário: Encefalite Transmitida por Carrapatos/virologia
Europa (Continente)/epidemiologia
Seres Humanos
Incidência
Modelos Teóricos
Periodicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817001662



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