Base de dados : MEDLINE
Pesquisa : G02.111.323 [Categoria DeCS]
Referências encontradas : 3556 [refinar]
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[PMID]:29268128
[Au] Autor:Jafari B; Ospanov M; Ejaz SA; Yelibayeva N; Khan SU; Amjad ST; Safarov S; Abilov ZA; Turmukhanova MZ; Kalugin SN; Ehlers P; Lecka J; Sévigny J; Iqbal J; Langer P
[Ad] Endereço:Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany.
[Ti] Título:2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study.
[So] Source:Eur J Med Chem;144:116-127, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Alkaline Phosphatases (APs) play a key role in maintaining a ratio of phosphate to inorganic pyrophosphate (P /PP ) and thus regulate extracellular matrix calcification during bone formation and growth. Among different isozymes of AP, aberrant increase in the level of tissue non-specific alkaline phosphatase (TNAP) is strongly associated with vascular calcification and end-stage renal diseases. In this context, we synthesized a novel series of fluorinated pyrimidone derivatives, i.e., 2-bromo-7-trifluoromethyl-5-oxo-5H-1,3,4-thiadiazolepyrimidones. The bromine functionality was further used for derivatisation by nucleophilic aromatic substitution using amines as nucleophiles as well as by Palladium catalysed Suzuki-Miyaura reactions. The synthesized derivatives were found potent but non-selective inhibitors of both isozymes of AP. Arylated thiadiazolopyrimidones exhibited stronger inhibitory activities than 2-amino-thiadiazolopyrimidones. The binding modes and possible interactions of the most active inhibitor within the active site of the enzyme were observed by molecular docking studies.
[Mh] Termos MeSH primário: Fosfatase Alcalina/antagonistas & inibidores
Inibidores Enzimáticos/química
Inibidores Enzimáticos/farmacologia
Pirimidinonas/química
Pirimidinonas/farmacologia
Tiadiazóis/química
Tiadiazóis/farmacologia
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Inibidores Enzimáticos/síntese química
Halogenação
Seres Humanos
Simulação de Acoplamento Molecular
Pirimidinonas/síntese química
Relação Estrutura-Atividade
Tiadiazóis/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Pyrimidinones); 0 (Thiadiazoles); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29264676
[Au] Autor:Faraji H; Helalizadeh M; Kordi MR
[Ad] Endereço:Department of Chemistry, Varamin-Pishva Branch, Islamic Azad University, Varamin, 338177489, Iran. hakimfaraji@yahoo.com.
[Ti] Título:Overcoming the challenges of conventional dispersive liquid-liquid microextraction: analysis of THMs in chlorinated swimming pools.
[So] Source:Anal Bioanal Chem;410(2):605-614, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A rapid, simple, and sensitive approach to the analysis of trihalomethanes (THMs) in swimming pool water samples has been developed. The main goal of this study was to overcome or to improve the shortcomings of conventional dispersive liquid-liquid microextraction (DLLME) and to maximize the realization of green analytical chemistry principles. The method involves a simple vortex-assisted microextraction step, in the absence of the dispersive solvent, followed by salting-out effect for the elimination of the centrifugation step. A bell-shaped device and a solidifiable solvent were used to simplify the extraction solvent collection after phase separation. Optimization of the independent variables was performed by using chemometric methods in three steps. The method was statistically validated based on authentic guidance documents. The completion time for extraction was less than 8 min, and the limits of detection were in the range between 4 and 72 ng L . Using this method, good linearity and precision were achieved. The results of THMs determination in different real samples showed that in some cases the concentration of total THMs was more than threshold values of THMs determined by accredited healthcare organizations. This method indicated satisfactory analytical figures of merit. Graphical Abstract A novel green microextraction technique for overcoming the challenges of conventional DLLME. The proposed procedure complies with the principles of green/sustainable analytical chemistry, comprising decreasing the sample size, making easy automation of the process, reducing organic waste, diminishing energy consumption, replacing toxic reagents with safer reagents, and enhancing operator safety.
[Mh] Termos MeSH primário: Microextração em Fase Líquida/métodos
Piscinas
Trialometanos/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Halogenação
Limite de Detecção
Solventes
Trialometanos/isolamento & purificação
Água/análise
Poluentes Químicos da Água/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Solvents); 0 (Trihalomethanes); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0762-3


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[PMID]:29175406
[Au] Autor:Sohn SY; Kuntze K; Nijenhuis I; Häggblom MM
[Ad] Endereço:Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences, Rutgers University, 76 Lipman Drive, New Brunswick, NJ 08901, USA.
[Ti] Título:Evaluation of carbon isotope fractionation during anaerobic reductive dehalogenation of chlorinated and brominated benzenes.
[So] Source:Chemosphere;193:785-792, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Compound specific stable isotope analysis (CSIA) has been established as a useful tool to evaluate in situ biodegradation. Here, CSIA was used to determine microbial dehalogenation of chloro- and bromobenzenes in microcosms derived from Hackensack River sediments. Gas chromatography-isotope ratio mass spectrometry (GC-IRMS) was used to measure carbon isotope fractionation during reductive dehalogenation of hexachlorobenzene (HCB), pentachlorobenzene (PeCB), 1,2,3,5-tetrachlorobenzene (TeCB), 1,2,3,5-tetrabromobenzene (TeBB), and 1,3,5-tribromobenzene (TriBB). Strong evidence of isotope fractionation coupled to dehalogenation was not observed in the substrate, possibly due to the low solubilities of the highly halogenated benzene substrates and a dilution of the isotope signal. Nonetheless, we could measure a depletion of the δ C value in the dichlorobenzene product during dechlorination of HCB, the sequential depletion and enrichment of δ C value for trichlorobenzene in TeCB dechlorinating cultures, and the enrichment of δ C during debromination of TriBB. This indicates that a measurable isotope fractionation occurred during reductive dehalogenation of highly halogenated chloro- and bromobenzenes in aquatic sediments. Thus, although more quantitative measurements will be needed, the data suggests that CSIA may have application for monitoring in situ microbial reductive dehalogenation of highly halogenated benzenes.
[Mh] Termos MeSH primário: Benzeno
Biodegradação Ambiental
Bromobenzenos/metabolismo
Fracionamento Químico
Clorobenzenos/metabolismo
[Mh] Termos MeSH secundário: Bromobenzenos/análise
Isótopos de Carbono/química
Clorobenzenos/análise
Monitoramento Ambiental/métodos
Cromatografia Gasosa-Espectrometria de Massas
Halogenação
Rios/química
Rios/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bromobenzenes); 0 (Carbon Isotopes); 0 (Chlorobenzenes); J64922108F (Benzene)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29406093
[Au] Autor:Ge F; Xiao Y; Yang Y; Wang W; Moe B; Li XF
[Ad] Endereço:College of Environment and Resources, Xiangtan University, Xiangtan, Hunan 411105, China. Electronic address: gefei@xtu.edu.cn.
[Ti] Título:Formation of water disinfection byproduct 2,6-dichloro-1,4-benzoquinone from chlorination of green algae.
[So] Source:J Environ Sci (China);63:1-8, 2018 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We report that green algae in lakes and rivers can serve as precursors of halobenzoquinone (HBQ) disinfection byproducts (DBPs) produced during chlorination. Chlorination of a common green alga, Chlorella vulgaris, produced 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ), the most prevalent HBQ DBP in disinfected water. Under varying pH conditions (pH6.0-9.0), 2,6-DCBQ formation ranged from 0.3 to 2.1µg/mg C with maximum formation at pH8.0. To evaluate the contribution of organic components of C. vulgaris to 2,6-DCBQ formation, we separated the organics into two fractions, the protein-rich fraction of intracellular organic matter (IOM) and the polysaccharide-laden fraction of extracellular organic matter (EOM). Chlorination of IOM and EOM produced 1.4µg/mg C and 0.7µg/mg C of 2,6-DCBQ, respectively. The IOM generated a two-fold higher 2,6-DCBQ formation potential than the EOM fraction, suggesting that proteins are potent 2,6-DCBQ precursors. This was confirmed by the chlorination of proteins extracted from C. vulgaris: the amount of 2,6-DCBQ produced is linearly correlated with the concentration of total algal protein (R =0.98). These results support that proteins are the primary precursors of 2,6-DCBQ in algae, and control of green algal bloom outbreaks in source waters is important for management of HBQ DBPs.
[Mh] Termos MeSH primário: Benzoquinonas/metabolismo
Chlorella vulgaris/fisiologia
Desinfetantes/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Benzoquinonas/análise
Clorófitas
Desinfetantes/análise
Desinfecção
Halogenação
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoquinones); 0 (Disinfectants); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:28992474
[Au] Autor:Liu J; Ye J; Chen Y; Li C; Ou H
[Ad] Endereço:School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China.
[Ti] Título:UV-driven hydroxyl radical oxidation of tris(2-chloroethyl) phosphate: Intermediate products and residual toxicity.
[So] Source:Chemosphere;190:225-233, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Organophosphorus esters (OPEs) are emerging contaminants widely applied as annexing agents in a variety of industrial products, and they are robust against conventional wastewater treatments. Ultraviolet-driven (UV) radical-based advanced oxidation processes have a potential to become cost-effective treatment technologies for the removal of OPEs in water matrix, but residual and newly generated toxicities of degradation products are a concern. This study is a comprehensive attempt to evaluate UV/H O for the degradation of a water dissolved OPE, tris(2-chloroethyl) phosphate (TCEP). In ultrapure water, a pseudo-first order reaction was observed, and the degradation rate constant reached 0.155 min for 3.5 µM TCEP using 7.0 mW cm UV irradiation with 44.0 µM H O . Hydroxyl radicals were involved in the oxidative degradation of TCEP, as demonstrated by the quenching of the degradation reaction in the presences of tertiary butanol or ethanol. High resolution mass spectroscopy data showed a partial transformation of TCEP to a series of hydroxylated and dechlorinated products e.g., C H Cl O P, C H Cl O P and C H ClO P. Based on proteomics data at molecular and metabolic network levels, the toxicity of TCEP products was reduced obviously as the reaction proceeded, which was confirmed by the up-regulated tricarboxylic acid cycle, fatty acid metabolism and amino acid metabolism in Escherichia coli cells exposed to degradation products mixture. In conclusion, incomplete hydroxylation and dechlorination of TCEP likewise are effective for its detoxification, indicating that UV/H O can be a promising treatment method for OPEs removal.
[Mh] Termos MeSH primário: Peróxido de Hidrogênio/química
Radical Hidroxila/química
Organofosfatos/química
Raios Ultravioleta
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Escherichia coli/metabolismo
Halogenação
Cinética
Organofosfatos/isolamento & purificação
Oxirredução
Águas Residuais/química
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organophosphates); 0 (Waste Water); 0 (Water Pollutants, Chemical); 3352-57-6 (Hydroxyl Radical); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE


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[PMID]:28987410
[Au] Autor:Woods A; Kuntze K; Gelman F; Halicz L; Nijenhuis I
[Ad] Endereço:Department for Isotope Biogeochemistry, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, D-04318, Leipzig, Germany.
[Ti] Título:Variable dual carbon-bromine stable isotope fractionation during enzyme-catalyzed reductive dehalogenation of brominated ethenes.
[So] Source:Chemosphere;190:211-217, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The potential of compound-specific stable isotope analysis (CSIA) to characterize biotransformation of brominated organic compounds (BOCs) was assessed and compared to chlorinated analogues. Sulfurospirillum multivorans and Desulfitobacterium hafniense PCE-S catalyzed the dehalogenation of tribromoethene (TBE) to either vinyl bromide (VB) or ethene, respectively. Significantly lower isotope fractionation was observed for TBE dehalogenation by S. multivorans (ε = -1.3 ± 0.2‰) compared to D. hafniense (ε = -7.7 ± 1.5‰). However, higher fractionation was observed for dibromoethene (DBE) dehalogenation by S. multivorans (ε = -16.8 ± 1.8‰ and -21.2 ± 1.6‰ for trans- and cis-1,2- (DBE) respectively), compared to D. hafniense PCE-S (ε = -9.5 ± 1.2‰ and -14.5 ± 0.7‰ for trans-1,2-DBE and cis-1,2-DBE, respectively). Significant, but similar, bromine fractionation was observed for for S. multivorans (ε = -0.53 ± 0.15‰, -1.03 ± 0.26‰, and -1.18 ± 0.13‰ for trans-1,2-DBE, cis-1,2-DBE and TBE, respectively) and D. hafniense PCE-S (ε = -0.97 ± 0.28‰, -1.16 ± 0.36‰, and -1.34 ± 0.32‰ for cis-1,2-DBE, TBE and trans-1,2-DBE, respectively). Variable CBr dual-element slopes were estimated at Λ (ε /ε ) = 1.03 ± 0.2, 17.9 ± 5.8, and 29.9 ± 11.0 for S. multivorans debrominating TBE, cis-1,2-DBE and trans-1,2-DBE, respectively, and at 7.14 ± 1.6, 8.27 ± 3.7, and 8.92 ± 2.4 for D. hafniense PCE-S debrominating trans-1,2-DBE, TBE and cis-1,2-DBE, respectively. A high variability in isotope fractionation, which was substrate property related, was observed for S. multivorans but not D. hafniense, similar as observed for chlorinated ethenes, and may be due to rate-limiting steps preceding the bond-cleavage or differences in the reaction mechanism. Overall, significant isotope fractionation was observed and, therefore, CSIA can be applied to monitor the fate of brominated ethenes in the environment. Isotope effects differences, however, are not systematically comparable to chlorinated ethenes.
[Mh] Termos MeSH primário: Bromo/química
Carbono/química
Desulfitobacterium/metabolismo
Dibrometo de Etileno/metabolismo
Halogenação
[Mh] Termos MeSH secundário: Biotransformação
Isótopos de Carbono/química
Catálise
Fracionamento Químico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Isotopes); 1N41638RNO (Ethylene Dibromide); 7440-44-0 (Carbon); SBV4XY874G (Bromine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


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[PMID]:28923662
[Au] Autor:Kammoonah S; Prasad B; Balaraman P; Mundhada H; Schwaneberg U; Plettner E
[Ad] Endereço:Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
[Ti] Título:Selecting of a cytochrome P450 SeSaM library with 3-chloroindole and endosulfan - Identification of mutants that dehalogenate 3-chloroindole.
[So] Source:Biochim Biophys Acta;1866(1):68-79, 2018 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cytochrome P450 (a camphor hydroxylase) from the soil bacterium Pseudomonas putida shows potential importance in environmental applications such as the degradation of chlorinated organic pollutants. Seven P450 mutants generated from Sequence Saturation Mutagenesis (SeSaM) and isolated by selection on minimal media with either 3-chloroindole or the insecticide endosulfan were studied for their ability to oxidize of 3-chloroindole to isatin. The wild-type enzyme did not accept 3-chloroindole as a substrate. Mutant (E156G/V247F/V253G/F256S) had the highest maximal velocity in the conversion of 3-chloroindole to isatin, whereas mutants (T56A/N116H/D297N) and (G60S/Y75H) had highest k /K values. Six of the mutants had more than one mutation, and within this set, mutation of residues 297 and 179 was observed twice. Docking simulations were performed on models of the mutant enzymes; the wild-type did not accommodate 3-chloroindole in the active site, whereas all the mutants did. We propose two potential reaction pathways for dechlorination of 3-chloroindole. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Cânfora 5-Mono-Oxigenase/química
Endossulfano/metabolismo
Biblioteca Gênica
Indóis/metabolismo
Pseudomonas putida/enzimologia
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Substituição de Aminoácidos
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Sítios de Ligação
Biodegradação Ambiental
Cânfora 5-Mono-Oxigenase/genética
Cânfora 5-Mono-Oxigenase/metabolismo
Clonagem Molecular
Endossulfano/química
Escherichia coli/genética
Escherichia coli/metabolismo
Expressão Gênica
Halogenação
Indóis/química
Isatina/química
Isatina/metabolismo
Cinética
Simulação de Acoplamento Molecular
Mutação
Oxirredução
Ligação Proteica
Domínios e Motivos de Interação entre Proteínas
Estrutura Secundária de Proteína
Pseudomonas putida/química
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Indoles); 0 (Recombinant Proteins); 82X95S7M06 (Isatin); EC 1.14.15.1 (Camphor 5-Monooxygenase); OKA6A6ZD4K (Endosulfan)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


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[PMID]:29025657
[Au] Autor:Johari N; Madaah Hosseini HR; Samadikuchaksaraei A
[Ad] Endereço:Department of Materials Science and Engineering, Sharif University of Technology, Tehran 1458889694, Iran.
[Ti] Título:Novel fluoridated silk fibroin/ TiO nanocomposite scaffolds for bone tissue engineering.
[So] Source:Mater Sci Eng C Mater Biol Appl;82:265-276, 2018 Jan 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:It is known that Fluoride ions strongly affect bone mineralization and formation. In the present study, the engineered bone tissue scaffolds are fabricated using silk fibroin (SF) and flouridated TiO nanoparticles. TiO nanoparticles are modified by fluoride ions, and different levels (0, 5, 10, 15 and 20wt%) of the fluoridated TiO nanoparticles (TiO -F) were subsequently added to the SF matrix through phase separation method to prepare silk fibroin/flouridated TiO nanocomposite scaffolds (SF/TiO -F). Phase structure, functional groups, morphology and mechanical properties of the obtained scaffolds were evaluated by X-ray diffraction method (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and compressive testing, respectively. In vitro degradation studies of scaffolds were performed by incubating the samples in phosphate buffered saline (PBS) at 37°C and pH7.4 for 30days. Additionally, the bioactivity of scaffolds was estimated in a simulated body fluid (SBF) buffered at 37°C and pH7.4 for 28days. Moreover, MTT assay was used to confirm the biocompatibility of the scaffolds using human like SaOS-2 osteoblast cell line for 1, 3 and 5days. The obtained results indicated that the mechanical properties of scaffolds have been improved by increasing the TiO -F amount up to 15wt%. However, a detrimental effect was observed by a further increase in the TiO -F content. The bioactivity of SF/TiO -F nanocomposite scaffolds was promoted by flouridation of TiO . Furthermore, cell cytotoxicity results demonstrated that the SF/TiO -F nanocomposite scaffolds are nontoxic to osteoblasts. The cell fixation results after 3days of incubation revealed that the cell attachment and spreading on SF/TiO -F nanocomposite scaffolds are improved with respect to SF/TiO nanocomposite scaffolds control sample.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/química
Fibroínas/química
Nanocompostos/química
Titânio/química
[Mh] Termos MeSH secundário: Materiais Biocompatíveis/toxicidade
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Força Compressiva
Halogenação
Seres Humanos
Microscopia Eletrônica de Varredura
Porosidade
Seda/química
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Silk); 15FIX9V2JP (titanium dioxide); 9007-76-5 (Fibroins); D1JT611TNE (Titanium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE


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[PMID]:29107876
[Au] Autor:Shu WB; Zhao YB; Ni HG; Zeng H
[Ad] Endereço:Shenzhen Key Laboratory of Circular Economy, Shenzhen Graduate School, Peking University, Shenzhen 518055, China.
[Ti] Título:Size-dependent emission characteristics of airborne parent and halogenated PAHs from municipal solid waste incinerators in Shenzhen, China.
[So] Source:Chemosphere;192:250-257, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two waste incinerators were selected for investigation of size-dependent emission characteristics of airborne parent and halogenated PAHs (PAHs and HPAHs) and incidence of these pollutants from trash incineration. The concentrations of total PAHs (gas and particles with aerodynamic diameter 0.43-10 µm) in ambient air of Shenzhen incinerators were at the lower end of the global range while those of HPAHs were higher than those of urban air in other studies. High-ring PAHs dominated in PM (66%-86%), while low-ring PAHs dominated in PM (83%-86%). As for PAHs in gaseous phase, low-ring PAHs were collectively account for 86%-97%. ΣHPAH mainly enriched in coarse particles (>83%). The size distributions of ΣPAH and ΣHPAH were both characterized by bimodal peaks dominate in 9.0-10 µm and subordinate in 4.7-5.8 µm. PAHs and HPAHs enrichment in the coarse particles indicates that particle-bound PAHs and HPAHs from incinerators cannot travel great distances. Model simulation results showed the peak of airborne PAHs and HPAHs occurred in approximate 300 m from incinerator, then their concentrations reduced sharply. The extent of affected areas by municipal solid waste incinerators (MSWIs) seem very large, intensity of impacts can be neglected for the very low level of pollutants. Although waste incineration is perceived as most polluting way to manage waste, our study found the damage from incinerator to be far less than originally feared.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Gases/análise
Hidrocarbonetos Halogenados/análise
Hidrocarbonetos Aromáticos Policíclicos/análise
Resíduos Sólidos/análise
Gerenciamento de Resíduos/métodos
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/química
China
Gases/química
Halogenação
Seres Humanos
Hidrocarbonetos Halogenados/química
Incineração
Hidrocarbonetos Aromáticos Policíclicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Gases); 0 (Hydrocarbons, Halogenated); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Solid Waste)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE


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[PMID]:28993023
[Au] Autor:Ohura T; Horii Y; Yamashita N
[Ad] Endereço:Faculty of Agriculture, Meijo University, 1-501 Shiogamaguchi, Nagoya 468-8502, Japan. Electronic address: ohura@meijo-u.ac.jp.
[Ti] Título:Spatial distribution and exposure risks of ambient chlorinated polycyclic aromatic hydrocarbons in Tokyo Bay area and network approach to source impacts.
[So] Source:Environ Pollut;232:367-374, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chlorinated polycyclic aromatic hydrocarbons (ClPAHs) receive increasing attention as hazardous pollutants in terms of the high environmental persistence and toxicities. Ambient concentrations of 24 ClPAHs and 24 PAHs were investigated at 14 sites in the Tokyo Bay area of Japan. Twelve of 18 ClPAH species were detected in air samples, in spite of small sampling volumes. Mean concentrations of total PAHs in gas and particle phases were 5400 and 1400 pg/m , and mean concentrations of total ClPAHs in gas and particle phases were 40 and 14 pg/m , respectively. The spatial distributions of both total ClPAH and PAH concentrations indicated heavy pollution at sites in industrial activity areas. Principal component analysis suggested that the dominant sources of gaseous and particulate ClPAHs differed substantially from each other. In particular, gaseous ClPAHs could be produced by specific sources different from those of particulate ClPAHs. However, the dominant sources of particulate ClPAHs could be the same as those of particulate PAHs, including industrial activities such as steel and gas-production plants and natural gas-fired power plants. The influences of spatial relationships among sampling sites were represented using a network analysis. The constructed network showed that ambient ClPAHs and PAHs were dominated by local rather than regional pollution, because there were weaker relationships among nearby sites. Finally, exposure risks for ClPAHs were dominated by 7-chlorobenz[a]anthracene, followed by 9-chlorophenanthrene and 6-chlorobenzo[a]pyrene, and total risk was ∼1/200 that of PAHs.
[Mh] Termos MeSH primário: Exposição Ambiental/estatística & dados numéricos
Poluentes Ambientais/análise
Poluição Ambiental/estatística & dados numéricos
Hidrocarbonetos Aromáticos Policíclicos/análise
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/análise
Monitoramento Ambiental/métodos
Poluição Ambiental/análise
Halogenação
Indústrias
Japão
Tóquio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Environmental Pollutants); 0 (Polycyclic Aromatic Hydrocarbons)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE



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