Base de dados : MEDLINE
Pesquisa : G02.111.570.080.708.330 [Categoria DeCS]
Referências encontradas : 1069 [refinar]
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[PMID]:27774436
[Au] Autor:Huang J; Ma J; Shang K; Hu X; Liang Y; Li D; Wu Z; Dai L; Chen L; Wang L
[Ad] Endereço:Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University Nanjing, China.
[Ti] Título:Evolution and Diversity of the Antimicrobial Resistance Associated Mobilome in : A Probable Mobile Genetic Elements Reservoir for Other Streptococci.
[So] Source:Front Cell Infect Microbiol;6:118, 2016.
[Is] ISSN:2235-2988
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:is a previously neglected, newly emerging multidrug-resistant zoonotic pathogen. Mobile genetic elements (MGEs) play a key role in intra- and interspecies horizontal transfer of antimicrobial resistance (AMR) determinants. Although, previous studies showed the presence of several MGEs, a comprehensive analysis of AMR-associated mobilome as well as their interaction and evolution has not been performed. In this study, we presented the AMR-associated mobilome and their insertion hotspots in . Integrative conjugative elements (ICEs), prophages and tandem MGEs were located at different insertion sites, while 86% of the AMR-associated MGEs were inserted at and loci. Comprehensive analysis of insertions at and loci among four pathogenic species ( , and ) revealed the existence of different groups of MGEs, including Tn5252, ICE 1108, and TnGBS2 groups ICEs, Φm46.1 group prophage, ICE_ICE and ICE_prophage tandem MGEs. Comparative ICE genomics of ICE 2603 family revealed that module exchange and acquisition/deletion were the main mechanisms in MGEs' expansion and evolution. Furthermore, the observation of tandem MGEs reflected a novel mechanism for MGE diversity. Moreover, an competition assay showed no visible fitness cost was observed between different MGE-carrying isolates and a conjugation assay revealed the transferability of ICE 2603 family of ICEs. Our statistics further indicated that the prevalence and diversity of MGEs in is much greater than in other three species which prompted our hypothesis that is probably a MGEs reservoir for other streptococci. In conclusion, our results showed that acquisition of MGEs confers not only its capability as a multidrug resistance pathogen, but also represents a paradigm to study the modular evolution and matryoshkas of MGEs.
[Mh] Termos MeSH primário: Farmacorresistência Bacteriana
Sequências Repetitivas Dispersas
Streptococcus/efeitos dos fármacos
Streptococcus/genética
[Mh] Termos MeSH secundário: Conjugação Genética
Transferência Genética Horizontal
Loci Gênicos
Recombinação Genética
Análise de Sequência de DNA
Streptococcus/crescimento & desenvolvimento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171224
[Lr] Data última revisão:
171224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  2 / 1069 MEDLINE  
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[PMID]:28813691
[Au] Autor:Guo A; Gu J; Wang X; Zhang R; Yin Y; Sun W; Tuo X; Zhang L
[Ad] Endereço:College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, China.
[Ti] Título:Effects of superabsorbent polymers on the abundances of antibiotic resistance genes, mobile genetic elements, and the bacterial community during swine manure composting.
[So] Source:Bioresour Technol;244(Pt 1):658-663, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Superabsorbent polymers (SAPs) are considered suitable amendments for reducing the selection pressure due to heavy metals and the abundances of antibiotic resistance genes (ARGs) during composting. In this study, three SAP (sodium polyacrylate) levels (0, 5, and 15mgkg of compost) were applied and their effects on the abundances of ARGs, mobile genetic elements (MGEs), and the bacterial community were investigated. After composting, the abundances of ARGs and MGEs decreased to different extent, where the removal efficiencies for tetW, dfrA7, ermX, aac(6')-ib-cr and MGEs exceeded 90%. The high SAP concentration significantly reduced the abundances of ARGs and MGEs, and changed the microbial community. Redundancy analysis indicated that the moisture content mainly explained the changes in ARGs and MGEs. Network analysis determined the potential hosts of ARGs and MGEs, and their co-occurrence. The results suggested that applying 15mgkg SAP is appropriate for reducing ARGs in compost.
[Mh] Termos MeSH primário: Antibacterianos
Resistência Microbiana a Medicamentos
Esterco
[Mh] Termos MeSH secundário: Animais
Bactérias/genética
Genes Bacterianos
Sequências Repetitivas Dispersas
Polímeros
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Manure); 0 (Polymers)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE


  3 / 1069 MEDLINE  
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[PMID]:28697875
[Au] Autor:Yang C; Wan MT; Lauderdale TL; Yeh KS; Chen C; Hsiao YH; Chou CC
[Ad] Endereço:Department of Veterinary Medicine, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei, 10617, Taiwan.
[Ti] Título:Molecular characteristics of clinical methicillin-resistant Staphylococcus pseudintermedius harboring arginine catabolic mobile element (ACME) from dogs and cats.
[So] Source:Vet J;224:46-49, 2017 Jun.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to investigate the presence of arginine catabolic mobile element (ACME) and its associated molecular characteristics in methicillin-resistant Staphylococcus pseudintermedius (MRSP). Among the 72 S. pseudintermedius recovered from various infection sites of dogs and cats, 52 (72.2%) were MRSP. ACME-arcA was detected commonly (69.2%) in these MRSP isolates, and was more frequently detected in those from the skin than from other body sites (P=0.047). There was a wide genetic diversity among the ACME-arcA-positive MRSP isolates, which comprised three SCCmec types (II-III, III and V) and 15 dru types with two predominant clusters (9a and 11a). Most MRSP isolates were multidrug-resistant. Since S. pseudintermedius could serve as a reservoir of ACME, further research on this putative virulence factor is recommended.
[Mh] Termos MeSH primário: Doenças do Gato/microbiologia
Doenças do Cão/microbiologia
Sequências Repetitivas Dispersas/genética
Resistência a Meticilina
Infecções Estafilocócicas/veterinária
Staphylococcus/genética
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Gatos
Cães
Variação Genética
Hidrolases/genética
Testes de Sensibilidade Microbiana
Pele/microbiologia
Staphylococcus/química
Staphylococcus/efeitos dos fármacos
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Virulence Factors); EC 3.- (Hydrolases); EC 3.5.3.6 (arginine deiminase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


  4 / 1069 MEDLINE  
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[PMID]:28630130
[Au] Autor:Mao D; Grogan DW
[Ad] Endereço:Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
[Ti] Título:How a Genetically Stable Extremophile Evolves: Modes of Genome Diversification in the Archaeon Sulfolobus acidocaldarius.
[So] Source:J Bacteriol;199(17), 2017 Sep 01.
[Is] ISSN:1098-5530
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In order to analyze in molecular terms how genomes diverge, damage-induced mutations and natural polymorphisms (PMs) were identified in laboratory constructs and wild-type isolates, respectively, of Among wild-type isolates drawn from one local population, pairwise nucleotide divergence averaged 4 × 10 , which is about 0.15% of the corresponding divergence reported for The most variable features of wild-type genomes were homopolymer (mononucleotide) tracts and longer tandem repeats, consistent with the spontaneous mutations that occur under laboratory conditions. Natural isolates, however, also revealed large insertions/deletions and inversions, which did not occur in any of the laboratory-manipulated strains. Several of the large insertions/deletions could be attributed to the integration or excision of mobile genetic elements (MGEs), and each MGE represented a distinct system of site-specific recombination. The mode of recombination associated with one MGE, a provirus related to , was also seen in certain chromosomal inversions. Artificially induced mutations, non-MGE insertions/deletions, and small PMs exhibited different distributions over the genome, suggesting that large-scale patterning of genomes begins early in the divergence process. Unlike induced mutations, natural base pair substitutions occurred in clusters, and one cluster exhibited properties expected of nonreciprocal recombination (gene conversion) between dispersed imperfect repeats. Taken together, the results identify simple replication errors, slipped-strand events promoted by tandem repeats, homologous recombination, and rearrangements promoted by MGEs as the primary sources of genetic variation for this extremely acidophilic archaeon in its geothermal environment. The optimal growth temperatures of hyperthermophilic archaea accelerate DNA decomposition, which is expected to make DNA repair especially important for their genetic stability, yet these archaea lack certain broadly conserved types of DNA repair proteins. In this study, the genome of the extreme thermoacidophile was found to be remarkably stable, accumulating few mutations in many (though not all) laboratory manipulations and in natural populations. Furthermore, all the genetic processes that were inferred to diversify these genomes also operate in mesophilic bacteria and eukaryotes. This suggests that a common set of mechanisms produces most of the genetic variation in all microorganisms, despite the fundamental differences in physiology, DNA repair systems, and genome structure represented in the three domains of life.
[Mh] Termos MeSH primário: Evolução Molecular
Extremófilos/genética
Genoma Arqueal
Polimorfismo Genético
Sulfolobus acidocaldarius/genética
[Mh] Termos MeSH secundário: Replicação do DNA
Sequências Repetitivas Dispersas
Mutação
Recombinação Genética
Sulfolobus acidocaldarius/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170827
[Lr] Data última revisão:
170827
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE


  5 / 1069 MEDLINE  
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[PMID]:28628615
[Au] Autor:Cossu M; Badel C; Catchpole R; Gadelle D; Marguet E; Barbe V; Forterre P; Oberto J
[Ad] Endereço:Institute for Integrative Biology of the Cell (I2BC), Microbiology Department, CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
[Ti] Título:Flipping chromosomes in deep-sea archaea.
[So] Source:PLoS Genet;13(6):e1006847, 2017 Jun.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:One of the major mechanisms driving the evolution of all organisms is genomic rearrangement. In hyperthermophilic Archaea of the order Thermococcales, large chromosomal inversions occur so frequently that even closely related genomes are difficult to align. Clearly not resulting from the native homologous recombination machinery, the causative agent of these inversions has remained elusive. We present a model in which genomic inversions are catalyzed by the integrase enzyme encoded by a family of mobile genetic elements. We characterized the integrase from Thermococcus nautili plasmid pTN3 and showed that besides canonical site-specific reactions, it catalyzes low sequence specificity recombination reactions with the same outcome as homologous recombination events on DNA segments as short as 104bp both in vitro and in vivo, in contrast to other known tyrosine recombinases. Through serial culturing, we showed that the integrase-mediated divergence of T. nautili strains occurs at an astonishing rate, with at least four large-scale genomic inversions appearing within 60 generations. Our results and the ubiquitous distribution of pTN3-like integrated elements suggest that a major mechanism of evolution of an entire order of Archaea results from the activity of a selfish mobile genetic element.
[Mh] Termos MeSH primário: Inversão Cromossômica/genética
Evolução Molecular
Integrases/genética
Thermococcales/genética
[Mh] Termos MeSH secundário: Genoma Arqueal
Sequências Repetitivas Dispersas/genética
Plasmídeos/genética
Recombinação Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.7.- (Integrases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006847


  6 / 1069 MEDLINE  
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[PMID]:28591311
[Au] Autor:Rozo ZLC; Márquez-Ortiz RA; Castro BE; Gómez NV; Escobar-Pérez J
[Ad] Endereço:Universidad El Bosque, Bacterial Molecular Genetics Laboratory, Bogotá, Colombia.
[Ti] Título:Participation of the arcRACME protein in self-activation of the arc operon located in the arginine catabolism mobile element in pandemic clone USA300.
[So] Source:Mem Inst Oswaldo Cruz;112(7):499-503, 2017 Jul.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Staphylococcus aureus pandemic clone USA300 has, in addition to its constitutive arginine catabolism (arc) gene cluster, an arginine catabolism mobile element (ACME) carrying another such cluster, which gives this clone advantages in colonisation and infection. Gene arcR, which encodes an oxygen-sensitive transcriptional regulator, is inside ACME and downstream of the constitutive arc gene cluster, and this situation may have an impact on its activation. Different relative expression behaviours are proven here for arcRACME and the arcACME operon compared to the constitutive ones. We also show that the artificially expressed recombinant ArcRACME protein binds to the promoter region of the arcACME operon; this mechanism can be related to a positive feedback model, which may be responsible for increased anaerobic survival of the USA300 clone during infection-related processes.
[Mh] Termos MeSH primário: Arginina/genética
Proteínas de Bactérias/genética
Proteínas de Ligação a DNA/genética
Óperon/genética
Staphylococcus aureus/genética
[Mh] Termos MeSH secundário: Arginina/metabolismo
Regulação Bacteriana da Expressão Gênica/genética
Genes Bacterianos/genética
Seres Humanos
Sequências Repetitivas Dispersas/genética
Staphylococcus aureus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ArcR protein, bacteria); 0 (Bacterial Proteins); 0 (DNA-Binding Proteins); 94ZLA3W45F (Arginine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  7 / 1069 MEDLINE  
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[PMID]:28475713
[Au] Autor:Stedtfeld RD; Stedtfeld TM; Fader KA; Williams MR; Bhaduri P; Quensen J; Zacharewski TR; Tiedje JM; Hashsham SA
[Ad] Endereço:Department of Civil and Environmental Engineering, East Lansing, MI 48824, USA.
[Ti] Título:TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome.
[So] Source:FEMS Microbiol Ecol;93(5), 2017 May 01.
[Is] ISSN:1574-6941
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dysbiosis of the gut microbiome via antibiotics, changes in diet and infection can select for bacterial groups that more frequently harbor antimicrobial resistance genes (ARGs) and mobile genetic elements (MGEs). However, the impact of environmental toxicants on the reservoir of ARGs in the gut microbiome has received less attention. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent aryl hydrocarbon receptor (AhR) agonist with multiple toxic health effects including immune dysfunction. The selective pressure of TCDD on the abundance of ARG and MGE-harboring gut populations was examined using C57BL/6 mice exposed to 0-30 µg/kg TCDD for 28 and 92 days with the latter having a 30-day recovery period. DNA extracted from temporally collected fecal pellets was characterized using a qPCR array with 384 assays targeting ARGs and MGEs. Fourteen genes, typically observed in Enterobacteriaceae, increased significantly within 8 days of initial dosing, persisted throughout the treatment period, and remained induced 30 days post dosing. A qPCR primer set targeting Enterobacteriaceae also showed 10- to 100-fold higher abundance in TCDD-treated groups, which was further verified using metagenomics. Results show a bloom of ARG-harboring bacterial groups in the gut due to a xenobiotic compound that is not a metal, biocide or antimicrobial.
[Mh] Termos MeSH primário: Farmacorresistência Bacteriana/genética
Disbiose/induzido quimicamente
Enterobacteriaceae/efeitos dos fármacos
Enterobacteriaceae/genética
Microbioma Gastrointestinal/efeitos dos fármacos
Dibenzodioxinas Policloradas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Feminino
Sequências Repetitivas Dispersas/genética
Camundongos
Camundongos Endogâmicos C57BL
Receptores de Hidrocarboneto Arílico/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Polychlorinated Dibenzodioxins); 0 (Receptors, Aryl Hydrocarbon)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE
[do] DOI:10.1093/femsec/fix058


  8 / 1069 MEDLINE  
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[PMID]:28444231
[Au] Autor:Argemi X; Martin V; Loux V; Dahyot S; Lebeurre J; Guffroy A; Martin M; Velay A; Keller D; Riegel P; Hansmann Y; Paul N; Prévost G
[Ad] Endereço:Hôpitaux Universitaires, Maladies Infectieuses et Tropicales, Strasbourg, France.
[Ti] Título:Whole-Genome Sequencing of Seven Strains of Staphylococcus lugdunensis Allows Identification of Mobile Genetic Elements.
[So] Source:Genome Biol Evol;9(5), 2017 May 01.
[Is] ISSN:1759-6653
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Coagulase negative staphylococci are normal inhabitant of the human skin flora that account for an increasing number of infections, particularly hospital-acquired infections. Staphylococcus lugdunensis has emerged as a most virulent species causing various infections with clinical characteristics close to what clinicians usually observe with Staphylococcus aureus and both bacteria share more than 70% of their genome. Virulence of S. aureus relies on a large repertoire of virulence factors, many of which are encoded on mobile genetic elements. S. lugdunensis also bears various putative virulence genes but only one complete genome with extensive analysis has been published with one prophage sequence (φSL2) and a unique plasmid was previously described. In this study, we performed de novo sequencing, whole genome assembly and annotation of seven strains of S. lugdunensis from VISLISI clinical trial. We searched for the presence of virulence genes and mobile genetics elements using bioinformatics tools. We identified four new prophages, named φSL2 to φSL4, belonging to the Siphoviridae class and five plasmids, named pVISLISI_1 to pVISLISI_5. Three plasmids are homologous to known plasmids that include, amongst others, one S. aureus plasmid. The two other plasmids were not described previously. This study provides a new context for the study of S. lugdunensis virulence suggesting the occurrence of several genetic recombination' with other staphylococci.
[Mh] Termos MeSH primário: Staphylococcus lugdunensis/classificação
Staphylococcus lugdunensis/genética
[Mh] Termos MeSH secundário: Genoma Bacteriano
Ilhas Genômicas
Sequências Repetitivas Dispersas
Anotação de Sequência Molecular
Prófagos
Recombinação Genética
Infecções Estafilocócicas/microbiologia
Staphylococcus lugdunensis/patogenicidade
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Virulence Factors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1093/gbe/evx077


  9 / 1069 MEDLINE  
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[PMID]:28407482
[Au] Autor:Wotzka SY; Nguyen BD; Hardt WD
[Ad] Endereço:Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland.
[Ti] Título:Salmonella Typhimurium Diarrhea Reveals Basic Principles of Enteropathogen Infection and Disease-Promoted DNA Exchange.
[So] Source:Cell Host Microbe;21(4):443-454, 2017 Apr 12.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite decades of research, efficient therapies for most enteropathogenic bacteria are still lacking. In this review, we focus on Salmonella enterica Typhimurium (S. Typhimurium), a frequent cause of acute, self-limiting food-borne diarrhea and a model that has revealed key principles of enteropathogen infection. We review the steps of gut infection and the mucosal innate-immune defenses limiting pathogen burdens, and we discuss how inflammation boosts gut luminal S. Typhimurium growth. We also discuss how S. Typhimurium-induced inflammation accelerates the transfer of plasmids and phages, which may promote the transmission of antibiotic resistance and facilitate emergence of pathobionts and pathogens with enhanced virulence. The targeted manipulation of the microbiota and vaccination might offer strategies to prevent this evolution. As gut luminal microbes impact various aspects of the host's physiology, improved strategies for preventing enteropathogen infection and disease-inflicted DNA exchange may be of broad interest well beyond the acute infection.
[Mh] Termos MeSH primário: Diarreia/microbiologia
Diarreia/patologia
Transferência Genética Horizontal
Interações Hospedeiro-Patógeno
Infecções por Salmonella/microbiologia
Infecções por Salmonella/patologia
Salmonella typhimurium/patogenicidade
[Mh] Termos MeSH secundário: Imunidade Inata
Sequências Repetitivas Dispersas
Mucosa Intestinal/microbiologia
Mucosa Intestinal/patologia
Salmonella typhimurium/genética
Salmonella typhimurium/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


  10 / 1069 MEDLINE  
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[PMID]:28371770
[Au] Autor:Tong J; Lu X; Zhang J; Sui Q; Wang R; Chen M; Wei Y
[Ad] Endereço:State Key Joint Laboratory of Environmental Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Department of Water Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijin
[Ti] Título:Occurrence of antibiotic resistance genes and mobile genetic elements in enterococci and genomic DNA during anaerobic digestion of pharmaceutical waste sludge with different pretreatments.
[So] Source:Bioresour Technol;235:316-324, 2017 Jul.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pharmaceutical waste sludge harbors large amounts of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs), and it is necessary to study the reduction of ARGs and MGEs during sludge treatment. Therefore, the antibiotic resistance phenotypes and genotypes of enterococci, and the ARGs and MGEs in genomic DNA were investigated during anaerobic digestion (AD) with microwave (MW), thermal hydrolysis (TH) and ozone pretreatment. Results showed that sludge pretreatment increased the occurrence of the resistance phenotypes and genotypes of enterococci. During AD, the resistance of enterococci to macrolides decreased, except for in the MW-pretreated sludge. Horizontal gene transfer and co-occurrence of ermB and tetM in enterococci resulted in increased tetracycline resistance of enterococci throughout the sludge treatment. MGEs such as intI1, ISCR1 and Tn916/1545 had a significant effect on the distribution of ARGs. AD with pretreatment, especially TH pretreatment, resulted in greater ARGs and MGEs reduction and improved methane production.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Esgotos
[Mh] Termos MeSH secundário: Anaerobiose
DNA
Resistência Microbiana a Medicamentos/genética
Enterococcus/genética
Genômica
Sequências Repetitivas Dispersas
Preparações Farmacêuticas
Eliminação de Resíduos Líquidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Pharmaceutical Preparations); 0 (Sewage); 9007-49-2 (DNA)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE



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