Base de dados : MEDLINE
Pesquisa : G02.111.570.080.708.330.800.800.050 [Categoria DeCS]
Referências encontradas : 1281 [refinar]
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[PMID]:29369589
[Au] Autor:Karimov DD; Erdman VV; Nasibullin TR; Tuktarova IA; Somova RS; Timasheva YR; Mustafina OE
[Ti] Título:[Alu insertion-deletion polymorphism of COL13A1 and LAMA2 genes: The analysis of association with longevity].
[So] Source:Genetika;52(10):1185-93, 2016 Oct.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The distribution of allele and genotype frequencies of Alu(I/D) polymorphic sites in the COL13A1 and LAMA2 genes coding extracellular matrix protein subunits was characterized in an ethnically homogeneous group (Tatars from the Republic of Bashkortostan, Russia). It was established that the frequency of individuals with the COL13A1*D/*D genotype was higher in the senile age period. The LAMA2*I/*D genotype was predisposing to longevity among women. According to the observed results, the frequency of the LAMA2*I/*D genotype was increased in senile individuals older than 90 years. The observed associations can be explained on the basis of the contemporary view by the importance of Alu elements in gene expression regulation at transcriptional and post-transcriptional levels, the involvement of collagen and laminin in maintaining the structure and function of the extracellular matrix, and the relationship between the extracellular matrix state, pathological changes and aging.
[Mh] Termos MeSH primário: Elementos Alu
Colágeno/genética
Mutação INDEL
Laminina/genética
Longevidade/genética
Polimorfismo Genético
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Colágeno/biossíntese
Feminino
Regulação da Expressão Gênica
Seres Humanos
Laminina/biossíntese
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Laminin); 0 (laminin alpha 2); 9007-34-5 (Collagen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  2 / 1281 MEDLINE  
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[PMID]:29287712
[Au] Autor:Duan L; Hu J; Xiong X; Liu Y; Wang J
[Ad] Endereço:Department of Cardiology, Guang' An men Hospital, China Academy of Chinese Medical Science, No.5 Bei xiange, Xicheng District, Beijing, China; Graduate School, Beijing University of Traditional Chinese Medicine, No.11 North Third Ring Road, Chaoyang District, Beijing, China.
[Ti] Título:The role of DNA methylation in coronary artery disease.
[So] Source:Gene;646:91-97, 2018 Mar 10.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Epigenetic studies have identified DNA methylation in coronary artery disease (CAD). How the critical genes interact at the cellular level to cause CAD is still unknown. The discovery of DNA methylation inspired researchers to explore relationships in genomic coding and disease phenotype. In the past two decades, there have been many findings regarding the relationship between DNA methylation and CAD development, and the DNA methylation of critical genes have been found to be significantly changed during CAD, including DNA methylation at homocysteine, Alu and long Interspersed Element 1 (LINE-1) repetitive elements. Here, we provide a brief overview of the biology and mechanisms of DNA methylation and its roles in CAD. We also discuss recent findings regarding DNA methylation of homocysteine, Alu and LINE-1 and some genes on CAD in vitro and in vivo. Finally, we provide some perspectives on DNA methylation in CAD.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana/genética
Metilação de DNA
Predisposição Genética para Doença
[Mh] Termos MeSH secundário: Elementos Alu
Animais
Epigênese Genética
Feminino
Homocisteína/genética
Seres Humanos
Elementos Nucleotídeos Longos e Dispersos
Masculino
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0LVT1QZ0BA (Homocysteine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  3 / 1281 MEDLINE  
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[PMID]:29025590
[Au] Autor:Qian Y; Mancini-DiNardo D; Judkins T; Cox HC; Brown K; Elias M; Singh N; Daniels C; Holladay J; Coffee B; Bowles KR; Roa BB
[Ad] Endereço:Myriad Genetic Laboratories, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USA.
[Ti] Título:Identification of pathogenic retrotransposon insertions in cancer predisposition genes.
[So] Source:Cancer Genet;216-217:159-169, 2017 Oct.
[Is] ISSN:2210-7762
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cancer risks have been previously reported for some retrotransposon element (RE) insertions; however, detection of these insertions is technically challenging and very few oncogenic RE insertions have been reported. Here we evaluate RE insertions identified during hereditary cancer genetic testing using a comprehensive testing strategy. Individuals who had single-syndrome or pan-cancer hereditary cancer genetic testing from February 2004 to March 2017 were included. RE insertions were identified using Sanger sequencing, Next Generation Sequencing, or multiplex quantitative PCR, and further characterized using targeted PCR and sequencing analysis. Personal cancer history, ancestry, and haplotype were evaluated. A total of 37 unique RE insertions were identified in 10 genes, affecting 211 individuals. BRCA2 accounted for 45.9% (17/37) of all unique RE insertions. Several RE insertions were detected with high frequency in populations of conserved ancestry wherein up to 100% of carriers shared a high degree of haplotype conservation, suggesting founder effects. Our comprehensive testing strategy resulted in a substantial increase in the number of reported oncogenic RE insertions, several of which may have possible founder effects. Collectively, these data show that the detection of RE insertions is an important component of hereditary cancer genetic testing and may be more prevalent than previously reported.
[Mh] Termos MeSH primário: Genes Neoplásicos
Predisposição Genética para Doença
Mutagênese Insercional/genética
Neoplasias/genética
Retroelementos/genética
[Mh] Termos MeSH secundário: Elementos Alu/genética
Sequência de Bases
Efeito Fundador
Haplótipos/genética
Seres Humanos
Mutação/genética
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Retroelements)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE


  4 / 1281 MEDLINE  
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[PMID]:28911103
[Au] Autor:Zheng Y; Joyce BT; Liu L; Zhang Z; Kibbe WA; Zhang W; Hou L
[Ad] Endereço:Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
[Ti] Título:Prediction of genome-wide DNA methylation in repetitive elements.
[So] Source:Nucleic Acids Res;45(15):8697-8711, 2017 Sep 06.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:DNA methylation in repetitive elements (RE) suppresses their mobility and maintains genomic stability, and decreases in it are frequently observed in tumor and/or surrogate tissues. Averaging methylation across RE in genome is widely used to quantify global methylation. However, methylation may vary in specific RE and play diverse roles in disease development, thus averaging methylation across RE may lose significant biological information. The ambiguous mapping of short reads by and high cost of current bisulfite sequencing platforms make them impractical for quantifying locus-specific RE methylation. Although microarray-based approaches (particularly Illumina's Infinium methylation arrays) provide cost-effective and robust genome-wide methylation quantification, the number of interrogated CpGs in RE remains limited. We report a random forest-based algorithm (and corresponding R package, REMP) that can accurately predict genome-wide locus-specific RE methylation based on Infinium array profiling data. We validated its prediction performance using alternative sequencing and microarray data. Testing its clinical utility with The Cancer Genome Atlas data demonstrated that our algorithm offers more comprehensively extended locus-specific RE methylation information that can be readily applied to large human studies in a cost-effective manner. Our work has the potential to improve our understanding of the role of global methylation in human diseases, especially cancer.
[Mh] Termos MeSH primário: Algoritmos
Metilação de DNA
Genoma Humano
Neoplasias/genética
Sequências Repetitivas de Ácido Nucleico
Análise de Sequência de DNA/métodos
[Mh] Termos MeSH secundário: Elementos Alu
Ilhas de CpG
Feminino
Seres Humanos
Elementos Nucleotídeos Longos e Dispersos
Masculino
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkx587


  5 / 1281 MEDLINE  
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[PMID]:28602844
[Au] Autor:Awan HM; Shah A; Rashid F; Shan G
[Ad] Endereço:CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
[Ti] Título:Primate-specific Long Non-coding RNAs and MicroRNAs.
[So] Source:Genomics Proteomics Bioinformatics;15(3):187-195, 2017 Jun.
[Is] ISSN:2210-3244
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Non-coding RNAs (ncRNAs) are critical regulators of gene expression in essentially all life forms. Long ncRNAs (lncRNAs) and microRNAs (miRNAs) are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests primate-specific roles. It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs, and to develop potential ncRNA-based therapeutics. Here, we have summarized the studies regarding regulatory roles of some key primate-specific lncRNAs and miRNAs.
[Mh] Termos MeSH primário: MicroRNAs/metabolismo
RNA Longo não Codificante/metabolismo
[Mh] Termos MeSH secundário: Elementos Alu/genética
Doença de Alzheimer/genética
Doença de Alzheimer/patologia
Doença de Alzheimer/veterinária
Animais
Transtorno Depressivo Maior/genética
Transtorno Depressivo Maior/patologia
Evolução Molecular
Regulação da Expressão Gênica
MicroRNAs/genética
Primatas
RNA Longo não Codificante/genética
Cromossomo X/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (MicroRNAs); 0 (RNA, Long Noncoding)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  6 / 1281 MEDLINE  
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[PMID]:28586325
[Au] Autor:Elbarbary RA; Maquat LE
[Ad] Endereço:Department of Biochemistry and Biophysics, School of Medicine and Dentistry, and Center for RNA Biology, University of Rochester, Rochester, New York, USA.
[Ti] Título:Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism.
[So] Source:Nat Struct Mol Biol;24(6):496-498, 2017 06 06.
[Is] ISSN:1545-9985
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Adenosina Desaminase/metabolismo
Elementos Alu
RNA Helicases DEAD-box/metabolismo
Proteínas de Neoplasias/metabolismo
RNA de Cadeia Dupla/genética
RNA de Cadeia Dupla/metabolismo
RNA Mensageiro/metabolismo
Proteínas de Ligação a RNA/metabolismo
[Mh] Termos MeSH secundário: Animais
Apoptose
Linhagem Celular
Seres Humanos
Camundongos
Modelos Biológicos
Transporte Proteico
Processamento Pós-Transcricional do RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Neoplasm Proteins); 0 (RNA, Double-Stranded); 0 (RNA, Messenger); 0 (RNA-Binding Proteins); EC 3.5.4.37 (ADAR1 protein, human); EC 3.5.4.4 (Adenosine Deaminase); EC 3.6.1.- (DHX9 protein, human); EC 3.6.4.13 (DEAD-box RNA Helicases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1038/nsmb.3416


  7 / 1281 MEDLINE  
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[PMID]:28542625
[Au] Autor:Qin Z; Zhang X
[Ad] Endereço:MOE Key Laboratory of Bioinformatics, Bioinformatics Division and Center for Synthetic and Systems Biology, TNLIST / Department of Automation, Tsinghua University, Beijing, China.
[Ti] Título:The identification of switch-like alternative splicing exons among multiple samples with RNA-Seq data.
[So] Source:PLoS One;12(5):e0178320, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alternative splicing is an ubiquitous phenomenon in most human genes and has important functions. The switch-like exon is the type of exon that has a high level of usage in some tissues, but has a low level of usage in the other tissues. They usually undergo strong tissue-specific regulations. There is still a lack a systematic method to identify switch-like exons from multiple RNA-seq samples. We proposed a novel method called iterative Tertile Absolute Deviation around the mode (iTAD) to profile the distribution of exon relative usages among multiple samples and to identify switch-like exons and other types of exons using a robust statistic estimator. We validated the method with simulation data, and applied it on RNA-seq data of 16 human body tissues and detected 3,100 switch-like exons. We found that switch-like exons tend to be more associated with Alu elements in their flanking intron regions than other types of exons.
[Mh] Termos MeSH primário: Éxons/fisiologia
Sítios de Splice de RNA/fisiologia
[Mh] Termos MeSH secundário: Elementos Alu/genética
Éxons/genética
Seres Humanos
Modelos Genéticos
Sítios de Splice de RNA/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA Splice Sites)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178320


  8 / 1281 MEDLINE  
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[PMID]:28525578
[Au] Autor:Hirosawa M; Fujita Y; Parr CJC; Hayashi K; Kashida S; Hotta A; Woltjen K; Saito H
[Ad] Endereço:Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
[Ti] Título:Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch.
[So] Source:Nucleic Acids Res;45(13):e118, 2017 Jul 27.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The CRISPR-Cas9 system is a powerful genome-editing tool useful in a variety of biotechnology and biomedical applications. Here we developed a synthetic RNA-based, microRNA (miRNA)-responsive CRISPR-Cas9 system (miR-Cas9 switch) in which the genome editing activity of Cas9 can be modulated through endogenous miRNA signatures in mammalian cells. We created miR-Cas9 switches by using a miRNA-complementary sequence in the 5΄-UTR of mRNA encoding Streptococcus pyogenes Cas9. The miR-21-Cas9 or miR-302-Cas9 switches selectively and efficiently responded to miR-21-5p in HeLa cells or miR-302a-5p in human induced pluripotent stem cells, and post-transcriptionally attenuated the Cas9 activity only in the target cells. Moreover, the miR-Cas9 switches could differentially control the genome editing by sensing endogenous miRNA activities within a heterogeneous cell population. Our miR-Cas9 switch system provides a promising framework for cell-type selective genome editing and cell engineering based on intracellular miRNA information.
[Mh] Termos MeSH primário: Sistemas CRISPR-Cas
Edição de Genes/métodos
MicroRNAs/genética
[Mh] Termos MeSH secundário: Regiões 5' não Traduzidas
Elementos Alu
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Diferenciação Celular
Técnicas de Cocultura
Endonucleases/genética
Endonucleases/metabolismo
Genes de Troca
Genes Sintéticos
Proteínas de Fluorescência Verde/genética
Células HeLa
Seres Humanos
Células-Tronco Pluripotentes Induzidas/citologia
Células-Tronco Pluripotentes Induzidas/metabolismo
MicroRNAs/metabolismo
Neurônios/citologia
Neurônios/metabolismo
RNA Guia/genética
RNA Guia/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5' Untranslated Regions); 0 (Bacterial Proteins); 0 (MicroRNAs); 0 (RNA, Guide); 0 (enhanced green fluorescent protein); 147336-22-9 (Green Fluorescent Proteins); EC 3.1.- (Cas9 endonuclease Streptococcus pyogenes); EC 3.1.- (Endonucleases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkx309


  9 / 1281 MEDLINE  
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[PMID]:28472756
[Au] Autor:Loftus A; Murphy G; Brown H; Montgomery A; Tabak J; Baus J; Carroll M; Green A; Sikka S; Sinha S
[Ad] Endereço:InnoGenomics Technologies, 1441 Canal St., Suite 307, New Orleans, LA, 70112, United States. Electronic address: aloftus@innogenomics.com.
[Ti] Título:Development and validation of InnoQuant HY, a system for quantitation and quality assessment of total human and male DNA using high copy targets.
[So] Source:Forensic Sci Int Genet;29:205-217, 2017 Jul.
[Is] ISSN:1878-0326
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The development and validation of InnoQuant HY, a real-time PCR system containing four DNA targets-two RE autosomal targets of different sizes, male specific targets, and an internal positive control target-are described herein. The ratio of the two autosomal targets provides a Degradation Index, or a quantitative value of a sample's degradation state. The male specific targets are multi-copy targets located on the Y chromosome, which provides information about a sample's male DNA composition. The experimental results demonstrate InnoQuant HY as a robust qPCR method producing accurate DNA quantitation results even at low dynamic ranges, with reproducibility among population groups. The system is human specific with low level higher primate cross reactivity and is able to consistently and reproducibly detect sub-picogram concentrations of human and human male DNA. The use of high copy number Alu and SVA (>1000 copies per genome) retrotransposable elements as the two autosomal targets significantly enhances both sensitivity and reproducibility of determination of DNA quantitation as well as DNA degradation in forensic samples. The inclusion of a sensitive multi-copy Y-chromosome specific target provides accurate quantitation of DNA from a male in challenging male-female mixtures (i.e. sexual assault samples). Even in the presence of a large excess of DNA from a female, accurate quantitation was achieved with a male to female ratio of 1:128,000. Population database studies reveal an average Short/Y target ratio of the quantification values across all four populations tested was 1.124±0.282, exhibiting the system's reproducibility across multiple populations. The results from InnoQuant HY provide a tool equipping a forensic analyst with crucial data about a sample's DNA quantitation, male:female ratio, degradation state, and the presence or absence of PCR inhibitors. With the information gained from the InnoQuant HY kit, a more streamlined and efficient workflow can be created that minimizes unnecessary sample processing and retesting while maximizing recovery of probative DNA profiles from challenging biological evidence.
[Mh] Termos MeSH primário: Elementos Alu/genética
Cromossomos Humanos Y
Impressões Digitais de DNA
DNA/genética
Reação em Cadeia da Polimerase em Tempo Real/instrumentação
Retroelementos/genética
[Mh] Termos MeSH secundário: Degradação Necrótica do DNA
Marcadores Genéticos
Seres Humanos
Masculino
Mutagênese Insercional
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Genetic Markers); 0 (Retroelements); 9007-49-2 (DNA)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  10 / 1281 MEDLINE  
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[PMID]:28391141
[Au] Autor:Brown H; Thompson R; Murphy G; Peters D; La Rue B; King J; Montgomery AH; Carroll M; Baus J; Sinha S; Wendt FR; Song B; Chakraborty R; Budowle B; Sinha SK
[Ad] Endereço:InnoGenomics Technologies, LLC, 1441 Canal Street, Suite 307, New Orleans, LA 70112, USA. Electronic address: hbrown@innogenomics.com.
[Ti] Título:Development and validation of a novel multiplexed DNA analysis system, InnoTyper 21.
[So] Source:Forensic Sci Int Genet;29:80-99, 2017 Jul.
[Is] ISSN:1878-0326
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We report here a novel multiplexed DNA analysis system consisting of 20 Alu markers and Amelogenin for analysis of highly degraded forensic biological samples. The key to the success of the system in obtaining results from degraded samples is the primer design yielding small amplicon size (60-125bp) for all 20 markers. The markers included in the InnoTyper 21 system are bi-allelic, having two possible allelic states (insertion or null) and thus termed INNULs. The markers are short interspersed nuclear elements (SINEs), a category of retrotransposable elements (REs) which are non-coding genomic DNA repeat sequences, or "mobile insertion elements," comprising approximately 40% of the human genome. Alu elements are primate specific SINEs that have reached a copy number in excess of one million in the human genome, which makes these markers highly sensitive and desirable for forensic samples with extremely degraded DNA. Until now however, due to the inherent size difference associated with insertion and no insertion alleles, the use of Alu REs has not been practical for forensic applications. The novel primer design described herein has allowed the development of a multiplexed Alu system yielding fragment sizes amenable to degraded DNA samples, as frequently encountered in missing persons cases or forensic samples such as hair shafts. Although use of Alus in human identity has been studied using single marker amplification and reported before, we report for the first time development and validation of a system with multiplexed RE markers. Studies performed include PCR optimization, species specificity, sensitivity, degradation and inhibition, precision and accuracy, nonprobative samples, mixture, and population database studies. A population study using 592 samples including five populations was performed using InnoTyper 21. The data indicated the random match probability for the combination of these 20 Alu markers was greater than 1 in 3.8 million for the populations studied, indicating the greater statistical power of these autosomal nuclear DNA markers over haplotype systems typically used in such degraded samples. Results demonstrate the system is successful in obtaining results from highly degraded DNA. A sensitivity study performed demonstrated at least 95% recovery of alleles from as low as 50pg of total input DNA, and partial profiles from as low as 25pg. This study has demonstrated that the bi-allelic INNULs in the InnoTyper 21 system provide a sensitivity of detection and a power of discrimination that makes them useful for human identification of extremely degraded samples.
[Mh] Termos MeSH primário: Impressões Digitais de DNA/instrumentação
[Mh] Termos MeSH secundário: Alelos
Elementos Alu/genética
Amelogenina/genética
Animais
Grupos de Populações Continentais/genética
Degradação Necrótica do DNA
Eletroforese Capilar
Marcadores Genéticos
Variação Genética
Seres Humanos
Reação em Cadeia da Polimerase
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Amelogenin); 0 (Genetic Markers)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE



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