Base de dados : MEDLINE
Pesquisa : G02.111.820.690 [Categoria DeCS]
Referências encontradas : 6 [refinar]
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  1 / 6 MEDLINE  
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[PMID]:28436626
[Au] Autor:Wang Y; Wang Y; Chen Z
[Ad] Endereço:College of Pharmaceutial Science, Zhejiang University, Hangzhou 310058, China.
[Ti] Título:[The role of central cholinergic system in epilepsy].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;46(1):15-21, 2017 Jan 25.
[Is] ISSN:1008-9292
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Epilepsy is a chronic neurological disorder, which is not only related to the imbalance between excitatory glutamic neurons and inhibitory GABAergic neurons, but also related to abnormal central cholinergic regulation. This article summarizes the scientific background and experimental data about cholinergic dysfunction in epilepsy from both cellular and network levels, further discusses the exact role of cholinergic system in epilepsy. In the cellular level, several types of epilepsy are believed to be associated with aberrant metabotropic muscarinic receptors in several different brain areas, while the mutations of ionotropic nicotinic receptors have been reported to result in a specific type of epilepsy-autosomal dominant nocturnal frontal lobe epilepsy. In the network level, cholinergic projection neurons as well as their interaction with other neurons may regulate the development of epilepsy, especially the cholinergic circuit from basal forebrain to hippocampus, while cholinergic local interneurons have not been reported to be associated with epilepsy. With the development of optogenetics and other techniques, dissect and regulate cholinergic related epilepsy circuit has become a hotspot of epilepsy research.
[Mh] Termos MeSH primário: Neurônios Colinérgicos/química
Neurônios Colinérgicos/patologia
Neurônios Colinérgicos/fisiologia
Epilepsia/genética
Epilepsia/patologia
Epilepsia/fisiopatologia
Sistema Colinérgico não Neuronal/fisiologia
[Mh] Termos MeSH secundário: Acetilcolina/fisiologia
Prosencéfalo Basal/patologia
Química Encefálica/genética
Química Encefálica/fisiologia
Neurônios Colinérgicos/classificação
Epilepsia do Lobo Frontal/genética
Neurônios GABAérgicos/fisiologia
Hipocampo/patologia
Seres Humanos
Mutação/genética
Mutação/fisiologia
Neurônios
Sistema Colinérgico não Neuronal/genética
Receptores Muscarínicos/genética
Receptores Muscarínicos/fisiologia
Receptores Nicotínicos/genética
Receptores Nicotínicos/fisiologia
Transmissão Sináptica/genética
Transmissão Sináptica/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Muscarinic); 0 (Receptors, Nicotinic); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


  2 / 6 MEDLINE  
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[PMID]:27883993
[Au] Autor:Uberti F; Bardelli C; Morsanuto V; Ghirlanda S; Cochis A; Molinari C
[Ad] Endereço:Physiology Laboratory, Department of Translational Medicine, UPO, Novara, Italy.
[Ti] Título:Stimulation of the Nonneuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes.
[So] Source:Cells Tissues Organs;203(4):215-230, 2017.
[Is] ISSN:1422-6421
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The physiological effects of acetylcholine on keratinocytes depend on the presence of nicotinic and muscarinic receptors. The role of nonneuronal acetylcholine in keratinocytes could have important clinical implications for patients with various skin disorders such as nonhealing wounds. In order to evaluate the efficacy of highly diluted acetylcholine solutions obtained by sequential kinetic activation, we aimed to investigate the effects of these solutions on normal human keratinocytes. Two different concentrations (10 fg/mL and 1 pg/mL) and formulations (kinetically activated and nonkinetically activated) of acetylcholine were used to verify keratinocyte viability, proliferation, and migration and the intracellular pathways involved using MTT, crystal violet, wound healing, and Western blot compared to 147 ng/mL acetylcholine. The activated formulations (1 pg/mL and 10 fg/mL) revealed a significant capacity to increase migration, cell viability, and cell proliferation compared to 147 ng/mL acetylcholine, and these effects were more evident after a single administration. Sequential kinetic activation resulted in a statistically significant decrease in reactive oxygen species production accompanied by an increase in mitochondrial membrane potential and a decrease in oxygen consumption compared to 147 ng/mL acetylcholine. The M1 muscarinic receptor was involved in these effects. Finally, the involvement of ERK/mitogen-activated protein kinases (MAPK) and KI67 confirmed the effectiveness of the single treatment on cell proliferation. The intracellular pathways of calcium were investigated as well. Our results indicate for the first time that highly diluted and kinetically activated acetylcholine seems to play an active role in an in vitro model of wound healing. Moreover, the administration of acetylcholine within the physiological range may not only be effective but is also likely to be safe.
[Mh] Termos MeSH primário: Acetilcolina/farmacologia
Queratinócitos/metabolismo
Sistema Colinérgico não Neuronal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Sinalização do Cálcio/efeitos dos fármacos
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Seres Humanos
Queratinócitos/citologia
Queratinócitos/efeitos dos fármacos
Masculino
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Consumo de Oxigênio/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
Receptores Muscarínicos/metabolismo
Transdução de Sinais/efeitos dos fármacos
Soluções
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 0 (Receptors, Muscarinic); 0 (Solutions); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161125
[St] Status:MEDLINE
[do] DOI:10.1159/000451023


  3 / 6 MEDLINE  
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[PMID]:27556046
[Au] Autor:Xu QQ; Xu YJ; Yang C; Tang Y; Li L; Cai HB; Hou BN; Chen HF; Wang Q; Shi XG; Zhang SJ
[Ad] Endereço:Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
[Ti] Título:Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System.
[So] Source:Biomed Res Int;2016:9852536, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sodium Tanshinone IIA sulfonate (STS) is a derivative of Tanshinone IIA (Tan IIA). Tan IIA has been reported to possess neuroprotective effects against Alzheimer's disease (AD). However, whether STS possesses effect on AD remains unclear. This study aims to estimate whether STS could protect against scopolamine- (SCOP-) induced learning and memory deficit in Kunming mice. Morris water maze results showed that oral administration of STS (10 mg/kg and 20 mg/kg) and Donepezil shortened escape latency, increased crossing times of the original position of the platform, and increased the time spent in the target quadrant. STS decreased the activity of acetylcholinesterase (AChE) and increased the activity of choline acetyltransferase (ChAT) in the hippocampus and cortex of SCOP-treated mice. Oxidative stress results showed that STS increased the activity of superoxide dismutase (SOD) and decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in hippocampus and cortex. In addition, western blot was carried out to detect the expression of apoptosis related proteins (Bcl-2, Bax, and Caspase-3). STS upregulated the protein expression of Bcl-2 and downregulated the proteins expression of Bax and Caspase-3. These results indicated that STS might become a promising therapeutic candidate for attenuating AD-like pathological dysfunction.
[Mh] Termos MeSH primário: Doença de Alzheimer/tratamento farmacológico
Disfunção Cognitiva/tratamento farmacológico
Sistema Colinérgico não Neuronal/efeitos dos fármacos
Fenantrenos/administração & dosagem
[Mh] Termos MeSH secundário: Doença de Alzheimer/patologia
Animais
Disfunção Cognitiva/induzido quimicamente
Disfunção Cognitiva/patologia
Hipocampo/efeitos dos fármacos
Hipocampo/patologia
Seres Humanos
Transtornos de Aprendizagem/induzido quimicamente
Transtornos de Aprendizagem/tratamento farmacológico
Transtornos de Aprendizagem/patologia
Aprendizagem em Labirinto/efeitos dos fármacos
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Fenantrenos/química
Hidrobrometo de Escopolamina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenanthrenes); 451IFR0GXB (Scopolamine Hydrobromide); 69659-80-9 (tanshinone II A sodium sulfonate)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE
[do] DOI:10.1155/2016/9852536


  4 / 6 MEDLINE  
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[PMID]:27279915
[Au] Autor:Su Y; Zhu L; Yu X; Cai L; Lu Y; Zhang J; Li T; Li J; Xia J; Xu F; Hu Q
[Ad] Endereço:1. Key Laboratory of Pulmonary Diseases of Ministry of Health and Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan 430030, People's Republic of China (PRC);; 2. Department of Respiratory Medicine, Union Hospi
[Ti] Título:Mitochondrial Transplantation Attenuates Airway Hyperresponsiveness by Inhibition of Cholinergic Hyperactivity.
[So] Source:Theranostics;6(8):1244-60, 2016.
[Is] ISSN:1838-7640
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Increased cholinergic activity has been highlighted in the pathogenesis of airway hyperresponsiveness, and alternations of mitochondrial structure and function appear to be involved in many lung diseases including airway hyperresponsiveness. It is crucial to clarify the cause-effect association between mitochondrial dysfunction and cholinergic hyperactivity in the pathogenesis of airway hyperresponsiveness. Male SD rats and cultured airway epithelial cells were exposed to cigarette smoke plus lipopolysaccharide administration; mitochondria isolated from airway epithelium were delivered into epithelial cells in vitro and in vivo. Both the cigarette smoke plus lipopolysaccharide-induced cholinergic hyperactivity in vitro and the airway hyperresponsiveness to acetylcholine in vivo were reversed by the transplantation of exogenous mitochondria. The rescue effects of exogenous mitochondria were imitated by the elimination of excessive reactive oxygen species or blockage of muscarinic M3 receptor, but inhibited by M receptor enhancer. Mitochondrial transplantation effectively attenuates cigarette smoke plus lipopolysaccharide-stimulated airway hyperresponsiveness through the inhibition of ROS-enhanced epithelial cholinergic hyperactivity.
[Mh] Termos MeSH primário: Colinérgicos/metabolismo
Células Epiteliais/fisiologia
Mitocôndrias/metabolismo
Sistema Colinérgico não Neuronal/fisiologia
Hipersensibilidade Respiratória/terapia
[Mh] Termos MeSH secundário: Animais
Masculino
Ratos Sprague-Dawley
Espécies Reativas de Oxigênio/metabolismo
Receptor Muscarínico M3/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinergic Agents); 0 (Reactive Oxygen Species); 0 (Receptor, Muscarinic M3)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE
[do] DOI:10.7150/thno.13804


  5 / 6 MEDLINE  
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[PMID]:26896422
[Au] Autor:Hatakeyama M; Fukunaga A; Washio K; Ogura K; Yamada Y; Horikawa T; Nishigori C
[Ad] Endereço:Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan; Department of Dermatology, Nishi-Kobe Medical Center, 5-7-1 Kojidai, Nishi-ku, Kobe 651-2273, Japan; Division of Dermatology, Department of Interna
[Ti] Título:Addition of lafutidine can improve disease activity and lead to better quality of life in refractory cholinergic urticaria unresponsive to histamine H1 antagonists.
[So] Source:J Dermatol Sci;82(2):137-9, 2016 May.
[Is] ISSN:1873-569X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Acetamidas/uso terapêutico
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Antagonistas dos Receptores Histamínicos H2/uso terapêutico
Sistema Colinérgico não Neuronal
Piperidinas/uso terapêutico
Piridinas/uso terapêutico
Urticária/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Quimioterapia Combinada
Feminino
Seres Humanos
Masculino
Qualidade de Vida
Urticária/etiologia
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; LETTER
[Nm] Nome de substância:
0 (Acetamides); 0 (Histamine H1 Antagonists); 0 (Histamine H2 Antagonists); 0 (Piperidines); 0 (Pyridines); 49S4O7ADLC (lafutidine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160221
[St] Status:MEDLINE


  6 / 6 MEDLINE  
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[PMID]:26619922
[Au] Autor:Vadas P; Sinilaite A; Chaim M
[Ad] Endereço:Division of Allergy and Clinical Immunology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address: vadasp@smh.ca.
[Ti] Título:Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity.
[So] Source:J Allergy Clin Immunol Pract;4(2):284-91, 2016 Mar-Apr.
[Is] ISSN:2213-2201
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cholinergic urticaria is a form of physical urticaria triggered by high ambient temperature, strenuous physical activity, and strong emotion. These same triggers may cause multisystem reactions that can be life-threatening. A study of patients with cholinergic urticaria with anaphylaxis was undertaken to describe the demographic and clinical features of this form of anaphylaxis. OBJECTIVE: To describe a cohort of patients with anaphylaxis triggered by high ambient temperature, exertion, and stress. METHODS: Patients from an academic allergy practice in a university teaching hospital were identified by retrospective chart review. RESULTS: A total of 19 patients with recurrent episodes of anaphylaxis due to cholinergic triggers were identified. The female:male ratio was 15:4 (79% females). The mean age of onset was 27.5 years. Patients experienced a mean of 9.41 episodes per year. All 19 patients (100%) reported anaphylaxis triggered by high ambient temperature, 89.5% reported anaphylaxis triggered by strenuous exertion, and 78.9% reported anaphylaxis triggered by stress. Cutaneous involvement was present in 94.7%; 78.9% had upper airway obstructive symptoms, 78.9% had lower airway involvement, 57.9% had gastrointestinal involvement, and 78.9% had cardiovascular manifestations. Anaphylaxis severity scores were grade 1 (mild) in 11.1%, grade 2 (moderate) in 44.4%, and grade 3 (severe) in 44.4%. Baseline tryptase levels were normal in all but 1 patient. CONCLUSIONS: Anaphylaxis due to cholinergic triggers is underreported, with only several case reports in the literature. Reactions are multisystem with cutaneous, upper and lower airway, and cardiovascular involvement in most patients. Manifestations may be life-threatening, and reactions are often severe.
[Mh] Termos MeSH primário: Anafilaxia/diagnóstico
Sistema Colinérgico não Neuronal/fisiologia
Urticária/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anafilaxia/epidemiologia
Criança
Estudos de Coortes
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Fatores Socioeconômicos
Urticária/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151202
[St] Status:MEDLINE



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