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[PMID]: 29367484 [Au] Autor: Yamamoto Y; Yoshida H; Nagai T; Hara S [Ad] Endereço: Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima. [Ti] Título: Preparation of Chiral Triacylglycerols, sn-POO and sn-OOP, via Lipase-mediated Acidolysis Reaction. [So] Source: J Oleo Sci;67(2):207-214, 2018 Feb 01. [Is] ISSN: 1347-3352 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: It is well known that lipases are useful tools for preparing various structured triacylglycerols (TAGs). However, the lipase-mediated preparation of chiral TAGs has never been reported. This study aimed to prepare chiral TAGs (viz., 1-palmitoyl-2,3-dioleoyl-sn-glycerol (sn-POO) or 1,2-dioleoyl-3-palmitoyl-sn-glycerol (sn-OOP)) via lipase mediated acidolysis, using triolein (TO) and palmitic acid (P) as substrates. Three commercially available lipases (viz., Lipozyme RM-IM , Lipozyme TL-IM , and Lipase OF ) were used. Lipozyme RM-IM resulted in an increase 1P-2O (sn-POO + sn-OOP + 1,3-dioleoyl-2-palmitoyl-sn-glycerol) content with reaction time, which plateaued at 2~24 h (max. yield 47.1% at 4 h). The highest sn-POO/sn-OOP ratio of ca. 9 was obtained at 0.25 h, and the rate got close to 1 with reaction time (sn-POO/sn-OOP = 1.3 at 24 h). Lipozyme TL-IM resulted in a lower 1P-2O synthesis rate than Lipozyme RM-IM , where its highest sn-POO/sn-OOP ratio of ca. 2 was obtained at 0.25 h and did not vary much further with reaction time. In the case of Lipase OF , its reaction rate for 1P-2O synthesis was lower than that of the other two lipases, and the highest sn-POO/sn-OOP ratio of ca. 1.4 was obtained at 0.5 h, reaching closer to 1 with a longer reaction time. Reaction solvents (viz., hexane, acetone, and benzene) also affected the 1P-2O preparation, where the highest 1P-2O content was obtained with the solvent-free system. Furthermore, the solvent-free system showed a higher reaction rate for 1P-2O synthesis than did the hexane system, with no effect on chiral specificity of the lipase for the TAG molecules. These results suggested that among three types of commercial lipase, Lipozyme RM-IM is the most useful for the preparation of chiral TAGs by acidolysis reaction. [Mh] Termos MeSH primário: Lipase/química Triglicerídeos/síntese química [Mh] Termos MeSH secundário: Ácido Palmítico/química Solventes Estereoisomerismo Fatores de Tempo Triglicerídeos/química Trioleína/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Solvents); 0 (Triglycerides); 122-32-7 (Triolein); 2V16EO95H1 (Palmitic Acid); EC 3.1.1.3 (Lipase) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180126 [St] Status: MEDLINE [do] DOI: 10.5650/jos.ess17149

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[PMID]: 29320822 [Au] Autor: Park GM; Park H; Oh S; Lee S [Ad] Endereço: Department of Medical Environmental Biology, Catholic Kwandong University College of Medicine, Gangneung 25601, Korea. [Ti] Título: Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin. [So] Source: Korean J Parasitol;55(6):661-665, 2017 Dec. [Is] ISSN: 1738-0006 [Cp] País de publicação: Korea (South) [La] Idioma: eng [Ab] Resumo: We synthesized C-10 substituted triazolyl artemisinins by the Huisgen cycloaddition reaction between dihydroartemisinins (2) and variously substituted 1, 2, 3-triazoles (8a-8h). The antimalarial activities of 32 novel artemisinin derivatives were screened against a chloroquine-resistant parasite. Among them, triazolyl artemisinins with electron-withdrawing groups showed stronger antimalarial activities than those shown by the derivatives having electron-donating groups. In particularly, m-chlorotriazolyl artemisinin (9d-12d) showed antimalarial activity equivalent to that of artemisinin and could be a strong drug candidate. [Mh] Termos MeSH primário: Antimaláricos Artemisininas/química Triazóis/química [Mh] Termos MeSH secundário: Reação de Cicloadição Plasmodium falciparum/efeitos dos fármacos Estereoisomerismo Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antimalarials); 0 (Artemisinins); 0 (Triazoles); 6A9O50735X (dihydroartemisinin) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180112 [St] Status: MEDLINE [do] DOI: 10.3347/kjp.2017.55.6.661

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[PMID]: 28471385 [Au] Autor: Sun K; Tao ML; Tu YB; Wang JZ [Ad] Endereço: School of Physical Science and Technology, MOE Key Laboratory on Luminescence and Real-Time Analysis, Southwest University, Chongqing 400715, China. sun.andkai@163.com. [Ti] Título: Off-Center Rotation of CuPc Molecular Rotor on a Bi(111) Surface and the Chiral Feature. [So] Source: Molecules;22(5), 2017 May 04. [Is] ISSN: 1420-3049 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: Molecular rotors with an off-center axis and the chiral feature of achiral CuPc molecules on a semi-metallic Bi(111) surface have been investigated by means of a scanning tunneling microscopy (STM) at liquid nitrogen (LN2) temperature. The rotation axis of each CuPc molecular rotor is located at the end of a phthalocyanine group. As molecular coverage increases, the CuPc molecules are self-assembled into various nanoclusters and finally into two-dimensional (2D) domains, in which each CuPc molecule exhibits an apparent chiral feature. Such chiral features of the CuPc molecules can be attributed to the combined effect of asymmetric charge transfer between the CuPc and Bi(111) substrate, and the intermolecular van der Waals interactions. [Mh] Termos MeSH primário: Bismuto/química [Mh] Termos MeSH secundário: Dimerização Microscopia de Tunelamento Estereoisomerismo Propriedades de Superfície [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: U015TT5I8H (Bismuth) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE

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[PMID]: 28470986 [Au] Autor: Wang L; Wang Y; Chai Y; Kang Y; Sun C; Zeng S [Ad] Endereço: Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. [Ti] Título: Nickel(II)-assisted enantiomeric differentiation and quantitation of tadalafil by direct electrospray ionization mass spectrometry. [So] Source: J Mass Spectrom;52(7):411-416, 2017 Jul. [Is] ISSN: 1096-9888 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A facile method based on electrospray mass spectrometry was established and validated for the differentiation of enantiomeric tadalafil isomers without using chiral chromatographic separation. The enantiomers were coupled with a chiral selector to form diastereomeric complex ions. Nickel-tadalafil complexes, [Ni (tadalafil)(l-Trp)-H] , produced a characteristic fragment ion at m/z 524 by loss of 1-methyl-1,6-dihydropyrazine-2,5-dione via collision-induced dissociation. The relative abundance of this fragment ion to the precursor contributed to differentiate tadalafil enantiomers, and energy-resolved product-ion spectra were applied to determine the molar composition of tadalafil in the mixture (R,R and S,S) as well. In addition, the other two forms of stereomeric isomers of tadalafil (R,S and S,R) could be also distinguished and analyzed by this method. The method was validated in different types of mass spectrometers (AB quadrupole time-of-flight and Bruker ion trap) and also verified by a chiral high-performance liquid chromatography coupled with quadrupole time-of-flight. The chiral determination of tadalafil using MS method proved to be rapid (1-min run time for each sample) and to have the same accuracy and precision comparable to chiral liquid chromatography mass spectrometry methods. This method provides an alternative to commonly used chromatographic technique for chiral determination and is particularly useful in rapid screening in enantioselective synthesis and enantiomeric impurity detection in pharmaceutical industry. Copyright © 2017 John Wiley & Sons, Ltd. [Mh] Termos MeSH primário: Complexos de Coordenação/análise Níquel/química Inibidores da Fosfodiesterase 5/análise Tadalafila/análise [Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão/métodos Complexos de Coordenação/química Contaminação de Medicamentos Conformação Molecular Inibidores da Fosfodiesterase 5/química Espectrometria de Massas por Ionização por Electrospray/métodos Estereoisomerismo Tadalafila/química [Pt] Tipo de publicação: JOURNAL ARTICLE; VALIDATION STUDIES [Nm] Nome de substância: 0 (Coordination Complexes); 0 (Phosphodiesterase 5 Inhibitors); 742SXX0ICT (Tadalafil); 7OV03QG267 (Nickel) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1002/jms.3939

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[PMID]: 29172693 [Au] Autor: Ojeda-Montes MJ; Ardid-Ruiz A; Tomás-Hernández S; Gimeno A; Cereto-Massagué A; Beltrán-Debón R; Mulero M; Garcia-Vallvé S; Pujadas G; Valls C [Ad] Endereço: Research group in Cheminformatics & Nutrition, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Campus de Sescelades, Tarragona, Catalonia 43007, Spain. [Ti] Título: Ephedrine as a lead compound for the development of new DPP-IV inhibitors. [So] Source: Future Med Chem;9(18):2129-2146, 2017 12. [Is] ISSN: 1756-8927 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: AIM: Extracts from Ephedra species have been reported to be effective as antidiabetics. A previous in silico study predicted that ephedrine and five ephedrine derivatives could contribute to the described antidiabetic effect of Ephedra extracts by inhibiting dipeptidyl peptidase IV (DPP-IV). Finding selective DPP-IV inhibitors is a current therapeutic strategy for Type 2 diabetes mellitus management. Therefore, the main aim of this work is to experimentally determine whether these alkaloids are DPP-IV inhibitors. Materials & methods: The DPP-IV inhibition of Ephedra's alkaloids was determined via a competitive-binding assay. Then, computational analyses were used in order to find out the protein-ligand interactions and to perform a lead optimization. RESULTS: Our results show that all six molecules are DPP-IV inhibitors, with IC ranging from 124 µM for ephedrine to 28 mM for N-methylpseudoephedrine. CONCLUSION: Further computational analysis shows how Ephedra's alkaloids could be used as promising lead molecules for designing more potent and selective DPP-IV inhibitors. [Mh] Termos MeSH primário: Dipeptidil Peptidase 4/metabolismo Inibidores da Dipeptidil Peptidase IV/química Efedrina/análogos & derivados Hipoglicemiantes/química [Mh] Termos MeSH secundário: Alcaloides/química Alcaloides/metabolismo Sítios de Ligação Ligação Competitiva Dipeptidil Peptidase 4/química Desenho de Drogas Ephedra/química Ephedra/metabolismo Efedrina/metabolismo Hipoglicemiantes/metabolismo Concentração Inibidora 50 Simulação de Acoplamento Molecular Fenilpropanolamina/química Extratos Vegetais/química Isoformas de Proteínas/antagonistas & inibidores Isoformas de Proteínas/metabolismo Estrutura Terciária de Proteína Estereoisomerismo Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Alkaloids); 0 (Dipeptidyl-Peptidase IV Inhibitors); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 0 (Protein Isoforms); 33RU150WUN (Phenylpropanolamine); EC 3.4.14.5 (Dipeptidyl Peptidase 4); GN83C131XS (Ephedrine) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171128 [St] Status: MEDLINE [do] DOI: 10.4155/fmc-2017-0080

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[PMID]: 27774742 [Au] Autor: Krupcík J; Gorovenko R; Spánik I; Armstrong DW; Sandra P [Ad] Endereço: Institue of Analytical Chemistry, Faculty of Chemical and Food Technology, STU, Bratislava, Slovakia. [Ti] Título: Enantioselective comprehensive two-dimensional gas chromatography of lavender essential oil. [So] Source: J Sep Sci;39(24):4765-4772, 2016 Dec. [Is] ISSN: 1615-9314 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The enantiomeric composition of several chiral markers in lavender essential oil was studied by flow modulated comprehensive two-dimensional gas chromatography operated in the reverse flow mode and hyphenated to flame ionization and quadrupole mass spectrometric detection. Two capillary column series were used in this study, 2,3-di-O-ethyl-6-O-tert-butyldimethylsilyl-ß-cyclodextrin or 2,3,6-tri-O-methyl-ß-cyclodextrin, as the chiral column in the first dimension and α polyethylene glycol column in the second dimension. Combining the chromatographic data obtained on these column series, the enantiomeric and excess ratios for α-pinene, ß-pinene, camphor, lavandulol, borneol, and terpinen-4-ol were determined. This maybe a possible route to assess the authenticity of lavender essential oil. [Mh] Termos MeSH primário: Lavandula/química Óleos Voláteis/análise Compostos Fitoquímicos/análise Óleos Vegetais/análise [Mh] Termos MeSH secundário: Cromatografia Gasosa Cromatografia Gasosa-Espectrometria de Massas Estereoisomerismo beta-Ciclodextrinas [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Oils, Volatile); 0 (Phytochemicals); 0 (Plant Oils); 0 (beta-Cyclodextrins) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE [do] DOI: 10.1002/jssc.201600986

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[PMID]: 29413579 [Au] Autor: Hegstad S; Havnen H; Helland A; Spigset O; Frost J [Ad] Endereço: Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway. Electronic address: solfrid.hegstad@stolav.no. [Ti] Título: Enantiomeric separation and quantification of R/S-amphetamine in urine by ultra-high performance supercritical fluid chromatography tandem mass spectrometry. [So] Source: J Chromatogr B Analyt Technol Biomed Life Sci;1077-1078:7-12, 2018 Mar 01. [Is] ISSN: 1873-376X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: To distinguish between legal and illegal consumption of amphetamine reliable analytical methods for chiral separation of the R- and S-enantiomers of amphetamine in biological specimens are required. In this regard, supercritical fluid chromatography (SFC) has several potential advantages over liquid chromatography, including rapid separation of enantiomers due to low viscosity and high diffusivity of supercritical carbon dioxide, the main component in the SFC mobile phase. A method for enantiomeric separation and quantification of R- and S-amphetamine in urine was developed and validated using ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS). Sample preparation prior to UHPSFC-MS/MS analysis was a semi-automatic solid phase extraction method. The UHPSFC-MS/MS method used a Chiralpak AD-3 column with a mobile phase consisting of CO and 0.2% cyclohexylamine in 2-propanol. The injection volume was 2 µL and run-time was 6 min. MS/MS detection was performed with positive electrospray ionization and two multiple reaction monitoring transitions (m/z 136.1 > 119.0 and m/z 136.1 > 91.0). The calibration range was 50-10,000 ng/mL for each enantiomer. The between-assay relative standard deviations were in the range of 3.7-7.6%. Recovery was 92-93% and matrix effects ranged from 100 to 104% corrected with internal standard. After development and validation, the method has been successfully implemented in routine use at our laboratory for both separation and quantification of R/S-amphetamine, and has proved to be a reliable and useful tool for distinguishing intake of R- and S-amphetamine in authentic patient samples. [Mh] Termos MeSH primário: Anfetamina/química Anfetamina/urina Cromatografia Líquida de Alta Pressão/métodos Espectrometria de Massas em Tandem/métodos [Mh] Termos MeSH secundário: Adolescente Adulto Estabilidade de Medicamentos Feminino Seres Humanos Limite de Detecção Modelos Lineares Masculino Meia-Idade Reprodutibilidade dos Testes Estereoisomerismo Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: CK833KGX7E (Amphetamine) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180208 [St] Status: MEDLINE

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[PMID]: 29339755 [Au] Autor: Rout SK; Friedmann MP; Riek R; Greenwald J [Ad] Endereço: Laboratory of Physical Chemistry, ETH Zürich, Vladimir-Prelog-Weg 2, 8093, Zürich, Switzerland. [Ti] Título: A prebiotic template-directed peptide synthesis based on amyloids. [So] Source: Nat Commun;9(1):234, 2018 01 16. [Is] ISSN: 2041-1723 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The prebiotic replication of information-coding molecules is a central problem concerning life's origins. Here, we report that amyloids composed of short peptides can direct the sequence-selective, regioselective and stereoselective condensation of amino acids. The addition of activated DL-arginine and DL-phenylalanine to the peptide RFRFR-NH in the presence of the complementary template peptide Ac-FEFEFEFE-NH yields the isotactic product FRFRFRFR-NH , 1 of 64 possible triple addition products, under conditions in which the absence of template yields only single and double additions of mixed stereochemistry. The templating mechanism appears to be general in that a different amyloid formed by (Orn)V(Orn)V(Orn)V(Orn)V-NH and Ac-VDVDVDVDV-NH is regioselective and stereoselective for N-terminal, L-amino-acid addition while the ornithine-valine peptide alone yields predominantly sidechain condensation products with little stereoselectivity. Furthermore, the templating reaction is stable over a wide range of pH (5.6-8.6), salt concentration (0-4 M NaCl), and temperature (25-90 °C), making the amyloid an attractive model for a prebiotic peptide replicating system. [Mh] Termos MeSH primário: Aminoácidos/química Amiloide/química Técnicas de Química Sintética/métodos Peptídeos/química [Mh] Termos MeSH secundário: Sequência de Aminoácidos Aminoácidos/genética Aminoácidos/metabolismo Amiloide/metabolismo Amiloide/ultraestrutura Arginina/química Arginina/genética Arginina/metabolismo Concentração de Íons de Hidrogênio Microscopia Eletrônica Origem da Vida Biossíntese Peptídica/genética Peptídeos/genética Peptídeos/metabolismo Fenilalanina/química Fenilalanina/genética Fenilalanina/metabolismo Cloreto de Sódio/química Estereoisomerismo Temperatura Ambiente Moldes Genéticos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Amino Acids); 0 (Amyloid); 0 (Peptides); 451W47IQ8X (Sodium Chloride); 47E5O17Y3R (Phenylalanine); 94ZLA3W45F (Arginine) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180118 [St] Status: MEDLINE [do] DOI: 10.1038/s41467-017-02742-3

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[PMID]: 29248770 [Au] Autor: Hupert M; Elfgen A; Schartmann E; Schemmert S; Buscher B; Kutzsche J; Willbold D; Santiago-Schübel B [Ad] Endereço: Forschungszentrum Jülich GmbH, Central Institute for Engineering, Analytics (ZEA-3), Jülich, Germany. [Ti] Título: Development and validation of an UHPLC-ESI-QTOF-MS method for quantification of the highly hydrophilic amyloid-ß oligomer eliminating all-D-enantiomeric peptide RD2 in mouse plasma. [So] Source: J Chromatogr B Analyt Technol Biomed Life Sci;1073:123-129, 2018 Jan 15. [Is] ISSN: 1873-376X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: During preclinical drug development, a method for quantification of unlabeled compounds in blood plasma samples from treatment or pharmacokinetic studies in mice is required. In the current work, a rapid, specific, sensitive and validated liquid chromatography mass-spectrometric UHPLC-ESI-QTOF-MS method was developed for the quantification of the therapeutic compound RD2 in mouse plasma. RD2 is an all-D-enantiomeric peptide developed for the treatment of Alzheimer's disease, a progressive neurodegenerative disease finally leading to dementia. Due to RD2's highly hydrophilic properties, the sample preparation and the chromatographic separation and quantification were very challenging. The chromatographic separation of RD2 and its internal standard were accomplished on an Acquity UPLC BEH C18 column (2.1 × 100 mm, 1.7 µm particle size) within 6.5 min at 50 °C with a flow rate of 0.5 mL/min. Mobile phases consisted of water and acetonitrile with 1% formic acid and 0.025% heptafluorobutyric acid, respectively. Ions were generated by electrospray ionization (ESI) in the positive mode and the peptide was quantified by QTOF-MS. The developed extraction method for RD2 from mouse plasma revealed complete recovery. The linearity of the calibration curve was in the range of 5.3 ng/mL to 265 ng/mL (r > 0.999) with a lower limit of detection (LLOD) of 2.65 ng/mL and a lower limit of quantification (LLOQ) of 5.3 ng/mL. The intra-day and inter-day accuracy and precision of RD2 in plasma ranged from -0.54% to 2.21% and from 1.97% to 8.18%, respectively. Moreover, no matrix effects were observed and RD2 remained stable in extracted mouse plasma at different conditions. Using this validated bioanalytical method, plasma samples of unlabeled RD2 or placebo treated mice were analyzed. The herein developed UHPLC-ESI-QTOF-MS method is a suitable tool for the quantitative analysis of unlabeled RD2 in plasma samples of treated mice. [Mh] Termos MeSH primário: Peptídeos beta-Amiloides/sangue Cromatografia Líquida de Alta Pressão/métodos Espectrometria de Massas em Tandem/métodos [Mh] Termos MeSH secundário: Peptídeos beta-Amiloides/química Peptídeos beta-Amiloides/isolamento & purificação Animais Interações Hidrofóbicas e Hidrofílicas Limite de Detecção Modelos Lineares Masculino Camundongos Camundongos Transgênicos Oligonucleotídeos/isolamento & purificação Oligonucleotídeos/metabolismo Reprodutibilidade dos Testes Espectrometria de Massas por Ionização por Electrospray/métodos Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Amyloid beta-Peptides); 0 (Oligonucleotides) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171218 [St] Status: MEDLINE

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[PMID]: 28562088 [Au] Autor: Yoshida S; Suzuki T; Furuno H; Aboshi T; Murayama T; Koseki T; Shiono Y [Ad] Endereço: a Faculty of Agriculture, Department of Food, Life, and Environmental Science , Yamagata University , Yamagata , Japan. [Ti] Título: Spectroscopic characterisation of two polyketide metabolites from Cylindrocarpon sp. from driftwood. [So] Source: Nat Prod Res;32(1):60-64, 2018 Jan. [Is] ISSN: 1478-6427 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Two new polyketides, (5R,7R,9R)-7,9-dihydroxy-5-decanolide and (4E,6R,9R)- 6,9-dihydroxydec-4-enoic acid (2), were isolated from rice cultures of Cylindrocarpon sp. SY-39 discovered during screening of driftwood at a Shonai coast area in Yamagata, Japan. The structures of 1 and 2 were determined using a variety of spectroscopic methods. Compound 2 exhibited moderate antimicrobial activity against Staphylococcus aureus NBRC 13276 and Aspergillus clavatus F 318a at a concentration of 50 µg per disk. [Mh] Termos MeSH primário: Antibacterianos/farmacologia Antifúngicos/farmacologia Hypocreales/química Policetídeos/química [Mh] Termos MeSH secundário: Antibacterianos/química Antifúngicos/química Aspergillus/efeitos dos fármacos Japão Espectroscopia de Ressonância Magnética Estrutura Molecular Staphylococcus aureus/efeitos dos fármacos Estereoisomerismo Madeira/microbiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Polyketides) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170601 [St] Status: MEDLINE [do] DOI: 10.1080/14786419.2017.1332616

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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