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Pesquisa : G02.860.139 [Categoria DeCS]
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[PMID]:28464119
[Au] Autor:Cruz MA; McAnany S; Gupta N; Long RG; Nasser P; Eglin D; Hecht AC; Illien-Junger S; Iatridis JC
[Ad] Endereço:Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1188, New York, NY 10029.
[Ti] Título:Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks.
[So] Source:J Biomech Eng;139(8), 2017 Aug 01.
[Is] ISSN:1528-8951
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Annulus fibrosus (AF) defects from intervertebral disk (IVD) herniation and degeneration are commonly associated with back pain. Genipin-crosslinked fibrin hydrogel (FibGen) is an injectable, space-filling AF sealant that was optimized to match AF shear properties and partially restored IVD biomechanics. This study aimed to enhance mechanical behaviors of FibGen to more closely match AF compressive, tensile, and shear properties by adjusting genipin crosslink density and by creating a composite formulation by adding Poly(D,L-lactide-co-glycolide) (PDLGA). This study also evaluated effects of thrombin concentration and injection technique on gelation kinetics and adhesive strength. Increasing FibGen genipin concentration from 1 to 36 mg/mL significantly increased adhesive strength (∼5 to 35 kPa), shear moduli (∼10 to 110 kPa), and compressive moduli (∼25 to 150 kPa) with concentration-dependent effects, and spanning native AF properties. Adding PDLGA to FibGen altered the material microstructure on electron microscopy and nearly tripled adhesive strength, but did not increase tensile moduli, which remained nearly 5× below native AF, and had a small increase in shear moduli and significantly decreased compressive moduli. Increased thrombin concentration decreased gelation rate to < 5 min and injection methods providing a structural FibGen cap increased pushout strength by ∼40%. We conclude that FibGen is highly modifiable with tunable mechanical properties that can be formulated to be compatible with human AF compressive and shear properties and gelation kinetics and injection techniques compatible with clinical discectomy procedures. However, further innovations, perhaps with more efficient fiber reinforcement, will be required to enable FibGen to match AF tensile properties.
[Mh] Termos MeSH primário: Anel Fibroso/efeitos dos fármacos
Materiais Biocompatíveis/química
Materiais Biocompatíveis/farmacologia
Fibrina/química
Iridoides/química
[Mh] Termos MeSH secundário: Adesividade
Teste de Materiais
Fenômenos Mecânicos
Poliglactina 910/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Iridoids); 34346-01-5 (Polyglactin 910); 9001-31-4 (Fibrin); A3V2NE52YG (genipin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1115/1.4036623


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[PMID]:29172829
[Au] Autor:El Sharawy AM; Shukr MH; Elshafeey AH
[Ad] Endereço:a National Organization for Drug Control and Research (NODCAR) , Cairo , Egypt.
[Ti] Título:Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation.
[So] Source:Drug Deliv;24(1):1762-1769, 2017 Nov.
[Is] ISSN:1521-0464
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Duloxetine hydrochloride (DH) is a serotonin-norepinephrine reuptake inhibitor (SSNRI) indicated for the treatment of depression. Duloxetine suffers from reduced oral bioavailability (≈50%) due to hepatic metabolism. This study aims to develop DH buccoadhesive films to improve its bioavailability. DH buccoadhesive films were prepared adopting the solvent casting method using hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA). The prepared films were evaluated for weight uniformity, drug content, surface pH, swelling index, mucoadhesion strength and drug release percentages. Accelerated stability and bioavailability studies in healthy human volunteers were also performed for the selected films. Results of the evaluation tests showed that the optimum physicochemical characters were obtained by the films prepared with 2% HPMC using 10% propylene glycol (F2 films). Accelerated stability studies revealed that DH showed proved stability throughout the experiment time. DH bioavailability from F2 films was determined and compared with that of the marketed oral capsules (Cymbalta 30 mg). The pharmacokinetic results showed that C for F2 was higher than the market product. In addition, ANOVA analysis showed that a T of F2 film was significantly lower, while, the AUC of F2 was significantly higher than that of Cymbalta capsules. The percentage relative bioavailability of DH from F2 was found to be 296.39%. Therefore, the prepared buccal films offer an alternative route for the administration of DH with the possibility of improving its bioavailability.
[Mh] Termos MeSH primário: Cloridrato de Duloxetina/química
Cloridrato de Duloxetina/metabolismo
[Mh] Termos MeSH secundário: Adesividade
Administração Bucal
Animais
Disponibilidade Biológica
Química Farmacêutica/métodos
Galinhas/metabolismo
Estudos Cross-Over
Sistemas de Liberação de Medicamentos/métodos
Liberação Controlada de Fármacos/fisiologia
Seres Humanos
Derivados da Hipromelose/química
Mucosa Bucal/metabolismo
Álcool de Polivinil/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
3NXW29V3WO (Hypromellose Derivatives); 9002-89-5 (Polyvinyl Alcohol); 9044SC542W (Duloxetine Hydrochloride)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1080/10717544.2017.1402216


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[PMID]:28832260
[Au] Autor:Davoudi Z; Rabiee M; Houshmand B; Eslahi N; Khoshroo K; Rasoulianboroujeni M; Tahriri M; Tayebi L
[Ad] Endereço:a Biomaterials Group, Faculty of Biomedical Engineering , Amirkabir University of Technology , Tehran , Iran.
[Ti] Título:Development of chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate as a buccal mucoadhesive patch to treat desquamative gingivitis.
[So] Source:Drug Dev Ind Pharm;44(1):40-55, 2018 Jan.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this research was to develop chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate as a buccal mucoadhesive patch to treat desquamative gingivitis, which was fabricated through an environmental friendly process. Mucoadhesive films increase the advantage of higher efficiency and drug localization in the affected region. In this research, mucoadhesive films, for the release of hydrocortisone sodium succinate, were prepared using different ratios of chitosan, gelatin and keratin. In the first step, chitosan and gelatin proportions were optimized after evaluating the mechanical properties, swelling capacity, water uptake, stability, and biodegradation of the films. Then, keratin was added at different percentages to the optimum composite of chitosan and gelatin together with the drug. The results of surface pH showed that none of the samples were harmful to the buccal cavity. FTIR analysis confirmed the influence of keratin on the structure of the composite. The presence of a higher amount of keratin in the composite films resulted in high mechanical, mucoadhesive properties and stability, low water uptake and biodegradation in phosphate buffer saline (pH = 7.4) containing 10 U/ml lysozyme. The release profile of the films ascertained that keratin is a rate controller in the release of the hydrocortisone sodium succinate. Finally, chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate can be employed in dental applications.
[Mh] Termos MeSH primário: Quitosana/química
Gelatina/química
Gengivite/tratamento farmacológico
Hidrocortisona/análogos & derivados
Hidrocortisona/química
Queratinas/química
Succinatos/química
[Mh] Termos MeSH secundário: Adesividade
Hidrocortisona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Succinates); 68238-35-7 (Keratins); 9000-70-8 (Gelatin); 9012-76-4 (Chitosan); LIU00Z1Z84 (cortisol succinate); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1371738


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[PMID]:27770631
[Au] Autor:Guo J; Kim GB; Shan D; Kim JP; Hu J; Wang W; Hamad FG; Qian G; Rizk EB; Yang J
[Ad] Endereço:Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
[Ti] Título:Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives.
[So] Source:Biomaterials;112:275-286, 2017 01.
[Is] ISSN:1878-5905
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:For the first time, a convenient copper-catalyzed azide-alkyne cycloaddition (CuAAC, click chemistry) was successfully introduced into injectable citrate-based mussel-inspired bioadhesives (iCMBAs, iCs) to improve both cohesive and wet adhesive strengths and elongate the degradation time, providing numerous advantages in surgical applications. The major challenge in developing such adhesives was the mutual inhibition effect between the oxidant used for crosslinking catechol groups and the Cu(II) reductant used for CuAAC, which was successfully minimized by adding a biocompatible buffering agent typically used in cell culture, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), as a copper chelating agent. Among the investigated formulations, the highest adhesion strength achieved (223.11 ± 15.94 kPa) was around 13 times higher than that of a commercially available fibrin glue (15.4 ± 2.8 kPa). In addition, dual-crosslinked (i.e. click crosslinking and mussel-inspired crosslinking) iCMBAs still preserved considerable antibacterial and antifungal capabilities that are beneficial for the bioadhesives used as hemostatic adhesives or sealants for wound management.
[Mh] Termos MeSH primário: Adesivos/administração & dosagem
Anti-Infecciosos/administração & dosagem
Fenômenos Fisiológicos Bacterianos/efeitos dos fármacos
Materiais Biomiméticos/síntese química
Bivalves/química
Ácido Cítrico/administração & dosagem
Ácido Cítrico/síntese química
[Mh] Termos MeSH secundário: Adesividade
Adesivos/química
Animais
Anti-Infecciosos/síntese química
Materiais Biomiméticos/administração & dosagem
Química Click/métodos
Desenho de Drogas
Teste de Materiais
Molhabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Adhesives); 0 (Anti-Infective Agents); 2968PHW8QP (Citric Acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180106
[Lr] Data última revisão:
180106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:28740040
[Au] Autor:Kawano Y; Otsu S; Bamba T; Hanawa T
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Tokyo University of Science.
[Ti] Título:[Study of Interaction between Fluorinated Coating Glass and the Medicines].
[So] Source:Yakugaku Zasshi;137(11):1409-1417, 2017 Nov 01.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The adsorption of active pharmaceutical ingredients on the surface of medical devices such as polyvinl chloride, ethylene-vinyl acetate copolymer and glass often prevent the acuurate dose of drug. At dispensing of pharmaceuticals, mètre glass (MG) has been widely used for dispensing syrup. When measuring the viscous syrup, it often takes long time to dispense the accurate volume due to their adhesiveness on the glass surface. In this study, we investigate the adhesion of various syrups to MG made with uncoated glass or glass with a strongly hydrophobic silicone or fluorinated coating in terms of the following formulation parameters: viscosity, surface tension, contact angle, and surface free energy. The contact angles for syrups on the coated glass surfaces were significantly higher than those on the uncoated glass surface. In addition, the relationship between surface tension and contact angle was examined. We found that the contact angle was independent of surface tension for the uncoated glass, while it increased with increasing surface tension for the coated glasses. These results can be explained as follows: the silicone or fluorinated coatings inhibit the hydrogen bonding that usually takes place between water and silanol and siloxane groups at glass surfaces. The coatings reduced the surface free energy and increased the hydrophobicity of the glass, reduced its wettability by the syrups, and thus reduced the adhesion loss for the syrups. It was considered that as for the hydrophobic action, properties of matter of sample influence the coated device by coating in order that it is reinforced.
[Mh] Termos MeSH primário: Adesividade
Formas de Dosagem
Polímeros de Fluorcarboneto
Vidro
Interações Hidrofóbicas e Hidrofílicas
Propriedades de Superfície
[Mh] Termos MeSH secundário: Ligações de Hidrogênio
Silanos
Silicones
Siloxanas
Viscosidade
Água
Molhabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dosage Forms); 0 (Fluorocarbon Polymers); 0 (Silanes); 0 (Silicones); 0 (Siloxanes); 059QF0KO0R (Water); 079V3J9O3X (silanol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00108


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[PMID]:28867712
[Au] Autor:Kondo H; Toyota H; Kamiya T; Yamashita K; Hakomori T; Imoto J; Kimura SI; Iwao Y; Itai S
[Ad] Endereço:Pharmaceutical Research and Technology Laboratories, Astellas Pharma Inc.
[Ti] Título:Effect of the External Lubrication Method for a Rotary Tablet Press on the Adhesion of the Film Coating Layer.
[So] Source:Chem Pharm Bull (Tokyo);65(9):848-853, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:External lubrication is a useful method which reduces the adhesion of powder to punches and dies by spraying lubricants during the tableting process. However, no information is available on whether the tablets prepared using an external lubrication system can be applicable for a film coating process. In this study, we evaluated the adhesion force of the film coating layer to the surface of tablets prepared using an external lubrication method, compared with those prepared using internal lubrication method. We also evaluated wettability, roughness and lubricant distribution state on the tablet surface before film coating, and investigated the relationship between peeling of the film coating layer and these tablet surface properties. Increasing lubrication through the external lubrication method decreased wettability of the tablet surface. However, no change was observed in the adhesion force of the film coating layer. On the other hand, increasing lubrication through the internal lubrication method, decreased both wettability of the tablet surface and the adhesion force of the film coating layer. The magnesium stearate distribution state on the tablet surface was assessed using an X-ray fluorescent analyzer and lubricant agglomerates were observed in the case of the internal lubrication method. However, the lubricant was uniformly dispersed in the external lubrication samples. These results indicate that the distribution state of the lubricant affects the adhesion force of the film coating layer, and external lubrication maintained sufficient lubricity and adhesion force of the film coating layer with a small amount of lubricant.
[Mh] Termos MeSH primário: Comprimidos/química
Tecnologia Farmacêutica/métodos
[Mh] Termos MeSH secundário: Adesividade
Lubrificantes/química
Ácidos Esteáricos/química
Propriedades de Superfície
Molhabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lubricants); 0 (Stearic Acids); 0 (Tablets); 4ELV7Z65AP (stearic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00376


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[PMID]:28865959
[Au] Autor:Liu X; Liang C; Zhang X; Li J; Huang J; Zeng L; Ye Z; Hu B; Wu W
[Ad] Endereço:Department of Chemistry and Biology, College of Science, National University of Defense Technology, Changsha, 410073, China.
[Ti] Título:Amyloid fibril aggregation: An insight into the underwater adhesion of barnacle cement.
[So] Source:Biochem Biophys Res Commun;493(1):654-659, 2017 Nov 04.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Barnacles robustly adhere themselves to diverse submarine substrates through a proteinaceous complex termed the "barnacle cement". Previous studies have indicated that certain peptides derived from some barnacle cement proteins can self-assemble into amyloid fibrils. In this study, we assessed the self-assembly behavior of a full-length 19 kDa cement protein from Balanus albicostatus (Balcp19k) in different buffers. Results of Thioflavin T binding assay, transmission electron microscopy, and Fourier transform infrared spectroscopy suggested that the bacterial recombinant Balcp19k was able to aggregate into typical amyloid fibrils. The time required for the self-assembly process was close to that required for the complete curing of barnacle cement complex. Moreover, the solubility of Balcp19k amyloid deposits in guanidine hydrochloride and urea was same as that of the cured cement. These results indicated the inherent self-assembling nature of Balcp19k, implying that the amyloid fibril formation plays a critical role in barnacle cement curing procedure and its insolubility. Our results should be conducive to understanding barnacle underwater adhesion mechanisms and have implications in the development of new-generation antifouling techniques and in the designing of novel wet adhesives for biomedical and technical applications.
[Mh] Termos MeSH primário: Amiloide/química
Amiloide/metabolismo
Proteínas de Artrópodes/química
Proteínas de Artrópodes/metabolismo
Thoracica/química
Thoracica/metabolismo
[Mh] Termos MeSH secundário: Adesividade
Adesivos
Animais
Ligação Proteica
Tiazóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adhesives); 0 (Amyloid); 0 (Arthropod Proteins); 0 (Thiazoles); 2390-54-7 (thioflavin T)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170904
[St] Status:MEDLINE


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[PMID]:28832132
[Au] Autor:Kyne C; Crowley PB
[Ad] Endereço:School of Chemistry, National University of Ireland Galway , University Road, Galway, H91 TK33, Ireland.
[Ti] Título:Short Arginine Motifs Drive Protein Stickiness in the Escherichia coli Cytoplasm.
[So] Source:Biochemistry;56(37):5026-5032, 2017 Sep 19.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although essential to numerous biotech applications, knowledge of molecular recognition by arginine-rich motifs in live cells remains limited. H, N HSQC and F NMR spectroscopies were used to investigate the effects of C-terminal -GR (n = 1-5) motifs on GB1 interactions in Escherichia coli cells and cell extracts. While the "biologically inert" GB1 yields high-quality in-cell spectra, the -GR fusions with n = 4 or 5 were undetectable. This result suggests that a tetra-arginine motif is sufficient to drive interactions between a test protein and macromolecules in the E. coli cytoplasm. The inclusion of a 12 residue flexible linker between GB1 and the -GR motif did not improve detection of the "inert" domain. In contrast, all of the constructs were detectable in cell lysates and extracts, suggesting that the arginine-mediated complexes were weak. Together these data reveal the significance of weak interactions between short arginine-rich motifs and the E. coli cytoplasm and demonstrate the potential of such motifs to modify protein interactions in living cells. These interactions must be considered in the design of (in vivo) nanoscale assemblies that rely on arginine-rich sequences.
[Mh] Termos MeSH primário: Arginina/química
Citoplasma/metabolismo
Proteínas de Escherichia coli/metabolismo
Escherichia coli/metabolismo
GTP Fosfo-Hidrolases/metabolismo
Modelos Moleculares
Fosfoproteínas/metabolismo
[Mh] Termos MeSH secundário: Adesividade
Motivos de Aminoácidos
Extratos Celulares/química
Fenômenos Químicos
Cromatografia em Gel
Proteínas de Escherichia coli/química
Proteínas de Escherichia coli/genética
GTP Fosfo-Hidrolases/química
GTP Fosfo-Hidrolases/genética
Proteínas Intrinsicamente Desordenadas/química
Proteínas Intrinsicamente Desordenadas/genética
Proteínas Intrinsicamente Desordenadas/metabolismo
Peso Molecular
Isótopos de Nitrogênio
Ressonância Magnética Nuclear Biomolecular
Oligopeptídeos/química
Oligopeptídeos/genética
Oligopeptídeos/metabolismo
Fosfoproteínas/química
Fosfoproteínas/genética
Domínios e Motivos de Interação entre Proteínas
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Extracts); 0 (Escherichia coli Proteins); 0 (Intrinsically Disordered Proteins); 0 (Nitrogen Isotopes); 0 (Oligopeptides); 0 (Phosphoproteins); 0 (Recombinant Fusion Proteins); 94ZLA3W45F (Arginine); EC 3.6.1.- (GTP Phosphohydrolases); EC 3.6.1.- (typA protein, E coli)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00731


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[PMID]:28665152
[Au] Autor:Çelik B; Özdemir S; Barla Demirkoz A; Üner M
[Ad] Endereço:a Department of Pharmaceutical Technology , Bezmialem Vakif University , Fatih, Istanbul , Turkey.
[Ti] Título:Optimization of piribedil mucoadhesive tablets for efficient therapy of Parkinson's disease: physical characterization and ex vivo drug permeation through buccal mucosa.
[So] Source:Drug Dev Ind Pharm;43(11):1836-1845, 2017 Nov.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was optimization of buccal piribedil (PR) mucoadhesive tablets to improve its low bioavailability and provide controlled release for the treatment of Parkinson's disease. METHODS: Buccal tablets were prepared by direct compression method using carbomer (CP), carboxymethyl cellulose (CMC), and hydroxypropyl methylcellulose (HPMC) as mucoadhesive polymers. Physical properties of powder mixtures and buccal tablets were evaluated. Physicochemical compatibility between ingredients was investigated with infrared spectroscopy and differential scanning calorimetry analysis. In vitro dissolution profiles and drug release kinetics of buccal tablets were investigated. Mucoadhesion and ex vivo permeation studies were performed using sheep buccal mucosa. RESULTS: Powder mixtures demonstrated sufficient flow properties and physical characteristics of all tablet formulations were within compendia limits. Tablet ingredients were absent of any chemical interactions. CP tablets displayed slower drug release compared to HPMC tablets with zero order release, while CMC tablets lost their integrity and released entire drug after 6 h following Higuchi model. All formulations displayed adequate mucoadhesion and steady state flux of PR through buccal mucosa were higher with HPMC compared to CP-containing tablets. CONCLUSION: Overall, HPMC was found to combine desired controlled release and mucoadhesion characteristics with sufficient pharmaceutical quality for optimization of buccal tablets. Piribedil mucoadhesive buccal tablets designed for the first time may introduce a new alternative for the treatment of Parkinson's disease.
[Mh] Termos MeSH primário: Resinas Acrílicas/química
Varredura Diferencial de Calorimetria/métodos
Derivados da Hipromelose/química
Mucosa Bucal/química
Doença de Parkinson/metabolismo
Doença de Parkinson/fisiopatologia
Piribedil/administração & dosagem
Piribedil/metabolismo
Comprimidos/química
[Mh] Termos MeSH secundário: Adesividade
Administração Bucal
Animais
Química Farmacêutica
Preparações de Ação Retardada
Piribedil/química
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Delayed-Action Preparations); 0 (Tablets); 0 (carbomer); 3NXW29V3WO (Hypromellose Derivatives); DO22K1PRDJ (Piribedil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1349785


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[PMID]:28617467
[Au] Autor:Baik S; Kim DW; Park Y; Lee TJ; Ho Bhang S; Pang C
[Ad] Endereço:School of Chemical Engineering, Sungkyunkwan University, Suwon, Kyunggi-do 16419, South Korea.
[Ti] Título:A wet-tolerant adhesive patch inspired by protuberances in suction cups of octopi.
[So] Source:Nature;546(7658):396-400, 2017 06 14.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Adhesion strategies that rely on mechanical interlocking or molecular attractions between surfaces can suffer when coming into contact with liquids. Thus far, artificial wet and dry adhesives have included hierarchical mushroom-shaped or porous structures that allow suction or capillarity, supramolecular structures comprising nanoparticles, and chemistry-based attractants that use various protein polyelectrolytes. However, it is challenging to develop adhesives that are simple to make and also perform well-and repeatedly-under both wet and dry conditions, while avoiding non-chemical contamination on the adhered surfaces. Here we present an artificial, biologically inspired, reversible wet/dry adhesion system that is based on the dome-like protuberances found in the suction cups of octopi. To mimic the architecture of these protuberances, we use a simple, solution-based, air-trap technique that involves fabricating a patterned structure as a polymeric master, and using it to produce a reversed architecture, without any sophisticated chemical syntheses or surface modifications. The micrometre-scale domes in our artificial adhesive enhance the suction stress. This octopus-inspired system exhibits strong, reversible, highly repeatable adhesion to silicon wafers, glass, and rough skin surfaces under various conditions (dry, moist, under water and under oil). To demonstrate a potential application, we also used our adhesive to transport a large silicon wafer in air and under water without any resulting surface contamination.
[Mh] Termos MeSH primário: Adesividade
Adesivos/química
Materiais Biomiméticos/química
Octopodiformes/anatomia & histologia
Polímeros/química
Adesivo Transdérmico
Molhabilidade
[Mh] Termos MeSH secundário: Animais
Biomimética
Pele
Suínos
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adhesives); 0 (Polymers); 059QF0KO0R (Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1038/nature22382



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