Base de dados : MEDLINE
Pesquisa : G03.015.500.374 [Categoria DeCS]
Referências encontradas : 199 [refinar]
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  1 / 199 MEDLINE  
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[PMID]:29254319
[Au] Autor:Musolino V; Gliozzi M; Carresi C; Maiuolo J; Mollace R; Bosco F; Scarano F; Scicchitano M; Maretta A; Palma E; Iannone M; Morittu VM; Gratteri S; Muscoli C; Fini M; Mollace V
[Ad] Endereço:Institute of Research for Food Safety and Health (IRC-FSH), Department of Health Science, Magna Græcia University of Catanzaro, Catanzaro, Italy.
[Ti] Título:Lipid-lowering effect of bergamot polyphenolic fraction: role of pancreatic cholesterol ester hydrolase.
[So] Source:J Biol Regul Homeost Agents;31(4):1087-1093, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Bergamot polyphenolic fraction (BPF) has been shown to positively modulate several mechanisms involved in metabolic syndrome, suggesting its use in therapy. In particular, it is able to induce a significant amelioration of serum lipid profile in hyperlipemic patients at different levels. The purpose of our study was to investigate the effect of BPF on cholesterol absorption physiologically mediated by pancreatic cholesterol ester hydrolase (pCEH). An in vitro activity assay was performed to study the effect of BPF on pCEH, whereas the rate of cholesterol absorption was evaluated through in vivo studies. In particular, male, Sprague-Dawley rats (200–225 g) were fed either normal chow or chow supplemented with 0.5% cholic acid, 5.5% peanut oil, and varying amounts of cholesterol (0 to 1.5%). BPF (10 mg/Kg) was daily administrated by means of a gastric gavage to animals fed with lipid supplemented diet for 4 weeks and, at the end of the study, plasma lipids and liver cholesteryl esters were measured in all experimental groups. Our results show that BPF was able to inhibit pCEH activity and this effect was confirmed, in vivo, via detection of lymphatic cholesteryl ester in rats fed with a cholesterol-rich diet. This evidence clarifies a further mechanism responsible for the hypolipemic properties of BPF previously observed in humans, confirming its beneficial effect in the therapy of hypercholesterolemia and in the treatment of metabolic syndrome.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Hiperlipidemias/tratamento farmacológico
Hipolipemiantes/farmacologia
Óleos Vegetais/farmacologia
Esterol Esterase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Colesterol/administração & dosagem
Colesterol/sangue
Ésteres do Colesterol/sangue
Ácido Cólico/administração & dosagem
Ácido Cólico/sangue
Absorção Gastrointestinal/fisiologia
Seres Humanos
Hiperlipidemias/metabolismo
Hiperlipidemias/patologia
Hipolipemiantes/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Síndrome Metabólica/tratamento farmacológico
Síndrome Metabólica/metabolismo
Síndrome Metabólica/patologia
Óleos Vegetais/metabolismo
Ratos
Ratos Sprague-Dawley
Esterol Esterase/metabolismo
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholesterol Esters); 0 (Hypolipidemic Agents); 0 (Plant Oils); 0 (Triglycerides); 39W1PKE3JI (bergamot oil); 97C5T2UQ7J (Cholesterol); EC 3.1.1.- (bile salt-stimulated lipase); EC 3.1.1.13 (Sterol Esterase); G1JO7801AE (Cholic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  2 / 199 MEDLINE  
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[PMID]:28562300
[Au] Autor:Heyman MB; Abrams SA; SECTION ON GASTROENTEROLOGY, HEPATOLOGY, AND NUTRITION; COMMITTEE ON NUTRITION
[Ti] Título:Fruit Juice in Infants, Children, and Adolescents: Current Recommendations.
[So] Source:Pediatrics;139(6), 2017 Jun.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Historically, fruit juice was recommended by pediatricians as a source of vitamin C and as an extra source of water for healthy infants and young children as their diets expanded to include solid foods with higher renal solute load. It was also sometimes recommended for children with constipation. Fruit juice is marketed as a healthy, natural source of vitamins and, in some instances, calcium. Because juice tastes good, children readily accept it. Although juice consumption has some benefits, it also has potential detrimental effects. High sugar content in juice contributes to increased calorie consumption and the risk of dental caries. In addition, the lack of protein and fiber in juice can predispose to inappropriate weight gain (too much or too little). Pediatricians need to be knowledgeable about juice to inform parents and patients on its appropriate uses.
[Mh] Termos MeSH primário: Carboidratos da Dieta/farmacocinética
Sucos de Frutas e Vegetais
Absorção Gastrointestinal
[Mh] Termos MeSH secundário: Adolescente
Criança
Fenômenos Fisiológicos da Nutrição Infantil
Pré-Escolar
Diarreia/etiologia
Dieta
Ingestão de Energia
Sucos de Frutas e Vegetais/efeitos adversos
Seres Humanos
Lactente
Pediatria
Estados Unidos
[Pt] Tipo de publicação:GUIDELINE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Carbohydrates)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171112
[Lr] Data última revisão:
171112
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE


  3 / 199 MEDLINE  
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[PMID]:28420125
[Au] Autor:Pepe G; Pagano F; Adesso S; Sommella E; Ostacolo C; Manfra M; Chieppa M; Sala M; Russo M; Marzocco S; Campiglia P
[Ad] Endereço:Department of Pharmacy, School of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano, Italy. gipepe@unisa.it.
[Ti] Título:Bioavailable Citrus sinensis Extract: Polyphenolic Composition and Biological Activity.
[So] Source:Molecules;22(4), 2017 Apr 15.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:plants contain large amounts of flavonoids with beneficial effects on human health. In the present study, the antioxidant and anti-inflammatory potential of bioavailable polyphenols from was evaluated in vitro and ex vivo, using the murine macrophages cell line J774A.1 and primary peritoneal macrophages. Following simulated gastro-intestinal digestion, the in vitro bioavailability of polyphenolic extract was assessed using the human cell line Caco-2 grown as monolayers on a transwell membrane. Data demonstrated a relative permeation of its compounds (8.3%). Thus, the antioxidant and anti-inflammatory effect of polyphenolic fraction (Cs) was compared to the bioavailable one (CsB). Results revealed that extract were able to reduce macrophages pro-inflammatory mediators, including nitric oxide, iNOS, COX-2 and different cytokines. Moreover, the effect of polyphenols was associated with antioxidant effects, such as a reduction of reactive oxygen species (ROS) and heme-oxygenase-1 (HO-1) increased expression. Our results provide evidence that the bioavailable polyphenolic constituents of the extract accumulate prevalently at intestinal level and could reach systemic circulation exerting their effect. The bioavailable fraction showed a higher anti-inflammatory and antioxidant potential compared to the initial extract, thus highlighting its potential nutraceutical value.
[Mh] Termos MeSH primário: Citrus sinensis/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios
Antioxidantes
Sobrevivência Celular/efeitos dos fármacos
Ciclo-Oxigenase 2/metabolismo
Citocinas/biossíntese
Flavonoides/química
Flavonoides/farmacologia
Sucos de Frutas e Vegetais
Absorção Gastrointestinal
Heme Oxigenase-1/metabolismo
Seres Humanos
Mediadores da Inflamação/metabolismo
Lipopolissacarídeos/imunologia
Macrófagos Peritoneais/efeitos dos fármacos
Macrófagos Peritoneais/imunologia
Macrófagos Peritoneais/metabolismo
Camundongos
Óxido Nítrico Sintase Tipo II/metabolismo
Compostos Fitoquímicos/química
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacocinética
Polifenóis/química
Polifenóis/farmacologia
Transporte Proteico
Espécies Reativas de Oxigênio/metabolismo
Análise Espectral
Fator de Transcrição RelA/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cytokines); 0 (Flavonoids); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Polyphenols); 0 (Reactive Oxygen Species); 0 (Transcription Factor RelA); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


  4 / 199 MEDLINE  
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[PMID]:28407909
[Au] Autor:Kuck LS; Wesolowski JL; Noreña CP
[Ad] Endereço:Institute of Food Science and Technology, Federal University of Rio Grande do Sul, Av. Bento Gonçalves, 9500, CEP 91501-970 Porto Alegre, RS, Brazil.
[Ti] Título:Effect of temperature and relative humidity on stability following simulated gastro-intestinal digestion of microcapsules of Bordo grape skin phenolic extract produced with different carrier agents.
[So] Source:Food Chem;230:257-264, 2017 Sep 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The stability of microparticles of Bordo grape skin aqueous extract, produced by spray-drying and freeze-drying using polydextrose (5%) and partially hydrolyzed guar gum (5%), was evaluated under accelerated conditions (75 and 90% relative humidity, at 35, 45, and 55°C for 35days) and simulated gastrointestinal digestion. The temperature had a significant effect on the reduction of phenolics content, with retentions varying from 82.5 to 93.5%. The retention of total monomer anthocyanins were in the range of 3.9-42.3%. The antioxidant activity had a final retention of 38.5-59.5%. In the simulated gastrointestinal digestion, a maximum release was observed for the phenolic compounds in the intestinal phase (90.6% for the spray-dried powder and 94.9% for the freeze-dried powder), as well as the antioxidant activity (69.4% for the spray-dried powder and 67.8% for the freeze-dried powder). However, a reduction of monomeric anthocyanins was observed in the intestinal phase.
[Mh] Termos MeSH primário: Antocianinas/química
Absorção Gastrointestinal/fisiologia
Fenóis/química
Vitis/química
[Mh] Termos MeSH secundário: Antioxidantes
Cápsulas
Liofilização
Umidade
Fenóis/análise
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Antioxidants); 0 (Capsules); 0 (Phenols)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


  5 / 199 MEDLINE  
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[PMID]:28389273
[Au] Autor:Kirman CR; Suh M; Proctor DM; Hays SM
[Ad] Endereço:Summit Toxicology, PO Box 3209, Bozeman, MT 59715, United States. Electronic address: ckirman@summittoxicology.com.
[Ti] Título:Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations.
[So] Source:Toxicol Appl Pharmacol;325:9-17, 2017 Jun 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A physiologically based pharmacokinetic (PBPK) model for hexavalent chromium [Cr(VI)] in mice, rats, and humans developed previously (Kirman et al., 2012, 2013), was updated to reflect an improved understanding of the toxicokinetics of the gastrointestinal tract following oral exposures. Improvements were made to: (1) the reduction model, which describes the pH-dependent reduction of Cr(VI) to Cr(III) in the gastrointestinal tract under both fasted and fed states; (2) drinking water pattern simulations, to better describe dosimetry in rodents under the conditions of the NTP cancer bioassay; and (3) parameterize the model to characterize potentially sensitive human populations. Important species differences, sources of non-linear toxicokinetics, and human variation are identified and discussed within the context of human health risk assessment.
[Mh] Termos MeSH primário: Cromo/farmacocinética
Modelos Biológicos
Poluentes da Água/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Adolescente
Adulto
Fatores Etários
Idoso
Animais
Criança
Pré-Escolar
Cromo/administração & dosagem
Cromo/toxicidade
Ritmo Circadiano
Ingestão de Líquidos
Absorção Gastrointestinal
Trato Gastrointestinal/metabolismo
Seres Humanos
Concentração de Íons de Hidrogênio
Lactente
Recém-Nascido
Camundongos
Meia-Idade
Dinâmica não Linear
Ratos
Medição de Risco
Especificidade da Espécie
Poluentes da Água/administração & dosagem
Poluentes da Água/toxicidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants); 0R0008Q3JB (Chromium); 18540-29-9 (chromium hexavalent ion)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170409
[St] Status:MEDLINE


  6 / 199 MEDLINE  
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[PMID]:28322896
[Au] Autor:Gonçalves D; Alves G; Fortuna A; Soares-da-Silva P; Falcão A
[Ad] Endereço:Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.
[Ti] Título:Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.
[So] Source:Toxicol Appl Pharmacol;323:9-15, 2017 May 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Opicapone is a novel potent, reversible and purely peripheral catechol-O-methyltransferase inhibitor that has been developed to be used as an adjunct to levodopa/aromatic L-amino acid decarboxylase inhibitor therapy for Parkinson's disease. Thus, this study aimed to compare the plasma pharmacokinetics of opicapone and its active metabolite (BIA 9-1079) after the administration of single and multiple oral doses to rats. Wistar rats (n=8 per group) were orally treated with single (30, 60 or 90mg/kg) or multiple (30mg/kg once-daily for seven consecutive days) oral doses of opicapone. Blood samples were collected up to 24h post-dosing through a cannula introduced in the tail vein of rats. After quantifying opicapone and BIA 9-1079 in plasma, a non-compartmental pharmacokinetic analysis was performed. Opicapone was quickly absorbed (time to reach the maximum plasma concentration≤2h) in both dosage regimens and the extent of systemic exposure to opicapone increased approximately in a dose-proportional manner after single-dosing within the studied dose range (30-90mg/kg). Opicapone and BIA 9-1079 showed a relatively short plasma elimination half-life (1.58-4.50h) and a small systemic accumulation after multiple-dosing. Hence, no pharmacokinetic concerns are expected when opicapone is administered with a once-daily dosing regimen.
[Mh] Termos MeSH primário: Inibidores de Catecol O-Metiltransferase/administração & dosagem
Inibidores de Catecol O-Metiltransferase/farmacocinética
Oxidiazóis/administração & dosagem
Oxidiazóis/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Animais
Área Sob a Curva
Inibidores de Catecol O-Metiltransferase/sangue
Inibidores de Catecol O-Metiltransferase/toxicidade
Esquema de Medicação
Absorção Gastrointestinal
Meia-Vida
Masculino
Taxa de Depuração Metabólica
Modelos Biológicos
Oxidiazóis/sangue
Oxidiazóis/toxicidade
Ratos Wistar
Medição de Risco
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechol O-Methyltransferase Inhibitors); 0 (Oxadiazoles); Y5929UIJ5N (opicapone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE


  7 / 199 MEDLINE  
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[PMID]:28322405
[Au] Autor:Oliveira H; Cai X; Zhang Q; de Freitas V; Mateus N; He J; Fernandes I
[Ad] Endereço:REQUIMTE/LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal. iva.fernandes@fc.up.pt.
[Ti] Título:Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells.
[So] Source:Food Funct;8(4):1672-1679, 2017 Apr 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The gastrointestinal absorption of the main carotenoids present in Gardenia jasminoides Ellis, crocetin, crocin-1 and crocin-2, was assayed through transport studies on MKN-28 and Caco-2 cell lines. Overall, crocetin was the compound that presented the highest gastrointestinal transport efficiency. Additionally, and since after absorption crocins are metabolized into crocetin, the antiproliferative capacity of crocetin was assayed in MKN-28 (stomach), MCF-7 (breast) and Caco-2 (colon) cancer cell lines. The results point to an antiproliferative effect of crocetin on the three cell lines tested. Anti-inflammatory properties were also assayed. Overall, crocetin showed a potential involvement in the downregulation of IL-1ß and TNF-α but not IL-6. Altogether, these results suggest that these compounds can have an important role against cancer proliferation, highlighting the importance of Gardenia jasminoides Ellis as a nutraceutical food source.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacocinética
Carotenoides/farmacocinética
Proliferação Celular/efeitos dos fármacos
Gardenia/química
Absorção Gastrointestinal/efeitos dos fármacos
Extratos Vegetais/farmacocinética
[Mh] Termos MeSH secundário: Anti-Inflamatórios/farmacologia
Carotenoides/farmacologia
Linhagem Celular Tumoral
Frutas/química
Seres Humanos
Interleucina-6/genética
Interleucina-6/metabolismo
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Interleukin-6); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00091j


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[PMID]:28282870
[Au] Autor:Borel P; Desmarchelier C
[Ad] Endereço:NORT, Aix-Marseille Université, INRA, INSERM, 13005 Marseille, France. patrick.borel@univ-amu.fr.
[Ti] Título:Genetic Variations Associated with Vitamin A Status and Vitamin A Bioavailability.
[So] Source:Nutrients;9(3), 2017 Mar 08.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Blood concentration of vitamin A (VA), which is present as different molecules, i.e., mainly retinol and provitamin A carotenoids, plus retinyl esters in the postprandial period after a VA-containing meal, is affected by numerous factors: dietary VA intake, VA absorption efficiency, efficiency of provitamin A carotenoid conversion to VA, VA tissue uptake, etc. Most of these factors are in turn modulated by genetic variations in genes encoding proteins involved in VA metabolism. Genome-wide association studies (GWAS) and candidate gene association studies have identified single nucleotide polymorphisms (SNPs) associated with blood concentrations of retinol and ß-carotene, as well as with ß-carotene bioavailability. These genetic variations likely explain, at least in part, interindividual variability in VA status and in VA bioavailability. However, much work remains to be done to identify all of the SNPs involved in VA status and bioavailability and to assess the possible involvement of other kinds of genetic variations, e.g., copy number variants and insertions/deletions, in these phenotypes. Yet, the potential usefulness of this area of research is exciting regarding the proposition of more personalized dietary recommendations in VA, particularly in populations at risk of VA deficiency.
[Mh] Termos MeSH primário: Estudos de Associação Genética
Polimorfismo de Nucleotídeo Único
Vitamina A/sangue
Vitamina A/farmacocinética
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Variações do Número de Cópias de DNA
Dieta
Absorção Gastrointestinal
Seres Humanos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Período Pós-Prandial
Recomendações Nutricionais
Vitamina A/administração & dosagem
Deficiência de Vitamina A/sangue
Deficiência de Vitamina A/genética
Deficiência de Vitamina A/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
11103-57-4 (Vitamin A)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


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[PMID]:28254113
[Au] Autor:Xu WK; Jiang H; Yang K; Wang YQ; Zhang Q; Zuo J
[Ad] Endereço:Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, China.
[Ti] Título:Development and in vivo evaluation of self-microemulsion as delivery system for α-mangostin.
[So] Source:Kaohsiung J Med Sci;33(3):116-123, 2017 Mar.
[Is] ISSN:1607-551X
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:eng
[Ab] Resumo:α-Mangostin (MG) is a versatile bioactive compound isolated from mangosteen and possesses significant pharmacokinetic shortages. To augment the potential clinical efficacy, MG-loaded self-microemulsion (MG-SME) was designed and prepared in this study, and its potential as a drug loading system was evaluated based on the pharmacokinetic performance and tissue distribution feature. The formula of MG-SME was optimized by an orthogonal test under the guidance of ternary phase diagram, and the prepared MG-SME was characterized by encapsulation efficiency, size distribution, and morphology. Optimized high performance liquid chromatography method was employed to determine concentrations of MG and characterize the pharmacokinetic and tissue distribution features of MG in rodents. It was found that diluted MG-SME was characterized as spherical particles with a mean diameter of 24.6 nm and an encapsulation efficiency of 87.26%. The delivery system enhanced the area under the curve of MG by 4.75 times and increased the distribution in lymphatic organs. These findings suggested that SME as a nano-sized delivery system efficiently promoted the digestive tract absorption of MG and modified its distribution in tissues. The targeting feature and high oral bioavailability of MG-SME promised a good clinical efficacy, especially for immune diseases.
[Mh] Termos MeSH primário: Composição de Medicamentos/métodos
Sistemas de Liberação de Medicamentos/métodos
Garcinia mangostana/química
Absorção Gastrointestinal/fisiologia
Xantonas/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Animais
Área Sob a Curva
Disponibilidade Biológica
Cromatografia Líquida de Alta Pressão
Emulsões
Análise Fatorial
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Especificidade de Órgãos
Tamanho da Partícula
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
Solubilidade
Distribuição Tecidual
Xantonas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Plant Extracts); 0 (Xanthones); U6RIV93RU1 (mangostin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:28240159
[Au] Autor:He L; Zang J; Liu P; Fan P; Song P; Chen J; Ma Y; Ding W; Ma X
[Ad] Endereço:State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, China Agricultural University, Beijing 100193. China.
[Ti] Título:Supplementation of Milky Flavors Improves the Reproductive Performance and Gut Function Using Sow Model.
[So] Source:Protein Pept Lett;24(5):449-455, 2017.
[Is] ISSN:1875-5305
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study was conducted to evaluate the effect of flavors on reproductive performance of sows and we also studied its effect on gut barrier function. Forty-eight Landrace × Yarkshire sows were randomly allotted and fed a basal diet added 0%, 0.05% or 0.10% flavor feed, respectively from parturition to day 28 of weaning. The results showed that supplementation of 0.05% or 0.10% flavors increased average daily feed intake (ADFI) of sows and average daily gain (ADG) of piglets, decreased the weight losses of sows, increased the survival ratio of weaning piglets (P < 0.05), especially shorten the post-weaning estrus interval significantly (P < 0.05). Supplementation of flavor additives tend to reduce the weight losses of sows and raise the survival ratio of piglet weaned (P > 0.05). Moreover, addition of flavors in diets reduced the intestinal permeability and enhanced digestibility of dry matter, crude protein, and energy (P < 0.05). Flavors supplementation significantly increased the level of gonadotropin releasing hormne (GnRH) of serum in sows after weaning. In conclusion, the results suggested that supplementation of dietary flavors could improve digestibility of nutrients and the reproductive performance of sows as well as the gut barrier function.
[Mh] Termos MeSH primário: Ração Animal
Suplementos Nutricionais
Lactação/fisiologia
Modelos Biológicos
Reprodução/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Lactentes
Feminino
Absorção Gastrointestinal/fisiologia
Hormônio Liberador de Gonadotropina/sangue
Sus scrofa
Suínos
Ganho de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.2174/0929866524666170223144728



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