Base de dados : MEDLINE
Pesquisa : G03.015.500.374.825 [Categoria DeCS]
Referências encontradas : 2 [refinar]
Mostrando: 1 .. 2   no formato [Detalhado]

página 1 de 1

  1 / 2 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:26689067
[Au] Autor:Shimoyama N; Shimoyama M; Kubota Y; Kato Y
[Ti] Título:[Understanding Oral and Nasal Mucosal Absorption of Fentanyl, and Rectal Absorption of Buprenorphine].
[So] Source:Masui;64(11):1160-5, 2015 Nov.
[Is] ISSN:0021-4892
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:One of the key issues in the treatment of pain is to choose the appropriate route and dosage form of analgesics for each individual patient in pain. New drug forms of fentanyl absorbed by oral or nasal mucosa, and buprenorphine absorbed by rectal mucosa are described in this chapter. Only lipophilic opioids such as fentanyl and buprenorphine can be absorbed via the mucosa of oral or nasal cavity of the human body. The T max of rapid onset opioids (ROO) such as fentanyl buccal or sublingual tablets is the fastest among various dosage forms of opioid analgesics. However, such rapid increase in plasma concentration of fentanyl by ROO formulations may cause the risk of respiratory depression. Safe ways to use ROO analgesics are described.
[Mh] Termos MeSH primário: Analgésicos Opioides/administração & dosagem
Buprenorfina/administração & dosagem
Mucosa Nasal/metabolismo
[Mh] Termos MeSH secundário: Administração através da Mucosa
Administração Oral
Analgésicos Opioides/uso terapêutico
Buprenorfina/uso terapêutico
Fentanila/administração & dosagem
Seres Humanos
Dor/tratamento farmacológico
Absorção Retal
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 40D3SCR4GZ (Buprenorphine); UF599785JZ (Fentanyl)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151222
[Lr] Data última revisão:
151222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE


  2 / 2 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:24642959
[Au] Autor:Rahat-Rozenbloom S; Fernandes J; Gloor GB; Wolever TM
[Ad] Endereço:Faculty of Medicine, Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans.
[So] Source:Int J Obes (Lond);38(12):1525-31, 2014 Dec.
[Is] ISSN:1476-5497
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Short-chain fatty acids (SCFA) are produced by colonic microbiota from dietary carbohydrates and proteins that reach the colon. It has been suggested that SCFA may promote obesity via increased colonic energy availability. Recent studies suggest obese humans have higher faecal SCFA than lean, but it is unclear whether this difference is due to increased SCFA production or reduced absorption. OBJECTIVES: To compare rectal SCFA absorption, dietary intake and faecal microbial profile in lean (LN) versus overweight and obese (OWO) individuals. DESIGN: Eleven LN and eleven OWO individuals completed a 3-day diet record, provided a fresh faecal sample and had SCFA absorption measured using the rectal dialysis bag method. The procedures were repeated after 2 weeks. RESULTS: Age-adjusted faecal SCFA concentration was significantly higher in OWO than LN individuals (81.3±7.4 vs 64.1±10.4 mmol kg(-1), P=0.023). SCFA absorption (24.4±0.8% vs 24.7±1.2%, respectively, P=0.787) and dietary intakes were similar between the groups, except for a higher fat intake in OWO individuals. However, fat intake did not correlate with SCFAs or bacterial abundance. OWO individuals had higher relative Firmicutes abundance (83.1±4.1 vs 69.5±5.8%, respectively, P=0.008) and a higher Firmicutes:Bacteriodetes ratio (P=0.023) than LN individuals. There was a positive correlation between Firmicutes and faecal SCFA within the whole group (r=0.507, P=0.044), with a stronger correlation after adjusting for available carbohydrate (r=0.615, P=0.005). CONCLUSIONS: The higher faecal SCFA in OWO individuals is not because of differences in SCFA absorption or diet. Our results are consistent with the hypothesis that OWO individuals produce more colonic SCFA than LN individuals because of differences in colonic microbiota. However, further studies are needed to prove this.
[Mh] Termos MeSH primário: Colo/metabolismo
Ácidos Graxos Voláteis/metabolismo
Fezes/microbiologia
Sobrepeso/metabolismo
Magreza/metabolismo
[Mh] Termos MeSH secundário: Adulto
Colo/microbiologia
Dieta
Registros de Dieta
Carboidratos da Dieta/metabolismo
Gorduras na Dieta/metabolismo
Feminino
Seres Humanos
Masculino
Sobrepeso/microbiologia
Projetos Piloto
Absorção Retal
Magreza/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats); 0 (Fatty Acids, Volatile)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140320
[St] Status:MEDLINE
[do] DOI:10.1038/ijo.2014.46



página 1 de 1
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde