Base de dados : MEDLINE
Pesquisa : G03.015.500.656 [Categoria DeCS]
Referências encontradas : 22 [refinar]
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  1 / 22 MEDLINE  
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[PMID]:28499206
[Au] Autor:Mao Z; Wang X; Liu Y; Huang Y; Liu Y; Di X
[Ad] Endereço:Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, PR China.
[Ti] Título:Simultaneous determination of seven alkaloids from Rhizoma Corydalis Decumbentis in rabbit aqueous humor by LC-MS/MS: Application to ocular pharmacokinetic studies.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1057:46-53, 2017 Jul 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study aims to establish a fast and sensitive LC-MS/MS method for simultaneous determination of seven alkaloids from Rhizoma Corydalis Decumbentis in rabbit aqueous humor. Aqueous humor samples were processed by protein precipitation and then separated on a Thermo Syncronis C column (50mm×2.1mm, 5µm) with a mobile phase using acetonitrile-0.05% formic acid (28:72, v/v). Detection of the analytes and the internal standard (coptisine) were performed in positive electrospray ionization with selected reaction monitoring. The method showed good linearity (r>0.9931) for all the seven alkaloids. This fully validated method was applied to the studies of aqueous humor pharmacokinetics of seven alkaloids from Rhizoma Corydalis Decumbentis and the effects of borneol on corneal penetration of these alkaloids into aqueous humor. This is the first work that presents a reliable LC-MS/MS method for simultaneous determination of seven alkaloids in rabbit aqueous humor and its application of ocular pharmacokinetics of seven alkaloids from Rhizoma Corydalis Decumbentis.
[Mh] Termos MeSH primário: Alcaloides/análise
Alcaloides/farmacocinética
Humor Aquoso/química
Humor Aquoso/metabolismo
Corydalis/química
Medicamentos de Ervas Chinesas/farmacocinética
[Mh] Termos MeSH secundário: Animais
Bornanos/farmacologia
Cromatografia Líquida de Alta Pressão
Medicamentos de Ervas Chinesas/química
Absorção Ocular
Coelhos
Rizoma/química
Sensibilidade e Especificidade
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Bornanes); 0 (Drugs, Chinese Herbal); L88RA8N5EG (isoborneol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE


  2 / 22 MEDLINE  
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[PMID]:28476958
[Au] Autor:Pandian S; Jeevanesan V; Ponnusamy C; Natesan S
[Ad] Endereço:Laboratory for Lipid Based Systems, Department of Pharmaceutical Technology, BIT Campus, Anna University, Tiruchirappalli 620 024, Tamil Nadu, India.
[Ti] Título:RES-loaded pegylated CS NPs: for efficient ocular delivery.
[So] Source:IET Nanobiotechnol;11(1):32-39, 2017 Feb.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The objective of this study is to develop resveratrol (RES) loaded polyethylene glycols (PEGs) modified chitosan (CS) nanoparticles (NPs) by ionic gelation method for the treatment of glaucoma. While increasing the concentration of PEG, the particle size and polydispersity index of the formulations increased. Entrapment efficiency and RES loading (RL) of NPs decreased while increasing PEG concentration. The in vitro release of NPs showed an initial burst release of RES (45%) followed by controlled release. Osmolality of formulations revealed that the prepared NPs were iso-osmolar with the tear. Ocular tolerance of the NPs was evaluated using hen's egg test on the chorioallantoic membrane and it showed that the NPs were non-irritant. RES-loaded PEG-modified CS NPs shows an improved corneal permeation compared with RES dispersion. Fluorescein isothiocyanate loaded CS NPs accumulated on the surface of the cornea but the PEG-modified CS NPs crossed the cornea and reached retinal choroid. RES-loaded PEG-modified CS NPs reduced the intra-ocular pressure (IOP) by 4.3 ± 0.5 mmHg up to 8 h in normotensive rabbits. These results indicate that the developed NPs have efficient delivery of RES to the ocular tissues and reduce the IOP for the treatment of glaucoma.
[Mh] Termos MeSH primário: Quitosana/química
Córnea/química
Preparações de Ação Retardada/administração & dosagem
Nanocápsulas/química
Polietilenoglicóis/química
Estilbenos/administração & dosagem
Estilbenos/química
[Mh] Termos MeSH secundário: Administração Oftálmica
Inibidores da Angiogênese/administração & dosagem
Inibidores da Angiogênese/química
Animais
Materiais Revestidos Biocompatíveis/administração & dosagem
Materiais Revestidos Biocompatíveis/química
Preparações de Ação Retardada/química
Difusão
Técnicas In Vitro
Nanocápsulas/administração & dosagem
Nanocápsulas/ultraestrutura
Absorção Ocular
Tamanho da Partícula
Coelhos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Coated Materials, Biocompatible); 0 (Delayed-Action Preparations); 0 (Nanocapsules); 0 (Stilbenes); 30IQX730WE (Polyethylene Glycols); 9012-76-4 (Chitosan); Q369O8926L (resveratrol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0069


  3 / 22 MEDLINE  
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[PMID]:26897134
[Au] Autor:Sanyal S; Das P; Law S
[Ad] Endereço:Stem Cell Research and Application Unit, Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical Medicine, 108, C.R. Avenue, Kolkata, 700073, West Bengal, India.
[Ti] Título:Effect of chronic pesticide exposure on murine cornea: a histopathological, cytological and flow cytometric approach to study ocular damage by xenobiotics.
[So] Source:Cell Biol Toxicol;32(1):7-22, 2016 Feb.
[Is] ISSN:1573-6822
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Pesticide exposure can occur directly or indirectly in an occupational setting or otherwise. The health hazards of pesticides have long been studied; however, little is known about the ocular insult of these potent chemicals. In this study, we examined the consequences of long-term pesticide exposure on the ocular tissue in animal model with special focus on the cornea. Swiss Albino mice were sacrificed to obtain the eye globes and various cytological, cytotoxic and histological evaluations, in vitro growth kinetic studies and flow cytometric analyses of select cytokeratins were performed to determine the structural and functional damage due to pesticide exposure. Our study revealed the detrimental impact of this xenobiotic insult by cataloguing the damage to each layer of the cornea wherein it was discovered that all the functional layers as well as the membranes were compromised. We hope that our investigation will pave the way for future studies in this oft overlooked area of affront caused by pesticide exposure to the ocular surface.
[Mh] Termos MeSH primário: Córnea/efeitos dos fármacos
Praguicidas/toxicidade
[Mh] Termos MeSH secundário: Animais
Córnea/citologia
Córnea/patologia
Feminino
Citometria de Fluxo
Masculino
Camundongos
Modelos Animais
Absorção Ocular/efeitos dos fármacos
Testes de Toxicidade Crônica
Xenobióticos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pesticides); 0 (Xenobiotics)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160222
[St] Status:MEDLINE
[do] DOI:10.1007/s10565-016-9314-4


  4 / 22 MEDLINE  
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[PMID]:26767658
[Au] Autor:Feller KD; Cronin TW
[Ad] Endereço:University of Bristol, Life Sciences Building Tyndall Avenue, Bristol, BS8 1TQ, UK. kate.feller@bristol.ac.uk.
[Ti] Título:Spectral absorption of visual pigments in stomatopod larval photoreceptors.
[So] Source:J Comp Physiol A Neuroethol Sens Neural Behav Physiol;202(3):215-23, 2016 Mar.
[Is] ISSN:1432-1351
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Larval stomatopod eyes appear to be much simpler versions of adult compound eyes, lacking most of the visual pigment diversity and photoreceptor specializations. Our understanding of the visual pigment diversity of larval stomatopods, however, is based on four species, which severely limits our understanding of stomatopod eye ontogeny. To investigate several poorly understood aspects of stomatopod larval eye function, we tested two hypotheses surrounding the spectral absorption of larval visual pigments. First, we examined a broad range of species to determine if stomatopod larvae generally express a single, spectral class of photoreceptor. Using microspectrophotometry (MSP) on larvae captured in the field, we found data which further support this long-standing hypothesis. MSP was also used to test whether larval species from the same geographical region express visual pigments with similar absorption spectra. Interestingly, despite occupation of the same geographical location, we did not find evidence to support our second hypothesis. Rather, there was significant variation in visual pigment absorption spectra among sympatric species. These data are important to further our understanding of larval photoreceptor spectral diversity, which is beneficial to ongoing investigations into the ontogeny, physiology, and molecular evolution of stomatopod eyes.
[Mh] Termos MeSH primário: Visão de Cores/fisiologia
Evolução Molecular
Larva/anatomia & histologia
Absorção Ocular/fisiologia
Células Fotorreceptoras de Invertebrados/fisiologia
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Decápodes (Crustáceos)
Complexo I de Transporte de Elétrons/genética
Complexo I de Transporte de Elétrons/metabolismo
Microespectrofotometria
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
EC 1.6.5.3 (Electron Transport Complex I)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160116
[St] Status:MEDLINE
[do] DOI:10.1007/s00359-015-1063-y


  5 / 22 MEDLINE  
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[PMID]:26085051
[Au] Autor:Yang X; Trinh HM; Agrahari V; Sheng Y; Pal D; Mitra AK
[Ad] Endereço:Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, Missouri, 64108, USA.
[Ti] Título:Nanoparticle-Based Topical Ophthalmic Gel Formulation for Sustained Release of Hydrocortisone Butyrate.
[So] Source:AAPS PharmSciTech;17(2):294-306, 2016 Apr.
[Is] ISSN:1530-9932
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was conducted to develop formulations of hydrocortisone butyrate (HB)-loaded poly(D,L-lactic-co-glycolic acid) nanoparticles (PLGA NP) suspended in thermosensitive gel to improve ocular bioavailability of HB for the treatment of bacterial corneal keratitis. PLGA NP with different surfactants such as polyvinyl alcohol (PVA), pluronic F-108, and chitosan were prepared using oil-in-water (O/W) emulsion evaporation technique. NP were characterized with respect to particle size, entrapment efficiency, polydispersity, drug loading, surface morphology, zeta potential, and crystallinity. In vitro release of HB from NP showed a biphasic release pattern with an initial burst phase followed by a sustained phase. Such burst effect was completely eliminated when nanoparticles were suspended in thermosensitive gels and zero-order release kinetics was observed. In HCEC cell line, chitosan-emulsified NP showed the highest cellular uptake efficiency over PVA- and pluronic-emulsified NP (59.09 ± 6.21%, 55.74 ± 6.26%, and 62.54 ± 3.30%, respectively) after 4 h. However, chitosan-emulsified NP indicated significant cytotoxicity of 200 and 500 µg/mL after 48 h, while PVA- and pluronic-emulsified NP exhibited no significant cytotoxicity. PLGA NP dispersed in thermosensitive gels can be considered as a promising drug delivery system for the treatment of anterior eye diseases.
[Mh] Termos MeSH primário: Preparações de Ação Retardada/administração & dosagem
Preparações de Ação Retardada/química
Géis/administração & dosagem
Géis/química
Hidrocortisona/análogos & derivados
Nanopartículas/química
[Mh] Termos MeSH secundário: Administração Oftálmica
Administração Tópica
Disponibilidade Biológica
Linhagem Celular
Química Farmacêutica
Quitosana/química
Ceratócitos da Córnea/efeitos dos fármacos
Portadores de Fármacos/química
Sistemas de Liberação de Medicamentos/métodos
Emulsões/administração & dosagem
Emulsões/química
Oftalmopatias/tratamento farmacológico
Seres Humanos
Hidrocortisona/administração & dosagem
Hidrocortisona/química
Nanopartículas/administração & dosagem
Absorção Ocular
Tamanho da Partícula
Poloxâmero/química
Álcool de Polivinil/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Drug Carriers); 0 (Emulsions); 0 (Gels); 05RMF7YPWN (hydrocortisone-17-butyrate); 106392-12-5 (Poloxamer); 9002-89-5 (Polyvinyl Alcohol); 9012-76-4 (Chitosan); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150619
[St] Status:MEDLINE
[do] DOI:10.1208/s12249-015-0354-5


  6 / 22 MEDLINE  
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[PMID]:26084629
[Au] Autor:Babizhayev MA; Yegorov YE
[Ad] Endereço:Innovative Vision Products, Inc., Moscow Division, Ivanovskaya 20, Suite 74 Moscow 127434 Russian Federation. markbabizhayev@mail.ru.
[Ti] Título:Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-Dependent Separation of Therapeutic Targeting: Transcorneal Penetration and Delivery of L-Carnosine in the Aqueous Humor and Hormone-Like Hypothalamic Antiaging Effects of the Instilled Ophthalmic Drug Through a Safe Eye Medication Technique.
[So] Source:Recent Pat Drug Deliv Formul;10(2):82-129, 2016.
[Is] ISSN:2212-4039
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Visual impairment broadly impacts the ability of affected people to maintain their function and to remain independent during their daily occupations as they grow older. Visual impairment affects survival of older patients, quality of life, can affect a person's self-ranking of health, may be associated with social and functional decline, use of community support services, depression, falls, nursing home placement, and increased mortality. It has been hypothesized that senile cataract may serve as a marker for generalised tissue aging, since structural changes occurring in the proteins of the lens during cataract formation are similar to those which occur elsewhere as part of the aging process. The published analysis revealed a strong age-dependent relationship between undergoing cataract surgery and subsequent mortality. METHODS: Nuclear opacity, particularly severe nuclear opacity, and mixed opacities with nuclear were significant predictors of mortality independent of body mass index, comorbid conditions, smoking, age, race, and sex. The lens opacity status is considered as an independent predictor of 2-year mortality, an association that could not be explained by potential confounders. Telomeres have become important biomarkers for aging as well as for oxidative stress-related disease. The lens epithelium is especially vulnerable to oxidative stress. Oxidative damage to the cuboidal epithelial cells on the anterior surface of the lens mediated by reactive oxygen species and phospholipid hydroperoxides can precede and contribute to human lens cataract formation. The erosion and shortening of telomeres in human lens epithelial cells in the lack of telomerase activity has been recognized as a primary cause of premature lens senescence phenotype that trigger human cataractogenesis. In this study we aimed to be focused on research defining the mechanisms that underlie linkages among telomere attrition in human lens epithelial cells associated with oxidative stress, biology of the lens response to oxidative damages, aging and health, cataract versus neuroendocrine regulation and disease. The cumulative results demonstrate that carnosine, released ophthalmically from the patented 1% Nacetylcarnosine prodrug lubricant eye drops, at physiological concentration might remarkably reduce the rate of telomere shortening in the lens cells subjected to oxidative stress in the lack of efficient antioxidant lens protection. Carnosine promotes the protection of normal cells from acquiring phenotypic characteristics of cellular senescence. The data of visual functions (visual acuity, glare sensitivity) in older adult subjects and older subjects with cataract treated with 1% N-acetylcarnosine lubricant eye drops showed significant improvement as compared, by contrast with the control group which showed generally no improvement in visual functions, with no difference from baseline in visual acuity and glare sensitivity readings. RESULTS: N-acetylcarnosine derived from the lubricant eye drops may be transported into the hypothalamic tuberomammillary nucleus (TMN) histamine neurons and gradually hydrolyzed. The resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of carnosine on neurotransmission and hormone-like antiaging and anti-cataract physiological function. CONCLUSION: The research utilizing the N-acetylcarnosine lubricant eye drops powerful therapeutic platform provides the findings related to the intraocular uptake exposure sources as well as a timing dosage and duration systemic absorption of said preparation from the conjunctional sac reaching the hypothalamus with activities transfer into the hypothalamic-neuroendocrine pathways affecting across the hypothalamus metabolic pathway the telomere biology and cataract disease occurrence, reversal and prevention and the average expected lifespan of an individual. Such findings can be translated into clinical practice and may provide a basis for personalized cataract disease and aging prevention and treatment approaches.
[Mh] Termos MeSH primário: Antioxidantes/administração & dosagem
Carnosina/análogos & derivados
Catarata/prevenção & controle
Células Epiteliais/efeitos dos fármacos
Cristalino/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Homeostase do Telômero/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oftálmica
Fatores Etários
Envelhecimento/genética
Envelhecimento/metabolismo
Envelhecimento/patologia
Animais
Antioxidantes/efeitos adversos
Antioxidantes/química
Antioxidantes/farmacocinética
Carnosina/administração & dosagem
Carnosina/efeitos adversos
Carnosina/química
Carnosina/farmacocinética
Catarata/genética
Catarata/metabolismo
Catarata/patologia
Córnea/metabolismo
Composição de Medicamentos
Sistemas de Liberação de Medicamentos
Células Epiteliais/metabolismo
Células Epiteliais/patologia
Seres Humanos
Cristalino/metabolismo
Cristalino/patologia
Absorção Ocular
Soluções Oftálmicas
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Ophthalmic Solutions); 0TPN86OQIF (N-acetylcarnosine); 8HO6PVN24W (Carnosine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150619
[St] Status:MEDLINE


  7 / 22 MEDLINE  
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[PMID]:26606856
[Au] Autor:Laffleur F; Dachs S
[Ad] Endereço:Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck Innrain 80/82, 6020 Innsbruck, Austria.
[Ti] Título:Development of novel mucoadhesive hyaluronic acid derivate as lubricant for the treatment of dry eye syndrome.
[So] Source:Ther Deliv;6(10):1211-9, 2015.
[Is] ISSN:2041-6008
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Dry eye - a disease affecting between 4 and 34% of the population worldwide. Stressful conditions to ocular surface, contact lenses as well as systemic disease cause dry eye. Novel synthesized hyaluronic acid derivate was evaluated in terms of its potential as mucoadhesive and lubricant. Results & methodology: Hyaluronic acid was chemically modified with cysteine ethyl ester (hyaluronic acid-cysteine ethyl ester). Mucoadhesion, disintegration and water uptake capacity, moreover, safety as the hen's egg test for mucous membrane compatibility were evaluated. According to the results, hyaluronic acid-cysteine ethyl ester achieved 3.81-fold increased swelling capacity, 30.5-fold more improvement mucoadhesive properties and 9.72-fold higher stability of hyaluronic acid, which was achieved due to the chemical modification. SUMMARY: Thus, the promising results underpin further exploitation of this versatile polysaccharide for treating dry eye syndrome.
[Mh] Termos MeSH primário: Membrana Corioalantoide/efeitos dos fármacos
Síndromes do Olho Seco
Ácido Hialurônico/análogos & derivados
Lubrificantes Oftálmicos/administração & dosagem
Membrana Mucosa/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Células CACO-2
Adesão Celular
Galinhas
Membrana Corioalantoide/metabolismo
Síndromes do Olho Seco/tratamento farmacológico
Síndromes do Olho Seco/metabolismo
Feminino
Seres Humanos
Ácido Hialurônico/administração & dosagem
Ácido Hialurônico/síntese química
Ácido Hialurônico/metabolismo
Lubrificantes Oftálmicos/síntese química
Lubrificantes Oftálmicos/metabolismo
Membrana Mucosa/metabolismo
Absorção Ocular/efeitos dos fármacos
Absorção Ocular/fisiologia
Suínos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lubricant Eye Drops); 111745-19-8 (hyaluronic acid ethyl ester); 9004-61-9 (Hyaluronic Acid)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151126
[Lr] Data última revisão:
151126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151127
[St] Status:MEDLINE
[do] DOI:10.4155/tde.15.55


  8 / 22 MEDLINE  
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[PMID]:26205681
[Au] Autor:Sheshala R; Kok YY; Ng JM; Thakur RR; Dua K
[Ad] Endereço:School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia. ravi_sheshala@imu.edu.my.
[Ti] Título:In Situ Gelling Ophthalmic Drug Delivery System: An Overview and Its Applications.
[So] Source:Recent Pat Drug Deliv Formul;9(3):237-48, 2015.
[Is] ISSN:2212-4039
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:Ophthalmic drug delivery system is very interesting and challenging due to the normal physiologically factor of eyes which reduces the bioavailability of ocular products. The development of new ophthalmic dosage forms for existing drugs to improve efficacy and bioavailability, patient compliance and convenience has become one of the main trend in the pharmaceuticals industry. The present review encompasses various conventional and novel ocular drug delivery systems, methods of preparation, characterization and recent research in this area. Furthermore, the information on various commercially available in situ gel preparations and the existing patents of in situ drug delivery systems i.e. in situ gel formation of pectin, in situ gel for therapeutic use, medical uses of in situ formed gels and in situ gelling systems as sustained delivery for front of eye are also covered in this review.
[Mh] Termos MeSH primário: Portadores de Fármacos
Preparações Farmacêuticas/administração & dosagem
Polímeros/química
Tecnologia Farmacêutica/métodos
[Mh] Termos MeSH secundário: Administração Oftálmica
Animais
Disponibilidade Biológica
Preparações de Ação Retardada
Composição de Medicamentos
Olho/metabolismo
Géis
Seres Humanos
Absorção Ocular
Patentes como Assunto
Preparações Farmacêuticas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Drug Carriers); 0 (Gels); 0 (Pharmaceutical Preparations); 0 (Polymers)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150725
[St] Status:MEDLINE


  9 / 22 MEDLINE  
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[PMID]:25643990
[Au] Autor:Dong Y; Dong P; Huang D; Mei L; Xia Y; Wang Z; Pan X; Li G; Wu C
[Ad] Endereço:School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou, China.
[Ti] Título:Fabrication and characterization of silk fibroin-coated liposomes for ocular drug delivery.
[So] Source:Eur J Pharm Biopharm;91:82-90, 2015 Apr.
[Is] ISSN:1873-3441
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The unique structure and protective mechanisms of the eye result in low bioavailability of ocular drugs. Using a mucoadhesive material is an efficient solution to improve ocular drug therapeutic efficacy. This study was designed to prepare a liposomal formulation coated by a novel adhesive excipient, silk fibroin (SF), for topical ocular drug delivery. The regenerated silk fibroins (SFs) with different dissolving time were coated onto the ibuprofen-loaded liposomes. The morphology, drug encapsulation efficiency, in vitro release and in vitro corneal permeation of SF-coated liposomes (SLs) were investigated in comparison with the conventional liposome. Cellular adhesion and cytotoxicity assay of SF and SLs were tested using human corneal epithelial cells (HCEC). SLs showed sustained drug release and in vitro corneal permeation of ibuprofen as compared to drug solution and conventional liposome. The cellular fluorescence appeared after 7 min of exposure to SF, and the intensity increased sustainedly up to 12h with no detectable cytotoxicity. Higher fluorescence intensity of Nile red in SLs was observed in a short period of 15 min showing a rapid uptake. These favorable properties make SF-coated liposome be a promising ocular drug delivery system.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/química
Córnea/metabolismo
Sistemas de Liberação de Medicamentos
Excipientes/química
Fibroínas/química
Ibuprofeno/química
Absorção Ocular
[Mh] Termos MeSH secundário: Adesividade
Administração Oftálmica
Animais
Anti-Inflamatórios não Esteroides/administração & dosagem
Anti-Inflamatórios não Esteroides/efeitos adversos
Anti-Inflamatórios não Esteroides/metabolismo
Bombyx/química
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Córnea/citologia
Córnea/efeitos dos fármacos
Preparações de Ação Retardada/administração & dosagem
Preparações de Ação Retardada/efeitos adversos
Preparações de Ação Retardada/química
Preparações de Ação Retardada/metabolismo
Composição de Medicamentos
Sistemas de Liberação de Medicamentos/efeitos adversos
Liberação Controlada de Fármacos
Excipientes/efeitos adversos
Excipientes/isolamento & purificação
Fibroínas/efeitos adversos
Fibroínas/isolamento & purificação
Seres Humanos
Ibuprofeno/administração & dosagem
Ibuprofeno/efeitos adversos
Ibuprofeno/metabolismo
Lipossomos
Tamanho da Partícula
Estrutura Secundária de Proteína
Pupa/química
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Delayed-Action Preparations); 0 (Excipients); 0 (Liposomes); 0 (fibroin, silkworm); 9007-76-5 (Fibroins); WK2XYI10QM (Ibuprofen)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150323
[Lr] Data última revisão:
150323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150204
[St] Status:MEDLINE


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[PMID]:25609376
[Au] Autor:Asasutjarit R; Theerachayanan T; Kewsuwan P; Veeranodha S; Fuongfuchat A; Ritthidej GC
[Ad] Endereço:Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, Pathumthani, 12120, Thailand. rathapona@hotmail.com.
[Ti] Título:Development and Evaluation of Diclofenac Sodium Loaded-N-Trimethyl Chitosan Nanoparticles for Ophthalmic Use.
[So] Source:AAPS PharmSciTech;16(5):1013-24, 2015 Oct.
[Is] ISSN:1530-9932
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ophthalmic preparation of diclofenac sodium (DC) for relieving ocular inflammation is presently available in the market only as an eye drop solution. Due to its low occular bioavailability, it requires frequent application leading to low patients' compliance and quality of life. This study was conducted to develop formulations of DC loaded-N-trimethyl chitosan nanoparticles (DC-TMCNs) for ophthalmic use to improve ocular biavailabiltiy of DC. DC-TMCNs varied in formulation compositions were prepared using ionic gelation technique and evaluated for their physicochemical properties, drug release, eye irritation potential, and ophthalmic absorption of diclofenac sodium. N-Trimethyl chitosan (TMC) with a 49.8% degree of quaternization was synthesized and used for DC-TMCNs production. The obtained DC-TMCNs had particle size in a range of 130-190 nm with zeta potential values of +4 to +9 mV and drug entrapment efficiencies of more than 70% depending on the content of TMC and sodium tripolyphosphate (TPP). The optimized DC-TMCNs formulation contained TMC, DC, and TPP at a weight ratio of TMC/DC/TPP = 3:1:1. Their lyophilized product reconstituted with phosphate buffer solution pH 5.5 possessed a drug release pattern that fitted within the zero-order model. The eye irritation tests showed that DC-TMCNs were safe for ophthalmic use. The in vivo ophthalmic drug absorption study performed on rabbits indicated that DC-TMCNs could improve ophthalmic bioavailability of DC. Results of this study suggested that DC-TMCNs had potential for use as an alternative to conventional DC eye drops for ophthalmic inflammation treatment.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/administração & dosagem
Quitosana/química
Diclofenaco/administração & dosagem
Portadores de Fármacos
Nanopartículas
[Mh] Termos MeSH secundário: Administração Oftálmica
Animais
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/farmacocinética
Humor Aquoso/metabolismo
Disponibilidade Biológica
Quitosana/toxicidade
Diclofenaco/química
Diclofenaco/farmacocinética
Composição de Medicamentos
Seres Humanos
Concentração de Íons de Hidrogênio
Modelos Químicos
Nanomedicina/métodos
Absorção Ocular
Soluções Oftálmicas
Tamanho da Partícula
Polifosfatos/química
Coelhos
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Drug Carriers); 0 (N-trimethyl chitosan chloride); 0 (Ophthalmic Solutions); 0 (Polyphosphates); 144O8QL0L1 (Diclofenac); 9012-76-4 (Chitosan); NU43IAG5BC (triphosphoric acid)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150123
[St] Status:MEDLINE
[do] DOI:10.1208/s12249-015-0290-4



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