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Pesquisa : G03.015.500.703.500 [Categoria DeCS]
Referências encontradas : 29 [refinar]
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  1 / 29 MEDLINE  
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[PMID]:28154262
[Au] Autor:Tanaka A; Furubayashi T; Enomura Y; Hori T; Shimomura R; Maeda C; Kimura S; Inoue D; Kusamori K; Katsumi H; Sakane T; Yamamoto A
[Ad] Endereço:Department of Biopharmaceutics, Kyoto Pharmaceutical University.
[Ti] Título:Nasal Drug Absorption from Powder Formulations: Effect of Fluid Volume Changes on the Mucosal Surface.
[So] Source:Biol Pharm Bull;40(2):212-219, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The effect of changes in the mucosal fluid volume on the nasal drug absorption of powder formulations was evaluated using warfarin (WF), piroxicam (PXC), and norfloxacin (NFX) as model drugs. Lactose and sodium chloride (NaCl), which are water soluble and small-sized chemicals that increase osmotic pressure after dissolution, were used as excipients to change the mucosal fluid volume. The in vitro study using a Madin-Darby canine kidney (MDCK) cell monolayer indicated that lactose and NaCl, sprayed over the surface of air interface monolayers, increased the fluid volume on the monolayer surface and enhanced the transepithelial transport of the model drugs. The in vivo animal study indicated that the nasal absorption of PXC is enhanced by lactose and NaCl after nasal administration of the powder formulations. This is likely due to the enhanced dissolution of PXC on fluid-rich nasal mucosa and an increase in the effective surface area for drug permeation, which lead to better nasal absorption. However, both excipients failed to increase the nasal absorption of WF and NFX. To clarify the mechanism of the drug-dependent effect of lactose and NaCl, the nasal residence of the formulation was examined using FD70 as a non-absorbable marker. The nasal clearance of FD70 was enhanced by lactose and NaCl, leading to a decrease in the nasal drug absorption. Lactose and NaCl caused no damage to the nasal tissue. These results indicate that the addition of water-soluble excipients such as lactose to powder formulations can enhance the nasal absorption of highly permeable but poorly soluble drugs.
[Mh] Termos MeSH primário: Excipientes/metabolismo
Absorção Nasal/fisiologia
Mucosa Nasal/metabolismo
Migração Transendotelial e Transepitelial/fisiologia
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Química Farmacêutica
Cães
Excipientes/administração & dosagem
Excipientes/química
Seres Humanos
Células Madin Darby de Rim Canino
Masculino
Absorção Nasal/efeitos dos fármacos
Mucosa Nasal/efeitos dos fármacos
Pós
Ratos
Ratos Wistar
Migração Transendotelial e Transepitelial/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excipients); 0 (Powders)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b16-00787


  2 / 29 MEDLINE  
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[PMID]:27664332
[Au] Autor:Tanaka A; Furubayashi T; Tomisaki M; Kawakami M; Kimura S; Inoue D; Kusamori K; Katsumi H; Sakane T; Yamamoto A
[Ad] Endereço:Department of Biopharmaceutics, Kyoto Pharmaceutical University, Yamashina, Kyoto 607-8414, Japan.
[Ti] Título:Nasal drug absorption from powder formulations: The effect of three types of hydroxypropyl cellulose (HPC).
[So] Source:Eur J Pharm Sci;96:284-289, 2017 Jan 01.
[Is] ISSN:1879-0720
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Despite the numerous advantages of powder formulations, few studies have described their nasal drug absorption. The first aim of this study was to compare the drug absorption from powder formulation with that from a liquid formulation in rats. Since pharmaceutical excipients are usually added to most powder formulations, the second aim of the study was to investigate the effect of hydroxypropyl cellulose (HPC) on nasal drug absorption from the powder. Three types of HPC with different polymerization degrees were used: HPC(SL), HPC(M), and HPC(H). The model drugs were warfarin (BCS Class I), piroxicam (BCS Class II), and sumatriptan (BCS Class III). The absorption of these model drugs in the powder form was higher than that from the solution. All HPCs failed to enhance warfarin absorption, while the piroxicam absorption was enhanced only by HPC(M). Sumatriptan absorption was not enhanced by HPC(SL), but by HPC(M) and HPC(H). The differences in nasal absorption of the three model drugs promoted by HPCs depend on the permeability and solubility of the drug. Moreover, the nasal retention of different formulations was increased by HPCs. Because HPCs showed no toxic effect on the nasal epithelium. These findings indicate that powder formulations supplemented with HPC are a valuable and promising approach to increase the nasal absorption of highly soluble and poorly permeable drugs.
[Mh] Termos MeSH primário: Celulose/análogos & derivados
Absorção Nasal/fisiologia
Mucosa Nasal/metabolismo
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Celulose/administração & dosagem
Celulose/sangue
Celulose/química
Química Farmacêutica
Masculino
Absorção Nasal/efeitos dos fármacos
Mucosa Nasal/efeitos dos fármacos
Pós
Ratos
Ratos Wistar
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Powders); 9004-34-6 (Cellulose); RFW2ET671P (hydroxypropylcellulose)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


  3 / 29 MEDLINE  
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[PMID]:27749254
[Au] Autor:Gu F; Ma W; Meng G; Wu C; Wang Y
[Ti] Título:Preparation and in vivo evaluation of a gel-based nasal delivery system for risperidone.
[So] Source:Acta Pharm;66(4):555-562, 2016 Dec 01.
[Is] ISSN:1846-9558
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to prepare a nasal gel of risperidone and to investigate the pharmacokinetics and relative bioavailability of the drug in rats. Compared with oral dosing, the risperidone nasal gel exhibited very fast absorption and high bioavailability. Maximal plasma concentration (cmax) and the time to reach cmax (tmax) were 15.2 µg mL-1 and 5 min for the nasal gel, 3.6 µg mL-1 and 30 min for the oral drug suspension, respectively. Pharmacokinetic parameters such as tmax', cmax and AUC of oral and nasal routes were significantly different (p < 0.01). Relative bioavailability of the drug nasal preparation to the oral suspension was up to 1600.0 %. Further, the in vitro effect of the risperidone nasal gel on nasal mucociliary movement was also investigated using a toad palate model. The risperidone nasal formulation showed mild ciliotoxicity, but the adverse effect was temporary and reversible.
[Mh] Termos MeSH primário: Antipsicóticos/administração & dosagem
Antagonistas dos Receptores de Dopamina D2/administração & dosagem
Sistemas de Liberação de Medicamentos
Absorção Nasal
Mucosa Nasal/metabolismo
Risperidona/administração & dosagem
Antagonistas do Receptor 5-HT2 de Serotonina/administração & dosagem
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Antipsicóticos/efeitos adversos
Antipsicóticos/sangue
Antipsicóticos/farmacocinética
Anuros
Disponibilidade Biológica
Cílios/efeitos dos fármacos
Cílios/metabolismo
Antagonistas dos Receptores de Dopamina D2/efeitos adversos
Antagonistas dos Receptores de Dopamina D2/sangue
Antagonistas dos Receptores de Dopamina D2/farmacocinética
Composição de Medicamentos
Géis
Técnicas In Vitro
Masculino
Mucosa Bucal/efeitos dos fármacos
Mucosa Bucal/metabolismo
Mucosa Nasal/efeitos dos fármacos
Palato
Distribuição Aleatória
Ratos Wistar
Risperidona/efeitos adversos
Risperidona/sangue
Risperidona/farmacocinética
Antagonistas do Receptor 5-HT2 de Serotonina/efeitos adversos
Antagonistas do Receptor 5-HT2 de Serotonina/sangue
Antagonistas do Receptor 5-HT2 de Serotonina/farmacocinética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Dopamine D2 Receptor Antagonists); 0 (Gels); 0 (Serotonin 5-HT2 Receptor Antagonists); L6UH7ZF8HC (Risperidone)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


  4 / 29 MEDLINE  
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[PMID]:27598527
[Au] Autor:Tanaka A; Furubayashi T; Matsushita A; Inoue D; Kimura S; Katsumi H; Sakane T; Yamamoto A
[Ad] Endereço:Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan.
[Ti] Título:Nasal Absorption of Macromolecules from Powder Formulations and Effects of Sodium Carboxymethyl Cellulose on Their Absorption.
[So] Source:PLoS One;11(9):e0159150, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The nasal absorption of macromolecules from powder formulations and the effect of sodium carboxymethyl cellulose (CMC-Na) as a pharmaceutical excipient on their absorption were studied. Model macromolecules were fluorescein isothiocyanate-labeled dextran (average molecular weight of 4.4kDa, FD4) and insulin. The plasma concentration of FD4 after application of the powder containing 50% starch (control) was higher than that after application of the solution, and the absorption from 50% starch powder was enhanced by the substitution of starch with CMC-Na. The fractional absorption of FD4 after administration of the CMC-Na powder formulation was 30% and 40% higher than that after administration from the solution and the starch powder, respectively. The nasal absorption of insulin from the powder and the effect of CMC-Na were similar with those of FD4. The effective absorption of FD4 and insulin after application of powder with CMC-Na could be due to the increase in the nasal residence of FD4 and insulin. No damage in the nasal mucosa or dysfunction of the mucociliary clearance was observed after application of the drug powder and CMC-Na. The present findings indicate that nasal delivery of powder formulations with the addition of CMC-Na as an excipient is a promising approach for improving the nasal absorption of macromolecules.
[Mh] Termos MeSH primário: Carboximetilcelulose Sódica/administração & dosagem
Dextranos/administração & dosagem
Excipientes/administração & dosagem
Fluoresceína-5-Isotiocianato/análogos & derivados
Absorção Nasal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Carboximetilcelulose Sódica/química
Dextranos/química
Composição de Medicamentos
Excipientes/química
Fluoresceína-5-Isotiocianato/administração & dosagem
Fluoresceína-5-Isotiocianato/química
Seres Humanos
Insulina/administração & dosagem
Insulina/química
Peso Molecular
Mucosa Nasal/efeitos dos fármacos
Pós/administração & dosagem
Pós/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dextrans); 0 (Excipients); 0 (Insulin); 0 (Powders); 0 (fluorescein isothiocyanate dextran); I223NX31W9 (Fluorescein-5-isothiocyanate); K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0159150


  5 / 29 MEDLINE  
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[PMID]:27260088
[Au] Autor:Horváth T; Ambrus R; Völgyi G; Budai-Szucs M; Márki Á; Sipos P; Bartos C; Seres AB; Sztojkov-Ivanov A; Takács-Novák K; Csányi E; Gáspár R; Szabó-Révész P
[Ad] Endereço:Department of Pharmaceutical Technology, University of Szeged, Szeged, Hungary; Goodwill Pharma Ltd., Szeged, Hungary.
[Ti] Título:Effect of solubility enhancement on nasal absorption of meloxicam.
[So] Source:Eur J Pharm Sci;95:96-102, 2016 Dec 01.
[Is] ISSN:1879-0720
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Besides the opioids the standard management of the World Health Organization suggests NSAIDs (non-steroidal anti-inflammatory drugs) alone or in combination to enhance analgesia in malignant and non-malignant pain therapy. The applicability of NSAIDs in a nasal formulation is a new approach in pharmaceutical technology. In order to enhance the nasal absorption of meloxicam (MX) as an NSAID, its salt form, meloxicam potassium monohydrate (MXP), registered by Egis Plc., was investigated in comparison with MX. The physico-chemical properties of the drugs (structural analysis, solubility and dissolution rate) and the mucoadhesivity of nasal formulations were controlled. In vitro and in vivo studies were carried out to determine the nasal applicability of MXP as a drug candidate in pain therapy. It can be concluded that MX and MXP demonstrated the same equilibrium solubility at the pH5.60 of the nasal mucosa (0.017mg/ml); nonetheless, MXP indicated faster dissolution and a higher permeability through the synthetic membrane. The animal studies justified the short T value (15min) and the high AUC of MXP, which is important in acute pain therapy. It can be assumed that the low mucoadhesivity of MXP spray did not increase the residence time in the nasal cavity, and the elimination from the nasal mucosa was therefore faster than in the case of MX. Further experiments are necessary to prove the therapeutic relevance of this MXP-containing innovative intranasal formulation.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/administração & dosagem
Anti-Inflamatórios não Esteroides/química
Absorção Nasal/efeitos dos fármacos
Tiazinas/administração & dosagem
Tiazinas/química
Tiazóis/administração & dosagem
Tiazóis/química
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Anti-Inflamatórios não Esteroides/metabolismo
Masculino
Absorção Nasal/fisiologia
Ratos
Ratos Sprague-Dawley
Solubilidade/efeitos dos fármacos
Tiazinas/metabolismo
Tiazóis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Thiazines); 0 (Thiazoles); VG2QF83CGL (meloxicam)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE


  6 / 29 MEDLINE  
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[PMID]:27145560
[Au] Autor:Greaves A
[Ti] Título:The use of Midazolam as an Intranasal Sedative in Dentistry.
[So] Source:SAAD Dig;32:46-9, 2016 Jan.
[Is] ISSN:0049-1160
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The administration of midazolam intranasally exploits the unique structure of the nasopharynx thus ensuring rapid delivery to the systemic circulation (The Nose - Brain Pathway). The absorption of midazolam nasally is influenced by the volume and concentration of midazolam, its physicochemical properties and the characteristics of the nasal mucosa. Delivering midazolam intranasally is non-titratable. The level of conscious sedation may be equivalent to that achieved by intravenous routes but is approached in a less controlled manner. Randomised Control trials using intranasal sedation in children have shown the technique to be safe and effective in secondary care for dental procedures at concentrations varying from 0.2 mg/kg to 0.5 mg/kg. A combined technique of intranasal midazolam (to facilitate cannulation) and intravenous midazolam is used for adults with moderate to severe learning disabilities. This has revolutionised dental treatment for this group of patients as treatment under General Anaesthesia (GA) may be avoided. Intranasal delivery of midazolam is emerging as a significant tool in our dental armamentarium for the treatment of anxious children, phobic adult patients and patients with learning disabilities.
[Mh] Termos MeSH primário: Anestesia Dentária/métodos
Sedação Consciente/métodos
Hipnóticos e Sedativos/administração & dosagem
Midazolam/administração & dosagem
[Mh] Termos MeSH secundário: Administração Intranasal
Adulto
Aerossóis
Disponibilidade Biológica
Criança
Ansiedade ao Tratamento Odontológico/prevenção & controle
Seres Humanos
Concentração de Íons de Hidrogênio
Hipnóticos e Sedativos/farmacocinética
Midazolam/farmacocinética
Absorção Nasal/efeitos dos fármacos
Mucosa Nasal/metabolismo
Nasofaringe/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Hypnotics and Sedatives); R60L0SM5BC (Midazolam)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160505
[Lr] Data última revisão:
160505
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE


  7 / 29 MEDLINE  
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[PMID]:27074799
[Au] Autor:Tian L; Inthavong K; Lidén G; Shang Y; Tu J
[Ad] Endereço:1Department of Mechanical and Automotive Engineering, School of Engineering, RMIT University, Building 251.3, Plenty Road, Bundoora, Victoria 3083, Australia;
[Ti] Título:Transport and Deposition of Welding Fume Agglomerates in a Realistic Human Nasal Airway.
[So] Source:Ann Occup Hyg;60(6):731-47, 2016 Jul.
[Is] ISSN:1475-3162
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Welding fume is a complex mixture containing ultra-fine particles in the nanometer range. Rather than being in the form of a singular sphere, due to the high particle concentration, welding fume particles agglomerate into long straight chains, branches, or other forms of compact shapes. Understanding the transport and deposition of these nano-agglomerates in human respiratory systems is of great interest as welding fumes are a known health hazard. The neurotoxin manganese (Mn) is a common element in welding fumes. Particulate Mn, either as soluble salts or oxides, that has deposited on the olfactory mucosa in human nasal airway is transported along the olfactory nerve to the olfactory bulb within the brain. If this Mn is further transported to the basal ganglia of the brain, it could accumulate at the part of the brain that is the focal point of its neurotoxicity. Accounting for various dynamic shape factors due to particle agglomeration, the current computational study is focused on the exposure route, the deposition pattern, and the deposition efficiency of the inhaled welding fume particles in a realistic human nasal cavity. Particular attention is given to the deposition pattern and deposition efficiency of inhaled welding fume agglomerates in the nasal olfactory region. For particles in the nanoscale, molecular diffusion is the dominant transport mechanism. Therefore, Brownian diffusion, hydrodynamic drag, Saffman lift force, and gravitational force are included in the model study. The deposition efficiencies for single spherical particles, two kinds of agglomerates of primary particles, two-dimensional planar and straight chains, are investigated for a range of primary particle sizes and a range of number of primary particles per agglomerate. A small fraction of the inhaled welding fume agglomerates is deposited on the olfactory mucosa, approximately in the range 0.1-1%, and depends on particle size and morphology. The strong size dependence of the deposition in olfactory mucosa on particle size implies that the occupation deposition of welding fume manganese can be expected to vary with welding method.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/toxicidade
Nanopartículas/análise
Absorção Nasal
Soldagem/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Exposição por Inalação
Masculino
Manganês/análise
Manganês/toxicidade
Modelos Estatísticos
Nanopartículas/toxicidade
Exposição Ocupacional/efeitos adversos
Tamanho da Partícula
Sistema Respiratório/química
Sistema Respiratório/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 42Z2K6ZL8P (Manganese)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160415
[St] Status:MEDLINE
[do] DOI:10.1093/annhyg/mew018


  8 / 29 MEDLINE  
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[PMID]:27001956
[Au] Autor:Kamijo S; Suzuki M; Hara M; Shimura S; Ochi H; Maruyama N; Matsuda A; Saito H; Nakae S; Suto H; Ichikawa S; Ikeda S; Ogawa H; Okumura K; Takai T
[Ad] Endereço:Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan;
[Ti] Título:Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes.
[So] Source:J Immunol;196(9):3559-69, 2016 05 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Protease activity of papain, a plant-derived occupational allergen homologous to mite major allergens, is essential to IgE/IgG1 production and lung eosinophilia induced by intranasal papain administration in mice, and IL-33 contributes to these responses. In this work, we investigate skin and Ab responses induced by s.c. papain administration into ear lobes and responses induced by subsequent airway challenge with papain. Subcutaneous papain injection induced swelling associated with increased epidermal thickness, dermal inflammation, serum IgE/IgG1 responses, and Th2 cytokine production in draining lymph node cells restimulated in vitro. These responses were markedly less upon s.c. administration of protease inhibitor-treated papain. Results obtained by using mast cell-deficient mice and reconstitution of tissue mast cells suggested the contribution of mast cells to papain-specific IgE/IgG1 responses and eosinophil infiltration. The responses were equivalent between wild-type and IL-33(-/-) mice. After the subsequent airway challenge, the s.c. presensitized wild-type mice showed more severe lung eosinophilia than those without the presensitization. The presensitized IL-33(-/-) mice showed modest lung eosinophilia, which was absent without the presensitization, but its severity and IgE boost by the airway challenge were markedly less than the presensitized wild-type mice, in which protease activity of inhaled papain contributed to the responses. The results suggest that mechanisms for the protease-dependent sensitization differ between skin and airway and that cooperation of mast cell-dependent, IL-33-independent initial sensitization via skin and protease-induced, IL-33-mediated mechanism in re-exposure via airway to protease allergens maximizes the magnitude of the transition from skin inflammation to asthma in natural history of progression of allergic diseases.
[Mh] Termos MeSH primário: Alérgenos/administração & dosagem
Alérgenos/imunologia
Hipersensibilidade/imunologia
Interleucina-33/imunologia
Mastócitos/imunologia
Absorção Nasal
Peptídeo Hidrolases/imunologia
Absorção Subcutânea
[Mh] Termos MeSH secundário: Animais
Asma
Hiper-Reatividade Brônquica/imunologia
Hiper-Reatividade Brônquica/patologia
Eosinófilos/imunologia
Hipersensibilidade/patologia
Imunoglobulina E/sangue
Imunoglobulina G/sangue
Inflamação
Interleucina-33/deficiência
Pulmão/imunologia
Camundongos
Papaína/administração & dosagem
Papaína/imunologia
Peptídeo Hidrolases/administração & dosagem
Eosinofilia Pulmonar/imunologia
Eosinofilia Pulmonar/patologia
Pele/imunologia
Pele/patologia
Células Th2/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Allergens); 0 (Il33 protein, mouse); 0 (Immunoglobulin G); 0 (Interleukin-33); 37341-29-0 (Immunoglobulin E); EC 3.4.- (Peptide Hydrolases); EC 3.4.22.2 (Papain)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1500717


  9 / 29 MEDLINE  
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[PMID]:26996366
[Au] Autor:Phukan K; Nandy M; Sharma RB; Sharma HK
[Ti] Título:Nanosized Drug Delivery Systems for Direct Nose to Brain Targeting: A Review.
[So] Source:Recent Pat Drug Deliv Formul;10(2):156-64, 2016.
[Is] ISSN:2212-4039
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Drug targeting to brain has always been problematic due to Blood-Brain Barrier (BBB), which, does not allow most of the drugs to pass through it as they are hydrophilic and macromolecular drugs. So, in order to bypass the BBB, alternative modes of administration were searched and nasal to brain delivery route was tried by many workers. Such studies yielded patented nano-formulations with the ability to cross blood brain barrier. METHODS: Nanoparticles being smaller in size and large surface area help in increasing the rate of drug permeation to the brain. In this review work, emphasis has been laid on discussion on various works done in the field of nasal delivery of drugs to brain over the last decade. RESULTS: The works that are discussed in this paper show better drug targeting of brain when given through nasal route as nanoparticles. Experiments performed in animal models have clearly exhibited that nano-sized formulations are able to facilitate the delivery of drugs to brain through nose in comparison to tantamount drug solutions. CONCLUSION: However, it is not yet confirmed whether the drug is freed from the formulation in the nasal cavity and then absorbed or the nanoparticles themselves are absorbed and then the drug is released in the CNS. Furthermore, the toxicity studies were not carried out extensively in suitably designed model, which should be considered before going for further studies and application.
[Mh] Termos MeSH primário: Barreira Hematoencefálica/metabolismo
Portadores de Fármacos
Sistemas de Liberação de Medicamentos/métodos
Nanomedicina/métodos
Nanopartículas
Preparações Farmacêuticas/administração & dosagem
Polímeros/química
Tecnologia Farmacêutica/métodos
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Composição de Medicamentos
Seres Humanos
Absorção Nasal
Mucosa Nasal/metabolismo
Permeabilidade
Preparações Farmacêuticas/química
Preparações Farmacêuticas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Pharmaceutical Preparations); 0 (Polymers)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160322
[St] Status:MEDLINE


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[PMID]:26887679
[Au] Autor:Engelhardt L; Röhm M; Mavoungou C; Schindowski K; Schafmeister A; Simon U
[Ad] Endereço:Scientific Computing Centre Ulm, Ulm University, Helmholtzstraße 20, 89081, Ulm, Germany.
[Ti] Título:First Steps to Develop and Validate a CFPD Model in Order to Support the Design of Nose-to-Brain Delivered Biopharmaceuticals.
[So] Source:Pharm Res;33(6):1337-50, 2016 06.
[Is] ISSN:1573-904X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Aerosol particle deposition in the human nasal cavity is of high interest in particular for intranasal central nervous system (CNS) drug delivery via the olfactory cleft. The objective of this study was the development and comparison of a numerical and experimental model to investigate various parameters for olfactory particle deposition within the complex anatomical nasal geometry. METHODS: Based on a standardized nasal cavity, a computational fluid and particle dynamics (CFPD) model was developed that enables the variation and optimization of different parameters, which were validated by in vitro experiments using a constructed rapid-prototyped human nose model. RESULTS: For various flow rates (5 to 40 l/min) and particle sizes (1 to 10 µm), the airflow velocities, the calculated particle airflow patterns and the particle deposition correlated very well with the experiment. Particle deposition was investigated numerically by varying particle sizes at constant flow rate and vice versa assuming the particle size distribution of the used nebulizer. CONCLUSIONS: The developed CFPD model could be directly translated to the in vitro results. Hence, it can be applied for parameter screening and will contribute to the improvement of aerosol particle deposition at the olfactory cleft for CNS drug delivery in particular for biopharmaceuticals.
[Mh] Termos MeSH primário: Biofarmácia/métodos
Simulação por Computador
Modelos Anatômicos
Modelos Biológicos
Absorção Nasal
Cavidade Nasal/metabolismo
Bulbo Olfatório/metabolismo
Preparações Farmacêuticas/administração & dosagem
Tecnologia Farmacêutica/métodos
[Mh] Termos MeSH secundário: Administração Intranasal
Aerossóis
Feminino
Seres Humanos
Cinética
Masculino
Cavidade Nasal/anatomia & histologia
Cavidade Nasal/diagnóstico por imagem
Análise Numérica Assistida por Computador
Tamanho da Partícula
Permeabilidade
Preparações Farmacêuticas/química
Preparações Farmacêuticas/metabolismo
Reologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Aerosols); 0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160219
[St] Status:MEDLINE
[do] DOI:10.1007/s11095-016-1875-7



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