Base de dados : MEDLINE
Pesquisa : G03.493.875 [Categoria DeCS]
Referências encontradas : 856 [refinar]
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[PMID]:28460114
[Au] Autor:Reynolds HT; Slot JC; Divon HH; Lysøe E; Proctor RH; Brown DW
[Ad] Endereço:Department of Plant Pathology, The Ohio State University, Columbus, OH.
[Ti] Título:Differential Retention of Gene Functions in a Secondary Metabolite Cluster.
[So] Source:Mol Biol Evol;34(8):2002-2015, 2017 Aug 01.
[Is] ISSN:1537-1719
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In fungi, distribution of secondary metabolite (SM) gene clusters is often associated with host- or environment-specific benefits provided by SMs. In the plant pathogen Alternaria brassicicola (Dothideomycetes), the DEP cluster confers an ability to synthesize the SM depudecin, a histone deacetylase inhibitor that contributes weakly to virulence. The DEP cluster includes genes encoding enzymes, a transporter, and a transcription regulator. We investigated the distribution and evolution of the DEP cluster in 585 fungal genomes and found a wide but sporadic distribution among Dothideomycetes, Sordariomycetes, and Eurotiomycetes. We confirmed DEP gene expression and depudecin production in one fungus, Fusarium langsethiae. Phylogenetic analyses suggested 6-10 horizontal gene transfers (HGTs) of the cluster, including a transfer that led to the presence of closely related cluster homologs in Alternaria and Fusarium. The analyses also indicated that HGTs were frequently followed by loss/pseudogenization of one or more DEP genes. Independent cluster inactivation was inferred in at least four fungal classes. Analyses of transitions among functional, pseudogenized, and absent states of DEP genes among Fusarium species suggest enzyme-encoding genes are lost at higher rates than the transporter (DEP3) and regulatory (DEP6) genes. The phenotype of an experimentally-induced DEP3 mutant of Fusarium did not support the hypothesis that selective retention of DEP3 and DEP6 protects fungi from exogenous depudecin. Together, the results suggest that HGT and gene loss have contributed significantly to DEP cluster distribution, and that some DEP genes provide a greater fitness benefit possibly due to a differential tendency to form network connections.
[Mh] Termos MeSH primário: Alcadienos/metabolismo
Compostos de Epóxi/metabolismo
Álcoois Graxos/metabolismo
Genoma Fúngico/genética
Família Multigênica/genética
[Mh] Termos MeSH secundário: Ascomicetos/genética
Bases de Dados de Ácidos Nucleicos
Evolução Molecular
Proteínas Fúngicas/genética
Fusarium/genética
Perfilação da Expressão Gênica/métodos
Regulação Fúngica da Expressão Gênica/genética
Transferência Genética Horizontal/genética
Filogenia
Metabolismo Secundário/genética
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkadienes); 0 (Epoxy Compounds); 0 (Fatty Alcohols); 0 (Fungal Proteins); 139508-73-9 (depudecin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/molbev/msx145


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[PMID]:29273556
[Au] Autor:Sobhani Najafabadi A; Naghavi MR
[Ad] Endereço:Agricultural Biotechnology Research Institute of Iran - Isfahan Branch, Agricultural Research, Education and Extension Organization (AREEO), P.O. Box: 85135-487, Isfahan, Iran. Electronic address: ahmad.sobhani@ut.ac.ir.
[Ti] Título:Mining Ferula gummosa transcriptome to identify miRNAs involved in the regulation and biosynthesis of terpenes.
[So] Source:Gene;645:41-47, 2018 Mar 01.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ferula gummosa is a well-known medicinal and industrial plant for its oleo-gum-resin named galbanum. So far, there is no information about the role of miRNAs on the production of terpenes as the major secondary metabolite of galbanum. In the present study, RNA-seq data on the root and flower of the plant were used to predict miRNAs and their targets using computational approaches. Additionally, biological network analyses were used to unravel the direct or indirect regulatory effects of miRNAs on the targets involved in terpene biosynthesis. For the first time, 220 miRNAs from 94 families have been reported in F. gummosa. miR5658, miR1533, miR5021, miR414, and miR1436 are the top five miRNAs with high abundance. Gene ontology (GO) analysis of the identified targets showed that in the biological process category, the miRNA-regulated genes were highly involved in transcription. According to the KEGG and PlantCyc results, six miRNAs from five miRNA families including miR2919, miR5251, miR838, miR5021, and miR5658 were found to be related to the pathway of terpene biosynthesis. Moreover, network analysis showed that three terpene-regulating TFs namely SPL7, SPL11, and ATHB13 are putatively regulated by three miRNAs including miR1533, miR5021, and miR5658 respectively. Differential gene expression results showed that the expression levels of these miRNAs are negatively correlated to the expression levels of both TFs and their co-expressed terpene biosynthesis genes.
[Mh] Termos MeSH primário: Ferula/genética
Perfilação da Expressão Gênica/métodos
MicroRNAs/genética
Análise de Sequência de RNA/métodos
[Mh] Termos MeSH secundário: Regulação da Expressão Gênica de Plantas
Ontologia Genética
Redes Reguladoras de Genes
Proteínas de Plantas/genética
RNA de Plantas/genética
Metabolismo Secundário
Terpenos/metabolismo
Fatores de Transcrição/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); 0 (Plant Proteins); 0 (RNA, Plant); 0 (Terpenes); 0 (Transcription Factors)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


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[PMID]:27775185
[Au] Autor:Oakley CE; Ahuja M; Sun WW; Entwistle R; Akashi T; Yaegashi J; Guo CJ; Cerqueira GC; Russo Wortman J; Wang CC; Chiang YM; Oakley BR
[Ad] Endereço:Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, Kansas, 66045, USA.
[Ti] Título:Discovery of McrA, a master regulator of Aspergillus secondary metabolism.
[So] Source:Mol Microbiol;103(2):347-365, 2017 Jan.
[Is] ISSN:1365-2958
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fungal secondary metabolites (SMs) are extremely important in medicine and agriculture, but regulation of their biosynthesis is incompletely understood. We have developed a genetic screen in Aspergillus nidulans for negative regulators of fungal SM gene clusters and we have used this screen to isolate mutations that upregulate transcription of the non-ribosomal peptide synthetase gene required for nidulanin A biosynthesis. Several of these mutations are allelic and we have identified the mutant gene by genome sequencing. The gene, which we designate mcrA, is conserved but uncharacterized, and it encodes a putative transcription factor. Metabolite profiles of mcrA deletant, mcrA overexpressing, and parental strains reveal that mcrA regulates at least ten SM gene clusters. Deletion of mcrA stimulates SM production even in strains carrying a deletion of the SM regulator laeA, and deletion of mcrA homologs in Aspergillus terreus and Penicillum canescens alters the secondary metabolite profile of these organisms. Deleting mcrA in a genetic dereplication strain has allowed us to discover two novel compounds as well as an antibiotic not known to be produced by A. nidulans. Deletion of mcrA upregulates transcription of hundreds of genes including many that are involved in secondary metabolism, while downregulating a smaller number of genes.
[Mh] Termos MeSH primário: Aspergillus nidulans/genética
Aspergillus nidulans/metabolismo
Peptídeo Sintases/genética
Peptídeo Sintases/metabolismo
[Mh] Termos MeSH secundário: Proteínas Fúngicas/genética
Proteínas Fúngicas/metabolismo
Regulação Fúngica da Expressão Gênica
Genes Fúngicos
Família Multigênica
Mutação
Metabolismo Secundário
Deleção de Sequência
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
Ativação Transcricional
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins); 0 (Transcription Factors); EC 6.3.2.- (Peptide Synthases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/mmi.13562


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[PMID]:28451907
[Au] Autor:Bennett JW
[Ad] Endereço:Department of Plant Biology, Rutgers University, New Brunswick, NJ, 08901, USA. profmycogirl@yahoo.com.
[Ti] Título:On being an honorary member of Arny's army: some musings about fungal fermentations, secondary metabolism, and scientific communities.
[So] Source:J Ind Microbiol Biotechnol;44(4-5):507-516, 2017 May.
[Is] ISSN:1476-5535
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This essay is an unabashed celebration of applied microbiology and secondary metabolism, and how one scientist-Arnold Demain-has been a spokesman for industrial microbiology and biotechnology. There are many reasons for Arny's professional success. During his long and distinguished career, Arnold Demain has expanded and enriched our understanding of the importance secondary metabolism. He has studied topics that ranged from pickles, to pectinolytic enzymes, to penicillin. His experimental versatility was conducted under the unifying theme of fermentation microbiology. In addition, one of his most positive achievements was his ability to bring scientists from different disciplines and national backgrounds together and thereby nucleate new collaborations. I am one of many people who has benefited from Arny's generous mentoring and speak from the heart when I say that industrial microbiology could not have a better representative. Arny has been the catalyst for much of that has gone right in my professional life and the lives of the many other applied microbiologists who have had the good fortune to know him.
[Mh] Termos MeSH primário: Fermentação
Fungos/metabolismo
[Mh] Termos MeSH secundário: Aflatoxinas
Microbiologia Industrial
Metabolismo Secundário
Sociedades Científicas
[Pt] Tipo de publicação:NEWS; PORTRAITS
[Nm] Nome de substância:
0 (Aflatoxins)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s10295-017-1923-2


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[PMID]:28806739
[Au] Autor:Mao B; Yin H; Wang Y; Zhao TH; Tian RR; Wang W; Ye JS
[Ad] Endereço:Postdoctoral Research Station of Crop Science, College of Agronomy, Shenyang Agricultural University, Shenyang, China.
[Ti] Título:Combined effects of O3 and UV radiation on secondary metabolites and endogenous hormones of soybean leaves.
[So] Source:PLoS One;12(8):e0183147, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Enhanced ultraviolet radiation (UV) and elevated tropospheric ozone (O3) may individually cause reductions in the growth and productivity of important agricultural crops. However, research regarding their combined effects on important agricultural crops is still scarce, especially on changes in secondary metabolites and endogenous hormones, which are important protective substances and signal components that control plant responses to environment stresses. In this study, using an experimental setup of open top chambers, we monitored the responses of seed yield per plant, leaf secondary metabolites and leaf endogenous hormones under the stress of elevated O3 and enhanced UV radiation individually, as well as their combined stress. The results indicated that elevated O3 (110 ± 10 nmol mol-1 for 8 hours per day) and enhanced UV radiation (1.73 kJ h-1 m-2) significantly decreased seed yield per plant. Concentrations of rutin, queretin and total flavonoids were significantly increased under the elevated O3 treatment or the enhanced UV radiation treatment or the combination treatment at flowering and podding stages, and concentrations of rutin, queretin and total flavonoids showed significant correlations with seed yield per plant. Concentrations of ABA and IAA decreased under the three treatments. There was a significant positive correlation between the ABA concentration and seed yield and a negative correlation between the IAA concentration and seed yield. We concluded that the combined stress of elevated O3 and UV radiation significantly decreased seed yield per plant. Yield reduction was associated with changes in the concentrations of flavonoids, ABA and IAA in soybean leaves. The effects of the combined O3 and UV stress were always greater than those of the individual stresses alone.
[Mh] Termos MeSH primário: Ozônio/farmacologia
Reguladores de Crescimento de Planta/farmacologia
Folhas de Planta/metabolismo
Metabolismo Secundário/efeitos dos fármacos
Metabolismo Secundário/efeitos da radiação
Feijão de Soja/metabolismo
Raios Ultravioleta
[Mh] Termos MeSH secundário: Condutividade Elétrica
Flores/efeitos dos fármacos
Flores/fisiologia
Malondialdeído/metabolismo
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/efeitos da radiação
Análise de Componente Principal
Sementes/efeitos dos fármacos
Sementes/metabolismo
Sementes/efeitos da radiação
Feijão de Soja/efeitos dos fármacos
Feijão de Soja/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Growth Regulators); 4Y8F71G49Q (Malondialdehyde); 66H7ZZK23N (Ozone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183147


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[PMID]:28771348
[Au] Autor:Uchimiya M; Knoll JE; Anderson WF; Harris-Shultz KR
[Ad] Endereço:USDA-ARS Southern Regional Research Center , 1100 Robert E. Lee Boulevard, New Orleans, Louisiana 70124, United States.
[Ti] Título:Chemical Analysis of Fermentable Sugars and Secondary Products in 23 Sweet Sorghum Cultivars.
[So] Source:J Agric Food Chem;65(35):7629-7637, 2017 Sep 06.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sorghum (Sorghum bicolor (L.) Moench) is a heat- and drought-tolerant crop that has promise to supplement corn (Zea mays L.) for biofuel production from fermentable sugars (for sweet cultivars) and lignocellulosic biomass. Quantitative relationships are lacking to predict the accumulation of primary (stem sugars) and secondary (organic acids, phenolics, and inorganic species) products that could either expand (as the value-added product) or limit (as the fermentation inhibitor) the market value of a cultivar. Five male (Atlas, Chinese, Dale, Isidomba, N98) and three female (N109B, N110B, and N111B) inbred lines and their hybrids (23 cultivars total) were planted on a Tifton loamy sand in April, May, and June of 2015 in a triplicate split-plot design and were harvested at the hard-dough maturity stage. Stalk juices were analyzed for sugar (glucose, fructose, and sucrose) and organic acid (citrate, oxalate, and cis- and trans-aconitic acid) concentrations, Brix, pH, electric conductivity (EC), total organic carbon (TOC), and total nitrogen (TN), and by fluorescence excitation emission spectrophotometry with parallel factor analysis (EEM/PARAFAC). Later plantings consistently (p < 0.05) (1) increased sucrose, total sugar, and trans-aconitic acid concentrations, Brix, and TOC and (2) decreased EC. Sucrose, total sugar, pH, EC, and Brix showed significant cultivar × planting date interactions. Observed linear relationships (Pearson's) could be used to deploy simple and inexpensive electrode (EC) and fluorescence-based field methods to predict the primary products from secondary products, and vise versa.
[Mh] Termos MeSH primário: Metabolismo dos Carboidratos
Sorghum/química
Sorghum/metabolismo
[Mh] Termos MeSH secundário: Ácidos/química
Ácidos/metabolismo
Biomassa
Carboidratos/química
Metabolismo Secundário
Sorghum/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids); 0 (Carbohydrates)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00675


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[PMID]:28714761
[Au] Autor:Vardhan PV; Shukla LI
[Ad] Endereço:a Department of Biotechnology, School of Life Sciences , Pondicherry University , Pondicherry , India.
[Ti] Título:Gamma irradiation of medicinally important plants and the enhancement of secondary metabolite production.
[So] Source:Int J Radiat Biol;93(9):967-979, 2017 Sep.
[Is] ISSN:1362-3095
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The profitable production of some important plant-based secondary metabolites (ginsenosides, saponins, camptothecin, shikonins etc.) in vitro by gamma irradiation is a current area of interest. We reviewed different types of secondary metabolites, their mode of synthesis and effect of γ-radiation on their yield for different plants, organs and in vitro cultures (callus, suspension, hairy root). Special effort has been made to review the biochemical mechanisms underlying the increase in secondary metabolites. A comparison of yield improvement with biotic and abiotic stresses was made. RESULTS: Phenolic compounds increase with γ-irradiation in whole plants/plant parts; psoralen content in the common herb babchi (Psoralea corylifolia) was increased as high as 32-fold with γ-irradiation of seeds at 20 kGy. The capsaicinoids, a phenolic compound increased about 10% with 10 kGy in paprika (Capsicum annum L.). The in vitro studies show all the three types of secondary metabolites are reported to increase with γ-irradiation. Stevioside, total phenolic and flavonoids content were slightly increased in 15 Gy-treated callus cultures of stevia (Stevia rebaudiana Bert.). In terpenoids, total saponin and ginsenosides content were increased 1.4- and 1.8-fold, respectively, with 100 Gy for wild ginseng (Panax ginseng Meyer) hairy root cultures. In alkaloids, camptothecin yield increased as high as 20-fold with 20 Gy in callus cultures of ghanera (Nothapodytes foetida). Shikonins increased up to 4-fold with 16 Gy in suspension cultures of purple gromwell (Lithospermum erythrorhizon S.). The enzymes associated with secondary metabolite production were increased with γ-irradiation of 20 Gy; namely, phenylalanine ammonia-lyase (PAL) for phenolics, chalcone synthase (CHS) for flavonoids, squalene synthase (SS), squalene epoxidase (SE) and oxidosqualene cyclases (OSC) for ginsenosides and PHB (p-hydroxylbenzoic acid) geranyl transferase for shikonins. CONCLUSIONS: An increase in secondary metabolites in response to various biotic and abiotic stresses is compared with ionizing radiation. A ∼5- to 20-fold increase is noted with ∼20 Gy irradiation dose. It increases the yield of secondary metabolites by enhancing the activity of certain key biosynthetic enzymes. Identification of the optimum dose is the important step in the large-scale production of secondary metabolites at industrial level.
[Mh] Termos MeSH primário: Raios gama
Extratos Vegetais/metabolismo
Estruturas Vegetais/metabolismo
Estruturas Vegetais/efeitos da radiação
Plantas Medicinais/metabolismo
Plantas Medicinais/efeitos da radiação
Metabolismo Secundário/efeitos da radiação
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Plantas Medicinais/classificação
Dose de Radiação
Metabolismo Secundário/fisiologia
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1080/09553002.2017.1344788


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[PMID]:28704611
[Au] Autor:Poutaraud A; Michelot-Antalik A; Plantureux S
[Ad] Endereço:Laboratoire Agronomie et Environnement, INRA , UMR 1121, Colmar, 29 rue de Herrlisheim, F-68021 Colmar Cedex, France.
[Ti] Título:Grasslands: A Source of Secondary Metabolites for Livestock Health.
[So] Source:J Agric Food Chem;65(31):6535-6553, 2017 Aug 09.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The need for environmentally friendly practices in animal husbandry, in conjunction with the reduction of the use of synthetic chemicals, leads us to reconsider our agricultural production systems. In that context, grassland secondary metabolites (GSMs) could offer an alternative way to support to livestock health. In fact, grasslands, especially those with high dicotyledonous plant species, present a large, pharmacologically active reservoir of secondary metabolites (e.g., phenolic compounds, alkaloids, saponins, terpenoids, carotenoids, and quinones). These molecules have activities that could improve or deteriorate health and production. This Review presents the main families of GSMs and uses examples to describe their known impact on animal health in husbandry. Techniques involved for their study are also described. A particular focus is put on anti-oxidant activities of GSMs. In fact, numerous husbandry pathologies, such as inflammation, are linked to oxidative stress and can be managed by a diet rich in anti-oxidants. The different approaches and techniques used to evaluate grassland quality for livestock health highlight the lack of efficient and reliable technics to study the activities of this complex phytococktail. Better knowledge and management of this animal health resource constitute a new multidisciplinary research field and a challenge to maintain and valorize grasslands.
[Mh] Termos MeSH primário: Ração Animal/análise
Gado/metabolismo
Poaceae/química
[Mh] Termos MeSH secundário: Criação de Animais Domésticos
Animais
Pradaria
Gado/crescimento & desenvolvimento
Poaceae/classificação
Poaceae/metabolismo
Metabolismo Secundário
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00425


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[PMID]:28644879
[Au] Autor:Wu Q; Sun R; Ni M; Yu J; Li Y; Yu C; Dou K; Ren J; Chen J
[Ad] Endereço:Department of Environment and Resource, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
[Ti] Título:Identification of a novel fungus, Trichoderma asperellum GDFS1009, and comprehensive evaluation of its biocontrol efficacy.
[So] Source:PLoS One;12(6):e0179957, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Due to its efficient broad-spectrum antimicrobial activity, Trichoderma has been established as an internationally recognized biocontrol fungus. In this study, we found and identified a novel strain of Trichoderma asperellum, named GDFS1009. The mycelium of T. asperellum GDFS1009 exhibits a high growth rate, high sporulation capacity, and strong inhibitory effects against pathogens that cause cucumber fusarium wilt and corn stalk rot. T. asperellum GDFS1009 secretes chitinase, glucanase, and protease, which can degrade the cell walls of fungi and contribute to mycoparasitism. The secreted xylanases are good candidates for inducing plant resistance and enhancing plant immunity against pathogens. RNA sequencing (RNA-seq) and gas chromatography-mass spectrometry (GC-MS) showed that T. asperellum GDFS1009 produces primary metabolites that are precursors of antimicrobial compounds; it also produces a variety of antimicrobial secondary metabolites, including polyketides and alkanes. In addition, this study speculated the presence of six antimicrobial peptides via ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF-MS/MS). Future studies should focus on these antimicrobial metabolites for facilitating widespread application in the field of agricultural bio-control.
[Mh] Termos MeSH primário: Agentes de Controle Biológico
Fusarium/crescimento & desenvolvimento
Doenças das Plantas/prevenção & controle
Trichoderma/metabolismo
[Mh] Termos MeSH secundário: Alcanos/metabolismo
Anti-Infecciosos/química
Anti-Infecciosos/metabolismo
Antibiose
Cromatografia Líquida
Análise por Conglomerados
Cucumis sativus/microbiologia
Proteínas Fúngicas/química
Proteínas Fúngicas/metabolismo
Cromatografia Gasosa-Espectrometria de Massas
Expressão Gênica
Filogenia
Doenças das Plantas/microbiologia
Policetídeos/metabolismo
Metabolismo Secundário
Análise de Sequência de RNA
Microbiologia do Solo
Tabaco/microbiologia
Trichoderma/classificação
Trichoderma/genética
Trichoderma/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Anti-Infective Agents); 0 (Biological Control Agents); 0 (Fungal Proteins); 0 (Polyketides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179957


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[PMID]:28641557
[Au] Autor:Ortiz A; Sansinenea E
[Ad] Endereço:Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, C.P. 72570, Puebla, Pue. Mexico.
[Ti] Título:Cyclic Dipeptides: Secondary Metabolites Isolated from Different Microorganisms with Diverse Biological Activities.
[So] Source:Curr Med Chem;24(25):2773-2780, 2017.
[Is] ISSN:1875-533X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cyclic dipeptides are the simplest peptide derivatives commonly found in nature. These chiral molecules are easily synthesized from readily available α-amino acids using a simple methodology. They are privileged structures with the ability to bind to a wide range of receptors and have a broad variety of biological and pharmacological activities. We will give a brief overview of their status giving and interesting reference list about the last works.
[Mh] Termos MeSH primário: Bactérias/química
Bactérias/metabolismo
Fungos/química
Fungos/metabolismo
Peptídeos Cíclicos/metabolismo
Metabolismo Secundário
[Mh] Termos MeSH secundário: Peptídeos Cíclicos/química
Peptídeos Cíclicos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Peptides, Cyclic)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.2174/0929867324666170623092818



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