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Pesquisa : G03.787.151 [Categoria DeCS]
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[PMID]:29363337
[Au] Autor:Patti F; Chisari CG; D'Amico E; Zappia M
[Ad] Endereço:a Department "GF Ingrassia", Section of Neurosciences, Multiple Sclerosis Center , University of Catania , Catania , Italy.
[Ti] Título:Pharmacokinetic drug evaluation of daclizumab for the treatment of relapsing-remitting multiple sclerosis.
[So] Source:Expert Opin Drug Metab Toxicol;14(3):341-352, 2018 Mar.
[Is] ISSN:1744-7607
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Despite the availability of several disease-modifying therapies for relapsing MS, there is a need for highly efficacious targeted therapy with a favorable benefit-risk profile and a high level of treatment adherence. Daclizumab is a humanized monoclonal antibody directed against CD25, the α subunit of the high-affinity interleukin 2 (IL-2) receptor, that reversibly modulates IL-2 signaling. Areas covered: Daclizumab blocks the activation and expansion of autoreactive T cells that plays a role in the immune pathogenesis of MS. As its modulatory effects on the immune system, daclizumab's potential for use in MS was tested extensively showing a high efficacy in reducing relapse rate, disability progression and the number and volume of gadolinium-enhancing lesions on brain magnetic resonance imaging. Moreover, phase II and III trials showed a favorable pharmacokinetic (PK) profile with slow clearance, linear pharmacokinetics at doses above 100 mg and high subcutaneous bioavailability, not influenced by age, sex or other clinical parameters. Expert opinion: Among the new emerging drugs for MS, daclizumab also, thanks to a favorable PK profile, may represent an interesting and promising therapeutic option in the wide MS therapies armamentarium.
[Mh] Termos MeSH primário: Anticorpos Monoclonais Humanizados/administração & dosagem
Imunoglobulina G/administração & dosagem
Imunossupressores/administração & dosagem
Esclerose Múltipla Recidivante-Remitente/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais Humanizados/farmacocinética
Anticorpos Monoclonais Humanizados/farmacologia
Disponibilidade Biológica
Relação Dose-Resposta a Droga
Seres Humanos
Imunoglobulina G/farmacologia
Imunossupressores/farmacocinética
Imunossupressores/farmacologia
Subunidade alfa de Receptor de Interleucina-2/imunologia
Imagem por Ressonância Magnética
Adesão à Medicação
Esclerose Múltipla Recidivante-Remitente/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antibodies, Monoclonal, Humanized); 0 (IL2RA protein, human); 0 (Immunoglobulin G); 0 (Immunosuppressive Agents); 0 (Interleukin-2 Receptor alpha Subunit); CUJ2MVI71Y (daclizumab)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1080/17425255.2018.1432594


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[PMID]:28934710
[Au] Autor:Kovácik J; Dresler S
[Ad] Endereço:Department of Biology, University of Trnava, Priemyselná 4, 918 43 Trnava, Slovak Republic. Electronic address: jozkovacik@yahoo.com.
[Ti] Título:Calcium availability but not its content modulates metal toxicity in Scenedesmus quadricauda.
[So] Source:Ecotoxicol Environ Saf;147:664-669, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Impact of calcium nutrition (pre-culture on solid medium with standard or elevated Ca dose, i. e. 0.17 and 4.40mM marked as low and high Ca) on acute metal toxicity (Cd, Mn and Pb, 24h of exposure to 10µM) in freshwater green alga Scenedesmus quadricauda was studied. Surprisingly, Ca content differed only slightly between low and high Ca samples and applied metals rather suppressed its amount. Na content was higher in metal-exposed high Ca samples, indicating that Ca/Na ratio may affect accumulation of metals. Content of heavy metals increased in order Cd < Mn < Pb and high Ca samples contained less metal than low Ca samples at least in absorbed fraction. Accumulation of ascorbic acid and thiols (GSH - glutathione and PC2 - phytochelatin 2) was affected mainly by Cd, GSH also by Mn and PC2 by Pb with often significant differences between low Ca and high Ca samples. Calcium nutrition also affected responses of algae to metals at the level of antioxidative enzyme activities (SOD, APX, and CAT) and elevated values were typically found in high Ca samples while ROS (hydrogen peroxide and superoxide radical) were mainly depleted in Mn treatment. These data confirm that Ca nutrition affects accumulation of metals in algae and metabolic parameters as observed in vascular plants but, unlike them, rather Ca/Na ratio than absolute Ca content seems to regulate the uptake of metals.
[Mh] Termos MeSH primário: Cálcio/metabolismo
Monitoramento Ambiental/métodos
Metais Pesados/toxicidade
Scenedesmus/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Disponibilidade Biológica
Metais Pesados/metabolismo
Modelos Teóricos
Espécies Reativas de Oxigênio/metabolismo
Scenedesmus/metabolismo
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Metals, Heavy); 0 (Reactive Oxygen Species); 0 (Water Pollutants, Chemical); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE


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[PMID]:28968942
[Au] Autor:Tran TAT; Dinh QT; Cui Z; Huang J; Wang D; Wei T; Liang D; Sun X; Ning P
[Ad] Endereço:College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, China.
[Ti] Título:Comparing the influence of selenite (Se ) and selenate (Se ) on the inhibition of the mercury (Hg) phytotoxicity to pak choi.
[So] Source:Ecotoxicol Environ Saf;147:897-904, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Selenite (Se (IV)) and selenate (Se (IV)) have recently been demonstrated to be equally effective in inhibiting mercury (Hg) phytotoxicity to plants. This assertion is still unclear. In this study, we aimed to explore the potential effects of Se species (Se and Se ) on the inhibition of the mercury (Hg) bioavailability to pak choi in dry land. Pot experiments with exposure to different dosages of mercuric chloride (HgCl ) and selenite (Na SeO ) or selenate (Na SeO ) were treated. To compare the influence of Se (IV) and Se (VI) on the bioaccumulation and bioavailability of Hg, the levels of total Hg in different pak choi (Brassica chinensis L.) tissues (roots and shoots) and the distribution changes of Hg fractions in soil before planting and after harvest were determined as well as the Hg I values in soils (relative binding intensity) were analyzed. Results showed that application Se (IV) reduced the concentrations of Hg in pak choi roots more than Se (VI). Hg concentrations were also decreased in pak choi shoots in Se (IV) treatments, while which notably increased in Se (VI) treatments. Thus, Se (IV) plays a more important role than Se (VI) in limiting the absorption and bioaccumulation of Hg in pak choi. Moreover, this inhibition may only significantly occur when Se (IV) is at an appropriate level (2.5mg/kg). In addition, the good correlations between the proportions of mobile Hg fractions (soluble and exchangeable fractions), I values with the Hg concentrations in plants were observed. This affirmed the importance of the Hg fractions transformation and the I indicator of Hg in the assessment of their bioavailability. Our findings regarding the importance of Se (IV) influence in reducing Hg bioaccumulation not only provided the correct appraisal about the effect of Se species on the inhibition of the Hg phytotoxicity to pak choi in dry land, but also be a good reference for selecting Se fertilizer forms (Se or Se ).
[Mh] Termos MeSH primário: Brassica/efeitos dos fármacos
Mercúrio/toxicidade
Ácido Selênico/farmacologia
Ácido Selenioso/farmacologia
Poluentes do Solo/toxicidade
Solo/química
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Brassica/metabolismo
China
Fertilizantes
Mercúrio/metabolismo
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/metabolismo
Poluentes do Solo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fertilizers); 0 (Soil); 0 (Soil Pollutants); F6A27P4Q4R (Selenious Acid); FXS1BY2PGL (Mercury); HV0Y51NC4J (Selenic Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


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[PMID]:28968923
[Au] Autor:Filipovic L; Romic M; Romic D; Filipovic V; Ondrasek G
[Ad] Endereço:University of Zagreb Faculty of Agriculture, Department of Soil Amelioration, Svetosimunska 2510000 Zagreb, Croatia. Electronic address: lfilipovic@agr.hr.
[Ti] Título:Organic matter and salinity modify cadmium soil (phyto)availability.
[So] Source:Ecotoxicol Environ Saf;147:824-831, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Although Cd availability depends on its total concentration in soil, it is ultimately defined by the processes which control its mobility, transformations and soil solution speciation. Cd mobility between different soil fractions can be significantly affected by certain pedovariables such as soil organic matter (SOM; over formation of metal-organic complexes) and/or soil salinity (over formation of metal-inorganic complexes). Phytoavailable Cd fraction may be described as the proportion of the available Cd in soil which is actually accessible by roots and available for plant uptake. Therefore, in a greenhouse pot experiment Cd availability was observed in the rhizosphere of faba bean exposed to different levels of SOM, NaCl salinity (50 and 100mM) and Cd contamination (5 and 10mgkg ). Cd availability in soil does not linearly follow its total concentration. Still, increasing soil Cd concentration may lead to increased Cd phytoavailability if the proportion of Cd pool in soil solution is enhanced. Reduced Cd (phyto)availability by raised SOM was found, along with increased proportion of Cd-DOC complexes in soil solution. Data suggest decreased Cd soil (phyto)availability with the application of salts. NaCl salinity affected Cd speciation in soil solution by promoting the formation of CdCl complexes. Results possibly suggest that increased Cd mobility in soil does not result in its increased availability if soil adsorption capacity for Cd has not been exceeded. Accordingly, chloro-complex possibly operated just as a Cd carrier between different soil fractions and resulted only in transfer between solid phases and not in increased (phyto)availability.
[Mh] Termos MeSH primário: Cádmio/análise
Substâncias Húmicas/análise
Salinidade
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Croácia
Modelos Teóricos
Raízes de Plantas/química
Rizosfera
Cloreto de Sódio/análise
Vicia faba/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Humic Substances); 0 (Soil); 0 (Soil Pollutants); 00BH33GNGH (Cadmium); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


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[PMID]:28822260
[Au] Autor:Omouri Z; Hawari J; Fournier M; Robidoux PY
[Ad] Endereço:INRS-Institut Armand Frappier, 531 boulevard des Prairies, Laval, Québec, Canada H7V 1B7; National Research Council of Canada, 6100 Avenue Royalmount, Montréal, Québec, Canada H4P 2R2. Electronic address: Zohra.Omouri@iaf.inrs.ca.
[Ti] Título:Bioavailability and chronic toxicity of bismuth citrate to earthworm Eisenia andrei exposed to natural sandy soil.
[So] Source:Ecotoxicol Environ Saf;147:1-8, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study describes bioavailability and chronic effects of bismuth to earthworms Eisenia andrei using OECD reproduction test. Adult earthworms were exposed to natural sandy soil contaminated artificially by bismuth citrate. Average total concentrations of bismuth in soil recovered by HNO digestion ranged from 75 to 289mg/kg. Results indicate that bismuth decreased significantly all reproduction parameters of Eisenia andrei at concentrations ≥ 116mg/kg. However, number of hatched cocoons and number of juveniles seem to be more sensitive than total number of cocoons, as determined by IC ; i.e., 182, 123 and > 289mg/kg, respectively. Bismuth did not affect Eisenia andrei growth and survival, and had little effect on phagocytic efficiency of coelomocytes. The low immunotoxicity effect might be explained by the involvement of other mechanisms i.e. bismuth sequestered by metal-binding compounds. After 28 days of exposure bismuth concentrations in earthworms tissue increased with increasing bismuth concentrations in soil reaching a stationary state of 21.37mg/kg dry tissue for 243mg Bi/kg dry soil total content. Data indicate also that after 56 days of incubation the average fractions of bismuth available extracted by KNO aqueous solution in soil without earthworms varied from 0.0051 to 0.0229mg/kg, while in soil with earthworms bismuth concentration ranged between 0.310-1.347mg/kg dry soil. We presume that mucus and chelating agents produced by earthworms and by soil or/and earthworm gut microorganisms could explain this enhancement, as well as the role of dermal and ingestion routes of earthworms uptake to soil contaminant.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Oligoquetos/efeitos dos fármacos
Compostos Organometálicos/toxicidade
Poluentes do Solo/toxicidade
Solo/química
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Biomarcadores/análise
Relação Dose-Resposta a Droga
Nível de Efeito Adverso não Observado
Oligoquetos/metabolismo
Compostos Organometálicos/análise
Compostos Organometálicos/metabolismo
Fagocitose/efeitos dos fármacos
Reprodução/efeitos dos fármacos
Poluentes do Solo/análise
Poluentes do Solo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Organometallic Compounds); 0 (Soil); 0 (Soil Pollutants); HS813P8QPX (bismuth tripotassium dicitrate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE


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[PMID]:29200853
[Au] Autor:Briot T; Roger E; Lautram N; Verger A; Clavreul A; Lagarce F
[Ad] Endereço:Micro & Nanomédecines Translationelles - MINT, UNIV Angers, INSERM 1066, CNRS 6021, Université Bretagne Loire, MINT IBS-CHU.
[Ti] Título:Development and in vitro evaluations of new decitabine nanocarriers for the treatment of acute myeloid leukemia.
[So] Source:Int J Nanomedicine;12:8427-8442, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Decitabine is a hydrophilic drug that acts by hypomethylating DNA. Decitabine is used in Europe for the treatment of acute myeloid leukemia (AML) in patients aged ≥65 years. However, it can only be administered intravenously due to very low oral bioavailability and a large distribution volume. Oral administration would allow outpatient treatment, improving quality of life and reducing treatment costs. The present study proposes to develop lipid nanocapsules (LNCs), originally designed for lipophilic drugs, to encapsulate decitabine. Two different formulations of LNCs were designed: LNCs based on a high proportion of Transcutol HP (THP-LNCs) and LNCs associated with a mixture of Transcutol HP and Tween 80 (THP-T80-LNCs). The second formulation had a diameter of 26.5±0.5 nm, high encapsulation efficiency (>85%), and a drug payload of 472±64 µg/mL. Decitabine-loaded THP-T80-LNC cytotoxicity was evaluated on two AML cell lines depending on their decitabine resistance: HEL (not resistant) and HL-60 (resistant). The permeability of decitabine-loaded THP-T80-LNCs was also evaluated on Caco-2 cell monolayers. Decitabine cytotoxicity against HEL and HL-60 was higher when decitabine was loaded in THP-T80-LNCs than when free. Apparent permeability on Caco-2 cell monolayers was also increased, suggesting a potentially useful formulation to increase the oral bioavailability of decitabine.
[Mh] Termos MeSH primário: Azacitidina/análogos & derivados
Portadores de Fármacos/química
Leucemia Mieloide Aguda/tratamento farmacológico
Nanocápsulas/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Antimetabólitos Antineoplásicos/administração & dosagem
Antimetabólitos Antineoplásicos/farmacocinética
Azacitidina/administração & dosagem
Azacitidina/farmacocinética
Disponibilidade Biológica
Células CACO-2
Linhagem Celular Tumoral
Portadores de Fármacos/administração & dosagem
Liberação Controlada de Fármacos
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
Estabilidade de Medicamentos
Etilenoglicóis/química
Seres Humanos
Lipídeos/química
Nanocápsulas/química
Polissorbatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimetabolites, Antineoplastic); 0 (Drug Carriers); 0 (Ethylene Glycols); 0 (Lipids); 0 (Nanocapsules); 0 (Polysorbates); 776B62CQ27 (decitabine); A1A1I8X02B (carbitol); M801H13NRU (Azacitidine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S147659


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[PMID]:28627258
[Au] Autor:Manjunath BN; Shenvi S; Raja A; Reddy GC
[Ad] Endereço:a Chemical Sciences Division , Vittal Mallya Scientific Research Foundation , Bangalore , India.
[Ti] Título:New water soluble glycosides of 11-keto-ß-boswellic acid: A paradigm.
[So] Source:Nat Prod Res;32(2):154-161, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Though several glycosides of various triterpenes are known, but surprisingly no boswellic acid glycosides are reported so far. With a view to make water soluble boswellic acids, prepared glycosides of 11-keto boswellic acid for the first time. Naturally occurring boswellic acids which are anti-inflammatory agents are lipophylic in nature and thus, become a limiting factor in terms of their bioavailability. Among boswellic acids, 11-keto-ß-boswellic acid is found to exhibit superior biological activity and hence successfully prepared its glucosyl and maltosyl derivatives viz., 11-keto-ß-boswellic acid-24-O-ß-D-glucopyranoside (9) and 11-keto-ß-boswellic acid-24-O-α-D-glucopyranosyl-(1 â†’ 4)-ß-D-glucopyranoside (15) which are water soluble. Both these compounds are soluble in water to the extent of 10% (w/w) which is very significant.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacocinética
Glicosídeos/farmacocinética
Triterpenos/síntese química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/síntese química
Anti-Inflamatórios/química
Disponibilidade Biológica
Boswellia/química
Glicosídeos/síntese química
Glicosídeos/química
Solubilidade
Triterpenos/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (11-keto-boswellic acid); 0 (Anti-Inflammatory Agents); 0 (Glycosides); 0 (Triterpenes); 059QF0KO0R (Water); 631-69-6 (boswellic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1342084


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[PMID]:29345918
[Au] Autor:Villalva M; Jaime L; Aguado E; Nieto JA; Reglero G; Santoyo S
[Ad] Endereço:Institute of Food Science Research (CIAL), Universidad Autónoma de Madrid (CEI UAM + CSIC) , 28049 Madrid, Spain.
[Ti] Título:Anti-Inflammatory and Antioxidant Activities from the Basolateral Fraction of Caco-2 Cells Exposed to a Rosmarinic Acid Enriched Extract.
[So] Source:J Agric Food Chem;66(5):1167-1174, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The potential use of Origanum majorana L. as a source of bioavailable phenolic compounds, specifically rosmarinic acid (RA), has been evaluated. Phenolic bioavailability was tested using an in vitro digestion process followed by a Caco-2 cellular model of intestinal absorption. The high-performance liquid chromatography-photodiode array detector-tandem mass spectrometry (HPLC-PAD-MS/MS) analysis showed the main components in the extract were 6-hydroxyluteolin-7-O-glucoside and rosmarinic acid, followed by luteolin-O-glucoside. After digestion process, the amount of total phenolic compounds (TPC) only decreased slightly, although a remarkable reduction in RA (near 50%) was detected. Bioavailable fraction contained 7.37 ± 1.39 mg/L digested extract of RA with small quantities of lithospermic acid and diosmin and presented an important antioxidant activity (0.89 ± 0.09 mmol Trolox/L digested extract). Besides, this bioavailable fraction produced a significant inhibition in TNF-α, IL-1ß, and IL-6 secretion, using a human THP-1 macrophages model. Therefore, RA content in the basolateral compartment could play an important role in the antioxidant and anti-inflammatory activities found.
[Mh] Termos MeSH primário: Anti-Inflamatórios
Antioxidantes
Cinamatos/farmacologia
Depsídeos/farmacologia
Origanum/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Células CACO-2
Cinamatos/análise
Cinamatos/farmacocinética
Depsídeos/análise
Depsídeos/farmacocinética
Seres Humanos
Absorção Intestinal
Fenóis/farmacocinética
Extratos Vegetais/farmacocinética
Folhas de Planta/química
Células THP-1
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cinnamates); 0 (Depsides); 0 (Phenols); 0 (Plant Extracts); MQE6XG29YI (rosmarinic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b06008


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[PMID]:29333856
[Au] Autor:Xie Y; Zhu X; Li Y; Wang C
[Ad] Endereço:School of Food Science and Technology, Henan University of Technology , Zhengzhou, Henan 450001, People's Republic of China.
[Ti] Título:Analysis of the pH-Dependent Fe(III) Ion Chelating Activity of Anthocyanin Extracted from Black Soybean [Glycine max (L.) Merr.] Coats.
[So] Source:J Agric Food Chem;66(5):1131-1139, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Fe(III) chelating activity of anthocyanin extracted from black soybean coats was investigated at pH 3.0, 5.0, 6.5, 7.0, and 7.4 with fluorescence spectroscopy and microscale thermophoresis (MST). Cyanidin-3-glucoside (C3G) was determined to be 98% of the total anthocyanin by high-performance liquid chromatography. The binding affinity (K ) exhibited significant pH-dependent behavior: K was 9.7167 × 10 , 1.0837 × 10 , 1.4284 × 10 , 5.4550 × 10 , and 3.0269 × 10 M at pH 3.0, 5.0, 6.5, 7.0, and 7.4, respectively (p < 0.05). The MST data showed that ΔG < 0 and ΔH < 0, demonstrating that chelation is spontaneous and exothermic. Because both ΔH and ΔS < 0, the chelation involves hydrogen bonds and/or van der Waals forces for pH 3.0, 5.0, and 6.5. Electrostatic interactions contributed to chelation at pH 7.0 and 7.4 with ΔH < 0 and ΔS > 0. With the formation of chelates, C3G improved the solubility of Fe(III) at pH 6.5, 7.0, and 7.4 to enhance the ferric ion bioavailability, except for aggregation observed at pH 5.0.
[Mh] Termos MeSH primário: Antocianinas/química
Antocianinas/isolamento & purificação
Compostos Férricos/química
Quelantes de Ferro/química
Feijão de Soja/química
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Ligações de Hidrogênio
Concentração de Íons de Hidrogênio
Solubilidade
Espectrometria de Fluorescência
Eletricidade Estática
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Ferric Compounds); 0 (Iron Chelating Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180116
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04719


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[PMID]:29328647
[Au] Autor:Hsieh HL; Lee CH; Lin KC
[Ad] Endereço:Department of Life Science, National Dong Hwa University , Hualien County 974, Taiwan.
[Ti] Título:Development of Yam Dioscorin-Loaded Nanoparticles for Paracellular Transport Across Human Intestinal Caco-2 Cell Monolayers.
[So] Source:J Agric Food Chem;66(5):1175-1183, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dioscorins, the major storage proteins of yam tubers, exert immunomodulatory activities. To improve oral bioavailability of dioscorins in the intestine, recombinant dioscorin (rDioscorin) was coated with N,N,N-trimethyl chitosan (TMC) and tripolyphosphate (TPP), resulting in the formation of TMC-rDio-TPP nanoparticles (NPs). The loading capacity and entrapment efficiency of rDioscorin in the NPs were 26 ± 0.7% and 61 ± 1.4%, respectively. The NPs demonstrated a substantial release profile in the pH environment of the jejunum. The rDioscorin released from the NPs stimulated proliferation and phagocytosis of the macrophage RAW264.7 and activated the gene expression of IL-1ß and IL-6. Incubation of the NPs in the Caco-2 cell monolayer led to a 5.2-fold increase of P compared with rDioscorin alone, suggesting that rDioscorin, with the assistance of TMC, can be promptly transported across the intestinal epithelia. These results demonstrate that the TMC-rDio-TPP NPs can be utilized for elucidating the immunopharmacological effects of dioscorins through oral delivery.
[Mh] Termos MeSH primário: Dioscorea/química
Intestinos/metabolismo
Nanopartículas/metabolismo
Proteínas de Plantas/metabolismo
[Mh] Termos MeSH secundário: Administração Oral
Disponibilidade Biológica
Transporte Biológico
Células CACO-2
Proliferação Celular/efeitos dos fármacos
Quitosana
Expressão Gênica/efeitos dos fármacos
Seres Humanos
Concentração de Íons de Hidrogênio
Interleucina-1beta/genética
Interleucina-6/genética
Mucosa Intestinal/metabolismo
Nanopartículas/administração & dosagem
Fagocitose/efeitos dos fármacos
Proteínas de Plantas/administração & dosagem
Proteínas de Plantas/farmacocinética
Tubérculos/química
Polifosfatos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (Interleukin-6); 0 (N-trimethyl chitosan chloride); 0 (Plant Proteins); 0 (Polyphosphates); 0 (dioscorin protein, Dioscorea); 9012-76-4 (Chitosan); NU43IAG5BC (triphosphoric acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04150



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