Base de dados : MEDLINE
Pesquisa : G03.857 [Categoria DeCS]
Referências encontradas : 9466 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 947 ir para página                         

  1 / 9466 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Lemos, Tadeu
Texto completo SciELO Brasil
[PMID]:29267663
[Au] Autor:Sordi MB; Massochin RC; Camargo AR; Lemos T; Munhoz EA
[Ad] Endereço:Universidade Federal de Santa Catarina - UFSC, Health Science Centre, Department of Stomatology, Florianópolis, SC, Brazil.
[Ti] Título:Oral health assessment for users of marijuana and cocaine/crack substances.
[So] Source:Braz Oral Res;31:e102, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to assess the oral health status of users of illicit drugs such as marijuana and cocaine/crack and compare it with individuals not using these chemical substances. Questionnaires were applied to 35 illicit drugs users to gather information on demographic status, general health, and use of drugs. Then, a clinical assessment of the oral health condition was performed to collect data on decayed, missing and filled teeth (DMFT) index, salivary flow rate (SFR), and mucosal lesions. The control group was composed of 35 non-illicit drug users. In the experimental group, 91.43% were males, 80% were smokers, and 42.85% were alcoholics. Cocaine was the most common drug used (77.15%), followed by marijuana (68.6%), and crack (51.4%). The average DMFT index was 9.8 and the SFR was reduced in 60% of subjects. Mucosal alterations were detected, but no potentially malignant disorders or oral cancer were diagnosed. Compared to control group, significantly higher values for gender (40%, p = 0.0001), smoking (22.86%) and heavy drinking (5.7%) habits (p = 0.0001), SFR (31.4%; p = 0.0308), and oral lesions (p = 0.0488) were found for the experimental group, although significantly higher values were found in the control group for DMFT index (p = 0.0148). It can be concluded that the use of illicit drugs contributed to an increased prevalence of oral mucosa lesions. In addition, a decline on SFR and a reduced DMFT index was observed for illicit drug users.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Cocaína/complicações
Abuso de Maconha/complicações
Doenças da Boca/induzido quimicamente
Mucosa Bucal/efeitos dos fármacos
Saúde Bucal/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Alcoolismo/complicações
Alcoolismo/epidemiologia
Estudos de Casos e Controles
Transtornos Relacionados ao Uso de Cocaína/epidemiologia
Estudos Transversais
Índice CPO
Feminino
Seres Humanos
Masculino
Abuso de Maconha/epidemiologia
Meia-Idade
Doenças da Boca/epidemiologia
Fatores de Risco
Salivação/efeitos dos fármacos
Taxa Secretória/efeitos dos fármacos
Distribuição por Sexo
Fumar/efeitos adversos
Fumar/epidemiologia
Fatores Socioeconômicos
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  2 / 9466 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28357897
[Au] Autor:MacDonald LA; Minahan CL
[Ad] Endereço:a Griffith University Sports Science, School of Allied Health Sciences , Griffith University , Gold Coast , Australia.
[Ti] Título:Mindfulness training attenuates the increase in salivary cortisol concentration associated with competition in highly trained wheelchair-basketball players.
[So] Source:J Sports Sci;36(4):378-383, 2018 Feb.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study determined the effect of 8 wk of mindfulness training (MT) on salivary cortisol (sCort) and rate of salivary Immunoglobulin-A (sIgA) secretion in wheelchair-basketball players during a competition period. The mindful group completed 8 weeks of MT in addition to training and competition. sCort and rate of sIgA secretion were measured at baseline, at 2-week intervals, the end and 2 weeks following the intervention. A significant time and group interaction was observed for sCort (F = 3.297, P = 0.040, ES = 0.191); sCort increased in the control group from MT-BL to MT-2wk (P = 0.001) and remained significantly elevated at MT-4wk (P = 0.013) and MT-6wk (P = 0.002). sCort decreased from MT-6wk to MT-8wk (P < 0.001) and concentrations were not different at MT-8wk and Post-2wk to MT-BL (P > 0.05). Mindful group sCort increased from MT-BL to MT-2wk (P = 0.042) but decreased to concentrations no different to MT-BL for the rest of the intervention period (P > 0.05). There were no group differences in rate of sIgA secretion during the intervention (P = 0.810). It was concluded that 8 weeks of MT attenuated the increase in sCort associated with the competition period.
[Mh] Termos MeSH primário: Basquetebol/fisiologia
Basquetebol/psicologia
Comportamento Competitivo/fisiologia
Atenção Plena
Estresse Psicológico/prevenção & controle
Cadeiras de Rodas
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hidrocortisona/metabolismo
Imunoglobulina A Secretora/metabolismo
Masculino
Aplicativos Móveis
Saliva/metabolismo
Taxa Secretória
Smartphone
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Immunoglobulin A, Secretory); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1308001


  3 / 9466 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:28591239
[Au] Autor:Antoniazzi RP; Sari AR; Casarin M; Moraes CMB; Feldens CA
[Ad] Endereço:Centro Universitário Franciscano, Santa Maria, RS, Brazil.
[Ti] Título:Association between crack cocaine use and reduced salivary flow.
[So] Source:Braz Oral Res;31:e42, 2017 Jun 05.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Crack cocaine use appears to have an impact on oral conditions. However, changes in the salivary flow among crack users have not been fully clarified. The aim of this study was to compare stimulated salivary flow and the occurrence of hyposalivation between crack users and non-users. A cross-sectional study was conducted involving 40 crack users and 40 controls matched for sex, age, and smoking habits. Interviews were conducted to acquire data on the perception of dry mouth (xerostomia) and drug use. Stimulated salivary flow was determined using the spitting method. A significant reduction in stimulated salivary flow was found among crack users in comparison to non-users (1.02 vs. 1.59 ml/min). A total of 42.5% and 15% of crack users had very low and low stimulated salivary flow, respectively. Moreover, 65% of users reported xerostomia in comparison to 37.5% non-users (p < 0.012). No significant association was found between xerostomia and hyposalivation (p = 0.384). A multivariate analysis revealed that individuals older than 26 years of age, those with a low household income, and crack users (prevalence ratio: 2.59) had a significant association with the occurrence of hyposalivation. A significant association was found between the use of crack and reduced salivary flow. The use of crack was associated with the occurrence of hyposalivation in the multivariate analysis.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Cocaína/fisiopatologia
Cocaína Crack/efeitos adversos
Salivação/efeitos dos fármacos
Xerostomia/induzido quimicamente
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos de Casos e Controles
Estudos Transversais
Índice CPO
Feminino
Seres Humanos
Masculino
Meia-Idade
Análise Multivariada
Salivação/fisiologia
Taxa Secretória/efeitos dos fármacos
Estatísticas não Paramétricas
Inquéritos e Questionários
Uso de Tabaco/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Crack Cocaine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  4 / 9466 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28165549
[Au] Autor:Foglio-Bonda PL; Brilli K; Pattarino F; Foglio-Bonda A
[Ad] Endereço:Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy. pierluigi.fogliobonda@unipmn.it.
[Ti] Título:Salivary flow rate and pH in patients with oral pathologies.
[So] Source:Eur Rev Med Pharmacol Sci;21(2):369-374, 2017 Jan.
[Is] ISSN:2284-0729
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Determine salivary pH and flow rate (FR) in a sample of 164 patients who came to Oral Pathology ambulatory, 84 suffering from oral lesions and 80 without oral lesions. Another aim was to evaluate factors that influence salivary flow rate. PATIENTS AND METHODS: Subjects underwent clinical examination and completed an anamnestic questionnaire in order to obtain useful information that was used to classify participants in different groups. Unstimulated whole saliva (UWS) was collected using the spitting method at 11:00 am. The FR was evaluated with the weighing technique and a portable pHmeter, equipped with a microelectrode, was used to measure pH. Both univariate and classification (single and Random Forest) analyses were performed. RESULTS: The data analysis showed that FR and pH showed significant differences (p < 0.001) between patients with oral lesions (FR = 0.336 mL/min, pH = 6.69) and the ones without oral lesions (FR = 0.492 mL/min, pH = 6.96). By Random Forest, oral lesions and antihypertensive drugs were ranked in the top two among the evaluated variables to discretize subjects with FR = 0.16 mL/min. CONCLUSIONS: Our study shows that there is a relationship between oral lesions, antihypertensive drugs and alteration of pH and FR.
[Mh] Termos MeSH primário: Concentração de Íons de Hidrogênio
Doenças da Boca/fisiopatologia
Saliva
[Mh] Termos MeSH secundário: Adulto
Idoso
Anti-Hipertensivos
Feminino
Seres Humanos
Masculino
Meia-Idade
Taxa Secretória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE


  5 / 9466 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:28099580
[Au] Autor:Niklander S; Veas L; Barrera C; Fuentes F; Chiappini G; Marshall M
[Ad] Endereço:Universidad Andres Bello, Dentistry Faculty, Viña del Mar, Chile.
[Ti] Título:Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life.
[So] Source:Braz Oral Res;31:e14, 2017 01 16.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:To determine xerostomia-related frequency, factors, salivary flow rates and Oral Health-Related Quality of Life (OHRQoL) of patients attending the Universidad Andrés Bello Dental School Clinic, in the city of Viña del Mar, Chile. The study involved 566 patients assessed with xerostomia, based on a single standardized questionnaire. The severity and impact of xerostomia on OHRQoL was assessed using a visual analogue scale (VAS) and the short version of the Oral Health Impact Profile Questionnaire (OHIP-14sp), respectively. Stimulated and non-stimulated salivary flow rates were obtained from a sample of patients. Xerostomia was reported in 61 patients (10.8%), comprising 50 women (83.3%) and 11 men (16.7%) (p < 0.013). The prevalence was 13% among the women and 6.1% among the men. Gender, age and medication were found to be independent risk factors for the development of xerostomia. Hyposalivation was found in 10 of the 35 patients with xerostomia (28.6%) and in 2 patients without it (p < 0.011). Patients with xerostomia had a reduced OHRQoL, compared with patients without xerostomia, as shown by the total OHIP-14sp score (p < 0.001). Xerostomia was a common, potentially debilitating condition with a major impact on the OHRQoL of a patient population attending a university-based dental clinic. Hyposalivation was present in almost 30% of the patients who complained of xerostomia. It is important that general dentists be aware of this condition, so that they can provide patients with a good diagnosis, treatment and follow-up.
[Mh] Termos MeSH primário: Saúde Bucal/estatística & dados numéricos
Qualidade de Vida
Xerostomia/epidemiologia
Xerostomia/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Distribuição por Idade
Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Chile/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Prevalência
Fatores de Risco
Saliva/secreção
Glândulas Salivares/fisiopatologia
Salivação/fisiologia
Taxa Secretória
Distribuição por Sexo
Estatísticas não Paramétricas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE


  6 / 9466 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:28099577
[Au] Autor:Ambrósio LM; Rovai ES; França BN; Balzarini DA; Abreu IS; Lopes SB; Nunes TB; Lourenço SV; Pasoto SG; Saraiva L; Holzhausen M
[Ad] Endereço:Universidade de São Paulo - USP, School of Dentistry, Department of Stomatology, Discipline of Periodontology, São Paulo, SP, Brazil.
[Ti] Título:Effects of periodontal treatment on primary sjÈ«gren's syndrome symptoms.
[So] Source:Braz Oral Res;31:e8, 2017 01 16.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (ESSDAI) and subjective (ESSPRI) indexes in patients with primary Sjögren's Syndrome (pSS). Twenty-eight female patients were divided into four groups: pSS patients with or without chronic periodontitis (SCP, SC, respectively), and systemically healthy patients with or without chronic periodontitis (CP, C, respectively). Periodontal clinical examination and immunological and microbiological sample collection were performed at baseline, 30 and 90 days after nonsurgical periodontal treatment (NSPT). Levels of interleukin IL-1ß, IL-8 and IL-10 in saliva and gingival crevicular fluid (GCF) were evaluated by ELISA, as well as the expression of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans, (Aa) Tannerella forsythia (Tf), and Treponema denticola (Td), by qPCR. Systemic activity and pSS symptoms were evaluated by ESSDAI and ESSPRI. NSPT resulted in improved periodontal clinical parameters in both SCP and CP groups (p>0.05). Pg, Aa, and Tf levels decreased after NSPT only in CP patients (p<0.05). Significantly greater levels of IL-10 in GCF were verified in both SCP and CP groups (p<0.05). SCP patients showed increased salivary flow rates and decreased ESSPRI scores after NSPT. In conclusion, NSPT in pSS patients resulted in improved clinical and immunological parameters, with no significant effects on microbiological status. pSS patients also showed increased salivary flow and lower ESSPRI scores after therapy. Therefore, it can be suggested that NSPT may improve the quality of life of pSS patients.
[Mh] Termos MeSH primário: Periodontite Crônica/etiologia
Periodontite Crônica/terapia
Síndrome de Sjogren/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Carga Bacteriana
Estudos de Casos e Controles
Periodontite Crônica/microbiologia
Periodontite Crônica/fisiopatologia
Ensaio de Imunoadsorção Enzimática
Feminino
Líquido do Sulco Gengival
Seres Humanos
Interleucinas/análise
Estudos Longitudinais
Meia-Idade
Reação em Cadeia da Polimerase
Estudos Prospectivos
Saliva/química
Salivação/fisiologia
Taxa Secretória
Síndrome de Sjogren/fisiopatologia
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE


  7 / 9466 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27545396
[Au] Autor:Gillum T; Kuennen M; McKenna Z; Castillo M; Jordan-Patterson A; Bohnert C
[Ad] Endereço:a Department of Kinesiology , California Baptist University , Riverside , CA , USA.
[Ti] Título:Exercise does not increase salivary lymphocytes, monocytes, or granulocytes, but does increase salivary lysozyme.
[So] Source:J Sports Sci;35(13):1294-1299, 2017 Jul.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An increase in salivary leukocytes may contribute to the exercise-induced increase in salivary antimicrobial proteins (AMPs). However, exercise-induced changes in salivary leukocytes have not been studied. The purpose of the study was to describe salivary leukocyte changes with exercise. Participants (n = 11, 20.3 ± 0.8 years, 57.2 ± 7.6 ml kg min peak oxygen uptake ((VO) ̇ peak), 11.1 ± 3.9% body fat) ran for 45 min at 75% of VO . Stimulated saliva (12 mL) was collected pre- and immediately post exercise. Saliva was filtered through a 30 µm filter before analysis of leukocytes (CD45 ), granulocytes (CD45 CD15 ), monocytes (CD45 CD14 ), T-cells (CD45 CD3 ), and B-cells (CD45 CD20 ) using flow cytometry. Saliva was analysed for Lysozyme (Lys) using ELISA. Exercise did not alter any leukocyte subset. The major constituent of leukocytes pre-exercise were granulocytes (57.9 ± 30.3% compared with monocytes: 5.1 ± 2.7%, T-cells: 17.1 ± 8.9%, B-cells: 12.1 ± 10.2%) (P < 0.05). In a subset of n = 6, Lys secretion rate increased after exercise (pre: 5,170 ± 5,215 ng/min; post: 7,639 ± 4,140 ng/min) (P < 0.05). Exercise does not result in increased granulocytes, but does increase Lys. Further, these data suggest that an increase in salivary leukocytes is not needed to increase Lys.
[Mh] Termos MeSH primário: Linfócitos B/metabolismo
Exercício/fisiologia
Granulócitos/metabolismo
Monócitos/metabolismo
Muramidase/metabolismo
Saliva/metabolismo
Linfócitos T/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Muramidase/secreção
Saliva/enzimologia
Taxa Secretória
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.2.1.17 (Muramidase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2016.1221522


  8 / 9466 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29045101
[Au] Autor:Glazar I; Urek MM; Kuis D; Prpic J; Miskovic I; Pavicic DK; Pezelj-Ribaric S
[Ti] Título:SALIVARY FLOW RATE, ORAL YEAST COLONIZATION AND DENTAL STATUS IN INSTITUTIONALIZED AND NON-INSTITUTIONALIZED ELDERLY.
[So] Source:Acta Clin Croat;55(3):390-5, 2016 09.
[Is] ISSN:0353-9466
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Elderly people, especially those institutionalized in long-term care facilities, are at risk of various oral diseases. The aim of the study was to determine the incidence of hyposalivation and colonization/oral fungal infection of oral cavity with yeasts, as well as dental status in institutionalized and non-institutionalized elderly. The study included 280 institutionalized and 61 non-institutionalized elderly people. Salivary flow rate, oral colonization with yeasts/oral infection and dental status were assessed and compared between the groups. The institutionalized elderly had a significantly lower salivary flow rate (p=0.035). Oral colonization with yeasts was more frequently found in institutionalized elderly (p<0.001) as compared with non-institutionalized elderly. A negative correlation was found between decreased salivary flow rate and oral yeast colonization and oral fungal infection in both the institutionalized (rs=-0.58; p<0.05) and non-institutionalized (rs=-0.52; p<0.05) groups. A significant difference in DMFT index was observed between the two groups (p<0.001). A negative correlation between decreased salivary flow rate and dental status was found in both the institutionalized (rs=-0.22; p<0.05) and non-institutionalized (rs=-0.56; p<0.05) groups. The results revealed a significantly higher level of hyposalivation and oral yeast colonization and poorer dental status in the institutionalized group as compared with the non-institutionalized group of elderly people.
[Mh] Termos MeSH primário: Candidíase Bucal/epidemiologia
Institucionalização/estatística & dados numéricos
Doenças da Boca/microbiologia
Mucosa Bucal/microbiologia
Saliva/microbiologia
[Mh] Termos MeSH secundário: Idoso
Síndrome da Ardência Bucal/microbiologia
Croácia/epidemiologia
Feminino
Seres Humanos
Masculino
Doenças da Boca/epidemiologia
Casas de Saúde/estatística & dados numéricos
Saúde Bucal
Taxa Secretória/fisiologia
Distúrbios do Paladar/microbiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE


  9 / 9466 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27865162
[Au] Autor:Bajaj MS; Kulkarni RS; Ghode SS; Limaye LS; Kale VP
[Ad] Endereço:Stem Cell Lab, National Centre for Cell Science, Ganeshkhind, Pune, Maharashtra 411007, India.
[Ti] Título:Irradiation-induced secretion of BMP4 by marrow cells causes marrow adipogenesis post-myelosuppression.
[So] Source:Stem Cell Res;17(3):646-653, 2016 Nov.
[Is] ISSN:1876-7753
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pre-transplant myeloablation is associated with marrow adipogenesis, resulting in delayed engraftment of hematopoietic stem cells (HSCs). This is strongly undesirable, especially when the donor HSCs are fewer in numbers or have compromised functionality. The molecular mechanisms behind irradiation-induced marrow adipogenesis have not been extensively investigated. Here we show that bone marrow (BM) cells, especially T-cells and stromal cells, express and secrete copious amounts of BMP4 in response to irradiation, which causes the bone marrow stromal cells to commit to adipocyte lineage, thereby contributing to an increase in bone marrow adipogenesis. We further demonstrate that Simvastatin inhibits the BMP4-mediated adipogenic commitment of marrow stromal cells by inhibiting Ppar-γ expression. Importantly, Simvastatin does not prevent BMP4 secretion by the BM cells, and thus does not interfere with its salutary role in post-transplant hematopoietic regeneration. Our data identify previously unknown mechanisms operative in marrow adipogenesis post-myeloablation. They also reveal the molecular mechanisms behind the advantage of using Simvastatin as a niche-targeting agent to improve HSC engraftment.
[Mh] Termos MeSH primário: Adipogenia/efeitos da radiação
Células da Medula Óssea/efeitos da radiação
Proteína Morfogenética Óssea 4/secreção
[Mh] Termos MeSH secundário: Adipócitos/citologia
Adipócitos/efeitos da radiação
Adipogenia/fisiologia
Animais
Células da Medula Óssea/secreção
Camundongos
Camundongos Endogâmicos C57BL
PPAR gama/biossíntese
Taxa Secretória/efeitos dos fármacos
Taxa Secretória/efeitos da radiação
Sinvastatina/farmacologia
Células Estromais/metabolismo
Células Estromais/efeitos da radiação
Linfócitos T/metabolismo
Linfócitos T/efeitos da radiação
Irradiação Corporal Total
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bmp4 protein, mouse); 0 (Bone Morphogenetic Protein 4); 0 (PPAR gamma); AGG2FN16EV (Simvastatin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE


  10 / 9466 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27845883
[Au] Autor:Saes Busato IM; Antoni CC; Calcagnotto T; Ignácio SA; Azevedo-Alanis LR
[Ti] Título:Salivary flow rate, buffer capacity, and urea concentration in adolescents with type 1 diabetes mellitus.
[So] Source:J Pediatr Endocrinol Metab;29(12):1359-1363, 2016 Dec 01.
[Is] ISSN:2191-0251
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The objective of the study was to analyze salivary flow rate, urea concentration, and buffer capacity in adolescents with type 1 diabetes mellitus (type 1 DM) in two different stages. METHODS: This study was performed on adolescents (14-19 years), allocated between two groups: type 1 DM group comprised 32 adolescents with type 1 DM, and non-type 1 DM group comprised 32 nondiabetics. The adolescents in type 1 DM group were evaluated at a baseline (T0) and after 15 months (T1), and those in non-type 1 DM group were only evaluated at T0. Diabetic status was determined by glycosylated hemoglobin (GHb) and capillary glucose tests. Measurement of salivary flow was performed by means of stimulated saliva (SSFR) collection. The buffer capacity (BC) was determined, and analysis of urea salivary concentration was performed using the colorimetric method. RESULTS: At T0, there were significant differences between diabetics and nondiabetics for SSFR and BC (p<0.05). In diabetics, SSFR was 0.790 mL/min in T0 and 0.881 mL/min in T1 (p>0.05). BC at T0 was 4.8, and at T1, it was 3.9 (p=0.000). Urea concentration mean value had a significant decrease at T1 (28.13) compared with T0 (34.88) (p=0.013). There was a negative correlation between SSFR and urea salivary concentration at both T0 (r=-0.426, p≤0.05) and T1 (r=-0.601, p≤0.01). CONCLUSIONS: In adolescents with type 1 DM, hyposalivation at T0 was associated with an increase in urea salivary concentration. At T1, hyposalivation was associated with a reduction in BC, and an increase in salivary urea.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/fisiopatologia
Saliva/química
Saliva/secreção
Ureia/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Tampões (Química)
Estudos de Casos e Controles
Feminino
Seguimentos
Hemoglobina A Glicada/análise
Seres Humanos
Concentração de Íons de Hidrogênio
Masculino
Prognóstico
Taxa Secretória
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Buffers); 0 (Glycated Hemoglobin A); 8W8T17847W (Urea)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE



página 1 de 947 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde