Base de dados : MEDLINE
Pesquisa : G04 [Categoria DeCS]
Referências encontradas : 5329 [refinar]
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  1 / 5329 MEDLINE  
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[PMID]:29274207
[Au] Autor:Dlugonska H
[Ad] Endereço:Department of Immunoparasitology, Faculty of Biology and Environmental Protection, University of Lodz, ul. Banacha 12/16, 90-237 Lódz; e-mail: hdlugo@biol.uni.lodz.pl
[Ti] Título:Autophagy as a universal intracellular process. A comment on the 2016 Nobel Prize in Physiology or Medicine
[So] Source:Ann Parasitol;63(3):153-157, 2017.
[Is] ISSN:2299-0631
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The 2016 Nobel Prize in Physiology or Medicine was awarded to molecular biologist Yoshinori Ohsumi for his work in the field of autophagy (Greek for "self eating"). This fact has once again directed the attention of many scientists to a common cellular phenomenon occurring in all eukaryotes from yeast to mammals, namely the process by which the cell digests and then recycles its components. Although the phenomenon of autophagy was discovered in mammals, a method for monitoring it by light microscopy was established in the unicellular eukaryote, the buddingy east Saccharomyces cerevisiae. The article describes the achievements of the Nobel Laureate, the mechanism of autophagy and its role in the cell physiology of organisms including the unicellular pathogen, the protozoan Toxoplasma gondii.
[Mh] Termos MeSH primário: Autofagia/fisiologia
Fenômenos Fisiológicos Celulares
Prêmio Nobel
[Mh] Termos MeSH secundário: Animais
História do Século XX
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE
[do] DOI:10.17420/ap6303.100


  2 / 5329 MEDLINE  
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[PMID]:29428128
[Au] Autor:Tia N; Singh AK; Pandey P; Azad CS; Chaudhary P; Gambhir IS
[Ad] Endereço:Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
[Ti] Título:Role of Forkhead Box O (FOXO) transcription factor in aging and diseases.
[So] Source:Gene;648:97-105, 2018 Mar 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fork head box O (FOXO) transcription factor is a key player in an evolutionarily conserved pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in their structure, function and regulation. To maintain optimum body function, the organisms have developed complex mechanisms for homeostasis. Importantly, it is well known that when these mechanisms dysregulate it results in the development of age-related disease. FOXO proteins are involved in a diverse cellular function and also have clinical significance including cell cycle arrest, cell differentiation, tumour suppression, DNA repair, longevity, diabetic complications, immunity, wound healing, regulation of metabolism and thus treatment of several types of diseases. By the combinations of post-translational modifications FOXO's serve as a 'molecular code' to sense external stimuli and recruit it as to specific regions of the genome and provide an integrated cellular response to changing physiological conditions. Akt/Protein kinase B a signaling pathway as a main regulator of FOXO to perform a diverse function in organisms. The present review summarizes the molecular and clinical aspects of FOXO transcription factor. And also elaborate the interaction of FOXO with the nucleosome remodelling complex to target genes, which is essential to cellular homeostasis.
[Mh] Termos MeSH primário: Envelhecimento/genética
Doença/genética
Fatores de Transcrição Forkhead/genética
Regulação da Expressão Gênica
[Mh] Termos MeSH secundário: Envelhecimento/metabolismo
Animais
Fenômenos Fisiológicos Celulares/genética
Fatores de Transcrição Forkhead/metabolismo
Seres Humanos
Longevidade/genética
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Forkhead Transcription Factors); 0 (Protein Isoforms)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180212
[St] Status:MEDLINE


  3 / 5329 MEDLINE  
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[PMID]:29195389
[Au] Autor:Yan H; Johnston JF; Cahn SB; King MC; Mochrie SGJ
[Ad] Endereço:Department of Physics, Yale University, New Haven, Connecticut 06511, USA.
[Ti] Título:Multiplexed fluctuation-dissipation-theorem calibration of optical tweezers inside living cells.
[So] Source:Rev Sci Instrum;88(11):113112, 2017 Nov.
[Is] ISSN:1089-7623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In order to apply optical tweezers-based force measurements within an uncharacterized viscoelastic medium such as the cytoplasm of a living cell, a quantitative calibration method that may be applied in this complex environment is needed. We describe an improved version of the fluctuation-dissipation-theorem calibration method, which has been developed to perform in situ calibration in viscoelastic media without prior knowledge of the trapped object. Using this calibration procedure, it is possible to extract values of the medium's viscoelastic moduli as well as the force constant describing the optical trap. To demonstrate our method, we calibrate an optical trap in water, in polyethylene oxide solutions of different concentrations, and inside living fission yeast (S. pombe).
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Celulares
Pinças Ópticas
[Mh] Termos MeSH secundário: Calibragem
Fenômenos Mecânicos
Saccharomyces/fisiologia
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE
[do] DOI:10.1063/1.5012782


  4 / 5329 MEDLINE  
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[PMID]:29221080
[Au] Autor:Lugnan A; Dambre J; Bienstman P
[Ti] Título:Integrated pillar scatterers for speeding up classification of cell holograms.
[So] Source:Opt Express;25(24):30526-30538, 2017 Nov 27.
[Is] ISSN:1094-4087
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The computational power required to classify cell holograms is a major limit to the throughput of label-free cell sorting based on digital holographic microscopy. In this work, a simple integrated photonic stage comprising a collection of silica pillar scatterers is proposed as an effective nonlinear mixing interface between the light scattered by a cell and an image sensor. The light processing provided by the photonic stage allows for the use of a simple linear classifier implemented in the electric domain and applied on a limited number of pixels. A proof-of-concept of the presented machine learning technique, which is based on the extreme learning machine (ELM) paradigm, is provided by the classification results on samples generated by 2D FDTD simulations of cells in a microfluidic channel.
[Mh] Termos MeSH primário: Holografia/métodos
Aprendizado de Máquina
[Mh] Termos MeSH secundário: Algoritmos
Fenômenos Fisiológicos Celulares
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE
[do] DOI:10.1364/OE.25.030526


  5 / 5329 MEDLINE  
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[PMID]:29328336
[Au] Autor:Li Y; Di J; Ma C; Zhang J; Zhong J; Wang K; Xi T; Zhao J
[Ti] Título:Quantitative phase microscopy for cellular dynamics based on transport of intensity equation.
[So] Source:Opt Express;26(1):586-593, 2018 Jan 08.
[Is] ISSN:1094-4087
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We demonstrate a simple method for quantitative phase imaging of tiny transparent objects such as living cells based on the transport of intensity equation. The experiments are performed using an inverted bright field microscope upgraded with a flipping imaging module, which enables to simultaneously create two laterally separated images with unequal defocus distances. This add-on module does not include any lenses or gratings and is cost-effective and easy-to-alignment. The validity of this method is confirmed by the measurement of microlens array and human osteoblastic cells in culture, indicating its potential in the applications of dynamically measuring living cells and other transparent specimens in a quantitative, non-invasive and label-free manner.
[Mh] Termos MeSH primário: Processamento de Imagem Assistida por Computador/métodos
Microscopia/métodos
Osteoblastos/fisiologia
[Mh] Termos MeSH secundário: Algoritmos
Fenômenos Fisiológicos Celulares
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1364/OE.26.000586


  6 / 5329 MEDLINE  
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[PMID]:29199256
[Au] Autor:Saito N
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Tohoku University.
[Ti] Título:[Synthesis, Aggregation, Self-assembly, and Dynamic Properties of Helicene Oligomers].
[So] Source:Yakugaku Zasshi;137(12):1483-1490, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Biological systems exhibit dynamic phenomena at the macroscopic level as a result of the hierarchical integration of phenomena at the molecular level. For example, a number of amino acids compose actin proteins, which form three-dimensional structures determined by the sequence of amino acids. They form fibers by self-assembly, which then form ordered structures such as meshes, lyotropic liquid crystals (LCs), and bundles. The dynamic and reversible polymorphism between these nano- to centimeter-sized ordered structures is essential for biological functions such as cell division, contraction, and locomotion. To understand biological systems and create new functional materials, it is essential to develop a methodology to integrate phenomena at the molecular level into those at the macroscopic level using synthetic molecules. In this research, synthetic oligomers containing helicenes, which exhibit reversible structural transitions between cylindrical double helices and random coils in response to thermal stimuli, were employed as building blocks for the development of such a methodology. The properties of homo- and hetero-double helices at the molecular level were first controlled by taking advantage of the diversity of their molecular structures. Then, nano- to micrometer-sized structures were constructed by the self-assembly of hetero-double helices, which include fibers/gels, vesicles, and lyotropic LCs, and their dynamic properties were controlled by molecular design.
[Mh] Termos MeSH primário: Fenômenos Biológicos
Compostos Policíclicos
[Mh] Termos MeSH secundário: Animais
Disciplinas das Ciências Biológicas
Biopolímeros
Fenômenos Fisiológicos Celulares
Química Orgânica
Sequências Hélice-Alça-Hélice
Seres Humanos
Biologia Molecular
Estrutura Molecular
Nanopartículas
Compostos Policíclicos/química
Compostos Policíclicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biopolymers); 0 (Polycyclic Compounds); 0 (helicenes)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00130


  7 / 5329 MEDLINE  
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[PMID]:29097535
[Au] Autor:Lombardi AA; Elrod JW
[Ad] Endereço:Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
[Ti] Título:Mediating ER-mitochondrial cross-talk.
[So] Source:Science;358(6363):591-592, 2017 11 03.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Linhagem Celular Tumoral
Mitocôndrias
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos Celulares
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE
[do] DOI:10.1126/science.aaq0141


  8 / 5329 MEDLINE  
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[PMID]:29096074
[Au] Autor:Rost BR; Schneider-Warme F; Schmitz D; Hegemann P
[Ad] Endereço:German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany; Neuroscience Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
[Ti] Título:Optogenetic Tools for Subcellular Applications in Neuroscience.
[So] Source:Neuron;96(3):572-603, 2017 Nov 01.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ability to study cellular physiology using photosensitive, genetically encoded molecules has profoundly transformed neuroscience. The modern optogenetic toolbox includes fluorescent sensors to visualize signaling events in living cells and optogenetic actuators enabling manipulation of numerous cellular activities. Most optogenetic tools are not targeted to specific subcellular compartments but are localized with limited discrimination throughout the cell. Therefore, optogenetic activation often does not reflect context-dependent effects of highly localized intracellular signaling events. Subcellular targeting is required to achieve more specific optogenetic readouts and photomanipulation. Here we first provide a detailed overview of the available optogenetic tools with a focus on optogenetic actuators. Second, we review established strategies for targeting these tools to specific subcellular compartments. Finally, we discuss useful tools and targeting strategies that are currently missing from the optogenetics repertoire and provide suggestions for novel subcellular optogenetic applications.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Celulares/fisiologia
Espaço Intracelular/genética
Neurônios/fisiologia
Neurociências/métodos
Optogenética/métodos
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Espaço Intracelular/química
Espaço Intracelular/metabolismo
Neurônios/química
Neurociências/tendências
Optogenética/tendências
Rodopsina/análise
Rodopsina/genética
Sistemas do Segundo Mensageiro/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
9009-81-8 (Rhodopsin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE


  9 / 5329 MEDLINE  
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[PMID]:29046344
[Au] Autor:Thomas GE; Renjith MR; Manna TK
[Ad] Endereço:School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, CET Campus, Thiruvananthapuram, Kerala 695016, India.
[Ti] Título:Kinetochore-microtubule interactions in chromosome segregation: lessons from yeast and mammalian cells.
[So] Source:Biochem J;474(21):3559-3577, 2017 Oct 18.
[Is] ISSN:1470-8728
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chromosome congression and segregation require robust yet dynamic attachment of the kinetochore with the spindle microtubules. Force generated at the kinetochore-microtubule interface plays a vital role to drive the attachment, as it is required to move chromosomes and to provide signal to sense correct attachments. To understand the mechanisms underlying these processes, it is critical to describe how the force is generated and how the molecules at the kinetochore-microtubule interface are organized and assembled to withstand the force and respond to it. Research in the past few years or so has revealed interesting insights into the structural organization and architecture of kinetochore proteins that couple kinetochore attachment to the spindle microtubules. Interestingly, despite diversities in the molecular players and their modes of action, there appears to be architectural similarity of the kinetochore-coupling machines in lower to higher eukaryotes. The present review focuses on the most recent advances in understanding of the molecular and structural aspects of kinetochore-microtubule interaction based on the studies in yeast and vertebrate cells.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Celulares/fisiologia
Segregação de Cromossomos/fisiologia
Cinetocoros/metabolismo
Microtúbulos/metabolismo
Leveduras/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Cinetocoros/química
Microtúbulos/química
Ligação Proteica/fisiologia
Saccharomyces cerevisiae/química
Saccharomyces cerevisiae/metabolismo
Leveduras/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1042/BCJ20170518


  10 / 5329 MEDLINE  
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[PMID]:28931565
[Au] Autor:Ebnet K
[Ad] Endereço:Institute-Associated Research Group "Cell Adhesion and Cell Polarity", Institute of Medical Biochemistry, ZMBE, Cells-In-Motion Cluster of Excellence (EXC1003-CiM), and Interdisciplinary Clinical Research Center (IZKF), University of Münster, Münster, Germany.
[Ti] Título:Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development.
[So] Source:Physiol Rev;97(4):1529-1554, 2017 Oct 01.
[Is] ISSN:1522-1210
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Junctional adhesion molecules (JAM)-A, -B and -C are cell-cell adhesion molecules of the immunoglobulin superfamily which are expressed by a variety of tissues, both during development and in the adult organism. Through their extracellular domains, they interact with other adhesion receptors on opposing cells. Through their cytoplasmic domains, they interact with PDZ domain-containing scaffolding and signaling proteins. In combination, these two properties regulate the assembly of signaling complexes at specific sites of cell-cell adhesion. The multitude of molecular interactions has enabled JAMs to adopt distinct cellular functions such as the regulation of cell-cell contact formation, cell migration, or mitotic spindle orientation. Not surprisingly, JAMs regulate diverse processes such as epithelial and endothelial barrier formation, hemostasis, angiogenesis, hematopoiesis, germ cell development, and the development of the central and peripheral nervous system. This review summarizes the recent progress in the understanding of JAMs, including their characteristic structural features, their molecular interactions, their cellular functions, and their contribution to a multitude of processes during vertebrate development and homeostasis.
[Mh] Termos MeSH primário: Adesão Celular/fisiologia
Fenômenos Fisiológicos Celulares
Regulação da Expressão Gênica/fisiologia
Moléculas de Adesão Juncional/genética
Moléculas de Adesão Juncional/metabolismo
[Mh] Termos MeSH secundário: Animais
Imunoglobulinas/genética
Imunoglobulinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunoglobulins); 0 (Junctional Adhesion Molecules)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1152/physrev.00004.2017



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