[PMID]: | 29173353 |
[Au] Autor: | Ratajczak MZ; Ratajczak J |
[Ad] Endereço: | Department of Medicine, Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky. Electronic address: mzrata01@louisville.edu. |
[Ti] Título: | Extracellular Microvesicles as Game Changers in Better Understanding the Complexity of Cellular Interactions-From Bench to Clinical Applications. |
[So] Source: | Am J Med Sci;354(5):449-452, 2017 11. |
[Is] ISSN: | 1538-2990 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Recent research has led to wide acceptance and better understanding of a novel mechanism for cell-cell communication that employs a network of extracellular microvesicles (ExMVs). Derived from the plasma membrane or the endosomal membrane compartment, these small, spherical membrane fragments are secreted from the cell surface or in the process of exocytosis from endosomal membrane compartment and (1) with ligands expressed on their surface directly stimulate target cells in a paracrine manner, (2) transfer cell membrane receptors to target cells or (3) deliver encapsulated messenger RNA, microRNA, proteins and bioactive lipids to target cells. This represents an evolutionarily ancient mechanism by which cells signal their presence in the microenvironment, communicate with each other and affect the biology of neighboring cells. Evidence suggests the pivotal role of ExMVs in almost all biological processes within the body as well as their involvement in certain pathologies. Moreover, liquid biopsies based on deciphering the molecular signature of ExMVs promise to revolutionize laboratory diagnostics. At the same time, there are ongoing attempts to employ them as delivery vehicles for drugs as well as therapeutics in regenerative medicine, oncology and immunotherapy. |
[Mh] Termos MeSH primário: |
Comunicação Celular Vesículas Extracelulares/metabolismo MicroRNAs/metabolismo Comunicação Parácrina RNA Mensageiro/metabolismo
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[Mh] Termos MeSH secundário: |
Seres Humanos Ligantes Proteínas/metabolismo Receptores Citoplasmáticos e Nucleares/metabolismo
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Ligands); 0 (MicroRNAs); 0 (Proteins); 0 (RNA, Messenger); 0 (Receptors, Cytoplasmic and Nuclear) |
[Em] Mês de entrada: | 1711 |
[Cu] Atualização por classe: | 180223 |
[Lr] Data última revisão:
| 180223 |
[Sb] Subgrupo de revista: | AIM; IM |
[Da] Data de entrada para processamento: | 171128 |
[St] Status: | MEDLINE |
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