Base de dados : MEDLINE
Pesquisa : G04.144.500 [Categoria DeCS]
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[PMID]:29325249
[Au] Autor:Liu C; Li X; Li H; Gong QX; Li Y; Wang Z; Zhang ZH
[Ad] Endereço:Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
[Ti] Título:[Clinicopathologic features of primary hepatic marginal zone lymphoma of mucosa-associated lymphoid tissue and hepatic pseudolymphoma].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(1):39-44, 2018 Jan 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To study the clinicopathological features of primary hepatic extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT lymphoma) and hepatic pseudolymphoma, and to discuss their differential diagnosis, treatment and prognosis. Three primary hepatic MALT lymphomas and two hepatic pseudolymphomas collected from January 2012 to March 2017 in the First Affiliated Hospital of Nanjing Medical University were evaluated by HE and immunohistochemistry(IHC), in-situ hybridization and immunoglobulin (Ig) gene rearrangement detection, and the relevant literature reviewed. In the three MALT lymphomas, tumor cells infiltrated the portal areas with nodular pattern, and invaded the surrounding normal liver with serpiginous configuration and formation of confluent sheets. A number of bile ducts were entrapped within the lesions, and showed lymphoepithelial lesion. Reactive lymphoid follicles were present and surrounded by tumor cells, consisting of predominantly centrocyte-like cells and monocytoid B cells. There were clusters of epithelioid histiocytes in one case. The tumor cells were positive for CD20, PAX5 and negative for CD5, CD23, CD10, bcl-6, and cyclin D1. In the two hepatic pseudolymphomas, the lesions presented as solitary nodules well-demarcated from the surrounding liver tissue; one case was partially encapsulated with fibrous tissue. Entrapped bile ducts were only found at the edge of the lesions without lymphoepithelial lesion. The lesions comprised of massive lymphoid proliferation consisting predominantly of reactive lymphoid follicles, but not monocytoid B-cells or atypical cells. By IHC, a mixture of B- and T-cell population was identified. A monoclonal rearrangement of the Ig gene was detected in all three MALT lymphomas but not in two pseudolymphomas. Interphase fluorescence in situ hybridiazation test for MALT1 break-apart gene was positive in two cases of MALT lymphomas and EBER was negative in all studied cases. Primary heptic MALT lymphoma and pseudolymphoma are both rare lymphoid proliferative lesions of liver. These two lesions have overlapping histological and IHC features and are top differential diagnosis to each other. A combination analysis of morphology, immunophenotype and Ig gene rearrangement is helpful to distinguish between them.
[Mh] Termos MeSH primário: Neoplasias Hepáticas/patologia
Tecido Linfoide/patologia
Linfoma de Zona Marginal Tipo Células B/patologia
Pseudolinfoma/patologia
[Mh] Termos MeSH secundário: Antígenos CD20
Linfócitos B/patologia
Diagnóstico Diferencial
Seres Humanos
Imuno-Histoquímica
Imunofenotipagem
Hibridização In Situ
Interfase
Neoplasias Hepáticas/química
Neoplasias Hepáticas/genética
Linfócitos/patologia
Tecido Linfoide/química
Linfoma de Zona Marginal Tipo Células B/química
Linfoma de Zona Marginal Tipo Células B/genética
Pseudolinfoma/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD20)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.01.008


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[PMID]:29196537
[Au] Autor:Kawasumi R; Abe T; Arakawa H; Garre M; Hirota K; Branzei D
[Ad] Endereço:The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology (IFOM), 20139 Milan, Italy.
[Ti] Título:ESCO1/2's roles in chromosome structure and interphase chromatin organization.
[So] Source:Genes Dev;31(21):2136-2150, 2017 11 01.
[Is] ISSN:1549-5477
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:ESCO1/2 acetyltransferases mediating SMC3 acetylation and sister chromatid cohesion (SCC) are differentially required for genome integrity and development. Here we established chicken DT40 cell lines with mutations in ESCO1/2, SMC3 acetylation, and the cohesin remover WAPL. Both ESCO1 and ESCO2 promoted SCC, while ESCO2 was additionally and specifically required for proliferation and centromere integrity. overexpression fully suppressed the slow proliferation and centromeric separation phenotypes of cells but only partly suppressed its chromosome arm SCC defects. Concomitant inactivation of ESCO1 and ESCO2 caused lethality owing to compromised mitotic chromosome segregation. Neither nor acetyl-mimicking mutations rescued lethality. Notably, conditional mutants showed very severe proliferation defects associated with catastrophic mitoses and also abnormal interphase chromatin organization patterns. The results indicate that cohesion establishment by vertebrate ESCO1/2 is linked to interphase chromatin architecture formation, a newly identified function of cohesin acetyltransferases that is both fundamentally and medically relevant.
[Mh] Termos MeSH primário: Acetiltransferases/metabolismo
Montagem e Desmontagem da Cromatina/genética
Proteínas Cromossômicas não Histona/metabolismo
Estruturas Cromossômicas/genética
Instabilidade Genômica/genética
[Mh] Termos MeSH secundário: Acetilação
Acetiltransferases/genética
Animais
Linhagem Celular
Proliferação Celular/genética
Centrômero/genética
Galinhas
Proteínas Cromossômicas não Histona/genética
Técnicas de Inativação de Genes
Inativação Gênica
Interfase/genética
Proteínas Nucleares/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chromosomal Proteins, Non-Histone); 0 (Nuclear Proteins); EC 2.3.1.- (Acetyltransferases)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE
[do] DOI:10.1101/gad.306084.117


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[PMID]:29184179
[Au] Autor:Moore HM; Vartiainen MK
[Ad] Endereço:Institute of Biotechnology, University of Helsinki, Helsinki, Finland Viikinkaari 5, 00014 Helsinki, Finland.
[Ti] Título:F-actin organizes the nucleus.
[So] Source:Nat Cell Biol;19(12):1386-1388, 2017 Nov 29.
[Is] ISSN:1476-4679
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:After mitosis, the nucleus must be rebuilt and chromatin decondensed to permit interphase genomic functions, but decondensation mechanisms are poorly understood. Now, the traditional cytoskeletal protein actin is shown to form transient nuclear filaments that are required for chromatin decondensation and nuclear expansion at mitotic exit.
[Mh] Termos MeSH primário: Actinas/metabolismo
Núcleo Celular/metabolismo
[Mh] Termos MeSH secundário: Cromatina/metabolismo
Montagem e Desmontagem da Cromatina/fisiologia
Interfase/fisiologia
Mitose/fisiologia
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actins); 0 (Chromatin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1038/ncb3650


  4 / 8510 MEDLINE  
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[PMID]:28977640
[Au] Autor:Galganski L; Urbanek MO; Krzyzosiak WJ
[Ad] Endereço:Department of Molecular Biomedicine, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
[Ti] Título:Nuclear speckles: molecular organization, biological function and role in disease.
[So] Source:Nucleic Acids Res;45(18):10350-10368, 2017 Oct 13.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also known as nuclear domains or nuclear subcompartments. These self-organizing structures gather machinery involved in various nuclear activities. Nuclear speckles (NSs) or splicing speckles, also called interchromatin granule clusters, were discovered as sites for splicing factor storage and modification. Further studies on transcription and mRNA maturation and export revealed a more general role for splicing speckles in RNA metabolism. Here, we discuss the functional implications of the localization of numerous proteins crucial for epigenetic regulation, chromatin organization, DNA repair and RNA modification to nuclear speckles. We highlight recent advances suggesting that NSs facilitate integrated regulation of gene expression. In addition, we consider the influence of abundant regulatory and signaling proteins, i.e. protein kinases and proteins involved in protein ubiquitination, phosphoinositide signaling and nucleoskeletal organization, on pre-mRNA synthesis and maturation. While many of these regulatory proteins act within NSs, direct evidence for mRNA metabolism events occurring in NSs is still lacking. NSs contribute to numerous human diseases, including cancers and viral infections. In addition, recent data have demonstrated close relationships between these structures and the development of neurological disorders.
[Mh] Termos MeSH primário: Núcleo Celular/metabolismo
Cromatina
Doença/genética
Substâncias Macromoleculares
Proteínas Nucleares
Precursores de RNA/metabolismo
Proteínas de Ligação a RNA/fisiologia
[Mh] Termos MeSH secundário: Cromatina/química
Cromatina/metabolismo
Epigênese Genética/fisiologia
Seres Humanos
Interfase/fisiologia
Substâncias Macromoleculares/química
Substâncias Macromoleculares/metabolismo
Microscopia de Fluorescência
Proteínas Nucleares/química
Proteínas Nucleares/genética
Proteínas Nucleares/metabolismo
Processamento de RNA/genética
Proteínas de Ligação a RNA/química
Proteínas de Ligação a RNA/genética
Proteínas de Ligação a RNA/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Chromatin); 0 (Macromolecular Substances); 0 (Nuclear Proteins); 0 (RNA Precursors); 0 (RNA-Binding Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkx759


  5 / 8510 MEDLINE  
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[PMID]:28825727
[Au] Autor:Kakui Y; Rabinowitz A; Barry DJ; Uhlmann F
[Ad] Endereço:Chromosome Segregation Laboratory, The Francis Crick Institute, London, UK.
[Ti] Título:Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast.
[So] Source:Nat Genet;49(10):1553-1557, 2017 Oct.
[Is] ISSN:1546-1718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The eukaryotic genome consists of DNA molecules far longer than the cells that contain them. They reach their greatest compaction during chromosome condensation in mitosis. This process is aided by condensin, a structural maintenance of chromosomes (SMC) family member. The spatial organization of mitotic chromosomes and how condensin shapes chromatin architecture are not yet fully understood. Here we use chromosome conformation capture (Hi-C) to study mitotic chromosome condensation in the fission yeast Schizosaccharomyces pombe. This showed that the interphase landscape characterized by small chromatin domains is replaced by fewer but larger domains in mitosis. Condensin achieves this by setting up longer-range, intrachromosomal DNA interactions, which compact and individualize chromosomes. At the same time, local chromatin contacts are constrained by condensin, with profound implications for local chromatin function during mitosis. Our results highlight condensin as a major determinant that changes the chromatin landscape as cells prepare their genomes for cell division.
[Mh] Termos MeSH primário: Adenosina Trifosfatases/fisiologia
Montagem e Desmontagem da Cromatina/fisiologia
Cromossomos Fúngicos/ultraestrutura
Proteínas de Ligação a DNA/fisiologia
Complexos Multiproteicos/fisiologia
Proteínas de Schizosaccharomyces pombe/fisiologia
Schizosaccharomyces/genética
[Mh] Termos MeSH secundário: Adenosina Trifosfatases/genética
Sequência de Bases
Cromatina/ultraestrutura
Montagem e Desmontagem da Cromatina/genética
Imunoprecipitação da Cromatina
DNA Fúngico/genética
Proteínas de Ligação a DNA/genética
Desoxirribonucleases de Sítio Específico do Tipo II
Interfase
Mitose
Complexos Multiproteicos/genética
Schizosaccharomyces/ultraestrutura
Proteínas de Schizosaccharomyces pombe/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromatin); 0 (DNA, Fungal); 0 (DNA-Binding Proteins); 0 (Multiprotein Complexes); 0 (Schizosaccharomyces pombe Proteins); 0 (condensin complexes); EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific); EC 3.1.21.4 (GATC-specific type II deoxyribonucleases); EC 3.6.1.- (Adenosine Triphosphatases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE
[do] DOI:10.1038/ng.3938


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[PMID]:28814570
[Au] Autor:Yang C; Wu J; de Heus C; Grigoriev I; Liv N; Yao Y; Smal I; Meijering E; Klumperman J; Qi RZ; Akhmanova A
[Ad] Endereço:Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands.
[Ti] Título:EB1 and EB3 regulate microtubule minus end organization and Golgi morphology.
[So] Source:J Cell Biol;216(10):3179-3198, 2017 Oct 02.
[Is] ISSN:1540-8140
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:End-binding proteins (EBs) are the core components of microtubule plus end tracking protein complexes, but it is currently unknown whether they are essential for mammalian microtubule organization. Here, by using CRISPR/Cas9-mediated knockout technology, we generated stable cell lines lacking EB2 and EB3 and the C-terminal partner-binding half of EB1. These cell lines show only mild defects in cell division and microtubule polymerization. However, the length of CAMSAP2-decorated stretches at noncentrosomal microtubule minus ends in these cells is reduced, microtubules are detached from Golgi membranes, and the Golgi complex is more compact. Coorganization of microtubules and Golgi membranes depends on the EB1/EB3-myomegalin complex, which acts as membrane-microtubule tether and counteracts tight clustering of individual Golgi stacks. Disruption of EB1 and EB3 also perturbs cell migration, polarity, and the distribution of focal adhesions. EB1 and EB3 thus affect multiple interphase processes and have a major impact on microtubule minus end organization.
[Mh] Termos MeSH primário: Complexo de Golgi/metabolismo
Membranas Intracelulares/metabolismo
Proteínas Associadas aos Microtúbulos/metabolismo
Microtúbulos/metabolismo
[Mh] Termos MeSH secundário: Movimento Celular/fisiologia
Polaridade Celular/fisiologia
Adesões Focais/genética
Adesões Focais/metabolismo
Complexo de Golgi/genética
Células HeLa
Seres Humanos
Interfase/fisiologia
Proteínas Associadas aos Microtúbulos/genética
Microtúbulos/genética
Proteínas Musculares/genética
Proteínas Musculares/metabolismo
Proteínas Nucleares/genética
Proteínas Nucleares/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MAPRE1 protein, human); 0 (MAPRE3 protein, human); 0 (Microtubule-Associated Proteins); 0 (Muscle Proteins); 0 (Nuclear Proteins); 0 (PDE4DIP protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1083/jcb.201701024


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[PMID]:28622508
[Au] Autor:Nozawa RS; Boteva L; Soares DC; Naughton C; Dun AR; Buckle A; Ramsahoye B; Bruton PC; Saleeb RS; Arnedo M; Hill B; Duncan RR; Maciver SK; Gilbert N
[Ad] Endereço:MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
[Ti] Título:SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs.
[So] Source:Cell;169(7):1214-1227.e18, 2017 Jun 15.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Higher eukaryotic chromosomes are organized into topologically constrained functional domains; however, the molecular mechanisms required to sustain these complex interphase chromatin structures are unknown. A stable matrix underpinning nuclear organization was hypothesized, but the idea was abandoned as more dynamic models of chromatin behavior became prevalent. Here, we report that scaffold attachment factor A (SAF-A), originally identified as a structural nuclear protein, interacts with chromatin-associated RNAs (caRNAs) via its RGG domain to regulate human interphase chromatin structures in a transcription-dependent manner. Mechanistically, this is dependent on SAF-A's AAA ATPase domain, which mediates cycles of protein oligomerization with caRNAs, in response to ATP binding and hydrolysis. SAF-A oligomerization decompacts large-scale chromatin structure while SAF-A loss or monomerization promotes aberrant chromosome folding and accumulation of genome damage. Our results show that SAF-A and caRNAs form a dynamic, transcriptionally responsive chromatin mesh that organizes large-scale chromosome structures and protects the genome from instability.
[Mh] Termos MeSH primário: Cromossomos/metabolismo
Instabilidade Genômica
Ribonucleoproteínas Nucleares Heterogêneas Grupo U/metabolismo
RNA Nuclear Pequeno/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Cromatina
Células HEK293
Ribonucleoproteínas Nucleares Heterogêneas Grupo U/química
Seres Humanos
Interfase
Modelos Moleculares
Alinhamento de Sequência
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromatin); 0 (Heterogeneous-Nuclear Ribonucleoprotein U); 0 (RNA, Small Nuclear); 0 (SAF-A protein, human)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE


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[PMID]:28611047
[Au] Autor:Emanuelli A; Borroni AP; Apel-Sarid L; Shah PA; Ayyathan DM; Koganti P; Levy-Cohen G; Blank M
[Ad] Endereço:Laboratory of Molecular and Cellular Cancer Biology, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.
[Ti] Título:Smurf2-Mediated Stabilization of DNA Topoisomerase IIα Controls Genomic Integrity.
[So] Source:Cancer Res;77(16):4217-4227, 2017 Aug 15.
[Is] ISSN:1538-7445
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:DNA topoisomerase IIα (Topo IIα) ensures genomic integrity and unaltered chromosome inheritance and serves as a major target of several anticancer drugs. Topo IIα function is well understood, but how its expression is regulated remains unclear. Here, we identify the E3 ubiquitin ligase Smurf2 as a physiologic regulator of Topo IIα levels. Smurf2 physically interacted with Topo IIα and modified its ubiquitination status to protect Topo IIα from the proteasomal degradation in dose- and catalytically dependent manners. Smurf2-depleted cells exhibited a reduced ability to resolve DNA catenanes and pathological chromatin bridges formed during mitosis, a trait of Topo IIα-deficient cells and a hallmark of chromosome instability. Introducing Topo IIα into Smurf2-depleted cells rescued this phenomenon. Smurf2 was a determinant of Topo IIα protein levels in normal and cancer cells and tissues, and its levels affected cell sensitivity to the Topo II-targeting drug etoposide. Our results identified Smurf2 as an essential regulator of Topo IIα, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2. .
[Mh] Termos MeSH primário: Antígenos de Neoplasias/metabolismo
DNA Topoisomerases Tipo II/metabolismo
Proteínas de Ligação a DNA/metabolismo
Neoplasias/genética
Neoplasias/metabolismo
Ubiquitina-Proteína Ligases/metabolismo
[Mh] Termos MeSH secundário: Animais
Antígenos de Neoplasias/genética
Linhagem Celular Tumoral
DNA Topoisomerases Tipo II/genética
Proteínas de Ligação a DNA/genética
Etoposídeo/farmacologia
Instabilidade Genômica
Seres Humanos
Interfase/fisiologia
Camundongos
Camundongos Knockout
Ubiquitina-Proteína Ligases/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Neoplasm); 0 (DNA-Binding Proteins); 6PLQ3CP4P3 (Etoposide); EC 2.3.2.26 (SMURF2 protein, human); EC 2.3.2.26 (Smurf2 protein, mouse); EC 2.3.2.27 (Ubiquitin-Protein Ligases); EC 5.99.1.3 (DNA Topoisomerases, Type II)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1158/0008-5472.CAN-16-2828


  9 / 8510 MEDLINE  
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[PMID]:28601076
[Au] Autor:Shakhov AS; Alieva IB
[Ad] Endereço:Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia. irina_alieva@belozersky.msu.ru.
[Ti] Título:The Centrosome as the Main Integrator of Endothelial Cell Functional Activity.
[So] Source:Biochemistry (Mosc);82(6):663-677, 2017 Jun.
[Is] ISSN:1608-3040
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The centrosome is an intracellular structure of the animal cell responsible for organization of cytoplasmic microtubules. According to modern concepts, the centrosome is a very important integral element of the living cell whose functions are not limited to its ability to polymerize microtubules. The centrosome localization in the geometric center of the interphase cell, the high concentration of various regulatory proteins in this area, the centrosome-organized radial system of microtubules for intracellular transport by motor proteins, the centrosome involvement in the perception of external signals and their transmission - all these features make this cellular structure a unique regulation and distribution center managing dynamic morphology of the animal cell. In conjunction with the tissue-specific features of the centrosome structure, this suggests the direct involvement of the centrosome in execution of cell functions. This review discusses the involvement of the centrosome in the vital activity of endothelial cells, as well as its possible participation in the implementation of barrier function, the major function of endothelium.
[Mh] Termos MeSH primário: Centrossomo/metabolismo
Citoplasma/metabolismo
Células Endoteliais/metabolismo
Microtúbulos/metabolismo
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Interfase/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170612
[St] Status:MEDLINE
[do] DOI:10.1134/S0006297917060037


  10 / 8510 MEDLINE  
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[PMID]:28595124
[Au] Autor:Zhang S; Quan X; Zheng JF; Wang D
[Ad] Endereço:Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Linggong Road 2, Dalian 116024, China; Tianjin Key Laboratory of Aquatic Science and Technology, School of Environmental and Municipal Engineerin
[Ti] Título:Probing the interphase "HO zone" originated by carbon nanotube during catalytic ozonation.
[So] Source:Water Res;122:86-95, 2017 Oct 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Carbon nanotube (CNT) is an attractive metal-free catalyst that can be explored in combination with ozone treatment. Using fluorescence microscopy image analysis, we investigated the production of hydroxyl radicals (HO) within the solid-liquid interphase for CNT-mediated catalytic ozonation. The visualized results suggest that HO was vastly generated via catalysis and accumulated within a surface region of the CNT (we defined this region as the interphase "HO zone"). In this region, using 7-hydroxycoumarin as a HO marker, the radical abundance was at least 1000 times higher than that in the aqueous bulk phase. Owing to the observed inhomogeneity of HO, the CNT/ozone system effectively decomposed perfluorooctane sulfonate that was fairly resistant to non-catalytic ozonation, and the decomposition kinetics was not much inhibited by tert-butanol as bulk-phase HO scavenger due to the remaining "HO zone" at surface region available for reaction. A longevity trial revealed the sustained formation of the interphase "HO zone" and strongly indicated that the graphitic structure may optimize the density of surface active sites responsible for the proliferation and local concentration of HO. CNT, with good catalytic efficiency, longevity and stability, is anticipated as the basis of future nanomaterials able to promote HO exposure in ozone treatment for advanced oxidation process.
[Mh] Termos MeSH primário: Nanotubos de Carbono
Poluentes Químicos da Água
Purificação da Água
[Mh] Termos MeSH secundário: Catálise
Interfase
Ozônio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nanotubes, Carbon); 0 (Water Pollutants, Chemical); 66H7ZZK23N (Ozone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE



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