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  1 / 20973 MEDLINE  
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[PMID]:28450163
[Au] Autor:Ganuza M; Hadland B; Chabot A; Li C; Kang G; Bernstein I; McKinney-Freeman S
[Ad] Endereço:Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN.
[Ti] Título:Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo.
[So] Source:Exp Hematol;51:25-35.e6, 2017 07.
[Is] ISSN:1873-2399
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hematopoietic stem and progenitor cells (HSPCs) sustain life-long hematopoiesis and are first detected in the embryo by transplantation at embryonic day 10.5 (E10.5). HSPCs are mesodermal in origin and ultimately emerge from a subset of arterial endothelium (i.e., hemogenic endothelium [HE]), which is highly concentrated in the aorta-gonad-mesonephros region of the midgestation embryo. Here, we used clonal ex vivo assays, in which endothelial cells isolated from the midgestation aorta and vitelline and umbilical arteries are co-cultured on supportive stroma, to show that only about 0.1%, 1.3%, and 0.29% of E9.5, E10.5, and E11.5 endothelium are functional HE, respectively. We further show high phenotypic and functional variability in the hematopoietic potential of individual hemogenic endothelial precursors. Using unique niche stroma capable of providing the signals necessary for definitive hematopoietic stem cell (dHSC) induction, we demonstrate that this variability in HE includes their potential to support phenotypic dHSCs. These data suggest the presence of a continuum of maturing HE with distinct hematopoietic potential or HE representative of a heterogeneous pool of precursors that give rise to HSPCs with disparate hematopoietic potential.
[Mh] Termos MeSH primário: Linhagem da Célula/fisiologia
Embrião de Mamíferos/embriologia
Células Endoteliais/metabolismo
Hematopoese/fisiologia
Células-Tronco Hematopoéticas/metabolismo
[Mh] Termos MeSH secundário: Animais
Embrião de Mamíferos/citologia
Células Endoteliais/citologia
Células-Tronco Hematopoéticas/citologia
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180224
[Lr] Data última revisão:
180224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  2 / 20973 MEDLINE  
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[PMID]:29265183
[Au] Autor:Kulkeaw K; Inoue T; Ishitani T; Nakanishi Y; Zon LI; Sugiyama D
[Ad] Endereço:Department of Research and Development of Next Generation Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
[Ti] Título:Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis.
[So] Source:Br J Haematol;180(3):420-431, 2018 02.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Zebrafish embryos are useful to study haematopoietic gene function in vertebrates, although lack of antibodies to zebrafish proteins has limited the purification of specific cell populations. Here, we purified primitive zebrafish erythrocytes using 1, 5-bis{[2-(di-methylamino)ethyl]amino}-4, 8-dihydroxyanthracene-9, 10-dione (DRAQ5 ), a DNA-staining fluorescent dye. At 48-h post-fertilization, we sorted small-sized cells from embryos using forward scatter and found that they consisted of DRAQ5 and DRAQ5 populations. DRAQ5 cells contained haemoglobin, lacked myeloperoxidase activity and expressed high levels of embryonic globin (hbae3 and hbbe1.1) mRNA, all characteristics of primitive erythrocytes. Following DRAQ5 analysis of gata1:dsRed transgenic embryos, we purified primitive DRAQ5 dsRed+ erythrocytes from haematopoietic progenitor cells. Using this method, we identified docking protein 2 (Dok2) as functioning in differentiation of primitive erythrocytes. We conclude that DRAQ5 -based flow cytometry enables purification of primitive zebrafish erythrocytes.
[Mh] Termos MeSH primário: Eritrócitos/citologia
Eritrócitos/metabolismo
Hematopoese
[Mh] Termos MeSH secundário: Animais
Biomarcadores
Separação Celular/métodos
Citometria de Fluxo
Regulação da Expressão Gênica
Hematopoese/genética
Imunofenotipagem
Especificidade de Órgãos/genética
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.15048


  3 / 20973 MEDLINE  
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[PMID]:29205259
[Au] Autor:Mainardi C; Ebinger M; Enkel S; Feuchtinger T; Teltschik HM; Eyrich M; Schumm M; Rabsteyn A; Schlegel P; Seitz C; Schwarze CP; Müller I; Greil J; Bader P; Schlegel PG; Martin D; Holzer U; Döring M; Handgretinger R; Lang P
[Ad] Endereço:Department of Paediatric Oncology, Children's University Hospital, University of Padova, Padova, Italy.
[Ti] Título:CD34 selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation.
[So] Source:Br J Haematol;180(1):90-99, 2018 01.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Poor graft function (PGF) is a severe complication of haematopoietic stem cell transplantation (HSCT) and administration of donor stem cell boosts (SCBs) represents a therapeutic option. We report 50 paediatric patients with PGF who received 61 boosts with CD34 selected peripheral blood stem cells (PBSC) after transplantation from matched unrelated (n = 25) or mismatched related (n = 25) donors. Within 8 weeks, a significant increase in median neutrophil counts (0·6 vs. 1·516 × 10 /l, P < 0·05) and a decrease in red blood cell and platelet transfusion requirement (median frequencies 1 and 7 vs. 0, P < 0·0001 and <0·001), were observed, and 78·8% of patients resolved one or two of their cytopenias. 36·5% had a complete haematological response. Median lymphocyte counts for CD3 , CD3 CD4 , CD19 and CD56 increased 8·3-, 14·2-, 22.- and 1·6-fold. The rate of de novo acute graft-versus-host disease (GvHD) grade I-III was only 6% and resolved completely. No GvHD grade IV or chronic GvHD occurred. Patients who responded to SCB displayed a trend toward better overall survival (OS) (P = 0·07). Thus, administration of CD34 selected SCBs from alternative donors is safe and effective. Further studies are warranted to clarify the impact on immune reconstitution and survival.
[Mh] Termos MeSH primário: Sobrevivência de Enxerto
Transplante de Células-Tronco Hematopoéticas
Células-Tronco Hematopoéticas
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antígenos CD34/metabolismo
Linhagem da Célula
Criança
Pré-Escolar
Estudos de Coortes
Feminino
Doença Enxerto-Hospedeiro/etiologia
Hematopoese
Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Transplante de Células-Tronco Hematopoéticas/métodos
Células-Tronco Hematopoéticas/metabolismo
Seres Humanos
Lactente
Masculino
Prognóstico
Retratamento
Estudos Retrospectivos
Quimeras de Transplante
Condicionamento Pré-Transplante
Transplante Homólogo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD34)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.15012


  4 / 20973 MEDLINE  
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[PMID]:28462532
[Au] Autor:Daley SR; Teh C; Hu DY; Strasser A; Gray DHD
[Ad] Endereço:Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.
[Ti] Título:Cell death and thymic tolerance.
[So] Source:Immunol Rev;277(1):9-20, 2017 05.
[Is] ISSN:1600-065X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The differentiation of hematopoietic precursors into the many functionally distinct T-cell types produced by the thymus is a complex process. It proceeds through a series of stages orchestrated by a variety of thymic microenvironments that shape the T-cell developmental processes. Numerous cytokine and cell surface receptors direct thymocyte differentiation but the primary determinant of cell fate is the engagement of the T-cell antigen receptor (TCR). The strength of the TCR signal and the maturation stage of the thymocyte receiving it can direct the various differentiation programs or, alternatively, end the process by inducing cell death. The regulation of thymocyte death is critical for the efficiency of thymic T-cell differentiation and the preservation of immune tolerance. A detailed knowledge of mechanisms that eliminate thymocytes from the T-cell repertoire is essential to understand the "logic" of T-cell selection in the thymus. This review focuses on the central role of the BCL-2 family of proteins in the apoptotic checkpoints that punctuate thymocyte differentiation and the consequences of defects in these processes.
[Mh] Termos MeSH primário: Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Linfócitos T/fisiologia
Timócitos/fisiologia
Timo/imunologia
[Mh] Termos MeSH secundário: Animais
Morte Celular
Diferenciação Celular
Microambiente Celular
Tolerância Central
Hematopoese
Seres Humanos
Receptores de Antígenos de Linfócitos T/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins c-bcl-2); 0 (Receptors, Antigen, T-Cell)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/imr.12532


  5 / 20973 MEDLINE  
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[PMID]:29274779
[Au] Autor:Ishibashi T; Yokota T; Satoh Y; Ichii M; Sudo T; Doi Y; Ueda T; Nagate Y; Hamanaka Y; Tanimura A; Ezoe S; Shibayama H; Oritani K; Kanakura Y
[Ad] Endereço:Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan.
[Ti] Título:Identification of MS4A3 as a reliable marker for early myeloid differentiation in human hematopoiesis.
[So] Source:Biochem Biophys Res Commun;495(3):2338-2343, 2018 01 15.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Information of myeloid lineage-related antigen on hematopoietic stem/progenitor cells (HSPCs) is important to clarify the mechanisms regulating hematopoiesis, as well as for the diagnosis and treatment of myeloid malignancies. We previously reported that special AT-rich sequence binding protein 1 (SATB1), a global chromatin organizer, promotes lymphoid differentiation from HSPCs. To search a novel cell surface molecule discriminating early myeloid and lymphoid differentiation, we performed microarray analyses comparing SATB1-overexpressed HSPCs with mock-transduced HSPCs. The results drew our attention to membrane-spanning 4-domains, subfamily A, member 3 (Ms4a3) as the most downregulated molecule in HSPCs with forced overexpression of SATB1. Ms4a3 expression was undetectable in hematopoietic stem cells, but showed a concomitant increase with progressive myeloid differentiation, whereas not only lymphoid but also megakaryocytic-erythrocytic progenitors were entirely devoid of Ms4a3 expression. Further analysis revealed that a subset of CD34 CD38 CD33 progenitor population in human adult bone marrow expressed MS4A3, and those MS4A3 progenitors only produced granulocyte/macrophage colonies, losing erythroid colony- and mixed colony-forming capacity. These results suggest that cell surface expression of MS4A3 is useful to distinguish granulocyte/macrophage lineage-committed progenitors from other lineage-related ones in early human hematopoiesis. In conclusion, MS4A3 is useful to monitor early stage of myeloid differentiation in human hematopoiesis.
[Mh] Termos MeSH primário: Proteínas de Ciclo Celular/metabolismo
Hematopoese/fisiologia
Células-Tronco Hematopoéticas/metabolismo
Proteínas de Membrana/metabolismo
Células Mieloides/citologia
Células Mieloides/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Diferenciação Celular
Células Cultivadas
Células-Tronco Hematopoéticas/citologia
Seres Humanos
Camundongos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cell Cycle Proteins); 0 (MS4A3 protein, human); 0 (Membrane Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171225
[St] Status:MEDLINE


  6 / 20973 MEDLINE  
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[PMID]:28458344
[Au] Autor:Li F; Tang R; Chen LB; Zhang KS; Huang XP; Deng CQ
[Ad] Endereço:Molecular Pathology Laboratory, Hunan University of Chinese Medicine.
[Ti] Título:Effects of Astragalus Combined with Angelica on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice.
[So] Source:Biol Pharm Bull;40(5):598-609, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism of Astragalus combined with Angelica in promoting hematopoiesis. Following establishment of the model, mice were administered with Astragalus (6.00 g·kg ), Angelica (3.00 g·kg ), and combinations of Astragalus and Angelica at different ratios, including 10 : 1 (Astragalus 9.81 g·kg +Angelica 0.98 g·kg ), 5 : 1 (Astragalus 9.00 g·kg +Angelica 1.80 g·kg ), 2 : 1 (Astragalus 7.71 g·kg +Angelica 3.08 g·kg ), 1 : 1 (Astragalus 5.40 g·kg +Angelica 5.40 g·kg ), 1 : 2.5 (Astragalus 3.08 g·kg +Angelica 7.71 g·kg ), 1 : 5 (Astragalus 1.80 g·kg +Angelica 9.00 g·kg ), and 1 : 10 (Astragalus 0.98 g·kg +Angelica 9.81 g·kg ). Our results suggested that Astragalus mixed with Angelica synergistically promoted hematopoiesis best when the combination ratio of Astragalus and Angelica was 1 : 1, 1 : 2.5 or 1 : 5; moreover, the effect of Angelica was greater than that of Astragalus. The potential mechanisms of the combinations of Astragalus and Angelica that promote hematopoiesis include the dissolution of the effective components, promoting the synthesis and secretion of hematopoietic growth factor (HGF) and the proliferation of hematopoietic progenitor cells (HPCs).
[Mh] Termos MeSH primário: Angelica sinensis/química
Astragalus membranaceus/química
Ciclofosfamida/antagonistas & inibidores
Ciclofosfamida/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Hematopoese/efeitos dos fármacos
Imunossupressores/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Células da Medula Óssea/efeitos dos fármacos
Células da Medula Óssea/ultraestrutura
Contagem de Células
Combinação de Medicamentos
Composição de Medicamentos
Eritropoetina/metabolismo
Fator Estimulador de Colônias de Granulócitos e Macrófagos/metabolismo
Camundongos
Camundongos Endogâmicos ICR
Trombopoetina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Drugs, Chinese Herbal); 0 (Immunosuppressive Agents); 0 (Plant Extracts); 0 (danggui buxue decoction); 11096-26-7 (Erythropoietin); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor); 8N3DW7272P (Cyclophosphamide); 9014-42-0 (Thrombopoietin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b16-00802


  7 / 20973 MEDLINE  
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[PMID]:29193421
[Au] Autor:Raghuwanshi S; Gutti U; Kandi R; Gutti RK
[Ad] Endereço:Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India.
[Ti] Título:MicroRNA-9 promotes cell proliferation by regulating RUNX1 expression in human megakaryocyte development.
[So] Source:Cell Prolif;51(1), 2018 02.
[Is] ISSN:1365-2184
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Subunidade alfa 2 de Fator de Ligação ao Core
Megacariócitos
[Mh] Termos MeSH secundário: Diferenciação Celular
Proliferação Celular
Hematopoese
Seres Humanos
MicroRNAs
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Core Binding Factor Alpha 2 Subunit); 0 (MicroRNAs)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1111/cpr.12414


  8 / 20973 MEDLINE  
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[PMID]:29300724
[Au] Autor:Draper JE; Sroczynska P; Fadlullah MZH; Patel R; Newton G; Breitwieser W; Kouskoff V; Lacaud G
[Ad] Endereço:Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, Manchester Cancer Research Centre, The University of Manchester, Manchester, United Kingdom.
[Ti] Título:A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects.
[So] Source:PLoS Genet;14(1):e1007127, 2018 01.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In recent years, highly detailed characterization of adult bone marrow (BM) myeloid progenitors has been achieved and, as a result, the impact of somatic defects on different hematopoietic lineage fate decisions can be precisely determined. Fetal liver (FL) hematopoietic progenitor cells (HPCs) are poorly characterized in comparison, potentially hindering the study of the impact of genetic alterations on midgestation hematopoiesis. Numerous disorders, for example infant acute leukemias, have in utero origins and their study would therefore benefit from the ability to isolate highly purified progenitor subsets. We previously demonstrated that a Runx1 distal promoter (P1)-GFP::proximal promoter (P2)-hCD4 dual-reporter mouse (Mus musculus) model can be used to identify adult BM progenitor subsets with distinct lineage preferences. In this study, we undertook the characterization of the expression of Runx1-P1-GFP and P2-hCD4 in FL. Expression of P2-hCD4 in the FL immunophenotypic Megakaryocyte-Erythroid Progenitor (MEP) and Common Myeloid Progenitor (CMP) compartments corresponded to increased granulocytic/monocytic/megakaryocytic and decreased erythroid specification. Moreover, Runx1-P2-hCD4 expression correlated with several endogenous cell surface markers' expression, including CD31 and CD45, providing a new strategy for prospective identification of highly purified fetal myeloid progenitors in transgenic mouse models. We utilized this methodology to compare the impact of the deletion of either total RUNX1 or RUNX1C alone and to determine the fetal HPCs lineages most substantially affected. This new prospective identification of FL progenitors therefore raises the prospect of identifying the underlying gene networks responsible with greater precision than previously possible.
[Mh] Termos MeSH primário: Linhagem da Célula/genética
Células-Tronco Hematopoéticas/citologia
Células Progenitoras Mieloides/citologia
[Mh] Termos MeSH secundário: Animais
Medula Óssea/embriologia
Diferenciação Celular
Subunidade alfa 2 de Fator de Ligação ao Core/genética
Subunidade alfa 2 de Fator de Ligação ao Core/metabolismo
Modelos Animais de Doenças
Granulócitos/citologia
Hematopoese/genética
Células-Tronco Hematopoéticas/metabolismo
Seres Humanos
Fígado/citologia
Fígado/embriologia
Fígado/metabolismo
Megacariócitos/citologia
Camundongos
Camundongos Transgênicos
Monócitos/citologia
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Core Binding Factor Alpha 2 Subunit); 0 (Runx1 protein, mouse)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180128
[Lr] Data última revisão:
180128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1007127


  9 / 20973 MEDLINE  
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[PMID]:28930521
[Au] Autor:Khawar MB; Mehmood R; Abbasi MH; Sheikh N
[Ad] Endereço:Cell and molecular biology lab, department of zoology, university of the Punjab, lahore, Pakistan.
[Ti] Título:Multifactorial role of long non-coding RNAs (LncRNAs) in hematopoiesis.
[So] Source:Front Biosci (Schol Ed);10:119-126, 2018 01 01.
[Is] ISSN:1945-0524
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human genome project unveiled that only 1.5.-2.0.% of the genome is protein coding. ENCODE and related studies showed that most part of the genome transcribed into RNAs, and most of them do not code for a functional proteins, hence the name non-coding RNAs (ncRNAs). ncRNAs are small ncRNAs (less than 200 nucleotides) and long ncRNAs (longer than 200 nucleotides up to 10 kb). They act as a direct link between highly ordered chromosome structures, gene expression and serve as a bridge between genome and chromatin modification complexes as guides, scaffolds, and decoys. Highly regulated hematopoietic differentiation is required for formation of all types of blood cells. Among a variety of lncRNAs only few hematopoitic lncRNAs have been studied extensivelyand most of them are not functionally characterized. The role of these lncRNAs remains partially undetermined but their involvement in the regulation of various genes and protein synthesis has been proved even in hematopoiesis. So, the present review is a mere effort to highlight the role of lncRNAs involved in the development and regulation of hematopoiesis.
[Mh] Termos MeSH primário: Hematopoese/genética
RNA Longo não Codificante/genética
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/genética
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Long Noncoding)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE


  10 / 20973 MEDLINE  
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[PMID]:29283518
[Au] Autor:Ivanova VV; Milto IV; Sukhodolo IV; Serebryakova ON; Buzenkova AV
[Ti] Título:Digestive and Nondigestive Functions of Rodents' Salivary Glands.
[So] Source:Usp Fiziol Nauk;48(1):66-79, 2017 Jan-Mar.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Major salivary glands play a role not only in digestion, but also in regulation of other functions in rodents. In this review, we analyzed and summarized the data about the rodents' parotid, submandibular and sublingual salivary glands functions, which is not limited to the production of saliva and action of its hydrolytic enzymes on food in the oral cavity. In recent decades significantly expanded understanding of major salivary glands nondigestive functions. They are involved in excretion of metabolic products, maintaining fluid and electrolyte balance. Special attention has been paid to the characteristics of specific (parotin, sialorphin, etc.) and nonspecific (epidermal growth factor, nerve growth factor, kallikrein, etc.) active substances of the major salivary glands and their involvement in wound healing, mineral metabolism, regulation of hematopoiesis and immunity system. Summarized and analyzed major salivary glands endocrine function in the organs and systems. Available literature data suggest: the structure of the major salivary glands, as well as the synthesis and secretion of a number of biologically active substances are controlled by sex hormones. In turn, these biologically active factors of the salivary glands, as epidermal growth factor, and parotin, sialorphin, whose expression is regulated by androgens, have an impact on the morphological and functional state of the gonads. Thus, major salivary glands operate a wide range of functions and involved in the regulation of sexual behavior of reproductive function and maintaining homeostasis in the body.
[Mh] Termos MeSH primário: Glândula Parótida/fisiologia
Roedores/fisiologia
Proteínas e Peptídeos Salivares/metabolismo
Glândula Sublingual/fisiologia
Glândula Submandibular/fisiologia
[Mh] Termos MeSH secundário: Animais
Fator de Crescimento Epidérmico/genética
Fator de Crescimento Epidérmico/metabolismo
Regulação da Expressão Gênica
Hormônios Esteroides Gonadais/genética
Hormônios Esteroides Gonadais/metabolismo
Hematopoese/fisiologia
Imunidade Inata/efeitos dos fármacos
Calicreínas/genética
Calicreínas/metabolismo
Fator de Crescimento Neural/genética
Fator de Crescimento Neural/metabolismo
Saliva/química
Saliva/fisiologia
Proteínas e Peptídeos Salivares/genética
Proteínas e Peptídeos Salivares/farmacologia
Equilíbrio Hidroeletrolítico/fisiologia
Cicatrização/efeitos dos fármacos
Cicatrização/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 0 (Salivary Proteins and Peptides); 62229-50-9 (Epidermal Growth Factor); 9061-61-4 (Nerve Growth Factor); EC 3.4.21.- (Kallikreins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE



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