Base de dados : MEDLINE
Pesquisa : G04.165 [Categoria DeCS]
Referências encontradas : 9 [refinar]
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  1 / 9 MEDLINE  
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[PMID]:26511712
[Au] Autor:Wang X
[Ad] Endereço:Institute of Life Sciences, the Key Laboratory of Normal Aging & Geriatric, the Chinese PLA General Hospital, Beijing 100853, P.R. China. xnwang88@163.com.
[Ti] Título:Cell-in-cell phenomenon: A New Paradigm in Life Sciences.
[So] Source:Curr Mol Med;15(9):810-8, 2015.
[Is] ISSN:1875-5666
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cell-in-cell, a phenomenon characterized by one or more viable cells entering actively into another cell, was observed more than a century and has only attracted more attention in recent years and is becoming a new hot topic in the biological field, owing its biological significance in evolutionary as well as physiological and pathological relevance in development, homeostasis and diseases. In this paper we focus on the diversity, evolutionary conservatism and clinical implication of cell-in-cell as well as latest opinions on the research strategies. Based on the findings from our laboratory and other research groups three working models of cell-in-cell are also proposed.
[Mh] Termos MeSH primário: Formação de Célula em Célula/fisiologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Disciplinas das Ciências Biológicas
Pesquisa Biomédica/tendências
Comunicação Celular
Seres Humanos
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151030
[St] Status:MEDLINE


  2 / 9 MEDLINE  
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[PMID]:26511708
[Au] Autor:Huang H; Chen Z; Sun Q
[Ti] Título:Mammalian Cell Competitions, Cell-in-Cell Phenomena and Their Biomedical Implications.
[So] Source:Curr Mol Med;15(9):852-60, 2015.
[Is] ISSN:1875-5666
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cell competition was first identified four decades ago as a mechanism to eliminate less fit cells during development in Drosophila melanogaster, and later postulated to be involved in tumorigenesis of human beings. However, evidence for a similar mechanism functional in mammals and tumors was missed until recent years. Like cell competition in fly, multiple forms of competition mechanisms were reported in mammalian system, and some of them were found participating in tumor initiation. Lately, entosis, a mechanism of cell cannibalisms responsible for the formation of cell-in-cell structures in human tumors, was identified as a novel member of ever-expanding family of mammalian cell competitions (MaCCs), and proposed to be able to promote clonal selection and tumor evolution. Thus, engulfment by neighboring cells other than the professional phagocytes, an issue still in debate in fly, was clearly demonstrated in mammals to be responsible for loser elimination. Competition mediated by cell-in-cell structures, formed by multiple cannibal mechanisms, constitutes a novel class of MaCCs. This review will summarize current research on mammalian cell competitions, followed by feature and mechanism analysis and their potential implications in the pathology and treatment of human tumors.
[Mh] Termos MeSH primário: Formação de Célula em Célula/fisiologia
[Mh] Termos MeSH secundário: Animais
Morte Celular
Transformação Celular Neoplásica
Evolução Clonal
Entose/fisiologia
Homeostase
Seres Humanos
Neoplasias/etiologia
Neoplasias/metabolismo
Neoplasias/patologia
Neoplasias/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151030
[St] Status:MEDLINE


  3 / 9 MEDLINE  
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[PMID]:26511706
[Au] Autor:Guyden JC; Martinez M; Chilukuri RV; Reid V; Kelly F; Samms MO
[Ti] Título:Thymic Nurse Cells Participate in Heterotypic Internalization and Repertoire Selection of Immature Thymocytes; Their Removal from the Thymus of Autoimmune Animals May be Important to Disease Etiology.
[So] Source:Curr Mol Med;15(9):828-35, 2015.
[Is] ISSN:1875-5666
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Thymic nurse cells (TNCs) are specialized epithelial cells that reside in the thymic cortex. The initial report of their discovery in 1980 showed TNCs to contain up to 200 thymocytes within specialized vacuoles in their cytoplasm. Much has been reported since that time to determine the function of this heterotypic internalization event that exists between TNCs and developing thymocytes. In this review, we discuss the literature reported that describes the internalization event and the role TNCs play during T cell development in the thymus as well as why these multicellular complexes may be important in inhibiting the development of autoimmune diseases.
[Mh] Termos MeSH primário: Formação de Célula em Célula/fisiologia
Células Epiteliais/fisiologia
Timócitos/citologia
Timócitos/fisiologia
Timo/citologia
Timo/fisiologia
[Mh] Termos MeSH secundário: Animais
Doenças Autoimunes/imunologia
Doenças Autoimunes/metabolismo
Autoimunidade
Comunicação Celular
Diferenciação Celular
Células Epiteliais/ultraestrutura
Antígenos de Histocompatibilidade/imunologia
Seres Humanos
Fenótipo
Timócitos/imunologia
Timócitos/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Nm] Nome de substância:
0 (Histocompatibility Antigens)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151030
[St] Status:MEDLINE


  4 / 9 MEDLINE  
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[PMID]:26511704
[Au] Autor:Ning X; Luo T; Chen Z; Sun Q
[Ti] Título:The physics for the formation of cell-in-cell structures.
[So] Source:Curr Mol Med;15(9):867-72, 2015.
[Is] ISSN:1875-5666
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The formations of cell-in-cell structures have been found in several important biological processes. Recent studies have shed light on the biochemical signaling pathways as well as the quantitative understandings of the underlying physics. Multiple new features that regulate the cellular engulfment have been identified. However, the driving forces promoting the structural formation are still under debate. This review focuses on the recent progress and discusses the potential significance of the existing physical models.
[Mh] Termos MeSH primário: Formação de Célula em Célula/fisiologia
Fenômenos Físicos
[Mh] Termos MeSH secundário: Animais
Citoesqueleto/metabolismo
Entose
Seres Humanos
Fenômenos Mecânicos
Modelos Biológicos
Fagocitose
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151030
[St] Status:MEDLINE


  5 / 9 MEDLINE  
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[PMID]:26511702
[Au] Autor:Overholtzer M; Wang X
[Ti] Título:Cell-in-Cell: A Century-Old Mystery Comes to the Table.
[So] Source:Curr Mol Med;15(9):802-4, 2015.
[Is] ISSN:1875-5666
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Formação de Célula em Célula/fisiologia
Pesquisa
[Mh] Termos MeSH secundário: Animais
Apoptose
História do Século XIX
História do Século XX
História do Século XXI
Seres Humanos
Fagocitose
Pesquisa/história
[Pt] Tipo de publicação:EDITORIAL; HISTORICAL ARTICLE; INTRODUCTORY JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151030
[St] Status:MEDLINE


  6 / 9 MEDLINE  
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[PMID]:26427717
[Au] Autor:Ni C; Huang L; Chen Y; He M; Hu Y; Liu S; Fang X; Li J; Sun Q; Wang X
[Ad] Endereço:School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, Guangdong 510006 & Institute of Life Sciences & Municipal Key Laboratory of Geriatric, Chinese PLA General Hospital, the State Key Laboratory of Kidney, Beijing 100853, China.
[Ti] Título:Implication of cell-in-cell structures in the transmission of HIV to epithelial cells.
[So] Source:Cell Res;25(11):1265-8, 2015 Nov.
[Is] ISSN:1748-7838
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Formação de Célula em Célula
Células Epiteliais/patologia
Infecções por HIV/patologia
Infecções por HIV/transmissão
HIV/fisiologia
[Mh] Termos MeSH secundário: Linhagem Celular
Seres Humanos
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151003
[St] Status:MEDLINE
[do] DOI:10.1038/cr.2015.119


  7 / 9 MEDLINE  
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[PMID]:26109430
[Au] Autor:Huang H; Chen A; Wang T; Wang M; Ning X; He M; Hu Y; Yuan L; Li S; Wang Q; Liu H; Chen Z; Ren J; Sun Q
[Ad] Endereço:Department of Oncology, Beijing Shijitan Hospital of Capital Medical University, Beijing, P. R. China.
[Ti] Título:Detecting cell-in-cell structures in human tumor samples by E-cadherin/CD68/CD45 triple staining.
[So] Source:Oncotarget;6(24):20278-87, 2015 Aug 21.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although Cell-in-cell structures (CICs) had been documented in human tumors for decades, it is unclear what types of CICs were formed largely due to low resolution of traditional way such as H&E staining. In this work, we employed immunofluorescent method to stain a panel of human tumor samples simultaneously with antibodies against E-cadherin for Epithelium, CD68 for Macrophage and CD45 for Leukocytes, which we termed as "EML method" based on the cells detected. Detail analysis revealed four types of CICs, with tumor cells or macrophage engulfing tumor cells or leukocytes respectively. Interestingly, tumor cells seem to be dominant over macrophage (93% vs 7%) as the engulfer cells in all CICs detected, whereas the overall amount of internalized tumor cells is comparable to that of internalized CD45+ leukocytes (57% vs 43%). The CICs profiles vary from tumor to tumor, which may indicate different malignant stages and/or inflammatory conditions. Given the potential impacts different types of CICs might have on tumor growth, we therefore recommend EML analysis of tumor samples to clarify the correlation of CICs subtypes with clinical prognosis in future researches.
[Mh] Termos MeSH primário: Antígenos CD/genética
Formação de Célula em Célula/genética
Neoplasias/genética
[Mh] Termos MeSH secundário: Caderinas
Seres Humanos
Neoplasias/patologia
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Cadherins)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150626
[St] Status:MEDLINE


  8 / 9 MEDLINE  
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[PMID]:24165024
[Au] Autor:Kahyo T; Sugimura H
[Ad] Endereço:Department of Tumor Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
[Ti] Título:Establishment and characterization of a mutagenized cell line exhibiting the 'cell-in-cell' phenotype at a high frequency.
[So] Source:Genes Cells;18(11):1042-52, 2013 Nov.
[Is] ISSN:1365-2443
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cell-in-cell structures represent live cell events in which one cell internalizes another. Because formation of cell-in-cell structures is a rare event in most cell types and the event is associated with cell death, there has been limited clarification of this phenomenon, and its physiological role and molecular mechanism are yet to be precisely elucidated. In this study, we established a mutagenized cell line that exhibited cell-in-cell structures at a more than 10-fold higher frequency as compared to the parent cells. Interestingly, both engulfment and invasion were increased in the mutagenized cell line as compared with that in the parent cell line in the suspension culture condition. This finding indicates that this mutagenized cell line showed an interchangeable status in terms of its ability to form cell-in-cell structures, and the system described here could be useful for elucidation of the mechanisms regulating the formation of cell-in-cell structures, including engulfment and invasion, in a given cellular environment. Further studies using this cell line are warranted to understand the mechanism of formation and biological significance of the cell-in-cell formation.
[Mh] Termos MeSH primário: Formação de Célula em Célula
Células HCT116/citologia
[Mh] Termos MeSH secundário: Aminacrina/análogos & derivados
Aminacrina/farmacologia
Células HCT116/metabolismo
Seres Humanos
Mutagênese
Taxa de Mutação
Compostos de Mostarda Nitrogenada/farmacologia
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Nitrogen Mustard Compounds); 78OY3Z0P7Z (Aminacrine); 96O8D10RM2 (acridine half-mustard)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131030
[St] Status:MEDLINE
[do] DOI:10.1111/gtc.12092


  9 / 9 MEDLINE  
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[PMID]:23681225
[Au] Autor:He MF; Wang S; Wang Y; Wang XN
[Ad] Endereço:The Institute of Life Sciences, Chinese PLA General Hospital and SCUT, the State Key Laboratory of Kidney Disease, Beijing 100853, China.
[Ti] Título:Modeling cell-in-cell structure into its biological significance.
[So] Source:Cell Death Dis;4:e630, 2013 May 16.
[Is] ISSN:2041-4889
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although cell-in-cell structure was noted 100 years ago, the molecular mechanisms of 'entering' and the destination of cell-in-cell remain largely unclear. It takes place among the same type of cells (homotypic cell-in-cell) or different types of cells (heterotypic cell-in-cell). Cell-in-cell formation affects both effector cells and their host cells in multiple aspects, while cell-in-cell death is under more intensive investigation. Given that cell-in-cell has an important role in maintaining homeostasis, aberrant cell-in-cell process contributes to the etiopathology in humans. Indeed, cell-in-cell is observed in many pathological processes of human diseases. In this review, we intend to discuss the biological models of cell-in-cell structures under physiological and pathological status.
[Mh] Termos MeSH primário: Formação de Célula em Célula
Modelos Biológicos
[Mh] Termos MeSH secundário: Fusão Celular
Núcleo Celular/metabolismo
Seres Humanos
Linfócitos/citologia
Linfócitos/fisiologia
Poliploidia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1310
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130518
[St] Status:MEDLINE
[do] DOI:10.1038/cddis.2013.147



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