Base de dados : MEDLINE
Pesquisa : G04.165.249 [Categoria DeCS]
Referências encontradas : 115 [refinar]
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[PMID]:29309811
[Au] Autor:Park EJ; Park SJ; Kim S; Lee K; Chang J
[Ad] Endereço:Graduate school of East-West Medical Science, Kyung Hee University, Yongin-si, Gyeonggi-do, 17104, Republic of Korea. Electronic address: pejtoxic@hanmail.net.
[Ti] Título:Lung fibroblasts may play an important role in clearing apoptotic bodies of bronchial epithelial cells generated by exposure to PHMG-P-containing solution.
[So] Source:Toxicol Lett;286:108-119, 2018 Apr.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Polyhexamethylene guanidine (PHMG) has been widely used in the industry owing to its excellent biocidal, anti-corrosive, and anti-biofouling properties. In Korea, consumers exposed to PHMG-phosphate (PHMG-P)-containing humidifier disinfectant have begun to suffer from fibrotic lung injury-related symptoms for unknown reasons. However, no appropriate treatment has yet been found because the detail toxic mechanism has not been identified. Herein, we first studied the toxic mechanism of PHMG-P-containing solution using human normal bronchial epithelial cells (BEAS-2B cells). When exposed for 24 h, PHMG-P-containing solution rapidly decreased cell viability from around 6 h after exposure and significantly increased of the phosphatidylserine exposure and the LDH release. At 6 h of exposure, the material contained in the solution was found to be bound to the cell membrane and the inner wall of vacuoles, and damaged the cell membrane and organelles. In addition, a significant increase of IFN-γ was observed among cytokines, the expression of apoptosis-, autophagy-, and membrane and DNA damage-related proteins was also enhanced. Meanwhile, the level of intracellular ROS and the secretion of IL-8 and CXCL-1, which are chemokines for professional phagocytes, decreased. Thus, we treated dead BEAS-2B cells to lung fibroblasts (HFL-1), non-professional phagocytes, and then we observed that the dead cells rapidly attached to HFL-1 cells and were taken up. Additionally, increased secretion of IL-8 and CXCL-1 was observed in the cells. Based on these results, we suggest that pulmonary exposure to PHMG-P induces apoptosis of bronchial epithelial cells and lung fibroblasts might play an important role in the clearance of the apoptotic debris.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Brônquios/efeitos dos fármacos
Citofagocitose
Desinfetantes/toxicidade
Células Epiteliais/efeitos dos fármacos
Fibroblastos/metabolismo
Guanidinas/toxicidade
[Mh] Termos MeSH secundário: Brônquios/metabolismo
Brônquios/ultraestrutura
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Quimiocina CXCL1/metabolismo
Relação Dose-Resposta a Droga
Células Epiteliais/metabolismo
Células Epiteliais/ultraestrutura
Fibroblastos/ultraestrutura
Seres Humanos
Interferon gama/metabolismo
Interleucina-8/metabolismo
L-Lactato Desidrogenase/metabolismo
Fosfatidilserinas/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CXCL1 protein, human); 0 (Chemokine CXCL1); 0 (Disinfectants); 0 (Guanidines); 0 (IFNG protein, human); 0 (IL8 protein, human); 0 (Interleukin-8); 0 (Phosphatidylserines); 31961-54-3 (polyhexamethyleneguanidine); 82115-62-6 (Interferon-gamma); EC 1.1.1.27 (L-Lactate Dehydrogenase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE


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[PMID]:29247646
[Au] Autor:Wakui H; Fuseya S; Suzuki R; Shimbo M; Okada R; Hamada M; Kuno A; Hagiwara K; Sato T; Narimatsu H; Kudo T; Takahashi S
[Ad] Endereço:Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Japan; Master's Program in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan.
[Ti] Título:Incomplete clearance of apoptotic cells by core 1-derived O-glycan-deficient resident peritoneal macrophages.
[So] Source:Biochem Biophys Res Commun;495(2):2017-2023, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The core 1 ß1,3-galactosyltransferase-specific molecular chaperon (Cosmc) is essential for the synthesis of the core 1 structure of mucin-type O-glycans. To clarify the physiological role of core 1-derived O-glycans in macrophages, we exploited the LysM-Cre transgene to generate a conditional Cosmc mutant allele (conditional Cosmc knockout; cKO) in myeloid cells. cKO mice developed normally with no gross phenotypic abnormalities or abnormal peripheral blood counts. Resident peritoneal macrophages (rpMacs) of cKO mice exhibited impaired engulfment of apoptotic cells but showed normal macrophage differentiation and counts. T-cell immunoglobulin and mucin domain-containing molecule 4 (Tim4) is a phosphatidylserine (PS) receptor expressed on rpMacs and possesses a heavily O-glycosylated domain. Tim4 tethers apoptotic cells through PS binding. Expression of the Tim4 transcript was unchanged in cKO rpMacs, whereas flow cytometric, Western and dot blot analyses revealed that Tim4 protein expression in cKO rpMacs was significantly lower than that in wild-type (WT) rpMacs. Moreover, the expression levels of other efferocytosis-related molecules, Mertk, Itgav and Itgb3, were normal in rpMacs. In addition, hypoglycosylated Tim4-FLAG fusion protein sufficiently recognized PS. These results demonstrated that core 1-derived O-glycan is required for Tim4-dependent normal efferocytosis and may contribute to the stable expression of the Tim4 glycoprotein.
[Mh] Termos MeSH primário: Apoptose/fisiologia
Citofagocitose/fisiologia
Macrófagos/citologia
Macrófagos/metabolismo
Chaperonas Moleculares/metabolismo
Peritônio/citologia
Peritônio/metabolismo
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cosmc protein, mouse); 0 (Molecular Chaperones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:28562515
[Au] Autor:Pekpak E; Sirvan Cetin B
[Ad] Endereço:Departments of *Pediatric Hematology and Oncology †Pediatric Infectious Disease, Gaziantep Cengiz Gokcek Maternity and Children Hospital, Gaziantep, Turkey.
[Ti] Título:Secondary Hemophagocytic Lymphohistocytosis in a Child With Brucellosis.
[So] Source:J Pediatr Hematol Oncol;39(8):e501-e503, 2017 Nov.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hemophagocytic lymphohistocytosis (HLH) is a potentially fatal hyperinflammatory syndrome that is characterized by proliferation of histiocytes and hemophagocytosis in different organs. The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high serum fasting triglyceride level or low fibrinogen level, and hemophagocytosis in the bone marrow, spleen, or lymph nodes. HLH can be classified as primary and secondary. Secondary HLH can be related to infections. Here we report a case of Brucella-related HLH, which has been rarely reported in the literature.
[Mh] Termos MeSH primário: Brucelose/complicações
Linfo-Histiocitose Hemofagocítica/diagnóstico
Linfo-Histiocitose Hemofagocítica/etiologia
[Mh] Termos MeSH secundário: Adolescente
Antibacterianos/uso terapêutico
Biomarcadores
Medula Óssea/patologia
Brucelose/diagnóstico
Brucelose/tratamento farmacológico
Citofagocitose
Feminino
Febre
Hepatomegalia
Seres Humanos
Imunoglobulinas Intravenosas/uso terapêutico
Linfo-Histiocitose Hemofagocítica/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Biomarkers); 0 (Immunoglobulins, Intravenous)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000849


  4 / 115 MEDLINE  
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[PMID]:28525591
[Au] Autor:Egashira M; Hirota Y; Shimizu-Hirota R; Saito-Fujita T; Haraguchi H; Matsumoto L; Matsuo M; Hiraoka T; Tanaka T; Akaeda S; Takehisa C; Saito-Kanatani M; Maeda KI; Fujii T; Osuga Y
[Ad] Endereço:Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
[Ti] Título:F4/80+ Macrophages Contribute to Clearance of Senescent Cells in the Mouse Postpartum Uterus.
[So] Source:Endocrinology;158(7):2344-2353, 2017 Jul 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cellular senescence, defined as an irreversible cell cycle arrest, exacerbates the tissue microenvironment. Our previous study demonstrated that mouse uterine senescent cells were physiologically increased according to gestational days and that their abnormal accumulation was linked to the onset of preterm delivery. We hypothesized that there is a mechanism for removal of senescent cells after parturition to maintain uterine function. In the current study, we noted abundant uterine senescent cells and their gradual disappearance in wild-type postpartum mice. F4/80+ macrophages were present specifically around the area rich in senescent cells. Depletion of macrophages in the postpartum mice using anti-F4/80 antibody enlarged the area of senescent cells in the uterus. We also found excessive uterine senescent cells and decreased second pregnancy success rate in a preterm birth model using uterine p53-deleted mice. Furthermore, a decrease in F4/80+ cells and an increase in CD11b+ cells with a senescence-associated inflammatory microenvironment were observed in the p53-deleted uterus, suggesting that uterine p53 deficiency affects distribution of the macrophage subpopulation, interferes with senescence clearance, and promotes senescence-induced inflammation. These findings indicate that the macrophage is a key player in the clearance of uterine senescent cells to maintain postpartum uterine function.
[Mh] Termos MeSH primário: Senescência Celular
Citofagocitose/fisiologia
Genes p53/fisiologia
Macrófagos/fisiologia
Período Pós-Parto/fisiologia
Útero/citologia
[Mh] Termos MeSH secundário: Animais
Antígenos de Diferenciação/metabolismo
Feminino
Macrófagos/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos ICR
Camundongos Transgênicos
Gravidez
Útero/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Differentiation); 0 (monocyte-macrophage differentiation antigen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1210/en.2016-1886


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[PMID]:28522599
[Au] Autor:Alvey C; Discher DE
[Ad] Endereço:Systems Pharmacology and Translational Therapeutics Graduate Group, Physical Sciences Oncology Center at Penn, Molecular and Cell Biophysics Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
[Ti] Título:Engineering macrophages to eat cancer: from "marker of self" CD47 and phagocytosis to differentiation.
[So] Source:J Leukoc Biol;102(1):31-40, 2017 Jul.
[Is] ISSN:1938-3673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ability of a macrophage to engulf and break down invading cells and other targets provides a first line of immune defense in nearly all tissues. This defining ability to "phagos" or devour can subsequently activate the entire immune system against foreign and diseased cells, and progress is now being made on a decades-old idea of directing macrophages to phagocytose specific targets, such as cancer cells. Engineered T cells provide precedence with recent clinical successes against liquid tumors, but solid tumors remain a challenge, and a handful of clinical trials seek to exploit the abundance of tumor-associated macrophages instead. Although macrophage differentiation into such phenotypes with deficiencies in phagocytic ability can raise challenges, newly recognized features of cancer cells that might be manipulated to increase the phagocytosis of those cells include ≥1 membrane protein, CD47, which broadly inhibits phagocytosis and is abundantly expressed on all healthy cells. Physical properties of the target also influence phagocytosis and again relate-via cytoskeleton forces-to differentiation pathways in solid tumors. Such pathways extend to mechanosensing by the nuclear lamina, which is known to influence signaling by soluble retinoids that can regulate the macrophage SIRPα, the receptor for CD47. Here, we highlight some of those past, present, and rapidly emerging efforts to understand and control macrophages for cancer therapy.
[Mh] Termos MeSH primário: Biomarcadores Tumorais
Antígeno CD47
Citofagocitose/genética
Engenharia Genética
Macrófagos/imunologia
Neoplasias
[Mh] Termos MeSH secundário: Animais
Antígenos de Diferenciação/genética
Antígenos de Diferenciação/imunologia
Biomarcadores Tumorais/genética
Biomarcadores Tumorais/imunologia
Antígeno CD47/genética
Antígeno CD47/imunologia
Seres Humanos
Neoplasias/genética
Neoplasias/imunologia
Neoplasias/terapia
Receptores Imunológicos/genética
Receptores Imunológicos/imunologia
Transdução de Sinais/genética
Transdução de Sinais/imunologia
Linfócitos T/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antigens, Differentiation); 0 (Biomarkers, Tumor); 0 (CD47 Antigen); 0 (Receptors, Immunologic); 0 (SIRPA protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1189/jlb.4RI1216-516R


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[PMID]:28343229
[Au] Autor:Kosaka N; Hasegawa K; Kiuchi K; Ochiai S; Nagai T; Machida H; Imai Y; Fukasawa I
[Ad] Endereço:Department of Obstetrics and Gynecology, Dokkyo Medical University, Mibu, Japan.
[Ti] Título:Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review.
[So] Source:Acta Cytol;61(2):165-171, 2017.
[Is] ISSN:1938-2650
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ovarian steroid cell tumors (SCTs) are rare and usually benign, although 25-43% are reportedly malignant. The cytologic findings of these rare ovarian tumors have almost never been reported. CASE: We report a rare case of a malignant ovarian SCT with peritoneal dissemination and malignant ascites in a 40-year-old woman. Her tumor was classified as stage IIB (pT2bNoM0) according to the FIGO (International Federation of Gynecology and Obstetrics) classification system, and she was treated with adjuvant chemotherapy following staging laparotomy. Cytology of the ascitic fluid revealed large, polygonal-to-round cells and multinucleated cells with atypia, appearing in clusters with slight overlapping or as isolated tumor cells. Numerous tumor cells had small central round or eccentric nuclei with conspicuous nucleoli, and a moderate-to-abundant amount of cytoplasm, varying from granular and eosinophilic to pale and multivacuolated (foamy), with cannibalism formations. The nuclear chromatin was fine and granular, with irregular distribution and nuclear-membrane thickening. CONCLUSION: These may be the first reported cytology results for ascites with a malignant SCT. Our patient's cytological ascitic findings, rather than the histopathologic features of the original and disseminated tumors, represent the malignant features of the tumor.
[Mh] Termos MeSH primário: Líquido Ascítico/patologia
Neoplasias Ovarianas/patologia
Neoplasias Peritoneais/secundário
[Mh] Termos MeSH secundário: Adulto
Líquido Ascítico/química
Biomarcadores Tumorais/análise
Biópsia
Núcleo Celular/patologia
Quimioterapia Adjuvante
Citofagocitose
Feminino
Seres Humanos
Imuno-Histoquímica
Imagem por Ressonância Magnética
Estadiamento de Neoplasias
Neoplasias Ovarianas/química
Neoplasias Ovarianas/terapia
Neoplasias Peritoneais/química
Neoplasias Peritoneais/terapia
Valor Preditivo dos Testes
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170327
[St] Status:MEDLINE
[do] DOI:10.1159/000458750


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[PMID]:28011901
[Au] Autor:Aflaki E; Borger DK; Grey RJ; Kirby M; Anderson S; Lopez G; Sidransky E
[Ad] Endereço:Section of Molecular Neurogenetics, Medical Genetics Branch, National Institutes of Health, Bethesda, MD, USA.
[Ti] Título:Efferocytosis is impaired in Gaucher macrophages.
[So] Source:Haematologica;102(4):656-665, 2017 Apr.
[Is] ISSN:1592-8721
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Gaucher disease, the inherited deficiency of lysosomal glucocerebrosidase, is characterized by the presence of glucosylceramide-laden macrophages resulting from impaired digestion of aged erythrocytes or apoptotic leukocytes. Studies of macrophages from patients with type 1 Gaucher disease with genotypes N370S/N370S, N370S/L444P or N370S/c.84dupG revealed that Gaucher macrophages have impaired efferocytosis resulting from reduced levels of p67 and Rab7. The decreased Rab7 expression leads to impaired fusion of phagosomes with lysosomes. Moreover, there is defective translocation of p67 to phagosomes, resulting in reduced intracellular production of reactive oxygen species. These factors contribute to defective deposition and clearance of apoptotic cells in phagolysosomes, which may have an impact on the inflammatory response and contribute to the organomegaly and inflammation seen in patients with Gaucher disease.
[Mh] Termos MeSH primário: Doença de Gaucher/genética
Doença de Gaucher/imunologia
Macrófagos/imunologia
Macrófagos/metabolismo
Fagocitose/genética
Fagocitose/imunologia
[Mh] Termos MeSH secundário: Biomarcadores
Citofagocitose/genética
Citofagocitose/imunologia
Genótipo
Glucosilceramidase/genética
Seres Humanos
Imuno-Histoquímica
Mutação
Fagossomos/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Explosão Respiratória/genética
Explosão Respiratória/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Reactive Oxygen Species); EC 3.2.1.45 (Glucosylceramidase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE
[do] DOI:10.3324/haematol.2016.155093


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[PMID]:27909219
[Au] Autor:Kupzig S; Parsons SF; Curnow E; Anstee DJ; Blair A
[Ad] Endereço:NIHR Blood and Transplant Research Unit, Bristol Institute for Transfusion Sciences, National Health Service Blood and Transplant, UK.
[Ti] Título:Superior survival of cultured human reticulocytes following transfusion into mice.
[So] Source:Haematologica;102(3):476-483, 2017 Mar.
[Is] ISSN:1592-8721
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The generation of cultured red blood cells from stem cell sources may fill an unmet clinical need for transfusion-dependent patients, particularly in countries that lack a sufficient and safe blood supply. Cultured red blood cells were generated from human CD34 cells from adult peripheral blood or cord blood by expansion, and a comprehensive survival comparison with standard red cell concentrates was undertaken. Significant amplification (>10 -fold) was achieved using CD34 cells from both cord blood and peripheral blood, generating high yields of enucleated cultured red blood cells. Following transfusion, higher levels of cultured red cells could be detected in the murine circulation compared to standard adult red cells. The proportions of cultured blood cells from cord or peripheral blood sources remained high 24 hours post-transfusion (82±5% and 78±9%, respectively), while standard adult blood cells declined rapidly to only 49±9% by this time. In addition, the survival time of cultured blood cells in mice was longer than that of standard adult red cells. A paired comparison of cultured blood cells and standard adult red blood cells from the same donor confirmed the enhanced survival capacity of the cultured cells. The study herein represents the first demonstration that generated cultured red blood cells survive longer than donor red cells using an model that more closely mimics clinical transfusion. Cultured red blood cells may offer advantages for transfusion-dependent patients by reducing the number of transfusions required.
[Mh] Termos MeSH primário: Transfusão de Componentes Sanguíneos
Sobrevivência Celular
Reticulócitos/metabolismo
Reticulócitos/transplante
[Mh] Termos MeSH secundário: Animais
Antígenos CD34/metabolismo
Diferenciação Celular
Células Cultivadas
Citofagocitose
Eritrócitos/metabolismo
Células-Tronco Hematopoéticas/citologia
Células-Tronco Hematopoéticas/metabolismo
Seres Humanos
Imunofenotipagem
Macrófagos
Camundongos
Fenótipo
Reticulócitos/citologia
Transplante Heterólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD34)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE
[do] DOI:10.3324/haematol.2016.154443


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[PMID]:27842058
[Au] Autor:Abdu Y; Maniscalco C; Heddleston JM; Chew TL; Nance J
[Ad] Endereço:Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, New York 10016, USA.
[Ti] Título:Developmentally programmed germ cell remodelling by endodermal cell cannibalism.
[So] Source:Nat Cell Biol;18(12):1302-1310, 2016 Dec.
[Is] ISSN:1476-4679
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Primordial germ cells (PGCs) in many species associate intimately with endodermal cells, but the significance of such interactions is largely unexplored. Here, we show that Caenorhabditis elegans PGCs form lobes that are removed and digested by endodermal cells, dramatically altering PGC size and mitochondrial content. We demonstrate that endodermal cells do not scavenge lobes PGCs shed, but rather, actively remove lobes from the cell body. CED-10 (Rac)-induced actin, DYN-1 (dynamin) and LST-4 (SNX9) transiently surround lobe necks and are required within endodermal cells for lobe scission, suggesting that scission occurs through a mechanism resembling vesicle endocytosis. These findings reveal an unexpected role for endoderm in altering the contents of embryonic PGCs, and define a form of developmentally programmed cell remodelling involving intercellular cannibalism. Active roles for engulfing cells have been proposed in several neuronal remodelling events, suggesting that intercellular cannibalism may be a more widespread method used to shape cells than previously thought.
[Mh] Termos MeSH primário: Reprogramação Celular
Citofagocitose
Endoderma/citologia
Células Germinativas/citologia
[Mh] Termos MeSH secundário: Animais
Caenorhabditis elegans/citologia
Proteínas de Caenorhabditis elegans/metabolismo
Dinaminas/metabolismo
Células Germinativas/metabolismo
Mitocôndrias/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); EC 3.6.5.5 (Dynamins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE
[do] DOI:10.1038/ncb3439


  10 / 115 MEDLINE  
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[PMID]:27794145
[Au] Autor:Sarode GS; Sarode SC; Batra A; Patil S
[Ad] Endereço:Department of Oral Pathology and Microbiology, Dr DY Patil Dental College and Hospital, Dr DY Patil Vidyapeeth, Pune Maharashtra, India, Phone: +919823871462, e-mail: gargi14@gmail.com.
[Ti] Título:Bipartite Task of Immunity in Cancer Progression.
[So] Source:J Contemp Dent Pract;17(10):783-785, 2016 Oct 01.
[Is] ISSN:1526-3711
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:The spontaneous regression and remission from malignancy was defined by Everson and Cole as "the partial or complete disappearance of a malignant tumor in the absence of all treatment, or in the presence of therapy which is considered inadequate to exert significant influence on neoplastic disease."
[Mh] Termos MeSH primário: Citofagocitose
Regressão Neoplásica Espontânea
Neoplasias/imunologia
[Mh] Termos MeSH secundário: Progressão da Doença
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE



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