Base de dados : MEDLINE
Pesquisa : G05 [Categoria DeCS]
Referências encontradas : 133 [refinar]
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  1 / 133 MEDLINE  
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[PMID]:28372547
[Au] Autor:Arguello JR; Benton R
[Ad] Endereço:Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, CH-1015, Lausanne, Switzerland.
[Ti] Título:Open questions: Tackling Darwin's "instincts": the genetic basis of behavioral evolution.
[So] Source:BMC Biol;15(1):26, 2017 Apr 03.
[Is] ISSN:1741-7007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:All of us have marveled at the remarkable diversity of animal behaviors in nature.None of us has much idea of how these have evolved.
[Mh] Termos MeSH primário: Comportamento
Evolução Biológica
Fenômenos Genéticos
Instinto
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Neurobiologia
Seleção Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1186/s12915-017-0369-3


  2 / 133 MEDLINE  
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[PMID]:28131342
[Au] Autor:Juszczak I; Bartels D
[Ad] Endereço:Institute of Molecular Physiology and Biotechnology of Plants, University of Bonn, Kirschallee 1, D-53115 Bonn, Germany.
[Ti] Título:LEA gene expression, RNA stability and pigment accumulation in three closely related Linderniaceae species differing in desiccation tolerance.
[So] Source:Plant Sci;255:59-71, 2017 Feb.
[Is] ISSN:1873-2259
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Desiccation-tolerant plants (Craterostigma plantagineum and Lindernia brevidens) evolved a highly efficient strategies to prevent dehydration-induced irreversible damage. The protection system involves synthesis of LEA proteins, decrease of photosynthetic activity and activation of antioxidant systems. The regulation of these processes requires joint action of multiple proteins. Here, we present comparative analyses of accumulation of transcripts encoding components of the protection machinery, such as selected LEA proteins, enzymes of the chlorophyll degradation pathway and anthocyanin biosynthesis enzymes in total and polysomal RNA pools. The analyses revealed that desiccation-tolerant plants recruit mRNAs to ribosomes with higher efficiency than the desiccation-sensitive species L. subracemosa. Desiccation-tolerant species accumulated high amounts of LEA transcripts during dehydration and precisely controlled the amounts of chlorophyll keeping it at a level sufficient to activate photosynthesis after rehydration. In contrast, mRNA of L. subracemosa was prone to dehydration-induced degradation, decomposition of the photosynthetic apparatus and degradation of free chlorophyll. Thus, the results of the studies point to differences in the control of gene expression and degradation of chlorophyll in desiccation-tolerant versus desiccation-sensitive species when the plants were subjected to dehydration.
[Mh] Termos MeSH primário: Adaptação Fisiológica
Clorofila/metabolismo
Secas
Magnoliopsida/genética
Proteínas de Plantas/genética
Estabilidade de RNA
Água/metabolismo
[Mh] Termos MeSH secundário: Antocianinas/metabolismo
Craterostigma/genética
Craterostigma/metabolismo
Desidratação
Regulação da Expressão Gênica de Plantas
Fenômenos Genéticos
Magnoliopsida/metabolismo
Fotossíntese
Pigmentos Biológicos/metabolismo
Proteínas de Plantas/metabolismo
RNA Mensageiro/metabolismo
RNA de Plantas/metabolismo
Especificidade da Espécie
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Pigments, Biological); 0 (Plant Proteins); 0 (RNA, Messenger); 0 (RNA, Plant); 0 (late embryogenesis abundant protein, plant); 059QF0KO0R (Water); 1406-65-1 (Chlorophyll)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


  3 / 133 MEDLINE  
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[PMID]:28063738
[Au] Autor:Langford R; Hurrion E; Dawson PA
[Ad] Endereço:Mater Research Institute, University of Queensland, Woolloongabba, 4102, Queensland, Australia.
[Ti] Título:Genetics and pathophysiology of mammalian sulfate biology.
[So] Source:J Genet Genomics;44(1):7-20, 2017 Jan 20.
[Is] ISSN:1673-8527
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Nutrient sulfate is essential for numerous physiological functions in mammalian growth and development. Accordingly, disruptions to any of the molecular processes that maintain the required biological ratio of sulfonated and unconjugated substrates are likely to have detrimental consequences for mammalian physiology. Molecular processes of sulfate biology can be broadly grouped into four categories: firstly, intracellular sulfate levels are maintained by intermediary metabolism and sulfate transporters that mediate the transfer of sulfate across the plasma membrane; secondly, sulfate is converted to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), which is the universal sulfonate donor for all sulfonation reactions; thirdly, sulfotransferases mediate the intracellular sulfonation of endogenous and exogenous substrates; fourthly, sulfate is removed from substrates via sulfatases. From the literature, we curated 91 human genes that encode all known sulfate transporters, enzymes in pathways of sulfate generation, PAPS synthetases and transporters, sulfotransferases and sulfatases, with a focus on genes that are linked to human and animal pathophysiology. The predominant clinical features linked to these genes include neurological dysfunction, skeletal dysplasias, reduced fecundity and reproduction, and cardiovascular pathologies. Collectively, this review provides reference information for genetic investigations of perturbed mammalian sulfate biology.
[Mh] Termos MeSH primário: Fenômenos Genéticos
Sulfatos/metabolismo
[Mh] Termos MeSH secundário: Animais
Enzimas/genética
Enzimas/metabolismo
Homeostase/genética
Seres Humanos
Preparações Farmacêuticas/metabolismo
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Enzymes); 0 (Pharmaceutical Preparations); 0 (Sulfates)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE


  4 / 133 MEDLINE  
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[PMID]:28057826
[Au] Autor:Ramdya P; Schneider J; Levine JD
[Ad] Endereço:Department of Biology and Bioengineering, California Institute of Technology, Pasadena, CA 91106, USA pavan.ramdya@epfl.ch j.schneider@utoronto.ca joel.levine@utoronto.ca.
[Ti] Título:The neurogenetics of group behavior in Drosophila melanogaster.
[So] Source:J Exp Biol;220(Pt 1):35-41, 2017 Jan 01.
[Is] ISSN:1477-9145
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Organisms rarely act in isolation. Their decisions and movements are often heavily influenced by direct and indirect interactions with conspecifics. For example, we each represent a single node within a social network of family and friends, and an even larger network of strangers. This group membership can affect our opinions and actions. Similarly, when in a crowd, we often coordinate our movements with others like fish in a school, or birds in a flock. Contributions of the group to individual behaviors are observed across a wide variety of taxa but their biological mechanisms remain largely unknown. With the advent of powerful computational tools as well as the unparalleled genetic accessibility and surprisingly rich social life of Drosophila melanogaster, researchers now have a unique opportunity to investigate molecular and neuronal determinants of group behavior. Conserved mechanisms and/or selective pressures in D. melanogaster can likely inform a much wider phylogenetic scale. Here, we highlight two examples to illustrate how quantitative and genetic tools can be combined to uncover mechanisms of two group behaviors in D. melanogaster: social network formation and collective behavior. Lastly, we discuss future challenges towards a full understanding how coordinated brain activity across many individuals gives rise to the behavioral patterns of animal societies.
[Mh] Termos MeSH primário: Comportamento Animal
Drosophila melanogaster/genética
Drosophila melanogaster/fisiologia
[Mh] Termos MeSH secundário: Animais
Genes de Insetos
Fenômenos Genéticos
Genética
Fenômenos Fisiológicos do Sistema Nervoso
Vias Neurais
Neurociências
Comportamento Social
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1242/jeb.141457


  5 / 133 MEDLINE  
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[PMID]:28087850
[Au] Autor:Mirian NS; Sedehi M; Kheiri S; Ahmadi A
[Ad] Endereço:Department of Biostatistics and Epidemiology, Faculty of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.
[Ti] Título:A Hybrid ANN-GA Model to Prediction of Bivariate Binary Responses: Application to Joint Prediction of Occurrence of Heart Block and Death in Patients with Myocardial Infarction.
[So] Source:J Res Health Sci;16(4):190-194, 2016.
[Is] ISSN:2228-7809
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In medical studies, when the joint prediction about occurrence of two events should be anticipated, a statistical bivariate model is used. Due to the limitations of usual statistical models, other methods such as Artificial Neural Network (ANN) and hybrid models could be used. In this paper, we propose a hybrid Artificial Neural Network-Genetic Algorithm (ANN-GA) model to prediction the occurrence of heart block and death in myocardial infarction (MI) patients simultaneously. METHODS: For fitting and comparing the models, 263 new patients with definite diagnosis of MI hospitalized in Cardiology Ward of Hajar Hospital, Shahrekord, Iran, from March, 2014 to March, 2016 were enrolled. Occurrence of heart block and death were employed as bivariate binary outcomes. Bivariate Logistic Regression (BLR), ANN and hybrid ANN-GA models were fitted to data. Prediction accuracy was used to compare the models. The codes were written in Matlab 2013a and Zelig package in R3.2.2. RESULTS: The prediction accuracy of BLR, ANN and hybrid ANN-GA models was obtained 77.7%, 83.69% and 93.85% for the training and 78.48%, 84.81% and 96.2% for the test data, respectively. In both training and test data set, hybrid ANN-GA model had better accuracy. CONCLUSIONS: ANN model could be a suitable alternative for modeling and predicting bivariate binary responses when the presuppositions of statistical models are not met in actual data. In addition, using optimization methods, such as hybrid ANN-GA model, could improve precision of ANN model.
[Mh] Termos MeSH primário: Algoritmos
Bloqueio Cardíaco/complicações
Modelos Biológicos
Modelos Estatísticos
Infarto do Miocárdio/mortalidade
[Mh] Termos MeSH secundário: Idoso
Feminino
Fenômenos Genéticos
Hospitalização
Hospitais
Seres Humanos
Irã (Geográfico)
Modelos Logísticos
Masculino
Meia-Idade
Infarto do Miocárdio/complicações
Redes Neurais (Computação)
Software
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE


  6 / 133 MEDLINE  
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[PMID]:27585988
[Au] Autor:Du L; Huang H; Yan J; Kim S; Risacher S; Inlow M; Moore J; Saykin A; Shen L; Alzheimer's Disease Neuroimaging Initiative
[Ad] Endereço:School of Medicine, Indiana University, Indianapolis, USA.
[Ti] Título:Structured sparse CCA for brain imaging genetics via graph OSCAR.
[So] Source:BMC Syst Biol;10 Suppl 3:68, 2016 Aug 26.
[Is] ISSN:1752-0509
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recently, structured sparse canonical correlation analysis (SCCA) has received increased attention in brain imaging genetics studies. It can identify bi-multivariate imaging genetic associations as well as select relevant features with desired structure information. These SCCA methods either use the fused lasso regularizer to induce the smoothness between ordered features, or use the signed pairwise difference which is dependent on the estimated sign of sample correlation. Besides, several other structured SCCA models use the group lasso or graph fused lasso to encourage group structure, but they require the structure/group information provided in advance which sometimes is not available. RESULTS: We propose a new structured SCCA model, which employs the graph OSCAR (GOSCAR) regularizer to encourage those highly correlated features to have similar or equal canonical weights. Our GOSCAR based SCCA has two advantages: 1) It does not require to pre-define the sign of the sample correlation, and thus could reduce the estimation bias. 2) It could pull those highly correlated features together no matter whether they are positively or negatively correlated. We evaluate our method using both synthetic data and real data. Using the 191 ROI measurements of amyloid imaging data, and 58 genetic markers within the APOE gene, our method identifies a strong association between APOE SNP rs429358 and the amyloid burden measure in the frontal region. In addition, the estimated canonical weights present a clear pattern which is preferable for further investigation. CONCLUSIONS: Our proposed method shows better or comparable performance on the synthetic data in terms of the estimated correlations and canonical loadings. It has successfully identified an important association between an Alzheimer's disease risk SNP rs429358 and the amyloid burden measure in the frontal region.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Encéfalo/metabolismo
Gráficos por Computador
Fenômenos Genéticos
Processamento de Imagem Assistida por Computador/métodos
Neuroimagem
[Mh] Termos MeSH secundário: Algoritmos
Análise por Conglomerados
Aprendizado de Máquina
Modelos Estatísticos
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160903
[St] Status:MEDLINE
[do] DOI:10.1186/s12918-016-0312-1


  7 / 133 MEDLINE  
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[PMID]:27518838
[Au] Autor:El Kafsi H; Gorochov G; Larsen M
[Ad] Endereço:aCentre d'Immunologie et des Maladies Infectieuses (CIMI-Paris UMRS 1135), Sorbonne Universités, UPMC Univ Paris 06, INSERM bDépartement d'Immunologie, AP-HP, Groupement Hospitalier Pitié-Salpêtrière, Paris, France.
[Ti] Título:Host genetics affect microbial ecosystems via host immunity.
[So] Source:Curr Opin Allergy Clin Immunol;16(5):413-20, 2016 Oct.
[Is] ISSN:1473-6322
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Genetic evolution of multicellular organisms has occurred in response to environmental challenges, including competition for nutrients, climate change, physical and chemical stressors, and pathogens. However, fitness of an organism is dependent not only on defense efficacy, but also on the ability to take advantage of symbiotic organisms. Indeed, microbes not only encompass pathogenicity, but also enable efficient nutrient uptake from diets nondegradable by the host itself. Moreover, microbes play important roles in the development of host immunity. Here we review associations between specific host genes and variance in microbiota composition and compare with interactions between microbes and host immunity. RECENT FINDINGS: Recent genome-wide association studies reveal that symbiosis between host and microbiota is the exquisite result of genetic coevolution. Moreover, a subset of microbes from human and mouse microbiota have been identified to interact with humoral and cellular immunity. Interestingly, microbes associated with both host genetics and host immunity are taxonomically related. Most involved are Bifidobacterium, Lactobacillus, and Akkermansia, which are dually associated with both host immunity and host genetics. SUMMARY: We conclude that future therapeutics targeting microbiota in the context of chronic inflammatory diseases need to consider both immune and genetic host features associated with microbiota homeostasis.
[Mh] Termos MeSH primário: Interação Gene-Ambiente
Fenômenos Genéticos
Interações Hospedeiro-Patógeno
Imunidade/genética
Microbiota
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Ecossistema
Homeostase
Seres Humanos
Camundongos
Simbiose
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE
[do] DOI:10.1097/ACI.0000000000000302


  8 / 133 MEDLINE  
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[PMID]:27504518
[Ti] Título:[Germany joins the Nagoya Protocol: campaign against biopiracy].
[Ti] Título:Deutschland tritt dem Nagoya-Protokoll bei: Kampf gegen Bio-Piraterie..
[So] Source:Pflege Z;69(5):256, 2016 May.
[Is] ISSN:0945-1129
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Produtos Biológicos
Bioprospecção/legislação & jurisprudência
Fenômenos Genéticos
Propriedade Intelectual
Patentes como Assunto/legislação & jurisprudência
Roubo/legislação & jurisprudência
Roubo/prevenção & controle
[Mh] Termos MeSH secundário: Alemanha
Seres Humanos
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Biological Products)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE


  9 / 133 MEDLINE  
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[PMID]:27148874
[Au] Autor:Bernard A; André JB; Bredeche N
[Ad] Endereço:Sorbonne Universités, UPMC Univ Paris 06, CNRS, Institute of Intelligent Systems and Robotics (ISIR), Paris, France.
[Ti] Título:To Cooperate or Not to Cooperate: Why Behavioural Mechanisms Matter.
[So] Source:PLoS Comput Biol;12(5):e1004886, 2016 05.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mutualistic cooperation often requires multiple individuals to behave in a coordinated fashion. Hence, while the evolutionary stability of mutualistic cooperation poses no particular theoretical difficulty, its evolutionary emergence faces a chicken and egg problem: an individual cannot benefit from cooperating unless other individuals already do so. Here, we use evolutionary robotic simulations to study the consequences of this problem for the evolution of cooperation. In contrast with standard game-theoretic results, we find that the transition from solitary to cooperative strategies is very unlikely, whether interacting individuals are genetically related (cooperation evolves in 20% of all simulations) or unrelated (only 3% of all simulations). We also observe that successful cooperation between individuals requires the evolution of a specific and rather complex behaviour. This behavioural complexity creates a large fitness valley between solitary and cooperative strategies, making the evolutionary transition difficult. These results reveal the need for research on biological mechanisms which may facilitate this transition.
[Mh] Termos MeSH primário: Evolução Biológica
Comportamento Cooperativo
[Mh] Termos MeSH secundário: Algoritmos
Animais
Biologia Computacional
Simulação por Computador
Feminino
Teoria do Jogo
Fenômenos Genéticos
Seres Humanos
Masculino
Modelos Psicológicos
Redes Neurais (Computação)
Comportamento Predatório
Robótica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170320
[Lr] Data última revisão:
170320
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1004886


  10 / 133 MEDLINE  
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[PMID]:27056680
[Au] Autor:Fernández V; Llinares-Benadero C; Borrell V
[Ad] Endereço:Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant, Spain.
[Ti] Título:Cerebral cortex expansion and folding: what have we learned?
[So] Source:EMBO J;35(10):1021-44, 2016 May 17.
[Is] ISSN:1460-2075
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One of the most prominent features of the human brain is the fabulous size of the cerebral cortex and its intricate folding. Cortical folding takes place during embryonic development and is important to optimize the functional organization and wiring of the brain, as well as to allow fitting a large cortex in a limited cranial volume. Pathological alterations in size or folding of the human cortex lead to severe intellectual disability and intractable epilepsy. Hence, cortical expansion and folding are viewed as key processes in mammalian brain development and evolution, ultimately leading to increased intellectual performance and, eventually, to the emergence of human cognition. Here, we provide an overview and discuss some of the most significant advances in our understanding of cortical expansion and folding over the last decades. These include discoveries in multiple and diverse disciplines, from cellular and molecular mechanisms regulating cortical development and neurogenesis, genetic mechanisms defining the patterns of cortical folds, the biomechanics of cortical growth and buckling, lessons from human disease, and how genetic evolution steered cortical size and folding during mammalian evolution.
[Mh] Termos MeSH primário: Córtex Cerebral/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Fenômenos Biomecânicos
Córtex Cerebral/patologia
Córtex Cerebral/fisiologia
Fenômenos Genéticos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160409
[St] Status:MEDLINE
[do] DOI:10.15252/embj.201593701



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