Base de dados : MEDLINE
Pesquisa : G05.360.340.024.340.230 [Categoria DeCS]
Referências encontradas : 395 [refinar]
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[PMID]:28869352
[Au] Autor:Heikkinen LK; Kesäniemi JE; Knott KE
[Ad] Endereço:Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland.
[Ti] Título:De novo transcriptome assembly and developmental mode specific gene expression of Pygospio elegans.
[So] Source:Evol Dev;19(4-5):205-217, 2017 Jul.
[Is] ISSN:1525-142X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Species with multiple different larval developmental modes are interesting models for the study of mechanisms underlying developmental mode transitions and life history evolution. Pygospio elegans, a small, tube-dwelling polychaete worm commonly found in estuarine and marine habitats around the northern hemisphere, is one species with variable developmental modes. To provide new genomic resources for studying P. elegans and to address the differences in gene expression between individuals producing offspring with different larval developmental modes, we performed whole transcriptome Illumina RNA sequencing of adult worms from two populations and prepared a de novo assembly of the P. elegans transcriptome. The transcriptome comprises 66,233 unigenes, of which 33,807 contain predicted coding sequences, 26,448 have at least one functional annotation, and 3,076 are classified as putative long non-coding RNAs. We found more than 8,000 unigenes significantly differentially expressed between adult worms from populations producing either planktonic or benthic larvae. This comprehensive transcriptome resource for P. elegans adds to the available genomic data for annelids and can be used to uncover mechanisms allowing developmental variation in this and potentially other marine invertebrate species.
[Mh] Termos MeSH primário: Poliquetos/crescimento & desenvolvimento
Poliquetos/genética
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Perfilação da Expressão Gênica
Regulação da Expressão Gênica no Desenvolvimento
Genes Controladores do Desenvolvimento
Larva/genética
Larva/crescimento & desenvolvimento
Repetições de Microssatélites
Anotação de Sequência Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1111/ede.12230


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[PMID]:28780048
[Au] Autor:Malik A; Gildor T; Sher N; Layous M; Ben-Tabou de-Leon S
[Ad] Endereço:Bionformatics Core Unit, University of Haifa, Haifa 31905, Israel.
[Ti] Título:Parallel embryonic transcriptional programs evolve under distinct constraints and may enable morphological conservation amidst adaptation.
[So] Source:Dev Biol;430(1):202-213, 2017 10 01.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Embryonic development evolves by balancing stringent morphological constraints with genetic and environmental variation. The design principle that allows developmental transcriptional programs to conserve embryonic morphology while adapting to environmental changes is still not fully understood. To address this fundamental challenge, we compare developmental transcriptomes of two sea urchin species, Paracentrotus lividus and Strongylocentrotus purpuratus, that shared a common ancestor about 40 million years ago and are geographically distant yet show similar morphology. We find that both developmental and housekeeping genes show highly dynamic and strongly conserved temporal expression patterns. The expression of other gene sets, including homeostasis and response genes, show divergent expression which could result from either evolutionary drift or adaptation to local environmental conditions. The interspecies correlations of developmental gene expressions are highest between morphologically similar developmental time points whereas the interspecies correlations of housekeeping gene expression are high between all the late zygotic time points. Relatedly, the position of the phylotypic stage varies between these two groups of genes: developmental gene expression shows highest conservation at mid-developmental stage, in agreement with the hourglass model while the conservation of housekeeping genes keeps increasing with developmental time. When all genes are combined, the relationship between conservation of gene expression and morphological similarity is partially masked by housekeeping genes and genes with diverged expression. Our study illustrates various transcriptional programs that coexist in the developing embryo and evolve under different constraints. Apparently, morphological constraints underlie the conservation of developmental gene expression while embryonic fitness requires the conservation of housekeeping gene expression and the species-specific adjustments of homeostasis gene expression. The distinct evolutionary forces acting on these transcriptional programs enable the conservation of similar body plans while allowing adaption.
[Mh] Termos MeSH primário: Adaptação Fisiológica/genética
Desenvolvimento Embrionário/genética
Evolução Molecular
Strongylocentrotus purpuratus/embriologia
Strongylocentrotus purpuratus/genética
Transcrição Genética
[Mh] Termos MeSH secundário: Animais
Análise por Conglomerados
Perfilação da Expressão Gênica
Regulação da Expressão Gênica no Desenvolvimento
Genes Controladores do Desenvolvimento
Genes Essenciais
Homeostase/genética
Cinética
Filogenia
Análise de Componente Principal
Especificidade da Espécie
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE


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[PMID]:28666124
[Ti] Título:What Is the Future of Developmental Biology?
[So] Source:Cell;170(1):6-7, 2017 06 29.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Biologia do Desenvolvimento
[Mh] Termos MeSH secundário: Animais
Biologia do Desenvolvimento/tendências
Desenvolvimento Embrionário
Regulação da Expressão Gênica no Desenvolvimento
Genes Controladores do Desenvolvimento
Engenharia Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE


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[PMID]:28566535
[Au] Autor:Praggastis SA; Thummel CS
[Ad] Endereço:Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
[Ti] Título:Right time, right place: the temporal regulation of developmental gene expression.
[So] Source:Genes Dev;31(9):847-848, 2017 May 01.
[Is] ISSN:1549-5477
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many studies have focused on defining the critical transcription factors that specify tissue morphogenesis and differentiation. Our understanding of how these spatial regulators are deployed in the proper temporal order, however, has remained less clear. In this issue of , Uyehara and colleagues (pp. 862-875) provide new insights into the mechanisms by which temporal and spatial regulators are coordinated to control wing development during metamorphosis.
[Mh] Termos MeSH primário: Proteínas de Drosophila/genética
Ecdisona
[Mh] Termos MeSH secundário: Animais
Drosophila/genética
Drosophila melanogaster/genética
Regulação da Expressão Gênica no Desenvolvimento
Genes Controladores do Desenvolvimento
Metamorfose Biológica/genética
Fatores de Transcrição/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (Transcription Factors); 3604-87-3 (Ecdysone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1101/gad.301002.117


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[PMID]:27939217
[Au] Autor:Zhu Z; Li C; Zeng Y; Ding J; Qu Z; Gu J; Ge L; Tang F; Huang X; Zhou C; Wang P; Zheng D; Jin Y
[Ad] Endereço:Key Laboratory of Stem Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, 320 Yueyang Road, Shanghai 200032, China; University of Ch
[Ti] Título:PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs.
[So] Source:Cell Stem Cell;20(2):274-289.e7, 2017 Feb 02.
[Is] ISSN:1875-9777
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The chromatin landscape and cellular metabolism both contribute to cell fate determination, but their interplay remains poorly understood. Using genome-wide siRNA screening, we have identified prohibitin (PHB) as an essential factor in self-renewal of human embryonic stem cells (hESCs). Mechanistically, PHB forms protein complexes with HIRA, a histone H3.3 chaperone, and stabilizes the protein levels of HIRA complex components. Like PHB, HIRA is required for hESC self-renewal. PHB and HIRA act together to control global deposition of histone H3.3 and gene expression in hESCs. Of particular note, PHB and HIRA regulate the chromatin architecture at the promoters of isocitrate dehydrogenase genes to promote transcription and, thus, production of α-ketoglutarate, a key metabolite in the regulation of ESC fate. Our study shows that PHB has an unexpected nuclear role in hESCs that is required for self-renewal and that it acts with HIRA in chromatin organization to link epigenetic organization to a metabolic circuit.
[Mh] Termos MeSH primário: Proteínas de Ciclo Celular/metabolismo
Epigênese Genética
Chaperonas de Histonas/metabolismo
Células-Tronco Embrionárias Humanas/metabolismo
Proteínas Repressoras/metabolismo
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Autorrenovação Celular/genética
Cromatina/metabolismo
Imunoprecipitação da Cromatina
Genes Controladores do Desenvolvimento
Genoma Humano
Células HEK293
Histonas/metabolismo
Células-Tronco Embrionárias Humanas/citologia
Seres Humanos
Isocitrato Desidrogenase/metabolismo
Ácidos Cetoglutáricos/metabolismo
Masculino
Células-Tronco Pluripotentes/citologia
Células-Tronco Pluripotentes/metabolismo
Regiões Promotoras Genéticas
Ligação Proteica/genética
RNA Interferente Pequeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Cycle Proteins); 0 (Chromatin); 0 (HIRA protein, human); 0 (Histone Chaperones); 0 (Histones); 0 (Ketoglutaric Acids); 0 (RNA, Small Interfering); 0 (Repressor Proteins); 0 (Transcription Factors); 0 (prohibitin); 8ID597Z82X (alpha-ketoglutaric acid); EC 1.1.1.41 (Isocitrate Dehydrogenase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27159785
[Au] Autor:Watson C; Puelles L
[Ad] Endereço:Faculty of Health Science, Curtin University, Perth, Western Australia, 6845, Australia.
[Ti] Título:Developmental gene expression in the mouse clarifies the organization of the claustrum and related endopiriform nuclei.
[So] Source:J Comp Neurol;525(6):1499-1508, 2017 Apr 15.
[Is] ISSN:1096-9861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies on gene expression in the developing claustrum of the mouse have clarified the relationships and identity of the claustrum proper and related endopiriform nuclei. The cells of the claustrum primordium express Nr4a2; they are formed in combination with the Nr4a2-labeled subplate cells in the lateral pallium at the site of the future insular cortex. The insular cortex cells, which are born later and which are Nr4a2-negative, migrate through the claustrum toward the pial surface to form layers (2-6a) of the insular cortex. The claustrum is made up of distinct deep (subplate-like) and superficial (principal) parts. The cells of the dorsal endopiriform nucleus (which are also Nr4a2-positive) are formed in the deep part of the claustrum primordium in the lateral pallium, but they migrate ventrally to reach the ventral pallium deep to the piriform cortex at E14.5 in the mouse. On the other hand, the ventral endopiriform nucleus is formed by radially migrating Nr4a2-negative cells in the ventral pallium; it is therefore developmentally distinct from the Nr4a2-postive dorsal endopiriform nucleus, which is a lateral pallial derivative. J. Comp. Neurol. 525:1499-1508, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Gânglios da Base
Genes Controladores do Desenvolvimento
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Perfilação da Expressão Gênica
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160510
[St] Status:MEDLINE
[do] DOI:10.1002/cne.24034


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[PMID]:27832738
[Au] Autor:De Oliveira AL; Wollesen T; Kristof A; Scherholz M; Redl E; Todt C; Bleidorn C; Wanninger A
[Ad] Endereço:Department of Integrative Zoology, Faculty of Life Sciences, University of Vienna, Althanstraße 14, Vienna, 1090, Austria.
[Ti] Título:Comparative transcriptomics enlarges the toolkit of known developmental genes in mollusks.
[So] Source:BMC Genomics;17(1):905, 2016 11 10.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mollusks display a striking morphological disparity, including, among others, worm-like animals (the aplacophorans), snails and slugs, bivalves, and cephalopods. This phenotypic diversity renders them ideal for studies into animal evolution. Despite being one of the most species-rich phyla, molecular and in silico studies concerning specific key developmental gene families are still scarce, thus hampering deeper insights into the molecular machinery that governs the development and evolution of the various molluscan class-level taxa. RESULTS: Next-generation sequencing was used to retrieve transcriptomes of representatives of seven out of the eight recent class-level taxa of mollusks. Similarity searches, phylogenetic inferences, and a detailed manual curation were used to identify and confirm the orthology of numerous molluscan Hox and ParaHox genes, which resulted in a comprehensive catalog that highlights the evolution of these genes in Mollusca and other metazoans. The identification of a specific molluscan motif in the Hox paralog group 5 and a lophotrochozoan ParaHox motif in the Gsx gene is described. Functional analyses using KEGG and GO tools enabled a detailed description of key developmental genes expressed in important pathways such as Hedgehog, Wnt, and Notch during development of the respective species. The KEGG analysis revealed Wnt8, Wnt11, and Wnt16 as Wnt genes hitherto not reported for mollusks, thereby enlarging the known Wnt complement of the phylum. In addition, novel Hedgehog (Hh)-related genes were identified in the gastropod Lottia cf. kogamogai, demonstrating a more complex gene content in this species than in other mollusks. CONCLUSIONS: The use of de novo transcriptome assembly and well-designed in silico protocols proved to be a robust approach for surveying and mining large sequence data in a wide range of non-model mollusks. The data presented herein constitute only a small fraction of the information retrieved from the analysed molluscan transcriptomes, which can be promptly employed in the identification of novel genes and gene families, phylogenetic inferences, and other studies using molecular tools. As such, our study provides an important framework for understanding some of the underlying molecular mechanisms involved in molluscan body plan diversification and hints towards functions of key developmental genes in molluscan morphogenesis.
[Mh] Termos MeSH primário: Genes Controladores do Desenvolvimento
Moluscos/genética
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Análise por Conglomerados
Biologia Computacional/métodos
Perfilação da Expressão Gênica/métodos
Biblioteca Gênica
Ontologia Genética
Anotação de Sequência Molecular
Moluscos/classificação
Moluscos/embriologia
Fases de Leitura Aberta
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161112
[St] Status:MEDLINE


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[PMID]:27824919
[Au] Autor:Shi H; Zhang J; Zhu R; Hu N; Lu H; Yang M; Qin B; Shi J; Guan H
[Ad] Endereço:Eye Institute, Affiliated Hospital of Nantong University, Nantong, China.
[Ti] Título:Primary Angle Closure and Sequence Variants within MicroRNA Binding Sites of Genes Involved in Eye Development.
[So] Source:PLoS One;11(11):e0166055, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The formation of primary angle closure (PAC) and primary angle closure glaucoma (PACG) is regulated by a tissue remodeling pathway that plays a critical role in eye development. MicroRNAs (miRNAs) are powerful gene expression regulators and may exert their effects on tissue remodeling genes. This study investigated the associations between gene variants (single-nucleotide polymorphism, SNP) in miRNA binding sites in the 3'-UTR region of genes involved in eye development and PAC. METHODS: The sample consisted of 232 PAC subjects and 306 controls obtained from a population-based cohort in the Funing District of Jiangsu, China. The markers include 9 SNPs in the COL11A1, PCMTD1, ZNRF3, MTHFR, and ALPPL2 genes respectively. SNP genotyping was performed with a TaqMan-MGB probe using an RT-PCR system. RESULTS: Of the 9 SNPs studied, the frequency of the minor A allele of COL11A1 rs1031820 was higher in the PAC group than in the control group in allele analysis (p = 0.047). The genotype analysis indicated that MTHFR rs1537514 is marginally associated with PAC (p = 0.014). The CC genotype of rs1537514 was present solely in the PAC group. However, the differences lost significance after Bonferroni correction. CONCLUSION: Our study reveals a possible association of COL11A1 and MTHFR with PAC in the Han Chinese population. These results will contribute to an improved understanding of the genetic basis of PACG.
[Mh] Termos MeSH primário: Olho/crescimento & desenvolvimento
Genes Controladores do Desenvolvimento/genética
Glaucoma de Ângulo Fechado/genética
MicroRNAs/genética
Polimorfismo de Nucleotídeo Único/genética
[Mh] Termos MeSH secundário: Regiões 3' não Traduzidas/genética
Regiões 3' não Traduzidas/fisiologia
Idoso
Estudos de Casos e Controles
Feminino
Frequência do Gene
Genes Controladores do Desenvolvimento/fisiologia
Técnicas de Genotipagem
Seres Humanos
Masculino
MicroRNAs/fisiologia
Meia-Idade
Polimorfismo de Nucleotídeo Único/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3' Untranslated Regions); 0 (MicroRNAs)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0166055


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[PMID]:27702842
[Au] Autor:Lenser T; Graeber K; Cevik ÖS; Adigüzel N; Dönmez AA; Grosche C; Kettermann M; Mayland-Quellhorst S; Mérai Z; Mohammadin S; Nguyen TP; Rümpler F; Schulze C; Sperber K; Steinbrecher T; Wiegand N; Strnad M; Scheid OM; Rensing SA; Schranz ME; Theißen G; Mummenhoff K; Leubner-Metzger G
[Ad] Endereço:Department of Genetics, Friedrich Schiller University, 07743 Jena, Germany (T.L., F.R., G.T.).
[Ti] Título:Developmental Control and Plasticity of Fruit and Seed Dimorphism in Aethionema arabicum.
[So] Source:Plant Physiol;172(3):1691-1707, 2016 11.
[Is] ISSN:1532-2548
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding how plants cope with changing habitats is a timely and important topic in plant research. Phenotypic plasticity describes the capability of a genotype to produce different phenotypes when exposed to different environmental conditions. In contrast, the constant production of a set of distinct phenotypes by one genotype mediates bet hedging, a strategy that reduces the temporal variance in fitness at the expense of a lowered arithmetic mean fitness. Both phenomena are thought to represent important adaptation strategies to unstable environments. However, little is known about the underlying mechanisms of these phenomena, partly due to the lack of suitable model systems. We used phylogenetic and comparative analyses of fruit and seed anatomy, biomechanics, physiology, and environmental responses to study fruit and seed heteromorphism, a typical morphological basis of a bet-hedging strategy of plants, in the annual Brassicaceae species Aethionema arabicum Our results indicate that heteromorphism evolved twice within the Aethionemeae, including once for the monophyletic annual Aethionema clade. The dimorphism of Ae. arabicum is associated with several anatomic, biomechanical, gene expression, and physiological differences between the fruit and seed morphs. However, fruit ratios and numbers change in response to different environmental conditions. Therefore, the life-history strategy of Ae. arabicum appears to be a blend of bet hedging and plasticity. Together with the available genomic resources, our results pave the way to use this species in future studies intended to unravel the molecular control of heteromorphism and plasticity.
[Mh] Termos MeSH primário: Brassicaceae/embriologia
Frutas/embriologia
Sementes/embriologia
[Mh] Termos MeSH secundário: Brassicaceae/anatomia & histologia
Brassicaceae/genética
Brassicaceae/ultraestrutura
Regulação para Baixo/genética
Frutas/genética
Frutas/ultraestrutura
Regulação da Expressão Gênica no Desenvolvimento
Regulação da Expressão Gênica de Plantas
Genes Controladores do Desenvolvimento
Genes de Plantas
Germinação/genética
Modelos Biológicos
Fenótipo
Filogenia
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Dispersão de Sementes
Sementes/genética
Sementes/ultraestrutura
Homologia de Sequência de Aminoácidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


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[PMID]:27681428
[Au] Autor:Song HW; Bettegowda A; Lake BB; Zhao AH; Skarbrevik D; Babajanian E; Sukhwani M; Shum EY; Phan MH; Plank TM; Richardson ME; Ramaiah M; Sridhar V; de Rooij DG; Orwig KE; Zhang K; Wilkinson MF
[Ad] Endereço:School of Medicine, Department of Reproductive Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
[Ti] Título:The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment.
[So] Source:Cell Rep;17(1):149-164, 2016 Sep 27.
[Is] ISSN:2211-1247
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The developmental origins of most adult stem cells are poorly understood. Here, we report the identification of a transcription factor-RHOX10-critical for the initial establishment of spermatogonial stem cells (SSCs). Conditional loss of the entire 33-gene X-linked homeobox gene cluster that includes Rhox10 causes progressive spermatogenic decline, a phenotype indistinguishable from that caused by loss of only Rhox10. We demonstrate that this phenotype results from dramatically reduced SSC generation. By using a battery of approaches, including single-cell-RNA sequencing (scRNA-seq) analysis, we show that Rhox10 drives SSC generation by promoting pro-spermatogonia differentiation. Rhox10 also regulates batteries of migration genes and promotes the migration of pro-spermatogonia into the SSC niche. The identification of an X-linked homeobox gene that drives the initial generation of SSCs has implications for the evolution of X-linked gene clusters and sheds light on regulatory mechanisms influencing adult stem cell generation in general.
[Mh] Termos MeSH primário: Células-Tronco Germinativas Adultas/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Genes Ligados ao Cromossomo X
Proteínas de Homeodomínio/genética
Espermatogênese/genética
Espermatogônias/metabolismo
[Mh] Termos MeSH secundário: Células-Tronco Germinativas Adultas/citologia
Animais
Genes Controladores do Desenvolvimento
Proteínas de Homeodomínio/metabolismo
Masculino
Camundongos
Camundongos Knockout
Família Multigênica
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Análise de Sequência de RNA
Análise de Célula Única
Espermatogônias/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Homeodomain Proteins); 0 (Protein Isoforms); 0 (Rhox10 protein, mouse)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde