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Pesquisa : G05.360.340.024.340.361 [Categoria DeCS]
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[PMID]:28457900
[Au] Autor:Bardbari AM; Arabestani MR; Karami M; Keramat F; Alikhani MY; Bagheri KP
[Ad] Endereço:Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: Alimoh2412@gmail.com.
[Ti] Título:Correlation between ability of biofilm formation with their responsible genes and MDR patterns in clinical and environmental Acinetobacter baumannii isolates.
[So] Source:Microb Pathog;108:122-128, 2017 Jul.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Acinetobacter baumannii potential to form biofilm and exhibit multiple antibiotic resistances may be responsible in its survival in hospital environment. Accordingly, our study was aimed to determine the correlation between ability of biofilm formation and the frequency of biofilm related genes with antibiotic resistance phenotypes, and also the categorization of their patterns in clinical and environmental isolates. A total of 75 clinical and 32 environmental strains of the A. baumannii were collected and identified via API 20NE. Antibiotic susceptibility was evaluated by disk diffusion and microdilution broth methods. Biofilm formation assay was performed by microtiter plate method. OXA types and biofilm related genes including Bla , Bla , Bla , Bla , bap, bla , and ompA were amplified by PCR. The rate of MDR A. baumannii in clinical isolates (100%) was higher than environmental (81.2%) isolates (p < 0.05). Among 10 antibiotypes, the predominant resistance pattern in clinical and environmental isolates was antibiotypes I (85.3 and 78.1%, respectively). Analysis of the frequency of bla gene revealed a statistically significant difference between clinical (85.3%) and environmental (68.7%) isolates (p < 0.05). The prevalence of strong biofilm producers in clinical and environmental isolates were 31.2%-58.7%, respectively. In the clinical and environmental isolates, the frequencies of ompA, bla and bap genes were 100%, 53.3%, 82.7% and 100%, 37.5%, 84.4% respectively. Statistical analysis revealed a significant correlation between the frequency of MDR isolates and biofilm formation ability (p = 0.008). The high frequency of antibiotype I would be indicated that an outbreak has been happened earlier and an endemic strain is currently being settled in the hospital environment. It would be suggested that if there was no difference in the frequency of pattern I and biofilm formation ability between clinical and environmental isolates, it is a critical point representing the higher risk of bacterial transmission from environment to the patients. The resulting data would be assisted in the improvement of disinfection strategies to better control of nosocomial infections. One dominant resistance pattern has shown among clinical and environmental isolates. The frequency of blaOXA-23 had significant difference between clinical and environmental isolates. The presence of bap gene in the A. baumannii isolates was associated with biofilm formation. There was a significant correlation between multiple drug resistance and biofilm formation. The clinical isolates had a higher ability to form strong biofilms compared to the environmental samples.
[Mh] Termos MeSH primário: Acinetobacter baumannii/genética
Acinetobacter baumannii/fisiologia
Biofilmes/crescimento & desenvolvimento
Genes MDR/genética
Genes MDR/fisiologia
[Mh] Termos MeSH secundário: Infecções por Acinetobacter/microbiologia
Acinetobacter baumannii/efeitos dos fármacos
Acinetobacter baumannii/isolamento & purificação
Adulto
Idoso
Idoso de 80 Anos ou mais
Antibacterianos/farmacologia
Proteínas de Bactérias/genética
Técnicas Bacteriológicas
Biofilmes/efeitos dos fármacos
Infecção Hospitalar/microbiologia
Infecção Hospitalar/prevenção & controle
DNA Bacteriano/análise
Farmacorresistência Bacteriana Múltipla/genética
Microbiologia Ambiental
Feminino
Seres Humanos
Irã (Geográfico)
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (DNA, Bacterial)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28601971
[Au] Autor:Tsyganov MM; Freidin MB; Ibragimova MK; Deryusheva IV; Kazantseva PV; Slonimskaya EM; Cherdyntseva NV; Litviakov NV
[Ad] Endereço:Department of Experimental Oncology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5, Kooperativny Street, 634050, Tomsk, Russian Federation. TsyganovMM@yandex.ru.
[Ti] Título:Genetic variability in the regulation of the expression cluster of MDR genes in patients with breast cancer.
[So] Source:Cancer Chemother Pharmacol;80(2):251-260, 2017 Aug.
[Is] ISSN:1432-0843
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: We aimed to investigate the association between the polymorphism and expression patterns of multiple drug resistance genes (MDR) in breast cancer (BC). MATERIALS AND METHODS: The MDR gene expression levels were measured in tumor tissues of 106 breast cancer patients using quantitative real-time PCR. Affymetrix CytoScan™ HD Array chips were used to assess genotypes. Pairwise correlation analysis for ABCB1, ABCC1, ABCC2 and ABCG2 gene expression levels was carried out to reveal co-expression clusters. Associations between SNPs of MDR genes and their preoperative expression levels were assessed using analysis of covariance adjusting for covariates. RESULTS: The SNPs associated with the expression of the ABCB1, ABCC1, ABCC2 and ABCG2 genes before NAC were detected. In addition, 21 SNPs associated with the expression of four ABC-transporter genes and involved in the expression regulation were identified. Validation in an independent sample confirmed the association between the MDR cluster genes and 11 SNPs. CONCLUSIONS: Four MDR genes: ABCB1, ABCC1, ABCC2 and ABCG2 were shown to form the functional expression cluster in breast tumor. Further studies are required to discover precise mechanisms of the cluster regulation, thereby providing new approaches and targets to combat the development of the MDR phenotype during chemotherapy.
[Mh] Termos MeSH primário: Transportadores de Cassetes de Ligação de ATP/genética
Neoplasias da Mama/genética
Regulação Neoplásica da Expressão Gênica/genética
Genes MDR/genética
Proteínas Associadas à Resistência a Múltiplos Medicamentos/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Variação Genética
Genótipo
Seres Humanos
Meia-Idade
Família Multigênica
Análise de Sequência com Séries de Oligonucleotídeos/métodos
Polimorfismo de Nucleotídeo Único
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Multidrug Resistance-Associated Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170612
[St] Status:MEDLINE
[do] DOI:10.1007/s00280-017-3354-1


  3 / 1737 MEDLINE  
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[PMID]:28381709
[Au] Autor:Yamasaki S; Nakashima R; Sakurai K; Yamaguchi A; Nishino K
[Ad] Endereço:Institute of Scientific and Industrial Research, Osaka University.
[Ti] Título:Structural Analysis and New Drug Development against Multidrug Efflux Pumps.
[So] Source:Yakugaku Zasshi;137(4):377-382, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Multidrug efflux pumps are important in the multidrug resistance of Gram-negative pathogens. However, despite efforts to develop efflux inhibitors, clinically useful inhibitors are not available at present. ABI-PP (a pryridopyrimidine derivative) is a MexB-specific inhibitor that does not inhibit MexY; MexB and MexY are principal pumps in Pseudomonas aeruginosa. We previously found that drugs were exported through tandem proximal and distal multisite drug-binding pockets. Here we describe the first inhibitor-bound structures of pumps. ABI-PP binds tightly to a narrow pit located in the distal pocket and sterically hinders the functional rotation. Phenylalanine is located at the edge of this pit in MexB and contributes to the tight binding of the inhibitor molecule. On the other hand, the voluminous side chain of tryptophan located at the corresponding position in MexY prevents inhibitor binding. For the development of universal inhibitors of MexB and MexY, it is important to avoid the steric hindrance of tryptophan in MexY. Now we are developing clinically useful inhibitors on the basis of the structural information obtained. Started from the ABI-PP structure, we designed many compounds that can bind to the inhibitor-binding pits of MexB and MexY. Some of designed compounds were actually synthesized and their inhibitory activity determined. Finally, we obtained some lead compounds that showed complete prevention of the growth of strains expressing MexB and MexY with low concentrations of antibiotics.
[Mh] Termos MeSH primário: Antibacterianos
Descoberta de Drogas
Farmacorresistência Bacteriana Múltipla
Genes MDR
Bactérias Gram-Negativas/patogenicidade
Proteínas de Membrana Transportadoras/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana Múltipla/genética
Proteínas de Membrana Transportadoras/genética
Fenilalanina
Ligação Proteica
Pseudomonas aeruginosa
Piridinas/metabolismo
Piridinas/farmacologia
Pirimidinonas/metabolismo
Pirimidinonas/farmacologia
Triptofano
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (ABI-PP compound); 0 (Anti-Bacterial Agents); 0 (Membrane Transport Proteins); 0 (Pyridines); 0 (Pyrimidinones); 47E5O17Y3R (Phenylalanine); 8DUH1N11BX (Tryptophan)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.16-00235-2


  4 / 1737 MEDLINE  
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[PMID]:28333184
[Au] Autor:Alonso CA; Michael GB; Li J; Somalo S; Simón C; Wang Y; Kaspar H; Kadlec K; Torres C; Schwarz S
[Ad] Endereço:Department of Biochemistry and Molecular Biology, University of La Rioja, Logroño, Spain.
[Ti] Título:Analysis of blaSHV-12-carrying Escherichia coli clones and plasmids from human, animal and food sources.
[So] Source:J Antimicrob Chemother;72(6):1589-1596, 2017 Jun 01.
[Is] ISSN:1460-2091
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: This study aimed at characterizing 23 Escherichia coli isolates from various sources and their respective bla SHV-12 -carrying plasmids and sequencing one of these plasmids completely. Methods: Isolates were typed by XbaI-PFGE, MLST and PCR-based phylotyping. Transformed bla SHV-12 -carrying plasmids were examined by replicon typing, S1-nuclease, conjugation, EcoRI-HindIII-BamHI digests and plasmid MLST. Co-located resistance genes and integrons as well as the bla SHV-12 genetic environment were analysed by PCR and sequencing. One IncI1 plasmid was sequenced completely using HiSeq 2500 and gap closure by PCRs and Sanger sequencing. Results: Among the 23 SHV-12-positive E. coli , some isolates from different sources showed the same characteristics: ST23/phylogroup A (human, dog, livestock), ST57/D (wild bird, chicken meat) and ST117/D (chicken meat, chicken). All bla SHV-12 genes were horizontally transferable via 30-120 kb plasmids of incompatibility groups IncI1 ( n = 17), IncK ( n = 3), IncF ( n = 1), IncX3 ( n = 1) and a non-typeable plasmid. IncK plasmids, indistinguishable in size and restriction patterns, were found in isolates from different sources (ST57/D, meat; ST131/B2, meat; ST57/B1, dog). The IncI1- bla SHV-12 -carrying plasmids were mostly assigned to plasmid ST (pST) 26 and pST3. Three plasmids showed novel pSTs (pST214, pST215). The majority of the IncI1 transformants exhibited resistance to ß-lactams, chloramphenicol and streptomycin (in relation with a class 1 integron containing an estX - psp - aadA2 - cmlA1 - aadA1 - qacI gene cassette array), and to tetracycline. A novel bla SHV-12 environment was detected and whole plasmid sequencing revealed a Tn 21 -derived- bla SHV12 -ΔTn 1721 resistance complex. Conclusions: Results from this study suggest that the dissemination of bla SHV-12 genes occurs by vertical (clonal) and horizontal transfer, the latter mainly mediated through IncI1 multidrug-resistance plasmids.
[Mh] Termos MeSH primário: Escherichia coli/genética
Microbiologia de Alimentos
Plasmídeos
beta-Lactamases/genética
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Galinhas/microbiologia
Cloranfenicol/farmacologia
Cães/microbiologia
Escherichia coli/efeitos dos fármacos
Escherichia coli/enzimologia
Escherichia coli/isolamento & purificação
Transferência Genética Horizontal
Genes MDR
Seres Humanos
Integrons
Carne/microbiologia
Testes de Sensibilidade Microbiana
Tipagem de Sequências Multilocus
Plasmídeos/isolamento & purificação
Replicon
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 66974FR9Q1 (Chloramphenicol); EC 3.5.2.6 (beta-Lactamases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/jac/dkx024


  5 / 1737 MEDLINE  
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[PMID]:28271527
[Au] Autor:Li X; Liu R; Yang J; Sun L; Zhang L; Jiang Z; Puri P; Gurley EC; Lai G; Tang Y; Huang Z; Pandak WM; Hylemon PB; Zhou H
[Ad] Endereço:Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
[Ti] Título:The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice.
[So] Source:Hepatology;66(3):869-884, 2017 Sep.
[Is] ISSN:1527-3350
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The multidrug resistance 2 knockout (Mdr2 ) mouse is a well-established model of cholestatic cholangiopathies. Female Mdr2 mice develop more severe hepatobiliary damage than male Mdr2 mice, which is correlated with a higher proportion of taurocholate in the bile. Although estrogen has been identified as an important player in intrahepatic cholestasis, the underlying molecular mechanisms of gender-based disparity of cholestatic injury remain unclear. The long noncoding RNA H19 is an imprinted, maternally expressed, and estrogen-targeted gene, which is significantly induced in human fibrotic/cirrhotic liver and bile duct-ligated mouse liver. However, whether aberrant expression of H19 accounts for gender-based disparity of cholestatic injury in Mdr2 mice remains unknown. The current study demonstrated that H19 was markedly induced (∼200-fold) in the livers of female Mdr2 mice at advanced stages of cholestasis (100 days old) but not in age-matched male Mdr2 mice. During the early stages of cholestasis, H19 expression was minimal. We further determined that hepatic H19 was mainly expressed in cholangiocytes, not hepatocytes. Both taurocholate and estrogen significantly activated the extracellular signal-regulated kinase 1/2 signaling pathway and induced H19 expression in cholangiocytes. Knocking down H19 not only significantly reduced taurocholate/estrogen-induced expression of fibrotic genes and sphingosine 1-phosphate receptor 2 in cholangiocytes but also markedly reduced cholestatic injury in female Mdr2 mice. Furthermore, expression of small heterodimer partner was substantially inhibited at advanced stages of liver fibrosis, which was reversed by H19 short hairpin RNA in female Mdr2 mice. Similar findings were obtained in human primary sclerosing cholangitis liver samples. CONCLUSION: H19 plays a critical role in the disease progression of cholestasis and represents a key factor that causes the gender disparity of cholestatic liver injury in Mdr2 mice. (Hepatology 2017;66:869-884).
[Mh] Termos MeSH primário: Colangite Esclerosante/patologia
Colestase/patologia
Regulação da Expressão Gênica
RNA Longo não Codificante/genética
Receptores de Lisoesfingolipídeo/genética
[Mh] Termos MeSH secundário: Animais
Colangite Esclerosante/genética
Colestase/genética
Modelos Animais de Doenças
Regulação para Baixo
Estrogênios/farmacologia
Feminino
Técnicas de Inativação de Genes
Genes MDR
Seres Humanos
Cirrose Hepática/genética
Cirrose Hepática/patologia
Masculino
Camundongos
Camundongos Knockout
Proteína Quinase 1 Ativada por Mitógeno/metabolismo
Papel (Figurativo)
Fatores Sexuais
Ácido Taurocólico/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); 0 (H19 long non-coding RNA); 0 (RNA, Long Noncoding); 0 (Receptors, Lysosphingolipid); 0 (sphingosine-1-phosphate receptor-2, mouse); 5E090O0G3Z (Taurocholic Acid); EC 2.7.11.24 (Mapk1 protein, mouse); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1002/hep.29145


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[PMID]:28267571
[Au] Autor:Loy JD; Clawson ML
[Ad] Endereço:University of Nebraska-Lincoln, Institute of Agriculture and Natural Resources, School of Veterinary Medicine and Biomedical Sciences, Lincoln, NE, USA. Electronic address: jdloy@unl.edu.
[Ti] Título:Rapid typing of Mannheimia haemolytica major genotypes 1 and 2 using MALDI-TOF mass spectrometry.
[So] Source:J Microbiol Methods;136:30-33, 2017 May.
[Is] ISSN:1872-8359
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Genotype 2M. haemolytica predominantly associate over genotype 1 with the lungs of cattle with respiratory disease and ICEs containing antimicrobial resistance genes. Distinct protein masses were detected by MALDI-TOF MS between genotype 1 and 2 strains. MALDI-TOF MS could rapidly differentiate genotype 2 strains in veterinary diagnostic laboratories.
[Mh] Termos MeSH primário: Genótipo
Mannheimia haemolytica/genética
Mannheimia haemolytica/isolamento & purificação
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/genética
Bovinos
Doenças dos Bovinos/microbiologia
DNA Bacteriano/genética
Genes MDR/genética
Pulmão/microbiologia
Mannheimia haemolytica/classificação
Mannheimia haemolytica/patogenicidade
Infecções por Pasteurellaceae/diagnóstico
Infecções por Pasteurellaceae/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (DNA, Bacterial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28186558
[Au] Autor:Tang Y; Dai L; Sahin O; Wu Z; Liu M; Zhang Q
[Ad] Endereço:Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50010, USA.
[Ti] Título:Emergence of a plasmid-borne multidrug resistance gene cfr(C) in foodborne pathogen Campylobacter.
[So] Source:J Antimicrob Chemother;72(6):1581-1588, 2017 Jun 01.
[Is] ISSN:1460-2091
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: To identify and characterize a novel cfr variant that recently emerged and confers multidrug resistance in Campylobacter , a major foodborne pathogen. Methods: WGS was initially used to identify the cfr (C) gene in Campylobacter isolates and its function was further verified by cloning into an antibiotic-susceptible Campylobacter jejuni strain. Distribution of cfr (C) in various Campylobacter isolates was determined by PCR analysis. Genotyping of cfr (C)-positive strains was done by PFGE and MLST. Results: The cfr (C) gene is predicted to encode a protein that shares 55.1% and 54.9% identity with Cfr and Cfr(B), respectively. cfr (C) was located on a conjugative plasmid of ∼48 kb. Cloning of cfr (C) into C. jejuni NCTC 11168 and conjugative transfer of the cfr (C)-containing plasmid confirmed its role in conferring resistance to phenicols, lincosamides, pleuromutilins and oxazolidinones, and resulted in an 8-256-fold increase in their MICs in both C. jejuni and Campylobacter coli . The cfr (C) gene was detected in multiple C. coli (34 of 344; 10%) isolates derived from different cattle farms in different states, and molecular typing of the cfr (C)-positive C. coli isolates revealed its spread mainly via clonal expansion. Conclusions: These results identify cfr (C) as a new multidrug resistance mechanism in Campylobacter and suggest the potential transmission of this mechanism via the foodborne route, warranting enhanced efforts to monitor its spread in Campylobacter and other foodborne pathogens.
[Mh] Termos MeSH primário: Campylobacter/genética
Farmacorresistência Bacteriana Múltipla/genética
Microbiologia de Alimentos
Genes MDR
Plasmídeos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Campylobacter/efeitos dos fármacos
Campylobacter/isolamento & purificação
Campylobacter/patogenicidade
Campylobacter jejuni/genética
Bovinos/microbiologia
Clonagem Molecular
DNA Bacteriano/genética
Genoma Bacteriano
Genótipo
Seres Humanos
Testes de Sensibilidade Microbiana
Tipagem de Sequências Multilocus
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA, Bacterial)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1093/jac/dkx023


  8 / 1737 MEDLINE  
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[PMID]:28146652
[Au] Autor:Knox DC; Anderson PL; Harrigan PR; Tan DH
[Ad] Endereço:Maple Leaf Medical Clinic, Toronto, ON, Canada dknox@mlmedical.com.
[Ti] Título:Multidrug-Resistant HIV-1 Infection despite Preexposure Prophylaxis.
[So] Source:N Engl J Med;376(5):501-502, 2017 02 02.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Fármacos Anti-HIV/uso terapêutico
Farmacorresistência Viral Múltipla/genética
Combinação Emtricitabina e Fumarato de Tenofovir Desoproxila/uso terapêutico
Genes MDR
Infecções por HIV/prevenção & controle
HIV-1/genética
Profilaxia Pré-Exposição
[Mh] Termos MeSH secundário: Adulto
Infecções por HIV/virologia
Seres Humanos
Masculino
Mutação
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1611639


  9 / 1737 MEDLINE  
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[PMID]:28085074
[Au] Autor:Laudy AE; Kulinska E; Tyski S
[Ad] Endereço:Department of Pharmaceutical Microbiology, Medical University of Warsaw, Oczki 3 Str., 02-007 Warsaw, Poland. alaudy@wp.pl.
[Ti] Título:The Impact of Efflux Pump Inhibitors on the Activity of Selected Non-Antibiotic Medicinal Products against Gram-Negative Bacteria.
[So] Source:Molecules;22(1), 2017 Jan 11.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The potential role of non-antibiotic medicinal products in the treatment of multidrug-resistant Gram-negative bacteria has recently been investigated. It is highly likely that the presence of efflux pumps may be one of the reasons for the weak activity of non-antibiotics, as in the case of some non-steroidal anti-inflammatory drugs (NSAIDs), against Gram-negative rods. The activity of eight drugs of potential non-antibiotic activity, active substance standards, and relevant medicinal products were analysed with and without of efflux pump inhibitors against 180 strains of five Gram-negative rod species by minimum inhibitory concentration (MIC) value determination in the presence of 1 mM MgSO4. Furthermore, the influence of non-antibiotics on the susceptibility of clinical strains to quinolones with or without PAßN (Phe-Arg-ß-naphthylamide) was investigated. The impacts of PAßN on the susceptibility of bacteria to non-antibiotics suggests that amitriptyline, alendronate, nicergoline, and ticlopidine are substrates of efflux pumps in Gram-negative rods. Amitriptyline/Amitriptylinum showed the highest direct antibacterial activity, with MICs ranging 100-800 mg/L against all studied species. Significant decreases in the MIC values of other active substances (acyclovir, atorvastatin, and famotidine) tested with pump inhibitors were not observed. The investigated non-antibiotic medicinal products did not alter the MICs of quinolones in the absence and in the presence of PAßN to the studied clinical strains of five groups of species.
[Mh] Termos MeSH primário: Amitriptilina/farmacologia
Antibacterianos/farmacologia
Dipeptídeos/farmacologia
Genes MDR/efeitos dos fármacos
Pseudomonas aeruginosa/efeitos dos fármacos
[Mh] Termos MeSH secundário: Aciclovir/farmacologia
Alendronato/farmacologia
Atorvastatina Cálcica/farmacologia
Combinação de Medicamentos
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Farmacorresistência Bacteriana Múltipla/genética
Escherichia coli/efeitos dos fármacos
Escherichia coli/crescimento & desenvolvimento
Escherichia coli/metabolismo
Famotidina/farmacologia
Klebsiella pneumoniae/efeitos dos fármacos
Klebsiella pneumoniae/crescimento & desenvolvimento
Klebsiella pneumoniae/metabolismo
Sulfato de Magnésio/farmacologia
Testes de Sensibilidade Microbiana
Nicergolina/farmacologia
Pseudomonas aeruginosa/crescimento & desenvolvimento
Pseudomonas aeruginosa/metabolismo
Quinolonas/farmacologia
Salmonella/efeitos dos fármacos
Salmonella/crescimento & desenvolvimento
Salmonella/metabolismo
Ticlopidina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Dipeptides); 0 (Drug Combinations); 0 (Quinolones); 0 (phenylalanylarginine-naphthylamide); 1806D8D52K (Amitriptyline); 48A5M73Z4Q (Atorvastatin Calcium); 5QZO15J2Z8 (Famotidine); 7487-88-9 (Magnesium Sulfate); JCV8365FWN (Nicergoline); OM90ZUW7M1 (Ticlopidine); X1J18R4W8P (Alendronate); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE


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[PMID]:28066884
[Au] Autor:Campbell O; de Lorimier LP; Mealey KL
[Ad] Endereço:Department of Oncology, Centre Vétérinaire Rive-Sud, Brossard, Québec J4Y 1A2, Canada.
[Ti] Título:Adverse reaction to apomorphine in a Collie homozygous for the ABCB1-1∆ (MDR1) mutation.
[So] Source:J Small Anim Pract;58(2):119, 2017 Feb.
[Is] ISSN:1748-5827
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Membro 1 da Subfamília B de Cassetes de Ligação de ATP/genética
Apomorfina/efeitos adversos
Cães/genética
Eméticos/efeitos adversos
[Mh] Termos MeSH secundário: Acetaminofen/envenenamento
Animais
Feminino
Genes MDR
Mutação
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (ATP-Binding Cassette, Sub-Family B, Member 1); 0 (Emetics); 362O9ITL9D (Acetaminophen); N21FAR7B4S (Apomorphine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1111/jsap.12618



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