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[PMID]:28768854
[Au] Autor:Kawasaki J; Kawamura M; Ohsato Y; Ito J; Nishigaki K
[Ad] Endereço:Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
[Ti] Título:Presence of a Shared 5'-Leader Sequence in Ancestral Human and Mammalian Retroviruses and Its Transduction into Feline Leukemia Virus.
[So] Source:J Virol;91(20), 2017 Oct 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recombination events induce significant genetic changes, and this process can result in virus genetic diversity or in the generation of novel pathogenicity. We discovered a new recombinant feline leukemia virus (FeLV) gene harboring an unrelated insertion, termed the X region, which was derived from endogenous gammaretrovirus 4 (FcERV-gamma4). The identified FcERV-gamma4 proviruses have lost their coding capabilities, but some can express their viral RNA in feline tissues. Although the X-region-carrying recombinant FeLVs appeared to be replication-defective viruses, they were detected in 6.4% of tested FeLV-infected cats. All isolated recombinant FeLV clones commonly incorporated a middle part of the FcERV-gamma4 5'-leader region as an X region. Surprisingly, a sequence corresponding to the portion contained in all X regions is also present in at least 13 endogenous retroviruses (ERVs) observed in the cat, human, primate, and pig genomes. We termed this shared genetic feature the commonly shared (CS) sequence. Despite our phylogenetic analysis indicating that all CS-sequence-carrying ERVs are classified as gammaretroviruses, no obvious closeness was revealed among these ERVs. However, the Shannon entropy in the CS sequence was lower than that in other parts of the provirus genome. Notably, the CS sequence of human endogenous retrovirus T had 73.8% similarity with that of FcERV-gamma4, and specific signals were detected in the human genome by Southern blot analysis using a probe for the FcERV-gamma4 CS sequence. Our results provide an interesting evolutionary history for CS-sequence circulation among several distinct ancestral viruses and a novel recombined virus over a prolonged period. Recombination among ERVs or modern viral genomes causes a rapid evolution of retroviruses, and this phenomenon can result in the serious situation of viral disease reemergence. We identified a novel recombinant FeLV gene that contains an unrelated sequence, termed the X region. This region originated from the 5' leader of FcERV-gamma4, a replication-incompetent feline ERV. Surprisingly, a sequence corresponding to the X region is also present in the 5' portion of other ERVs, including human endogenous retroviruses. Scattered copies of the ERVs carrying the unique genetic feature, here named the commonly shared (CS) sequence, were found in each host genome, suggesting that ancestral viruses may have captured and maintained the CS sequence. More recently, a novel recombinant FeLV hijacked the CS sequence from inactivated FcERV-gamma4 as the X region. Therefore, tracing the CS sequences can provide unique models for not only the modern reservoir of new recombinant viruses but also the genetic features shared among ancient retroviruses.
[Mh] Termos MeSH primário: Regiões 5´ não Traduzidas/genética
Retrovirus Endógenos/genética
Genes gag
Genoma Viral
Vírus da Leucemia Felina/genética
Recombinação Genética
[Mh] Termos MeSH secundário: Animais
Gatos/virologia
Evolução Molecular
Gammaretrovirus/genética
Seres Humanos/virologia
Leucemia Felina/virologia
Mamíferos/genética
Mamíferos/virologia
Filogenia
Provírus/genética
Provírus/fisiologia
RNA Viral/genética
Suínos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5' Untranslated Regions); 0 (RNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE


  2 / 1263 MEDLINE  
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[PMID]:27999036
[Au] Autor:Kletenkov K; Hoffmann D; Böni J; Yerly S; Aubert V; Schöni-Affolter F; Struck D; Verheyen J; Klimkait T; Swiss HIV Cohort Study
[Ad] Endereço:Molecular Virology, Department of Biomedicine - Petersplatz, University of Basel, Basel, Switzerland.
[Ti] Título:Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors?
[So] Source:J Antimicrob Chemother;72(3):866-875, 2017 Mar 01.
[Is] ISSN:1460-2091
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background: HIV Gag mutations have been reported to confer PI drug resistance. However, clinical implications are still controversial and most current genotyping algorithms consider solely the protease gene for assessing PI resistance. Objectives: Our goal was to describe for HIV infections in Switzerland the potential role of the C-terminus of Gag (NC-p6) in PI resistance. We aimed to characterize resistance-relevant mutational patterns in Gag and protease and their possible interactions. Methods: Resistance information on plasma samples from 2004-12 was collected for patients treated by two diagnostic centres of the Swiss HIV Cohort Study. Sequence information on protease and the C-terminal Gag region was paired with the corresponding patient treatment history. The prevalence of Gag and protease mutations was analysed for PI treatment-experienced patients versus PI treatment-naive patients. In addition, we modelled multiple paths of an assumed ordered accumulation of genetic changes using random tree mixture models. Results: More than half of all PI treatment-experienced patients in our sample set carried HIV variants with at least one of the known Gag mutations, and 17.9% (66/369) carried at least one Gag mutation for which a phenotypic proof of PI resistance by in vitro mutagenesis has been reported. We were able to identify several novel Gag mutations that are associated with PI exposure and therapy failure. Conclusions: Our analysis confirmed the association of Gag mutations, well known and new, with PI exposure. This could have clinical implications, since the level of potential PI drug resistance might be underestimated.
[Mh] Termos MeSH primário: Farmacorresistência Viral/genética
Infecções por HIV/tratamento farmacológico
Inibidores da Protease de HIV/farmacologia
Protease de HIV/genética
HIV-1/genética
Mutação de Sentido Incorreto
Produtos do Gene gag do Vírus da Imunodeficiência Humana/genética
[Mh] Termos MeSH secundário: Estudos de Coortes
Genes gag
Genótipo
Infecções por HIV/sangue
Infecções por HIV/virologia
Inibidores da Protease de HIV/uso terapêutico
HIV-1/efeitos dos fármacos
Seres Humanos
Prevalência
RNA Viral/sangue
Análise de Sequência de DNA
Suíça
Falha de Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HIV Protease Inhibitors); 0 (RNA, Viral); 0 (gag Gene Products, Human Immunodeficiency Virus); EC 3.4.23.- (HIV Protease)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1093/jac/dkw493


  3 / 1263 MEDLINE  
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[PMID]:27095024
[Au] Autor:Kalloush RM; Vivet-Boudou V; Ali LM; Mustafa F; Marquet R; Rizvi TA
[Ad] Endereço:Department of Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
[Ti] Título:Packaging of Mason-Pfizer monkey virus (MPMV) genomic RNA depends upon conserved long-range interactions (LRIs) between U5 and gag sequences.
[So] Source:RNA;22(6):905-19, 2016 Jun.
[Is] ISSN:1469-9001
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:MPMV has great potential for development as a vector for gene therapy. In this respect, precisely defining the sequences and structural motifs that are important for dimerization and packaging of its genomic RNA (gRNA) are of utmost importance. A distinguishing feature of the MPMV gRNA packaging signal is two phylogenetically conserved long-range interactions (LRIs) between U5 and gag complementary sequences, LRI-I and LRI-II. To test their biological significance in the MPMV life cycle, we introduced mutations into these structural motifs and tested their effects on MPMV gRNA packaging and propagation. Furthermore, we probed the structure of key mutants using SHAPE (selective 2'hydroxyl acylation analyzed by primer extension). Disrupting base-pairing of the LRIs affected gRNA packaging and propagation, demonstrating their significance to the MPMV life cycle. A double mutant restoring a heterologous LRI-I was fully functional, whereas a similar LRI-II mutant failed to restore gRNA packaging and propagation. These results demonstrate that while LRI-I acts at the structural level, maintaining base-pairing is not sufficient for LRI-II function. In addition, in vitro RNA dimerization assays indicated that the loss of RNA packaging in LRI mutants could not be attributed to the defects in dimerization. Our findings suggest that U5-gag LRIs play an important architectural role in maintaining the structure of the 5' region of the MPMV gRNA, expanding the crucial role of LRIs to the nonlentiviral group of retroviruses.
[Mh] Termos MeSH primário: Genes gag
Vírus dos Macacos de Mason-Pfizer/genética
RNA Viral/genética
Montagem de Vírus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160421
[St] Status:MEDLINE
[do] DOI:10.1261/rna.055731.115


  4 / 1263 MEDLINE  
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[PMID]:26909909
[Au] Autor:Liu YP
[Ad] Endereço:Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
[Ti] Título:Reply to commentary by D. Elleder and J. Hejnar on the article "Avian sarcoma and leukosis virus gag gene in the Anser anser domesticus genome" published in Genetics and Molecular Research 14 (4): 14379-14386 to the letter published in Genet. Mol. Res. 15 (1): gmr.15014956.
[So] Source:Genet Mol Res;15(1), 2016 Jan 22.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Mh] Termos MeSH primário: Sarcoma Aviário
Viverridae
[Mh] Termos MeSH secundário: Animais
Galinhas
Genes gag
Seres Humanos
Doenças das Aves Domésticas
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160225
[Lr] Data última revisão:
160225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.150149561


  5 / 1263 MEDLINE  
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[PMID]:26909908
[Au] Autor:Elleder D; Hejnar J
[Ad] Endereço:Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
[Ti] Título:Avian sarcoma and leukosis virus gag gene--Genet. Mol. Res. 14 (4): 14379-14386 "Avian sarcoma and leukosis virus gag gene in the Anser anser domesticus genome".
[So] Source:Genet Mol Res;15(1), 2016 Jan 22.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Mh] Termos MeSH primário: Sarcoma Aviário
Viverridae
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Galinhas
Genes gag
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160225
[Lr] Data última revisão:
160225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15014956


  6 / 1263 MEDLINE  
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[PMID]:26773045
[Au] Autor:Dolcetti R; Gloghini A; Caruso A; Carbone A
[Ad] Endereço:Cancer Bio-Immunotherapy Unit, Centro di Riferimento Oncologico-Istituto di ricovero e cura a carattere scientifico, National Cancer Institute, Aviano, Italy; University of Queensland Diamantina Institute, Translational Research Institute, University of Queensland, Brisbane, QLD, Australia;
[Ti] Título:A lymphomagenic role for HIV beyond immune suppression?
[So] Source:Blood;127(11):1403-9, 2016 Mar 17.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the immune reconstitution promoted by combined antiretroviral therapy (cART), lymphomas still represent the most common type of cancer in HIV-infected individuals. Cofactors related to immunodeficiency such as oncogenic viruses, chronic antigenic stimulation, and cytokine overproduction are thought to be the main drivers of HIV lymphomagenesis, although the current scenario does not convincingly explain the still-high incidence of lymphomas and the occurrence of peculiar lymphoma histotypes in HIV-infected patients under cART. Recent findings are challenging the current view of a mainly indirect role of HIV in lymphoma development and support the possibility that HIV may directly contribute to lymphomagenesis. In fact, mechanisms other than immune suppression involve biologic effects mediated by HIV products that are secreted and accumulate in lymphoid tissues, mainly within lymph node germinal centers. Notably, HIV-infected patients with lymphomas, but not those not affected by these tumors, were recently shown to carry HIV p17 protein variants with enhanced B-cell clonogenic activity. HIV p17 protein variants were characterized by the presence of distinct insertions at the C-terminal region of the protein responsible for a structural destabilization and the acquisition of novel biologic properties. These data are changing the current paradigm assuming that HIV is only indirectly related to lymphomagenesis. Furthermore, these recent findings are consistent with a role of HIV as a critical microenvironmental factor promoting lymphoma development and pave the way for further studies that may lead to the design of more effective strategies for an early identification and improved control of lymphomas in the HIV setting.
[Mh] Termos MeSH primário: HIV/patogenicidade
Linfoma Relacionado a AIDS/etiologia
[Mh] Termos MeSH secundário: Animais
Linfócitos B/patologia
Linfócitos B/virologia
Transformação Celular Viral
Células Clonais
Perfilação da Expressão Gênica
Regulação Neoplásica da Expressão Gênica
Genes gag
Centro Germinativo/virologia
HIV/genética
Antígenos HIV/genética
Antígenos HIV/fisiologia
Seres Humanos
Hospedeiro Imunocomprometido
Ativação Linfocitária
Linfoma Relacionado a AIDS/classificação
Linfoma Relacionado a AIDS/patologia
Linfoma Relacionado a AIDS/virologia
Linfoma de Células B/etiologia
Linfoma de Células B/virologia
Camundongos
Camundongos Transgênicos
Microambiente Tumoral
Produtos do Gene gag do Vírus da Imunodeficiência Humana/genética
Produtos do Gene gag do Vírus da Imunodeficiência Humana/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (HIV Antigens); 0 (gag Gene Products, Human Immunodeficiency Virus); 0 (p17 protein, Human Immunodeficiency Virus Type 1); 0 (p17 protein, Human Immunodeficiency Virus Type 2)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160117
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2015-11-681411


  7 / 1263 MEDLINE  
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[PMID]:26415701
[Au] Autor:Gui T; Lu X; Li H; Li T; Liu Y; Bao Z; Li L; Li J
[Ti] Título:HIV-1 is spreading out of former high-risk population through heterosexual transmission in Hebei, China.
[So] Source:Curr HIV Res;14(2):148-53, 2016.
[Is] ISSN:1873-4251
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Multiple specific populations, including MSMs, IDUs, and FPDs, are involved in HIV epidemic in China. In the recent years, HIV transmission due to heterosexual transmission also contributed greatly to HIV epidemic in China. Very few studies have been fulfilled to characterize relationships of HIV-1 strains prevalent in different populations. In this study, the phylogenetic relationships of HIV-1 spreading in different populations were investigated. MATERIALS AND METHODS: HIV-1 sero-positive patients infected through different routes were enrolled into the study. Nested RT-PCR was used to amplify HIV gag and pol genes followed by sequencing. RESULTS: Multiple subtypes, including subtype B (52.1%), CRF01_AE (34.4%), CRF07_BC (6.3%), subtype C (4.2%), CRF02_AG (1.0%), CRF08_BC (1.0%) and unique recombination forms (1.0%) were identified. Phylogenetic analysis showed that strains from MSM, IDU, and FPDs grouped into clusters separately. However, strains identified in heterosexual transmitted population intermixed with all of other high risk populations. DISCUSSION AND CONCLUSION: The genetic data supposed that HIV-1 was spreading out of MSMs, IDUs, and FPDs through heterosexual transmission in Hebei, China. Urgent prevention and behavior intervention in the population will be necessary. Furthermore, the detailed sequence data will help the design of HIV-1 vaccines in China. Sequence Data: All of sequences have been deposited into the GenBank with the accession number: KJ820007-KJ820144.
[Mh] Termos MeSH primário: Infecções por HIV/epidemiologia
Infecções por HIV/transmissão
HIV-1
Heterossexualidade
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
China/epidemiologia
Feminino
Genes gag/genética
Genes pol/genética
Genótipo
HIV-1/classificação
HIV-1/genética
HIV-1/isolamento & purificação
Seres Humanos
Masculino
Meia-Idade
Epidemiologia Molecular
Filogenia
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150930
[St] Status:MEDLINE


  8 / 1263 MEDLINE  
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[PMID]:26024387
[Au] Autor:Zhao M; Li M; Zhang Z; Gong T; Sun X
[Ad] Endereço:a Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education , West China School of Pharmacy, Sichuan University , Chengdu , People's Republic of China.
[Ti] Título:Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA.
[So] Source:Drug Deliv;23(7):2596-2607, 2016 Sep.
[Is] ISSN:1521-0464
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In recent years, mRNA-based vaccines have emerged to be a great alternative to DNA-based vaccines due to the safety of not inserting into host genome. However, mRNA molecules are single-stranded nucleic acids that are vulnerable under RNase existing in human skin and tissues. In this study, a self-assembled cationic nanomicelles based on polyethyleneimine-stearic acid (PSA) copolymer were developed to delivery HIV-1 gag encoding mRNA to dendritic cells and BALB/c mice. We evaluated the transfection efficiency and cell uptake efficiency of naked EGFP mRNA, PSA, PEI-2k and PEI-25k nanoparticles format on DC2.4 cell lines. Immune responses after sub-cutaneous administration of gag mRNA to BALB/c mice were notably induced by PSA as compared with naked gag mRNA. We found the PSA/mRNA nanomicelles were potent systems that can effectively deliver mRNA and induce antigen-specific immune response, stimulating various new vaccine strategies using mRNA.
[Mh] Termos MeSH primário: Cátions/química
Células Dendríticas/química
Genes gag/efeitos dos fármacos
HIV-1/efeitos dos fármacos
RNA Mensageiro/imunologia
Ribonucleases/imunologia
Vacinas/imunologia
[Mh] Termos MeSH secundário: Animais
Genes gag/genética
Genes gag/imunologia
HIV-1/química
HIV-1/imunologia
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Micelas
RNA Mensageiro/química
RNA Mensageiro/genética
Ribonucleases/química
Ribonucleases/metabolismo
Ácidos Esteáricos/química
Transfecção
Vacinas/química
Vacinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations); 0 (Micelles); 0 (RNA, Messenger); 0 (Stearic Acids); 0 (Vaccines); 0 (polyethyleneimine-stearic acid); EC 3.1.- (Ribonucleases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150530
[St] Status:MEDLINE


  9 / 1263 MEDLINE  
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[PMID]:26610209
[Au] Autor:Moura GE; Lucena SV; Lima MA; Nascimento FD; Gesteira TF; Nader HB; Paredes-Gamero EJ; Tersariol IL
[Ad] Endereço:Departamento de Bioquímica, Universidade Federal de São Paulo, São Paulo, Brazil.
[Ti] Título:P2X7 receptor activity regulation: the role of CD44 proteoglycan GAG chains.
[So] Source:Cell Death Dis;6:e1997, 2015 Nov 26.
[Is] ISSN:2041-4889
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Genes gag
Receptores de Hialuronatos/genética
Proteoglicanas/metabolismo
Receptores Purinérgicos P2X7/genética
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Hyaluronan Receptors); 0 (Proteoglycans); 0 (Receptors, Purinergic P2X7)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151127
[St] Status:MEDLINE
[do] DOI:10.1038/cddis.2015.340


  10 / 1263 MEDLINE  
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[PMID]:26123125
[Au] Autor:Wu J; Shen Y; Zhong P; Feng Y; Xing H; Jin L; Qin Y; Liu A; Miao L; Cui L; Su B; Guo H
[Ad] Endereço:1 Anhui Provincial Center for Disease Control and Prevention , Hefei City, Anhui Province, China .
[Ti] Título:The predominant cluster of CRF01_AE circulating among newly diagnosed HIV-1-positive people in Anhui Province, China.
[So] Source:AIDS Res Hum Retroviruses;31(9):926-31, 2015 Sep.
[Is] ISSN:1931-8405
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CRF01_AE, which has led a new epidemic in many provinces in China and has displayed complex characteristics, has now evolved into multiple clusters in China. Some clusters often circulate in specific regions or among specific risk populations in China. To better determine the characteristics of CRF01_AE circulating in Anhui Province, we analyzed CRF01_AE based on gag and pol sequences. Our results showed that CRF01_AE circulating in Anhui Province was clearly divided into three clusters. Cluster 1 covered 90% of the sequences in all CRF01_AE. Among Cluster 1, the sequences from men who have sex with men (MSM) and heterosexuals were interwoven. It is suggested that MSM may play a bridge role in transmitting HIV-1 among the different risk groups.
[Mh] Termos MeSH primário: Genes gag
Genes pol
Infecções por HIV/virologia
HIV-1/genética
[Mh] Termos MeSH secundário: Adulto
China/epidemiologia
Feminino
Infecções por HIV/sangue
Infecções por HIV/diagnóstico
Infecções por HIV/transmissão
Heterossexualidade
Homossexualidade Masculina
Seres Humanos
Masculino
Meia-Idade
Epidemiologia Molecular
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150825
[Lr] Data última revisão:
150825
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:150701
[St] Status:MEDLINE
[do] DOI:10.1089/AID.2015.0107



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