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  1 / 170 MEDLINE  
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[PMID]:28081716
[Au] Autor:Sinha P; Singh K; Sachan M
[Ad] Endereço:Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, 211004, India.
[Ti] Título:Heterogeneous pattern of DNA methylation in developmentally important genes correlates with its chromatin conformation.
[So] Source:BMC Mol Biol;18(1):1, 2017 Jan 11.
[Is] ISSN:1471-2199
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: DNA methylation is a major epigenetic modification, playing a crucial role in the development and differentiation of higher organisms. DNA methylation is also known to regulate transcription by gene repression. Various developmental genes such as c-mos, HoxB5, Sox11, and Sry show tissue-specific gene expression that was shown to be regulated by promoter DNA methylation. The aim of the present study is to investigate the establishment of chromatin marks (active or repressive) in relation to heterogeneous methylation in the promoter regions of these developmentally important genes. RESULTS: Chromatin-immunoprecipitation (ChIP) assays were performed to immuno-precipitate chromatin by antibodies against both active (H3K4me3) and repressive (H3K9me3) chromatin regions. The analysis of ChIP results showed that both the percentage input and fold enrichment of activated chromatin was higher in tissues expressing the respective genes as compared to the tissues not expressing the same set of genes. This was true for all the genes selected for the study (c-mos, HoxB5, Sox11, and Sry). These findings illustrate that inconsistent DNA methylation patterns (sporadic, mosaic and heterogeneous) may also influence gene regulation, thereby resulting in the modulation of chromatin conformation. CONCLUSIONS: These findings illustrate that various patterns of DNA methylation (asynchronous, mosaic and heterogeneous) correlates with chromatin modification, resulting in the gene regulation.
[Mh] Termos MeSH primário: Cromatina/genética
Metilação de DNA
Epigênese Genética
Regulação da Expressão Gênica no Desenvolvimento
[Mh] Termos MeSH secundário: Animais
Cromatina/química
Montagem e Desmontagem da Cromatina
Imunoprecipitação da Cromatina
Genes mos
Proteínas de Homeodomínio/genética
Camundongos
Fatores de Transcrição SOXC/genética
Proteína da Região Y Determinante do Sexo/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromatin); 0 (Homeodomain Proteins); 0 (Hoxb5 protein, mouse); 0 (SOXC Transcription Factors); 0 (Sex-Determining Region Y Protein); 0 (Sox11 protein, mouse); 0 (Sry protein, mouse)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1186/s12867-016-0078-4


  2 / 170 MEDLINE  
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[PMID]:26087797
[Au] Autor:Yoon H; Kim N; Shin CM; Lee HS; Kim BK; Kang GH; Kim JM; Kim JS; Lee DH; Jung HC
[Ad] Endereço:Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
[Ti] Título:Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm.
[So] Source:Gut Liver;10(2):228-36, 2016 Mar.
[Is] ISSN:2005-1212
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: To identify the risk factors for metachronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm. METHODS: We prospectively collected clinicopathologic data and measured the methylation levels of HAND1, THBD, APC, and MOS in the gastric mucosa by methylation-specific real-time polymerase chain reaction in patients who underwent endoscopic resection of gastric neoplasms. RESULTS: A total of 257 patients with gastric neoplasms (113 low-grade dysplasias, 25 highgrade dysplasias, and 119 early gastric cancers) were enrolled. Metachronous gastric neoplasm developed in 7.4% of patients during a mean follow-up of 52 months. The 5-year cumulative incidence of metachronous gastric neoplasm was 4.8%. Multivariate analysis showed that moderate/severe corpus intestinal metaplasia and family history of gastric cancer were independent risk factors for metachronous gastric neoplasm development; the hazard ratios were 4.12 (95% confidence interval [CI], 1.23 to 13.87; p=0.022) and 3.52 (95% CI, 1.09 to 11.40; p=0.036), respectively. The methylation level of MOS was significantly elevated in patients with metachronous gastric neoplasms compared age- and sex-matched patients without metachronous gastric neoplasms (p=0.020). CONCLUSIONS: In patients who underwent endoscopic resection of gastric neoplasms, moderate/severe corpus intestinal metaplasia and a family history of gastric cancer were independent risk factors for metachronous gastric neoplasm, and MOS was significantly hypermethylated in patients with metachronous gastric neoplasms.
[Mh] Termos MeSH primário: Segunda Neoplasia Primária/genética
Neoplasias Gástricas/patologia
[Mh] Termos MeSH secundário: Idoso
Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética
Metilação de DNA
Feminino
Gastrectomia/métodos
Genes APC/fisiologia
Genes mos/genética
Seres Humanos
Incidência
Masculino
Meia-Idade
Análise Multivariada
Segunda Neoplasia Primária/epidemiologia
Segunda Neoplasia Primária/patologia
Modelos de Riscos Proporcionais
Fatores de Risco
Neoplasias Gástricas/genética
Neoplasias Gástricas/cirurgia
Trombomodulina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Transcription Factors); 0 (THBD protein, human); 0 (Thrombomodulin); 0 (helix-loop-helix protein, eHAND)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150620
[St] Status:MEDLINE
[do] DOI:10.5009/gnl14472


  3 / 170 MEDLINE  
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[PMID]:23579190
[Au] Autor:Kleene KC
[Ad] Endereço:Department of Biology, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, Massachusetts 02125-3393, USA. kenneth.kleene@umb.edu
[Ti] Título:Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.
[So] Source:Reproduction;146(1):R1-19, 2013 Jul.
[Is] ISSN:1741-7899
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:mRNA-specific regulation of translational activity plays major roles in directing the development of meiotic and haploid spermatogenic cells in mammals. Although many RNA-binding proteins (RBPs) have been implicated in normal translational control and sperm development, little is known about the keystone of the mechanisms: the interactions of RBPs and microRNAs with cis-elements in mRNA targets. The problems in connecting factors and elements with translational control originate in the enormous complexity of post-transcriptional regulation in mammalian cells. This creates confusion as to whether factors have direct or indirect and large or small effects on the translation of specific mRNAs. This review argues that gene knockouts, heterologous systems, and overexpression of factors cannot provide convincing answers to these questions. As a result, the mechanisms involving well-studied mRNAs (Ddx4/Mvh, Prm1, Prm2, and Sycp3) and factors (DICER1, CPEB1, DAZL, DDX4/MVH, DDX25/GRTH, translin, and ELAV1/HuR) are incompletely understood. By comparison, mutations in elements can be used to define the importance of specific pathways in regulating individual mRNAs. However, few elements have been studied, because the only reliable system to analyze mutations in elements, transgenic mice, is considered impractical. This review describes advances that may facilitate identification of the direct targets of RBPs and analysis of mutations in cis-elements. The importance of upstream reading frames in the developmental regulation of mRNA translation in spermatogenic cells is also documented.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica no Desenvolvimento
Espermatogênese
Espermatozoides/metabolismo
[Mh] Termos MeSH secundário: Regiões 3' não Traduzidas
Regiões 5' não Traduzidas
Animais
Proteínas de Ligação a DNA/metabolismo
Técnicas de Inativação de Genes
Genes mos
Haploidia
Seres Humanos
Masculino
Meiose
MicroRNAs/metabolismo
Proteínas Mitocondriais/genética
Proteínas Mitocondriais/metabolismo
Mutação
Fases de Leitura Aberta
Protaminas/genética
Protaminas/metabolismo
RNA Interferente Pequeno/metabolismo
Proteínas de Ligação a RNA/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (3' Untranslated Regions); 0 (5' Untranslated Regions); 0 (DNA-Binding Proteins); 0 (MicroRNAs); 0 (Mitochondrial Proteins); 0 (Protamines); 0 (RNA, Small Interfering); 0 (RNA-Binding Proteins)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:130617
[Lr] Data última revisão:
130617
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130413
[St] Status:MEDLINE
[do] DOI:10.1530/REP-12-0362


  4 / 170 MEDLINE  
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[PMID]:22430561
[Au] Autor:Guo P; Liu Q; Xu Y; Jiang K; Hou M; Ding L; Pyron RA; Burbrink FT
[Ad] Endereço:College of Life Sciences and Food Engineering, Yibin University, Yibin 644007, China.
[Ti] Título:Out of Asia: natricine snakes support the Cenozoic Beringian Dispersal Hypothesis.
[So] Source:Mol Phylogenet Evol;63(3):825-33, 2012 Jun.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Based on a combination of six mitochondrial gene fragments (12S RNA, cyt b, ND1, ND2, ND4 and CO1) and one nuclear gene (c-mos) from 22 genera we infer phylogenetic relationships among natricine snakes and examine the date and area of origin of these snakes. Our phylogenetic results indicate: (1) the subfamily Natricinae is strongly supported as monophyletic including a majority of extant genera, and a poorly known and previously unassigned species Trachischium monticola, (2) two main clades are inferred within Natricinae, one containing solely taxa from the Old World (OW) and the other comprising taxa from a monophyletic New World (NW) group with a small number of OW relatives. Within the first clade, the genera Xenochrophis and Amphiesma are apparently not monophyletic. Divergence dating and ancestral area estimation indicate that the natricines originated in tropical Asia during the later Eocene or the Oligocene. We recover two major dispersals events out of Asia, the first to Africa in the Oligocene (28 Ma) and the second to the Western Palearctic and the New World at 27 Ma. This date is consistent with the dispersal of numerous other OW groups into the NW.
[Mh] Termos MeSH primário: Colubridae/genética
Modelos Genéticos
[Mh] Termos MeSH secundário: Animais
Ásia
Teorema de Bayes
Genes Mitocondriais
Genes mos
Especiação Genética
Funções Verossimilhança
Dados de Sequência Molecular
Tipagem de Sequências Multilocus
Filogenia
Filogeografia
Proteínas de Répteis/genética
Alinhamento de Sequência
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Reptilian Proteins)
[Em] Mês de entrada:1208
[Cu] Atualização por classe:120423
[Lr] Data última revisão:
120423
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120321
[St] Status:MEDLINE
[do] DOI:10.1016/j.ympev.2012.02.021


  5 / 170 MEDLINE  
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[PMID]:22406530
[Au] Autor:Datta-Roy A; Singh M; Srinivasulu C; Karanth KP
[Ad] Endereço:Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560 012, India.
[Ti] Título:Phylogeny of the Asian Eutropis (Squamata: Scincidae) reveals an 'into India' endemic Indian radiation.
[So] Source:Mol Phylogenet Evol;63(3):817-24, 2012 Jun.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent generic rearrangement of the circumtropical distributed skink genus 'Mabuya' has raised a lot of debate. According to this molecular phylogeny based rearrangement, the tropical Asian members of this genus have been assigned to Eutropis. However, in these studies the Asian members of 'Mabuya' were largely sampled from Southeast (SE) Asia with very few species from Indian subcontinent. To test the validity of this assignment and to determine the evolutionary origin of Indian members of this group we sequenced one nuclear and two mitochondrial genes from most of the species from the Indian subregion. The nuclear and mitochondrial trees generated from these sequences confirmed the monophyly of the tropical Asian Eutropis. Furthermore, in the tree based on the combined mitochondrial and nuclear dataset an endemic Indian radiation was revealed that was nested within a larger Asian clade. Results of dispersal-vicariance analysis and molecular dating suggested an initial dispersal of Eutropis from SE Asia into India around 5.5-17 million years ago, giving rise to the extant members of the endemic Indian radiation. This initial dispersal was followed by two back dispersals from India into SE Asia. We also discuss the relationships within the endemic Indian radiation and its taxonomic implications.
[Mh] Termos MeSH primário: Lagartos/genética
Filogenia
[Mh] Termos MeSH secundário: Animais
Teorema de Bayes
Genes Mitocondriais
Genes mos
Índia
Funções Verossimilhança
Lagartos/classificação
Modelos Genéticos
Tipagem de Sequências Multilocus
Filogeografia
RNA Ribossômico/genética
RNA Ribossômico 16S/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Ribosomal); 0 (RNA, Ribosomal, 16S); 0 (RNA, ribosomal, 12S)
[Em] Mês de entrada:1208
[Cu] Atualização por classe:120423
[Lr] Data última revisão:
120423
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120313
[St] Status:MEDLINE
[do] DOI:10.1016/j.ympev.2012.02.022


  6 / 170 MEDLINE  
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[PMID]:22252584
[Au] Autor:Shin CM; Kim N; Park JH; Kang GH; Kim JS; Jung HC; Song IS
[Ad] Endereço:Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, Korea.
[Ti] Título:Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae.
[So] Source:J Pathol;226(4):654-65, 2012 Mar.
[Is] ISSN:1096-9896
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aberrant DNA methylation is frequently found during gastric carcinogenesis. Recently, we identified potential methylation markers important for Helicobacter pylori-induced gastric carcinogenesis using an Illumina methylation chip assay. In this study, we evaluated the candidate genes as markers for gastric cancer (GC) in a large Korean population. DNA methylation of PTPN6, MOS, DCC, CRK, and VAV1 was evaluated in non-neoplastic gastric specimens using quantitative methylation-specific PCR in patients with GC (n = 207) and their age- and gender-matched controls (n = 207). Methylation levels in 125 GC samples were also compared. H. pylori infection status was categorized as negative, active, or past infection according to the results of endoscopy-based tests (CLOtest, histology, and culture), H. pylori serology, and serum pepsinogen test. In the controls, active H. pylori infection increased methylation levels in DCC, CRK, MOS, and VAV1 but decreased methylation levels in PTPN6 (all p < 0.05); the methylation levels in MOS remained increased in patients with past H. pylori infection compared to H. pylori-negative subjects (p < 0.001). Methylation levels in MOS in non-neoplastic gastric mucosae increased in the presence of GC, regardless of H. pylori infection status (p < 0.01). Methylation levels in all genes but DCC decreased significantly in GC specimens compared to neoplastic gastric mucosae (p < 0.01); however, methylation levels in GC tissues were not correlated with those in their background gastric mucosae. Hypomethylation of MOS in GC tissues was associated with tumour invasion, nodal metastasis, and undifferentiated histology (p < 0.05). To summarize, among the candidate genes, DNA methylation of MOS may reflect the duration of H. pylori exposure and may be a marker for the development of GC.
[Mh] Termos MeSH primário: Metilação de DNA
Mucosa Gástrica/patologia
Gastrite/patologia
Predisposição Genética para Doença
Lesões Pré-Cancerosas/patologia
Neoplasias Gástricas/patologia
[Mh] Termos MeSH secundário: Feminino
Mucosa Gástrica/microbiologia
Gastrite/genética
Gastrite/microbiologia
Genes mos/genética
Infecções por Helicobacter/genética
Infecções por Helicobacter/microbiologia
Infecções por Helicobacter/patologia
Helicobacter pylori
Seres Humanos
Masculino
Meia-Idade
Lesões Pré-Cancerosas/genética
Lesões Pré-Cancerosas/microbiologia
Valor Preditivo dos Testes
Risco
Neoplasias Gástricas/genética
Neoplasias Gástricas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1203
[Cu] Atualização por classe:120203
[Lr] Data última revisão:
120203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120119
[St] Status:MEDLINE
[do] DOI:10.1002/path.2990


  7 / 170 MEDLINE  
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[PMID]:21908396
[Au] Autor:Nejepinska J; Malik R; Filkowski J; Flemr M; Filipowicz W; Svoboda P
[Ad] Endereço:Institute of Molecular Genetics AS CR, Videnska 1083, 14220 Prague 4, Czech Republic.
[Ti] Título:dsRNA expression in the mouse elicits RNAi in oocytes and low adenosine deamination in somatic cells.
[So] Source:Nucleic Acids Res;40(1):399-413, 2012 Jan.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Double-stranded RNA (dsRNA) can enter different pathways in mammalian cells, including sequence-specific RNA interference (RNAi), sequence-independent interferon (IFN) response and editing by adenosine deaminases. To study the routing of dsRNA to these pathways in vivo, we used transgenic mice ubiquitously expressing from a strong promoter, an mRNA with a long hairpin in its 3'-UTR. The expressed dsRNA neither caused any developmental defects nor activated the IFN response, which was inducible only at high expression levels in cultured cells. The dsRNA was poorly processed into siRNAs in somatic cells, whereas, robust RNAi effects were found in oocytes, suggesting that somatic cells lack some factor(s) facilitating siRNA biogenesis. Expressed dsRNA did not cause transcriptional silencing in trans. Analysis of RNA editing revealed that a small fraction of long dsRNA is edited. RNA editing neither prevented the cytoplasmic localization nor processing into siRNAs. Thus, a long dsRNA structure is well tolerated in mammalian cells and is mainly causing a robust RNAi response in oocytes.
[Mh] Termos MeSH primário: Adenosina/metabolismo
Oócitos/metabolismo
Interferência de RNA
RNA de Cadeia Dupla/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Células Cultivadas
Desaminação
Feminino
Inativação Gênica
Genes mos
Seres Humanos
Interferons/metabolismo
Camundongos
Camundongos Transgênicos
Edição de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Double-Stranded); 9008-11-1 (Interferons); K72T3FS567 (Adenosine)
[Em] Mês de entrada:1202
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110913
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkr702


  8 / 170 MEDLINE  
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[PMID]:21771716
[Au] Autor:Gilbert C; Hernandez SS; Flores-Benabib J; Smith EN; Feschotte C
[Ad] Endereço:Department of Biology, University of Texas, TX, USA. clement.gilbert30@gmail.com
[Ti] Título:Rampant horizontal transfer of SPIN transposons in squamate reptiles.
[So] Source:Mol Biol Evol;29(2):503-15, 2012 Feb.
[Is] ISSN:1537-1719
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transposable elements (TEs) are highly abundant in the genome and capable of mobility, two properties that make them particularly prone to transfer horizontally between organisms. Although the impact of horizontal transfer (HT) of TEs is well recognized in prokaryotes, the frequency of this phenomenon and its contribution to genome evolution in eukaryotes remain poorly appreciated. Here, we provide evidence that a DNA transposon called SPIN has colonized the genome of 17 species of reptiles representing nearly every major lineage of squamates, including 14 families of lizards, snakes, and amphisbaenians. Slot blot analyses indicate that SPIN has amplified to high copy numbers in most of these species, ranging from 2,000-28,000 copies per haploid genome. In contrast, we could not detect the presence of SPIN in any of the turtles (seven species from seven families) and crocodiles (four species) examined. Genetic distances between SPIN sequences from species belonging to different squamate families are consistently very low (average = 0.1), considering the deep evolutionary divergence of the families investigated (most are >100 My diverged). Furthermore, these distances fall below interfamilial distances calculated for two genes known to have evolved under strong functional constraint in vertebrates (RAG1, average = 0.24 and C-mos, average = 0.27). These data, combined with phylogenetic analyses, indicate that the widespread distribution of SPIN among squamates is the result of at least 13 independent events of HTs. Molecular dating and paleobiogeographical data suggest that these transfers took place during the last 50 My on at least three different continents (North America, South America and, Africa). Together, these results triple the number of known SPIN transfer events among tetrapods, provide evidence for a previously hypothesized transoceanic movement of SPIN transposons during the Cenozoic, and further underscore the role of HT in the evolution of vertebrate genomes.
[Mh] Termos MeSH primário: Elementos de DNA Transponíveis/genética
Evolução Molecular
Transferência Genética Horizontal
Répteis/genética
[Mh] Termos MeSH secundário: Animais
Genes RAG-1/genética
Genes mos/genética
Dados de Sequência Molecular
Filogenia
Répteis/classificação
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (DNA Transposable Elements)
[Em] Mês de entrada:1206
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110721
[St] Status:MEDLINE
[do] DOI:10.1093/molbev/msr181


  9 / 170 MEDLINE  
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[PMID]:20676137
[Au] Autor:Erenpreisa J; Cragg MS
[Ad] Endereço:Latvian Biomedicine Research and Study Centre, Riga, Latvia.
[Ti] Título:MOS, aneuploidy and the ploidy cycle of cancer cells.
[So] Source:Oncogene;29(40):5447-51, 2010 Oct 07.
[Is] ISSN:1476-5594
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:After DNA or spindle damage, p53-defective tumor cells undergo a complex cycle of reversible polyploidy. How this process occurs and more importantly, why, has recently become the focus of several research groups, prompting this review in which we discuss two related phenomena that accompany the reversible polyploidy of tumor cells: the induction of meiosis genes such as MOS and the decrease in genomic instability observed during the reversion from polyploidy to para-diploidy. The reversible polyploidy likely provides the means through which the balance between increased chromosome instability (CIN), driving genetic variation and decreased CIN, necessary for perpetuating these malignant clones, is maintained. These concepts are integrated with recent findings that many meiotic and self-renewal genes become activated during reversible polyploidy and lead us to the hypothesis that tumor cell immortality may be achieved through germline-like transmission.
[Mh] Termos MeSH primário: Aneuploidia
Regulação Neoplásica da Expressão Gênica
Genes mos/genética
Neoplasias/genética
Ploidias
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1011
[Cu] Atualização por classe:101007
[Lr] Data última revisão:
101007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100803
[St] Status:MEDLINE
[do] DOI:10.1038/onc.2010.310


  10 / 170 MEDLINE  
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[PMID]:20186124
[Au] Autor:Vitale I; Senovilla L; Jemaà M; Michaud M; Galluzzi L; Kepp O; Nanty L; Criollo A; Rello-Varona S; Manic G; Métivier D; Vivet S; Tajeddine N; Joza N; Valent A; Castedo M; Kroemer G
[Ad] Endereço:INSERM, Villejuif, France.
[Ti] Título:Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.
[So] Source:EMBO J;29(7):1272-84, 2010 Apr 07.
[Is] ISSN:1460-2075
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tetraploidy can constitute a metastable intermediate between normal diploidy and oncogenic aneuploidy. Here, we show that the absence of p53 is not only permissive for the survival but also for multipolar asymmetric divisions of tetraploid cells, which lead to the generation of aneuploid cells with a near-to-diploid chromosome content. Multipolar mitoses (which reduce the tetraploid genome to a sub-tetraploid state) are more frequent when p53 is downregulated and the product of the Mos oncogene is upregulated. Mos inhibits the coalescence of supernumerary centrosomes that allow for normal bipolar mitoses of tetraploid cells. In the absence of p53, Mos knockdown prevents multipolar mitoses and exerts genome-stabilizing effects. These results elucidate the mechanisms through which asymmetric cell division drives chromosomal instability in tetraploid cells.
[Mh] Termos MeSH primário: Carcinoma/metabolismo
Neoplasias do Colo/metabolismo
Genes mos
Mitose
Poliploidia
Proteína Supressora de Tumor p53/metabolismo
[Mh] Termos MeSH secundário: Aneuploidia
Animais
Carcinoma/genética
Linhagem Celular Tumoral
Centrossomo/metabolismo
Instabilidade Cromossômica
Neoplasias do Colo/genética
Feminino
Deleção de Genes
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Camundongos
Camundongos Nus
Proteína Supressora de Tumor p53/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Tumor Suppressor Protein p53)
[Em] Mês de entrada:1005
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100227
[St] Status:MEDLINE
[do] DOI:10.1038/emboj.2010.11



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