Base de dados : MEDLINE
Pesquisa : G05.360.340.024.340.700 [Categoria DeCS]
Referências encontradas : 3486 [refinar]
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[PMID]:29180807
[Au] Autor:Chiang JJ; Sparrer KMJ; van Gent M; Lässig C; Huang T; Osterrieder N; Hopfner KP; Gack MU
[Ad] Endereço:Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
[Ti] Título:Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.
[So] Source:Nat Immunol;19(1):53-62, 2018 Jan.
[Is] ISSN:1529-2916
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The sensor RIG-I detects double-stranded RNA derived from RNA viruses. Although RIG-I is also known to have a role in the antiviral response to DNA viruses, physiological RNA species recognized by RIG-I during infection with a DNA virus are largely unknown. Using next-generation RNA sequencing (RNAseq), we found that host-derived RNAs, most prominently 5S ribosomal RNA pseudogene 141 (RNA5SP141), bound to RIG-I during infection with herpes simplex virus 1 (HSV-1). Infection with HSV-1 induced relocalization of RNA5SP141 from the nucleus to the cytoplasm, and virus-induced shutoff of host protein synthesis downregulated the abundance of RNA5SP141-interacting proteins, which allowed RNA5SP141 to bind RIG-I and induce the expression of type I interferons. Silencing of RNA5SP141 strongly dampened the antiviral response to HSV-1 and the related virus Epstein-Barr virus (EBV), as well as influenza A virus (IAV). Our findings reveal that antiviral immunity can be triggered by host RNAs that are unshielded following depletion of their respective binding proteins by the virus.
[Mh] Termos MeSH primário: Proteína DEAD-box 58/imunologia
Herpesvirus Humano 1/imunologia
Imunidade/imunologia
RNA Ribossômico 5S/imunologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Cercopithecus aethiops
Proteína DEAD-box 58/metabolismo
Expressão Gênica/imunologia
Células HEK293
Herpesvirus Humano 1/fisiologia
Interações Hospedeiro-Patógeno/imunologia
Seres Humanos
Interferon Tipo I/genética
Interferon Tipo I/imunologia
Interferon Tipo I/metabolismo
Camundongos Knockout
Pseudogenes/genética
Transporte de RNA/imunologia
RNA Ribossômico 5S/genética
RNA Ribossômico 5S/metabolismo
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interferon Type I); 0 (RNA, Ribosomal, 5S); EC 3.6.1.- (DDX58 protein, human); EC 3.6.4.13 (DEAD Box Protein 58)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1038/s41590-017-0005-y


  2 / 3486 MEDLINE  
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[PMID]:29369561
[Au] Autor:Spiridonova LN; Valchuk OP; Red'kin YA; Kryukov AP
[Ti] Título:[Nuclear mtDNA pseudogenes as a source of new variants of the mtDNA cytochrome b haplotypes: A case study of Siberian rubythroat Luscinia calliope (Muscicapidae, Aves)].
[So] Source:Genetika;52(9):1069-80, 2016 Sep.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Sequence polymorphism of the mitochondrial DNA cytochrome b gene fragment was analyzed in 21 specimens of subspecies Luscinia calliope calliope (Pallas, 1776) and two specimens of L. c. anadyrensis (Portenko, 1939). On sequence chromatograms, in 19 specimens of L. c. calliope, double peaks of heteroplasmy type in the taxon-specific positions were revealed. Moreover, two clone variants were identified. The first variant was the calliope mitochondrial cyt b gene and the second was the nuclear cyt b pseudogene, similar to the mitochondrial haplotype anadyrensis-camtschatkensis. In L. c. anadyrensis, four clone variants, represented by the mitochondrial calliope and anadyrensis-camtschatkensis cyt b genes and nuclear calliope and sachalinensis cyt b pseudogenes, were identified. Some nuclear cyt b pseudogenes were highly similar (98­99%) to the mitochondrial genes of the subspecies L. c. anadyrensis, L. c. camtschatkensis, and L. c. sachalinensis. In the same time, the majority of nuclear pseudogene sequences were characterized by a high level of polymorphism, caused by nonsynonymous substitutions (up to five substitutions per sequence), the presence of indels in some of the clones, and TAA and TGA stop codons. In our opinion, the mitochondrial haplotypes anadyrensis-camtschatkensis and sachalinensis occurred as a result of intergenomic homologous recombination. This finding provides a new insight into the colonization history of the northeastern part of the range by L. calliope, according to which populating the territory of Chukotka, Kamchatka, and Sakhalin took place at different times and along the independent pathways.
[Mh] Termos MeSH primário: Proteínas Aviárias/genética
Citocromos b/genética
Genes Mitocondriais
Passeriformes/genética
Pseudogenes
[Mh] Termos MeSH secundário: Animais
Sibéria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Avian Proteins); 9035-37-4 (Cytochromes b)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  3 / 3486 MEDLINE  
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[PMID]:29253608
[Au] Autor:Bardella VB; Cabral-de-Mello DC
[Ad] Endereço:Departamento de Biologia, Instituto de Biociências/IB, UNESP - Universidade Estadual Paulista, Rio Claro, Brazil.
[Ti] Título:Uncovering the molecular organization of unusual highly scattered 5S rDNA: The case of Chariesterus armatus (Heteroptera).
[So] Source:Gene;646:153-158, 2018 Mar 10.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:One cluster of 5S rDNA per haploid genome is the most common pattern among Heteroptera. However, in Chariesterus armatus, highly scattered signals were noticed. We isolated and characterized the entire 5S rDNA unit of C. armatus aiming to a deeper knowledge of molecular organization of the 5S rDNA among Heteroptera and to understand possible causes and consequences of 5S rDNA chromosomal spreading. For a comparative analysis, we performed the same approach in Holymenia histrio with 5S rDNA restricted to one bivalent. Multiple 5S rDNA variants were observed in both species, though they were more variable in C. armatus, with some of variants corresponding to pseudogenes. These pseudogenes suggest birth-and-death mechanism, though homogenization was also observed (concerted evolution), indicating evolution through mixed model. Association between transposable elements and 5S rDNA was not observed, suggesting spreading of 5S rDNA through other mechanisms, like ectopic recombination. Scattered organization is a rare example for 5S rDNA, and such organization in C. armatus genome could have led to the high diversification of sequences favoring their pseudogenization.
[Mh] Termos MeSH primário: DNA Ribossômico/genética
Heterópteros/genética
RNA Ribossômico 5S/genética
[Mh] Termos MeSH secundário: Animais
Cromossomos de Insetos
Evolução Molecular
Heterópteros/classificação
Hibridização in Situ Fluorescente
Masculino
Família Multigênica
Filogenia
Pseudogenes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal); 0 (RNA, Ribosomal, 5S)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:25815560
[Au] Autor:Ahmed NS; Jaffar Ali HA
[Ad] Endereço:a Department of Biotechnology , Islamiah College (Autonomous) , Vaniyambadi , Tamil Nadu , India.
[Ti] Título:Numts: an impediment to DNA barcoding of Polyclinids, Tunicata.
[So] Source:Mitochondrial DNA A DNA Mapp Seq Anal;27(5):3395-8, 2016 Sep.
[Is] ISSN:2470-1408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The mitochondrial cytochrome c oxidase subunit I (COI) gene, a widely accepted molecular marker for species identification and classification, has been questioned because of the presence of Numts. In this study we found the presence of Numts in the COI chromatogram of two tunicates, Polyclinum indicum and Polyclinum madrasensis belonging to the genus Polyclinum. Numts were also present in our sequence (Accession Number: KJ944391) and in other sequences belonging to genus Polyclinum in the GenBank record. The GeneBank database of genus Polyclinum contains COI-like sequences and COI pseudogenes, but no record of COI gene from Polyclinids. The prevalence of Numts in Polyclinids belonging to Tunicata, is an impediment to DNA barcoding studies of Polyclinum species.
[Mh] Termos MeSH primário: Código de Barras de DNA Taxonômico/normas
Pseudogenes
Urocordados/genética
[Mh] Termos MeSH secundário: Animais
Complexo IV da Cadeia de Transporte de Elétrons/genética
Filogenia
Urocordados/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150328
[St] Status:MEDLINE
[do] DOI:10.3109/19401736.2015.1018238


  5 / 3486 MEDLINE  
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[PMID]:29273554
[Au] Autor:Shuwen H; Qing Z; Yan Z; Xi Y
[Ad] Endereço:Department of Medical Oncology, Huzhou Central Hospital, Huzhou, Zhejiang Province, China.
[Ti] Título:Competitive endogenous RNA in colorectal cancer: A systematic review.
[So] Source:Gene;645:157-162, 2018 Mar 01.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Colorectal cancer is one of the most common malignant tumours. Competitive endogenous RNA (ceRNA) networks have been hypothesized, in which various RNAs regulate each other's expression using microRNA response elements (MREs). Recent evidence has highlighted the crucial regulatory roles of ceRNA networks in colorectal cancer. In this review, we summarize the present research methods as well as the currently known ceRNA competitors and targets in colorectal cancer. In addition, we discuss the significance of ceRNA and shortcomings of current studies of colorectal cancer.
[Mh] Termos MeSH primário: Neoplasias Colorretais/genética
Pseudogenes/genética
RNA Longo não Codificante/genética
RNA/genética
[Mh] Termos MeSH secundário: Regulação Neoplásica da Expressão Gênica
Redes Reguladoras de Genes
Seres Humanos
MicroRNAs/genética
Elementos de Resposta
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (MicroRNAs); 0 (RNA, Long Noncoding); 0 (RNA, circular); 63231-63-0 (RNA)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


  6 / 3486 MEDLINE  
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[PMID]:29240807
[Au] Autor:Rotwein P
[Ad] Endereço:Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America.
[Ti] Título:Diversification of the insulin-like growth factor 1 gene in mammals.
[So] Source:PLoS One;12(12):e0189642, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Insulin-like growth factor 1 (IGF1), a small, secreted peptide growth factor, is involved in a variety of physiological and patho-physiological processes, including somatic growth, tissue repair, and metabolism of carbohydrates, proteins, and lipids. IGF1 gene expression appears to be controlled by several different signaling cascades in the few species in which it has been evaluated, with growth hormone playing a major role by activating a pathway involving the Stat5b transcription factor. Here, genes encoding IGF1 have been evaluated in 25 different mammalian species representing 15 different orders and ranging over ~180 million years of evolutionary diversification. Parts of the IGF1 gene have been fairly well conserved. Like rat Igf1 and human IGF1, 21 of 23 other genes are composed of 6 exons and 5 introns, and all 23 also contain recognizable tandem promoters, each with a unique leader exon. Exon and intron lengths are similar in most species, and DNA sequence conservation is moderately high in orthologous exons and proximal promoter regions. In contrast, putative growth hormone-activated Stat5b-binding enhancers found in analogous locations in rodent Igf1 and in human IGF1 loci, have undergone substantial variation in other mammals, and a processed retro-transposed IGF1 pseudogene is found in the sloth locus, but not in other mammalian genomes. Taken together, the fairly high level of organizational and nucleotide sequence similarity in the IGF1 gene among these 25 species supports the contention that some common regulatory pathways had existed prior to the beginning of mammalian speciation.
[Mh] Termos MeSH primário: Fator de Crescimento Insulin-Like I/genética
Mamíferos/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sequência Conservada
Bases de Dados Genéticas
Regulação da Expressão Gênica
Seres Humanos
Fator de Crescimento Insulin-Like I/química
Sinais Direcionadores de Proteínas
Pseudogenes
Homologia de Sequência de Aminoácidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protein Sorting Signals); 67763-96-6 (Insulin-Like Growth Factor I)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189642


  7 / 3486 MEDLINE  
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[PMID]:28916711
[Au] Autor:Huang P; Keller CA; Giardine B; Grevet JD; Davies JOJ; Hughes JR; Kurita R; Nakamura Y; Hardison RC; Blobel GA
[Ad] Endereço:Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
[Ti] Título:Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.
[So] Source:Genes Dev;31(16):1704-1713, 2017 Aug 15.
[Is] ISSN:1549-5477
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chromatin structure is tightly intertwined with transcription regulation. Here we compared the chromosomal architectures of fetal and adult human erythroblasts and found that, globally, chromatin structures and compartments A/B are highly similar at both developmental stages. At a finer scale, we detected distinct folding patterns at the developmentally controlled ß-globin locus. Specifically, new fetal stage-specific contacts were uncovered between a region separating the fetal (γ) and adult (δ and ß) globin genes (encompassing the and noncoding genes) and two distal chromosomal sites (HS5 and 3'HS1) that flank the locus. In contrast, in adult cells, the - region contacts the embryonic ε-globin gene, physically separating the fetal globin genes from the enhancer (locus control region [LCR]). Deletion of the region in adult cells alters contact landscapes in ways more closely resembling those of fetal cells, including increased LCR-γ-globin contacts. These changes are accompanied by strong increases in γ-globin transcription. Notably, the effects of removal on chromatin architecture and gene expression closely mimic those of deleting the fetal globin repressor BCL11A, implicating BCL11A in the function of the region. Our results uncover a new critical regulatory region as a potential target for therapeutic genome editing for hemoglobinopathies and highlight the power of chromosome conformation analysis in discovering new control elements.
[Mh] Termos MeSH primário: Cromatina/química
Eritroblastos/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Elementos Reguladores de Transcrição
Globinas beta/genética
[Mh] Termos MeSH secundário: Adulto
Proteínas de Transporte/genética
Feto
Inativação Gênica
Seres Humanos
Região de Controle de Locus Gênico
Proteínas Nucleares/genética
Pseudogenes
Transcriptoma
gama-Globinas/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BCL11A protein, human); 0 (Carrier Proteins); 0 (Chromatin); 0 (Nuclear Proteins); 0 (beta-Globins); 0 (gamma-Globins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171029
[Lr] Data última revisão:
171029
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE
[do] DOI:10.1101/gad.303461.117


  8 / 3486 MEDLINE  
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[PMID]:28854430
[Au] Autor:Thibodeau ML; Steinraths M; Brown L; Zong Z; Shomer N; Taubert S; Mungall KL; Ma YP; Mueller R; Birol I; Lehman A
[Ad] Endereço:Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
[Ti] Título:Genomic and Cytogenetic Characterization of a Balanced Translocation Disrupting NUP98.
[So] Source:Cytogenet Genome Res;152(3):117-121, 2017.
[Is] ISSN:1424-859X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A 41-year-old Asian woman with bilateral renal angiomyolipomas (AML) was incidentally identified to have a balanced translocation, 46,XX,t(11;12)(p15.4;q15). She had no other features or family history to suggest a diagnosis of tuberous sclerosis. Her healthy daughter had the same translocation and no renal AML at the age of 3 years. Whole-genome sequencing was performed on genomic maternal DNA isolated from blood. A targeted de novo assembly was then conducted with ABySS for chromosomes 11 and 12. Sanger sequencing was used to validate the translocation breakpoints. As a result, genomic characterization of chromosomes 11 and 12 revealed that the 11p breakpoint disrupted the NUP98 gene in intron 1, causing a separation of the promoter and transcription start site from the rest of the gene. The translocation breakpoint on chromosome 12q was located in a gene desert. NUP98 has not yet been associated with renal AML pathogenesis, but somatic NUP98 alterations are recurrently implicated in hematological malignancies, most often following a gene fusion event. We also found evidence for complex structural events involving chromosome 12, which appear to disrupt the TDG gene. We identified a TDGP1 partially processed pseudogene at 12p12.1, which adds complexity to the de novo assembly. In conclusion, this is the first report of a germline constitutional structural chromosome rearrangement disrupting NUP98 that occurred in a generally healthy woman with bilateral renal AML.
[Mh] Termos MeSH primário: Angiomiolipoma/genética
Cromossomos Humanos Par 11/genética
Cromossomos Humanos Par 12/genética
Neoplasias Renais/genética
Complexo de Proteínas Formadoras de Poros Nucleares/genética
Translocação Genética
[Mh] Termos MeSH secundário: Adulto
Amniocentese
Análise Citogenética/métodos
Feminino
Proteínas Ligadas por GPI/genética
Estudo de Associação Genômica Ampla
Genômica/métodos
Seres Humanos
Peptídeos e Proteínas de Sinalização Intercelular/genética
Proteínas de Neoplasias/genética
Regiões Promotoras Genéticas
Pseudogenes
Sítio de Iniciação de Transcrição
Esclerose Tuberosa/diagnóstico
Esclerose Tuberosa/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GPI-Linked Proteins); 0 (Intercellular Signaling Peptides and Proteins); 0 (Neoplasm Proteins); 0 (Nuclear Pore Complex Proteins); 0 (Nup98 protein, human); 0 (TDGF1 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1159/000479463


  9 / 3486 MEDLINE  
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[PMID]:28711665
[Au] Autor:Pérez T; Rodríguez F; Fernández M; Albornoz J; Domínguez A
[Ad] Endereço:Departamento de Biología Funcional, Área de Genética, Universidad de Oviedo, 33071 Oviedo, Spain.
[Ti] Título:Ancient mitochondrial pseudogenes reveal hybridization between distant lineages in the evolution of the Rupicapra genus.
[So] Source:Gene;628:63-71, 2017 Sep 10.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mitochondrial pseudogenes (numts) inserted in the nuclear genome are frequently found in population studies. Its presence is commonly connected with problems and errors when they are confounded with true mitochondrial sequences. In the opposite side, numts can provide valuable phylogenetic information when they are copies of ancient mitochondrial lineages. We show that Rupicapra individuals of different geographic origin from the Cantabrian Mountains to the Apennines and the Caucasus share a nuclear COI fragment. The numt copies are monophyletic, and their pattern of differentiation shows two outstanding features: a long evolution as differentiated true mitochondrial lineage, and a recent integration and spread through the chamois populations. The COI pseudogene is much older than the present day mitochondrial clades of Rupicapra and occupies a basal position within the Rupicapra-Ammotragus-Arabitragus node. Joint analysis of this numt and a cytb pseudogene with a similar pattern of evolution places the source mitochondrial lineage as a sister branch that separated from the Ammotragus-Arabitragus lineage 6millionyearsago (Mya). The occurrence of this sequence in the nucleus of chamois suggests hybridization between highly divergent lineages. The integration event seems to be very recent, more recent than the split of the present day mtDNA lineages of Rupicapra (1.9Mya). This observation invites to think of the spread across the genus by horizontal transfer through recent male-biased dispersal.
[Mh] Termos MeSH primário: Evolução Molecular
Hibridização Genética
Pseudogenes
Rupicapra/genética
[Mh] Termos MeSH secundário: Animais
Complexo IV da Cadeia de Transporte de Elétrons/genética
Mitocôndrias/genética
Filogenia
Rupicapra/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


  10 / 3486 MEDLINE  
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[PMID]:28602827
[Au] Autor:Tang L; Chen HY; Hao NB; Tang B; Guo H; Yong X; Dong H; Yang SM
[Ad] Endereço:Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
[Ti] Título:microRNA inhibitors: Natural and artificial sequestration of microRNA.
[So] Source:Cancer Lett;407:139-147, 2017 Oct 28.
[Is] ISSN:1872-7980
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:MicroRNA (miRNAs) is post-transcriptional regulator of mRNA. However, the prevalence and activity of miRNA are regulated by other regulators. miRNA inhibitors are natural or artificial RNA transcripts that sequestrate miRNAs and decrease or even eliminate miRNA activity. Competing endogenous RNAs (ceRNAs) are natural and intracellular miRNA inhibitors that compete to bind to shared miRNA recognition elements (MREs) to decrease microRNA availability and relieve the repression of target RNAs. In recent years, studies have revealed that ceRNA crosstalk is involved in many pathophysiological processes and adds a new dimension to miRNA regulation. Artificial miRNA inhibitors are RNA transcripts that are synthesized via chemical and genetic methods. Artificial miRNA inhibitors can be used in miRNA loss-of-function research and gene therapies for certain diseases. In this review, we summarize the recent advances in the two different types of miRNA inhibitors.
[Mh] Termos MeSH primário: Redes Reguladoras de Genes/genética
Terapia Genética/métodos
MicroRNAs/antagonistas & inibidores
Neoplasias/genética
[Mh] Termos MeSH secundário: Regulação Neoplásica da Expressão Gênica
Seres Humanos
MicroRNAs/genética
Neoplasias/terapia
Oligonucleotídeos/uso terapêutico
Pseudogenes/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); 0 (Oligonucleotides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE



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