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Pesquisa : G05.360.340.024.380.750 [Categoria DeCS]
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  1 / 6 MEDLINE  
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[PMID]:19544637
[Au] Autor:Yao PP; Zhu HP; Xu F; Xie RH; Mei LL; Lu QY; Zhu ZY; Deng XZ; Zhang Y
[Ad] Endereço:Zhejiang Center for Disease Prevention and Control, Hangzhou 310051, China. pingpingyao@yahoo.com.cn
[Ti] Título:[Molecular characterization and sequence comparison of the M and S segments of Hantavirus ZJ5 strain].
[So] Source:Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi;22(6):434-6, 2008 Dec.
[Is] ISSN:1003-9279
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: In order to understand the molecular characters of Hantavirus ZJ5 strain, its complete M and S genome were sequenced and compared with that of other hantavirus strains. METHODS: We prepared the total RNA from ZJ5. Infected cells and the raw or purified RT-PCR product was cloned and sequenced. RESULTS: With sequence compation, we found ZJ5 strain complete M and S segment had higher homology with SEO-type strains than other type of HV, but differential genes were 11.7%-19.2% and 6.7%-14.5% from SEOV. The phylogenetic trees constructed by complete M ind S segment showed that ZJ5 strain was located in SEOV group, and structured alone embranchment. CONCLUSION: The ZJ5 strain was believed to belong to SEO-type virus,and suggest that ZJ5 strain is a new subtype S SEOV group,and structured alone embranchment. CONCLUSION: The ZJ5 strain was believed to belong to SEO-type virus, and suggest that ZJ5 strain is a new subtype from other SEO viruses.
[Mh] Termos MeSH primário: Sequência de Bases
DNA Viral/análise
Hantavirus/genética
Febre Hemorrágica com Síndrome Renal/virologia
Locos Secundários de Estimulação Linfocitária/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Anticorpos Antivirais/genética
Bases de Dados Genéticas
Dados de Sequência Molecular
Filogenia
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Análise de Sequência de DNA
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (DNA, Viral)
[Em] Mês de entrada:0907
[Cu] Atualização por classe:090623
[Lr] Data última revisão:
090623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090624
[St] Status:MEDLINE


  2 / 6 MEDLINE  
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[PMID]:8660828
[Au] Autor:Munthe LA; Blichfeldt E; Sollien A; Dembic Z; Bogen B
[Ad] Endereço:Institute of Immunology and Rheumatology, University of Oslo, Oslo, Norway.
[Ti] Título:T cells with two Tcrbeta chains and reactivity to both MHC/idiotypic peptide and superantigen.
[So] Source:Cell Immunol;170(2):283-90, 1996 Jun 15.
[Is] ISSN:0008-8749
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:It is thought that Tcrbeta genes are effectively allelically excluded, while Tcralpha genes are not. We report here that endogenous Tcrbeta genes are expressed on as much as 5-7% of CD4+ T cells in 8-week-old Tcralphabeta-transgenic mice. In this model, the transgenic Tcr recognizes residues 91 - 101 of a lambda2(315) Ig light chain, presented on the I-Ed class II molecule. From such mice, a CD4+ T cell clone was isolated which not only responded to lambda2(315), but also mobilized Ca2+ and proliferated in response to Mls-1a. (Inadvertently we found that the C3H/Tif substrain, in contrast to C3H/HeJ, is Mls-1a positive.) The clone expressed the transgenic Tcr (Valpha1 and Vbeta8.2), and in addition an endogenous Vbeta6 chain, conferring the Mls-1a reactivity. On the population level, 1-2% of Tcr-transgenic lymph node cells displayed Vbeta6, in addition to the transgenic beta-chain. Such dual Tcrbeta expressor cells could be preferentially expanded in vitro by first stimulating with DBA/2 spleen cells and then with lambda2(315)-pulsed BALB/c antigen-presenting cells. In addition to demonstrating that allelic exclusion of Tcrbeta-chain genes is substantial but not complete in this model, the data show that the double beta-chain expressors can have two different specificities, and be signaled through both receptors, by physiological ligands. However, such dual-Tcr T cells appear to have reduced sensitivity to ligands, due to their decreased expression of each receptor. This holds true for both early (Ca2+ mobilization) and late (proliferation) T cells activation parameters. Dual Tcr cells may have a role in the pathogenesis of autoimmune diseases: If naive T cells are first stimulated by (infectious) superantigen, they could later, as activated T cells, respond to self-peptide/MHC on costimulation-deficient cells and cause autoimmunity. As a corollary, dual Tcr Id-specific T cells could, once activated, directly regulate Id+ B cells.
[Mh] Termos MeSH primário: Receptores de Antígenos de Linfócitos T alfa-beta/imunologia
Células Th1/imunologia
[Mh] Termos MeSH secundário: Animais
Células Clonais
Complexo Principal de Histocompatibilidade
Camundongos
Camundongos Endogâmicos
Camundongos SCID
Camundongos Transgênicos
Locos Secundários de Estimulação Linfocitária
Receptores de Antígenos de Linfócitos T alfa-beta/genética
Superantígenos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Antigen, T-Cell, alpha-beta); 0 (Superantigens); 0 (T cell receptor Vbeta6.7a, human)
[Em] Mês de entrada:9608
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:960615
[St] Status:MEDLINE


  3 / 6 MEDLINE  
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[PMID]:7696207
[Au] Autor:Marodon G; Rocha B
[Ad] Endereço:INSERM U345, CNRS UA122, Institut Necker, Paris, France.
[Ti] Título:Activation and 'deletion' of self-reactive mature and immature T cells during ontogeny of Mls-1a mice: implications for neonatal tolerance induction.
[So] Source:Int Immunol;6(12):1899-904, 1994 Dec.
[Is] ISSN:0953-8178
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We assessed the kinetics of V beta 6+ T cell elimination in the lymph nodes and thymus during Mls-1a mouse ontogeny. Our results suggest that induction of tolerance to Mls-1a antigens involves mechanisms other than clonal deletion of immature T cells in the thymus. Mature CD4+CD8- (CD4SP) T cells were affected by Mls-1a antigens earlier than immature thymocyte populations. Up to 2 weeks after birth, reduced frequencies of V beta 6+ T cells were detected only in CD4SP cells from the thymus and lymph nodes, and generation of CD4SP cells in the thymus was blocked at least 1 week earlier than that of their CD4+CD8loTCRhi immature precursors. The number of V beta 6+CD4SP T cells increased during the first 2 weeks of life and remained constant thereafter. We thus found no evidence of deletion of mature V beta 6+CD4SP T cells, as the reduced frequencies in adult mice can be attributed to the dilution of previously generated cells in lymphoid organs of growing mice, which increase in cellularity after birth. V beta 6+CD4+ T cells were activated in vivo shortly after birth, as shown by a selective increase in IL-2 receptor alpha chain expression in the thymus and lymph nodes from day 0 to day 2 after birth. It is therefore likely that endogenous expression of Mls-1a antigen shortly after birth activates V beta 6+CD4SP T cells and renders them anergic. This process of tolerance induction may precede the clonal deletion of immature T cells in the thymus, described in the adult mouse.
[Mh] Termos MeSH primário: Animais Recém-Nascidos/imunologia
Deleção Clonal/imunologia
Ativação Linfocitária/imunologia
Tecido Linfoide/crescimento & desenvolvimento
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos/crescimento & desenvolvimento
Diferenciação Celular/imunologia
Citometria de Fluxo
Linfonodos/crescimento & desenvolvimento
Tecido Linfoide/citologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos DBA
Locos Secundários de Estimulação Linfocitária/genética
Receptores de Antígenos de Linfócitos T alfa-beta/biossíntese
Receptores de Antígenos de Linfócitos T alfa-beta/imunologia
Receptores de Interleucina-2/biossíntese
Timo/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Antigen, T-Cell, alpha-beta); 0 (Receptors, Interleukin-2)
[Em] Mês de entrada:9505
[Cu] Atualização por classe:031114
[Lr] Data última revisão:
031114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:941201
[St] Status:MEDLINE


  4 / 6 MEDLINE  
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[PMID]:8389322
[Au] Autor:Taylor BA; Frankel WN
[Ad] Endereço:Jackson Laboratory, Bar Harbor, ME 04609.
[Ti] Título:A new strain congenic for the Mtv-7/Mls-1 locus of mouse chromosome 1.
[So] Source:Immunogenetics;38(3):235-7, 1993.
[Is] ISSN:0093-7711
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Camundongos Endogâmicos/genética
Locos Secundários de Estimulação Linfocitária
[Mh] Termos MeSH secundário: Animais
Southern Blotting
Mapeamento Cromossômico
Feminino
Vírus do Tumor Mamário do Camundongo/genética
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos DBA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Gs] Símbolo de gene:Mls-1; Mtv-7
[Em] Mês de entrada:9307
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:930101
[St] Status:MEDLINE


  5 / 6 MEDLINE  
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[PMID]:1352459
[Au] Autor:Yui K; Katsumata M; Komori S; Gill-Morse L; Greene MI
[Ad] Endereço:Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104-6082.
[Ti] Título:Response of V beta 8.1+ T cell clones to self Mls-1a: implications for the origin of autoreactive T cells.
[So] Source:Int Immunol;4(2):125-33, 1992 Feb.
[Is] ISSN:0953-8178
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Clonal deletion and anergy are two major mechanisms of self-tolerance. However, the molecular mechanisms underlying clonal deletion and anergy, as well as the threshold of TCR affinity/avidity required for these processes, are not known. Expression of the V beta 8.1 TCR correlates with the reactivity of the T cells to the minor lymphocyte stimulating locus-1a (Mls-1a) and T cells expressing this TCR are deleted in the thymus of Mls-1a mice. Similarly, in TCR V beta 8.1 transgenic mice, the number of CD4+CD8-T cells is reduced in Mls-1a mice. However, small numbers of CD4+CD8-T cells remain in the periphery of adult Mls-1a transgenic mice. We have generated T cell clones from TCR V beta 8.1 transgenic mice by stimulation of lymph node T cells with C57BL/6 alloantigens. Interestingly, CD4+CD8-V beta 8.1+ clones isolated from the transgenic mice of Mls-1a background responded to the self-antigen Mls-1a, to which they did not respond in primary assay. Reactive patterns of the clones were compared with clones derived from Mls-1b mice. Proliferation and cytokine production of the clones from Mls-1a mice to the self-antigen Mls-1a were generally reduced when compared with clones from Mls-1b mice. More importantly, T cell clones from Mls-1a mice required more Mls-1a antigen for their activation, and were more susceptible to the inhibitory effects of anti-CD4 antibody on the proliferative responses to Mls-1a than those from Mls-1b mice. These results suggest that the T cell receptor on clones derived from Mls-1a mice have functional but reduced affinity/avidity for self-antigen Mls-1a.
[Mh] Termos MeSH primário: Autoimunidade
Linfócitos T CD4-Positivos/imunologia
Locos Secundários de Estimulação Linfocitária/imunologia
Receptores de Antígenos de Linfócitos T alfa-beta/imunologia
[Mh] Termos MeSH secundário: Animais
Antígenos de Diferenciação de Linfócitos T/fisiologia
Antígenos CD2
Antígenos CD4/fisiologia
Células Clonais
Citometria de Fluxo
Interleucinas/secreção
Isoantígenos/imunologia
Ativação Linfocitária/imunologia
Antígeno-1 Associado à Função Linfocitária/fisiologia
Camundongos
Camundongos Endogâmicos
Camundongos Transgênicos
Antígenos Secundários de Estimulação de Linfócitos/imunologia
Receptores Imunológicos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Antigens, Differentiation, T-Lymphocyte); 0 (CD2 Antigens); 0 (CD4 Antigens); 0 (Interleukins); 0 (Isoantigens); 0 (Lymphocyte Function-Associated Antigen-1); 0 (Minor Lymphocyte Stimulatory Antigens); 0 (Receptors, Antigen, T-Cell, alpha-beta); 0 (Receptors, Immunologic)
[Em] Mês de entrada:9208
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:920201
[St] Status:MEDLINE


  6 / 6 MEDLINE  
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PubMed Central Texto completo
[PMID]:1783420
[Au] Autor:Mecheri S; Dannecker G; Dennig D; Hoffmann MK
[Ad] Endereço:Department of Microbiology & Immunology, New York Medical College, Valhalla 10595.
[Ti] Título:B cells control the aggregability of CD4 on T cells through continuous physical interactions.
[So] Source:Immunology;74(4):606-12, 1991 Dec.
[Is] ISSN:0019-2805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:It has previously been demonstrated that a gene on chromosome 1 in or near Mls-1 controls, on the surface of B cells, the mobility and aggregability of major histocompatibility complex (MHC) class II molecules but not the mobility or aggregability of other B-cell molecules, such as immunoglobulin (Ig) and class I antigens. We report here that this gene may also influence the aggregability of two class II antigen-reactive molecules on the surface of T cells, the T-cell receptor complex and CD4. The aggregability of the two membrane components is markedly higher on Mls-1+ T cells than on Mls-1- T cells. The properties of this phenomenon were examined in vitro as well as in vivo with particular emphasis on CD4 aggregability. It was found that, after removal of B cells, T cells lose the ability to aggregate CD4 in our standard CD4 aggregation assay. Similarly, T cells isolated from the B-cell-deficient environment of the thymus failed to aggregate CD4. Addition of B cells to either thymic T cells or B-cell-depleted peripheral T cells established CD4 aggregability within minutes. This process can be blocked with antibody against CD4 or antibody against Ia. The Mls-1 genotype predicts within the limited tests of this study the efficacy of the B-cell ability to impose a CD4 aggregation pattern on T cells: Mls-1+ B cells are markedly more effective in this respect than Mls-1- B cells. This can be demonstrated in tissue culture as well as in the animal. Similar to the Mls-1 response, this is a one-way process: Mls-1+ B cells confer to Mls-1- mice a CD4 aggregation pattern typical of the Mls-1+ mouse while Mls-1- B cells do not impose a Mls-1b-typical CD4 aggregation pattern in Mls-1a mice. Mls-1+ B cells also influence the composition of lymphocytes in the mouse. Mls-1+ mice or Mls-1- mice treated with Mls-1+ B cells have fewer T cells and more B cells in their spleen than Mls-1- animals. The gene that encodes stimulatory Mls-1 cell-surface structures has recently been identified as an endogenous mammary tumour virus (Mtv-7). We expect that the analysis of the virus genome will produce information whether the effects described here can be attributed to the virus or not.
[Mh] Termos MeSH primário: Linfócitos B/imunologia
Antígenos CD4/imunologia
Cooperação Linfocítica/imunologia
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Genótipo
Antígenos de Histocompatibilidade Classe II/imunologia
Camundongos
Camundongos Endogâmicos
Locos Secundários de Estimulação Linfocitária/imunologia
Baço/imunologia
Timo/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (CD4 Antigens); 0 (Histocompatibility Antigens Class II)
[Em] Mês de entrada:9203
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:911201
[St] Status:MEDLINE



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