Base de dados : MEDLINE
Pesquisa : G05.420.720 [Categoria DeCS]
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  1 / 7063 MEDLINE  
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[PMID]:27771146
[Au] Autor:Sardell RJ; Nittala MG; Adams LD; Laux RA; Cooke Bailey JN; Fuzzell D; Fuzzell S; Reinhart-Mercer L; Caywood LJ; Horst V; Mackay T; Dana D; Sadda SR; Scott WK; Stambolian D; Haines JL; Pericak-Vance MA
[Ad] Endereço:John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida.
[Ti] Título:Heritability of Choroidal Thickness in the Amish.
[So] Source:Ophthalmology;123(12):2537-2544, 2016 12.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the heritability of choroidal thickness and its relationship to age-related macular degeneration (AMD). DESIGN: Cohort study. PARTICIPANTS: Six hundred eighty-nine individuals from Amish families with early or intermediate AMD. METHODS: Ocular coherence tomography was used to quantify choroidal thickness, and fundus photography was used to classify eyes into categories using a modified Clinical Age-Related Maculopathy Staging (CARMS) system. Repeatability and heritability of choroidal thickness and its phenotypic and genetic correlations with the AMD phenotype (CARMS category) were estimated using a generalized linear mixed model (GLMM) approach that accounted for relatedness, repeated measures (left and right eyes), and the effects of age, gender, and refraction. MAIN OUTCOME MEASURES: Heritability of choroidal thickness and its phenotypic and genetic correlation with the AMD phenotype (CARMS category). RESULTS: Phenotypic correlation between choroidal thickness and CARMS category was moderate (Spearman's rank correlation, r = -0.24; n = 1313 eyes) and significant (GLMM posterior mean, -4.27; 95% credible interval [CI], -7.88 to -0.79; P = 0.02) after controlling for relatedness, age, gender, and refraction. Eyes with advanced AMD had thinner choroids than eyes without AMD (posterior mean, -73.8; 95% CI, -94.7 to -54.6; P < 0.001; n = 1178 eyes). Choroidal thickness was highly repeatable within individuals (repeatability, 0.78; 95% CI, 0.68 to 0.89) and moderately heritable (heritability, 0.40; 95% CI, 0.14 to 0.51), but did not show significant genetic correlation with CARMS category, although the effect size was moderate (genetic correlation, -0.18; 95% CI, -0.49 to 0.16). Choroidal thickness also varied with age, gender, and refraction. The CARMS category showed moderate heritability (heritability, 0.49; 95% CI, 0.26 to 0.72). CONCLUSIONS: We quantify the heritability of choroidal thickness for the first time, highlighting a heritable, quantitative trait that is measurable in all individuals regardless of AMD affection status, and moderately phenotypically correlated with AMD severity. Choroidal thickness therefore may capture variation not captured by the CARMS system. However, because the genetic correlation between choroidal thickness and AMD severity was not significant in our data set, genes associated with the 2 traits may not overlap substantially. Future studies should therefore test for genetic variation associated with choroidal thickness to determine the overlap in genetic basis with AMD.
[Mh] Termos MeSH primário: Amish/genética
Corioide/patologia
Característica Quantitativa Herdável
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Corioide/diagnóstico por imagem
Estudos de Coortes
Feminino
Seres Humanos
Degeneração Macular/genética
Masculino
Meia-Idade
Tamanho do Órgão/genética
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  2 / 7063 MEDLINE  
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[PMID]:28464791
[Au] Autor:Duggan BM; Rae AM; Clements DN; Hocking PM
[Ad] Endereço:The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK. Brendan.Duggan@roslin.ed.ac.uk.
[Ti] Título:Higher heritabilities for gait components than for overall gait scores may improve mobility in ducks.
[So] Source:Genet Sel Evol;49(1):42, 2017 05 02.
[Is] ISSN:1297-9686
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Genetic progress in selection for greater body mass and meat yield in poultry has been associated with an increase in gait problems which are detrimental to productivity and welfare. The incidence of suboptimal gait in breeding flocks is controlled through the use of a visual gait score, which is a subjective assessment of walking ability of each bird. The subjective nature of the visual gait score has led to concerns over its effectiveness in reducing the incidence of suboptimal gait in poultry through breeding. The aims of this study were to assess the reliability of the current visual gait scoring system in ducks and to develop a more objective method to select for better gait. RESULTS: Experienced gait scorers assessed short video clips of walking ducks to estimate the reliability of the current visual gait scoring system. Kendall's coefficients of concordance between and within observers were estimated at 0.49 and 0.75, respectively. In order to develop a more objective scoring system, gait components were visually scored on more than 4000 pedigreed Pekin ducks and genetic parameters were estimated for these components. Gait components, which are a more objective measure, had heritabilities that were as good as, or better than, those of the overall visual gait score. CONCLUSIONS: Measurement of gait components is simpler and therefore more objective than the standard visual gait score. The recording of gait components can potentially be automated, which may increase accuracy further and may improve heritability estimates. Genetic correlations were generally low, which suggests that it is possible to use gait components to select for an overall improvement in both economic traits and gait as part of a balanced breeding programme.
[Mh] Termos MeSH primário: Patos/genética
Característica Quantitativa Herdável
Velocidade de Caminhada/genética
[Mh] Termos MeSH secundário: Animais
Fenótipo
Seleção Artificial
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12711-017-0317-2


  3 / 7063 MEDLINE  
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[PMID]:28464407
[Au] Autor:Deng Y; Pan W
[Ad] Endereço:Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, United States of America.
[Ti] Título:Conditional analysis of multiple quantitative traits based on marginal GWAS summary statistics.
[So] Source:Genet Epidemiol;41(5):427-436, 2017 07.
[Is] ISSN:1098-2272
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There has been an increasing interest in joint association testing of multiple traits for possible pleiotropic effects. However, even in the presence of pleiotropy, most of the existing methods cannot distinguish direct and indirect effects of a genetic variant, say single-nucleotide polymorphism (SNP), on multiple traits, and a conditional analysis of a trait adjusting for other traits is perhaps the simplest and most common approach to addressing this question. However, without individual-level genotypic and phenotypic data but with only genome-wide association study (GWAS) summary statistics, as typical with most large-scale GWAS consortium studies, we are not aware of any existing method for such a conditional analysis. We propose such a conditional analysis, offering formulas of necessary calculations to fit a joint linear regression model for multiple quantitative traits. Furthermore, our method can also accommodate conditional analysis on multiple SNPs in addition to on multiple quantitative traits, which is expected to be useful for fine mapping. We provide numerical examples based on both simulated and real GWAS data to demonstrate the effectiveness of our proposed approach, and illustrate possible usefulness of conditional analysis by contrasting its result differences from those of standard marginal analyses.
[Mh] Termos MeSH primário: Estudo de Associação Genômica Ampla/métodos
Modelos Genéticos
Polimorfismo de Nucleotídeo Único/genética
Característica Quantitativa Herdável
[Mh] Termos MeSH secundário: Feminino
Genótipo
Seres Humanos
Masculino
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/gepi.22046


  4 / 7063 MEDLINE  
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[PMID]:29345075
[Au] Autor:Viklund Å; Eriksson S
[Ad] Endereço:Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.
[Ti] Título:Genetic analyses of linear profiling data on 3-year-old Swedish Warmblood horses.
[So] Source:J Anim Breed Genet;135(1):62-72, 2018 Feb.
[Is] ISSN:1439-0388
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A linear profiling protocol was introduced in 2013 at tests for 3-year-old Swedish Warmblood horses. In this protocol, traits are subjectively described on a nine-point linear scale from one biological extreme to the other. This complements the traditional scoring where horses are evaluated in relation to the breeding objective. This study aimed to investigate the suitability of the linear information for genetic evaluation. Data on 22 conformation traits, 17 movement traits, 14 jumping traits and one temperament trait from 3,410 horses tested between 2013 and 2016 were analysed using an animal model. For conformation traits, the heritabilities ranged from 0.10 for description of hock joint from behind to 0.52 for shape of the neck. For movement traits, the highest heritability (0.54) was estimated for elasticity in trot and the lowest (0.08) for energy in walk. The heritabilities for jumping traits ranged from 0.05 for the ability to focus on the assignment to 0.57 for scope. Genetic correlations between linear traits and corresponding traditionally scored traits were strong (-0.37 to in many cases <-0.9). The results show that the linear information is suitable for genetic evaluation and can be a useful tool for breeders.
[Mh] Termos MeSH primário: Cavalos/genética
[Mh] Termos MeSH secundário: Animais
Cruzamento
Feminino
Cavalos/anatomia & histologia
Modelos Lineares
Masculino
Característica Quantitativa Herdável
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1111/jbg.12311


  5 / 7063 MEDLINE  
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[PMID]:28748554
[Au] Autor:Martikainen K; Tyrisevä AM; Matilainen K; Pösö J; Uimari P
[Ad] Endereço:Department of Agricultural Sciences, University of Helsinki, Helsinki, Finland.
[Ti] Título:Estimation of inbreeding depression on female fertility in the Finnish Ayrshire population.
[So] Source:J Anim Breed Genet;134(5):383-392, 2017 Oct.
[Is] ISSN:1439-0388
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Single nucleotide polymorphism (SNP) data enable the estimation of inbreeding at the genome level. In this study, we estimated inbreeding levels for 19,075 Finnish Ayrshire cows genotyped with a low-density SNP panel (8K). The genotypes were imputed to 50K density, and after quality control, 39,144 SNPs remained for the analysis. Inbreeding coefficients were estimated for each animal based on the percentage of homozygous SNPs (F ), runs of homozygosity (F ) and pedigree (F ). Phenotypic records were available for 13,712 animals including non-return rate (NRR), number of inseminations (AIS) and interval from first to last insemination (IFL) for heifers and up to three parities for cows, as well as interval from calving to first insemination (ICF) for cows. Average F was 0.02, F 0.06 and F 0.63. A correlation of 0.71 was found between F and F , 0.66 between F and F and 0.94 between F and F . Pedigree-based inbreeding coefficients did not show inbreeding depression in any of the traits. However, when F or F was used as a covariate, significant inbreeding depression was observed; a 10% increase in F was associated with 5 days longer IFL0 and IFL1, 2 weeks longer IFL3 and 3 days longer ICF2 compared to non-inbred cows.
[Mh] Termos MeSH primário: Bovinos/genética
Bovinos/fisiologia
Fertilidade
Depressão por Endogamia
Polimorfismo de Nucleotídeo Único
Característica Quantitativa Herdável
[Mh] Termos MeSH secundário: Animais
Feminino
Finlândia
Genômica
Endogamia
Fenótipo
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1111/jbg.12285


  6 / 7063 MEDLINE  
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[PMID]:28470817
[Au] Autor:Onogi A; Sasaki S; Kobayashi M; Ogino A; Nozaki T; Kurogi K; Yasumori T; Togashi K; Iwata H
[Ad] Endereço:Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
[Ti] Título:A genetic analysis of meat compositions in Japanese Black cattle: Genetic parameters and sex influence.
[So] Source:J Anim Breed Genet;134(5):373-382, 2017 Oct.
[Is] ISSN:1439-0388
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Meat composition in beef is related to eating quality and food functionality. Genetic parameters for several meat compositions including free amino acid, peptide and sugar, however, remain poorly described. In this study, we estimated genetic parameters for 51 meat components, including free amino acids, peptides, sugars and fatty acid compositions, and two carcase traits in 1,354 heifers and 1,797 steers of Japanese Black cattle. Heritability estimates were generally equivalent to or moderately greater than those in previous studies of this breed. Genetic correlations between free amino acids, peptides and sugars and carcase traits were often negative, suggesting a trade-off between traits. Using two-trait animal models that treat records from the two sexes as different traits, we estimated sex-specific heritabilities and cross-sex genetic correlations which indicate the sex differences in genetic architecture. In these analyses, 12 traits showed significant heritability differences between sexes and cross-sex genetic correlations occasionally deviated from unity. These results could be used to inform future breeding schemes and investigations of the genetic architecture of meat compositions in beef.
[Mh] Termos MeSH primário: Bovinos/genética
Estudos de Associação Genética/veterinária
Carne/análise
Característica Quantitativa Herdável
[Mh] Termos MeSH secundário: Aminoácidos/análise
Animais
Cruzamento
Ácidos Graxos/análise
Feminino
Qualidade dos Alimentos
Masculino
Peptídeos/análise
Fenótipo
Fatores Sexuais
Açúcares/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Fatty Acids); 0 (Peptides); 0 (Sugars)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1111/jbg.12280


  7 / 7063 MEDLINE  
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[PMID]:28746715
[Au] Autor:Smeland OB; Frei O; Kauppi K; Hill WD; Li W; Wang Y; Krull F; Bettella F; Eriksen JA; Witoelar A; Davies G; Fan CC; Thompson WK; Lam M; Lencz T; Chen CH; Ueland T; Jönsson EG; Djurovic S; Deary IJ; Dale AM; Andreassen OA; NeuroCHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Cognitive Working Group
[Ad] Endereço:Norwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
[Ti] Título:Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function.
[So] Source:JAMA Psychiatry;74(10):1065-1075, 2017 Oct 01.
[Is] ISSN:2168-6238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Schizophrenia is associated with widespread cognitive impairments. Although cognitive deficits are one of the factors most strongly associated with functional outcome in schizophrenia, current treatment strategies largely fail to ameliorate these impairments. To develop more efficient treatment strategies in patients with schizophrenia, a better understanding of the pathogenesis of these cognitive deficits is needed. Accumulating evidence indicates that genetic risk of schizophrenia may contribute to cognitive dysfunction. Objective: To identify genomic regions jointly influencing schizophrenia and the cognitive domains of reaction time and verbal-numerical reasoning, as well as general cognitive function, a phenotype that captures the shared variation in performance across cognitive domains. Design, Setting, and Participants: Combining data from genome-wide association studies from multiple phenotypes using conditional false discovery rate analysis provides increased power to discover genetic variants and could elucidate shared molecular genetic mechanisms. Data from the following genome-wide association studies, published from July 24, 2014, to January 17, 2017, were combined: schizophrenia in the Psychiatric Genomics Consortium cohort (n = 79 757 [cases, 34 486; controls, 45 271]); verbal-numerical reasoning (n = 36 035) and reaction time (n = 111 483) in the UK Biobank cohort; and general cognitive function in CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) (n = 53 949) and COGENT (Cognitive Genomics Consortium) (n = 27 888). Main Outcomes and Measures: Genetic loci identified by conditional false discovery rate analysis. Brain messenger RNA expression and brain expression quantitative trait locus functionality were determined. Results: Among the participants in the genome-wide association studies, 21 loci jointly influencing schizophrenia and cognitive traits were identified: 2 loci shared between schizophrenia and verbal-numerical reasoning, 6 loci shared between schizophrenia and reaction time, and 14 loci shared between schizophrenia and general cognitive function. One locus was shared between schizophrenia and 2 cognitive traits and represented the strongest shared signal detected (nearest gene TCF20; chromosome 22q13.2), and was shared between schizophrenia (z score, 5.01; P = 5.53 × 10-7), general cognitive function (z score, -4.43; P = 9.42 × 10-6), and verbal-numerical reasoning (z score, -5.43; P = 5.64 × 10-8). For 18 loci, schizophrenia risk alleles were associated with poorer cognitive performance. The implicated genes are expressed in the developmental and adult human brain. Replicable expression quantitative trait locus functionality was identified for 4 loci in the adult human brain. Conclusions and Relevance: The discovered loci improve the understanding of the common genetic basis underlying schizophrenia and cognitive function, suggesting novel molecular genetic mechanisms.
[Mh] Termos MeSH primário: Disfunção Cognitiva
Esquizofrenia
[Mh] Termos MeSH secundário: Adulto
Cognição/fisiologia
Disfunção Cognitiva/diagnóstico
Disfunção Cognitiva/etiologia
Disfunção Cognitiva/genética
Feminino
Proteínas Ativadoras de GTPase/genética
Loci Gênicos
Variação Genética
Estudo de Associação Genômica Ampla
Seres Humanos
Desequilíbrio de Ligação
Masculino
Polimorfismo de Nucleotídeo Único
Característica Quantitativa Herdável
Tempo de Reação
Esquizofrenia/complicações
Esquizofrenia/diagnóstico
Esquizofrenia/genética
alfa Catenina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CTNNA2 protein, human); 0 (GTPase-Activating Proteins); 0 (TBC1D5 protein, human); 0 (alpha Catenin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1001/jamapsychiatry.2017.1986


  8 / 7063 MEDLINE  
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[PMID]:27770776
[Au] Autor:Jooste M; Dreyer LL; Oberlander KC
[Ad] Endereço:Department of Botany and Zoology, University of Stellenbosch, Private Bag X1, Matieland, 7602, South Africa. mich.jooste.m@gmail.com.
[Ti] Título:The phylogenetic significance of leaf anatomical traits of southern African Oxalis.
[So] Source:BMC Evol Biol;16(1):225, 2016 10 22.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The southern African Oxalis radiation is extremely morphologically variable. Despite recent progress in the phylogenetics of the genus, there are few morphological synapomorphies supporting DNA-based clades. Leaflet anatomy can provide an understudied and potentially valuable source of information on the evolutionary history and systematics of this lineage. Fifty-nine leaflet anatomical traits of 109 southern African Oxalis species were assessed in search of phylogenetically significant characters that delineate clades. RESULTS: A combination of 6 leaflet anatomical traits (stomatal position, adaxial epidermal cells, abaxial epidermal cells, mesophyll, sheath around vascular tissue, degree of leaflet conduplication) clearly support various clades defined by previous DNA-based phylogenetic work. Other, mostly continuous leaflet anatomical traits were highly variable and showed less phylogenetic pattern. CONCLUSIONS: Major and unexpected findings include the transition from ancestral hypostomatic leaflets to adaxially-located stomata in the vast majority of southern African Oxalis, the loss of semi-swollen AB epidermal cells and the gain of swollen adaxial and abaxial epidermal cells in selected clades, and multiple changes from ancestral bifacial mesophyll to isobilateral or homogenous mesophyll types. The information gathered in this study will aid in the taxonomic revision of this speciose member of the Greater Cape Floristic Region and provide a basis for future hypotheses regarding its radiation.
[Mh] Termos MeSH primário: Oxalidaceae/anatomia & histologia
Filogenia
Folhas de Planta/anatomia & histologia
[Mh] Termos MeSH secundário: Evolução Biológica
Duplicação Gênica
Células do Mesofilo/citologia
Oxalidaceae/genética
Fenótipo
Folhas de Planta/citologia
Folhas de Planta/genética
Estômatos de Plantas/citologia
Feixe Vascular de Plantas/citologia
Característica Quantitativa Herdável
Tricomas/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180128
[Lr] Data última revisão:
180128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  9 / 7063 MEDLINE  
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[PMID]:28453813
[Au] Autor:Zhou D; Du Q; Chen J; Wang Q; Zhang D
[Ad] Endereço:Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, P.R. China.
[Ti] Título:Identification and allelic dissection uncover roles of lncRNAs in secondary growth of Populus tomentosa.
[So] Source:DNA Res;24(5):473-486, 2017 Oct 01.
[Is] ISSN:1756-1663
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Long non-coding RNAs (lncRNAs) function in various biological processes. However, their roles in secondary growth of plants remain poorly understood. Here, 15,691 lncRNAs were identified from vascular cambium, developing xylem, and mature xylem of Populus tomentosa with high and low biomass using RNA-seq, including 1,994 lncRNAs that were differentially expressed (DE) among the six libraries. 3,569 cis-regulated and 3,297 trans-regulated protein-coding genes were predicted as potential target genes (PTGs) of the DE lncRNAs to participate in biological regulation. Then, 476 and 28 lncRNAs were identified as putative targets and endogenous target mimics (eTMs) of Populus known microRNAs (miRNAs), respectively. Genome re-sequencing of 435 individuals from a natural population of P. tomentosa found 34,015 single nucleotide polymorphisms (SNPs) within 178 lncRNA loci and 522 PTGs. Single-SNP associations analysis detected 2,993 associations with 10 growth and wood-property traits under additive and dominance model. Epistasis analysis identified 17,656 epistatic SNP pairs, providing evidence for potential regulatory interactions between lncRNAs and their PTGs. Furthermore, a reconstructed epistatic network, representing interactions of 8 lncRNAs and 15 PTGs, might enrich regulation roles of genes in the phenylpropanoid pathway. These findings may enhance our understanding of non-coding genes in plants.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica de Plantas
Polimorfismo de Nucleotídeo Único
Populus/metabolismo
Característica Quantitativa Herdável
RNA Longo não Codificante/fisiologia
[Mh] Termos MeSH secundário: Câmbio/genética
Câmbio/crescimento & desenvolvimento
Câmbio/metabolismo
Epistasia Genética
Estudos de Associação Genética
Populus/genética
Populus/crescimento & desenvolvimento
RNA Longo não Codificante/genética
RNA de Plantas/genética
RNA de Plantas/fisiologia
Análise de Sequência de DNA
Análise de Sequência de RNA
Transcriptoma
Xilema/genética
Xilema/crescimento & desenvolvimento
Xilema/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Long Noncoding); 0 (RNA, Plant)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/dnares/dsx018


  10 / 7063 MEDLINE  
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[PMID]:28743038
[Au] Autor:Durkovic J; Husárová H; Javoríková L; Canová I; Suleková M; Kardosová M; Lukácik I; Mamonová M; Lagana R
[Ad] Endereço:Department of Phytology, Technical University, T.G. Masaryka 24, 960 53 Zvolen, Slovak Republic. Electronic address: jaroslav.durkovic@tuzvo.sk.
[Ti] Título:Physiological, vascular and nanomechanical assessment of hybrid poplar leaf traits in micropropagated plants and plants propagated from root cuttings: A contribution to breeding programs.
[So] Source:Plant Physiol Biochem;118:449-459, 2017 Sep.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Micropropagated plants experience significant stress from rapid water loss when they are transferred from an in vitro culture to either greenhouse or field conditions. This is caused both by inefficient stomatal control of transpiration and the change to a higher light intensity and lower humidity. Understanding the physiological, vascular and biomechanical processes that allow micropropagated plants to modify their phenotype in response to environmental conditions can help to improve both field performance and plant survival. To identify changes between the hybrid poplar [Populus tremula × (Populus × canescens)] plants propagated from in vitro tissue culture and those from root cuttings, we assessed leaf performance for any differences in leaf growth, photosynthetic and vascular traits, and also nanomechanical properties of the tracheary element cell walls. The micropropagated plants showed significantly higher values for leaf area, leaf length, leaf width and leaf dry mass. The greater leaf area and leaf size dimensions resulted from the higher transpiration rate recorded for this stock type. Also, the micropropagated plants reached higher values for chlorophyll a fluorescence parameters and for the nanomechanical dissipation energy of tracheary element cell walls which may indicate a higher damping capacity within the primary xylem tissue under abiotic stress conditions. The performance of the plants propagated from root cuttings was superior for instantaneous water-use efficiency which signifies a higher acclimation capacity to stressful conditions during a severe drought particularly for this stock type. Similarities were found among the majority of the examined leaf traits for both vegetative plant origins including leaf mass per area, stomatal conductance, net photosynthetic rate, hydraulic axial conductivity, indicators of leaf midrib vascular architecture, as well as for the majority of cell wall nanomechanical traits. This research revealed that there were no drawbacks in the leaf physiological performance which could be attributed to the micropropagated plants of fast growing hybrid poplar.
[Mh] Termos MeSH primário: Melhoramento Vegetal/métodos
Folhas de Planta
Raízes de Plantas
Estômatos de Plantas
Populus
Característica Quantitativa Herdável
[Mh] Termos MeSH secundário: Quimera
Folhas de Planta/genética
Folhas de Planta/crescimento & desenvolvimento
Raízes de Plantas/genética
Raízes de Plantas/crescimento & desenvolvimento
Estômatos de Plantas/genética
Estômatos de Plantas/crescimento & desenvolvimento
Populus/genética
Populus/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE



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