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Pesquisa : G05.700.456 [Categoria DeCS]
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  1 / 4616 MEDLINE  
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[PMID]:28463050
[Au] Autor:Bai SN
[Ad] Endereço:a State Key Laboratory of Protein and Plant Gene Research , College of Life Science, Quantitative Biology Center, Peking University , Beijing , China.
[Ti] Título:Two types of germ cells, the sexual reproduction cycle, and the double-ring mode of plant developmental program.
[So] Source:Plant Signal Behav;12(7):e1320632, 2017 Jul 03.
[Is] ISSN:1559-2324
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this viewpoint, the usages of terms for progenitor cells to meiosis and gametogenesis are discussed. Terms for 2 types of germ cells, i.e. "diploid germ cells" and "haploid germ cells" were suggested to replace "archesporial cells" and "generative cells," respectively, in plant developmental research. This suggestion was based on 2 newly proposed concepts, the "sexual reproduction cycle" for eukaryotes, and a "double-ring mode" of plant developmental program.
[Mh] Termos MeSH primário: Células Germinativas Vegetais
Desenvolvimento Vegetal
[Mh] Termos MeSH secundário: Diploide
Haploidia
Reprodução
Terminologia como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1080/15592324.2017.1320632


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[PMID]:28457886
[Au] Autor:Guo A; Huang S; Yu J; Wang H; Li H; Pei G; Shen L
[Ad] Endereço:State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.
[Ti] Título:Single-Cell Dynamic Analysis of Mitosis in Haploid Embryonic Stem Cells Shows the Prolonged Metaphase and Its Association with Self-diploidization.
[So] Source:Stem Cell Reports;8(5):1124-1134, 2017 May 09.
[Is] ISSN:2213-6711
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The recent establishment of mammalian haploid embryonic stem cells (ESCs) provides new possibilities for genetic screening and for understanding genome evolution and function. However, the dynamics of mitosis in haploid ESCs is still unclear. Here, we report that the duration of mitosis in haploid ESCs, especially the metaphase, is significantly longer than that in diploid ESCs. Delaying mitosis by chemicals increased self-diploidization of haploid ESCs, while shortening mitosis stabilized haploid ESCs. Taken together, our study suggests that the delayed mitosis of haploid ESCs is associated with self-diploidization.
[Mh] Termos MeSH primário: Células-Tronco Embrionárias/citologia
Haploidia
Metáfase
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Diploide
Camundongos
Análise de Célula Única
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  3 / 4616 MEDLINE  
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[PMID]:29200436
[Au] Autor:Osthushenrich T; Frisch M; Herzog E
[Ad] Endereço:Institute of Agronomy and Plant Breeding II, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.
[Ti] Título:Genomic selection of crossing partners on basis of the expected mean and variance of their derived lines.
[So] Source:PLoS One;12(12):e0188839, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In a line or a hybrid breeding program superior lines are selected from a breeding pool as parental lines for the next breeding cycle. From a cross of two parental lines, new lines are derived by single-seed descent (SSD) or doubled haploid (DH) technology. However, not all possible crosses between the parental lines can be carried out due to limited resources. Our objectives were to present formulas to characterize a cross by the mean and variance of the genotypic values of the lines derived from the cross, and to apply the formulas to predict means and variances of flowering time traits in recombinant inbred line families of a publicly available data set in maize. We derived formulas which are based on the expected linkage disequilibrium (LD) between two loci and which can be used for arbitrary mating systems. Results were worked out for SSD and DH lines derived from a cross after an arbitrary number of intermating generations. The means and variances were highly correlated with results obtained by the simulation software PopVar. Compared with these simulations, computation time for our closed formulas was about ten times faster. The means and variances for flowering time traits observed in the recombinant inbred line families of the investigated data set showed correlations of around 0.9 for the means and of 0.46 and 0.65 for the standard deviations with the estimated values. We conclude that our results provide a framework that can be exploited to increase the efficiency of hybrid and line breeding programs by extending genomic selection approaches to the selection of crossing partners.
[Mh] Termos MeSH primário: Cruzamentos Genéticos
Modelos Genéticos
Melhoramento Vegetal/métodos
Seleção Genética
Zea mays/genética
[Mh] Termos MeSH secundário: Simulação por Computador
Loci Gênicos/genética
Genótipo
Haploidia
Desequilíbrio de Ligação
Fenótipo
Locos de Características Quantitativas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188839


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[PMID]:29176810
[Au] Autor:Hanson SJ; Byrne KP; Wolfe KH
[Ad] Endereço:UCD Conway Institute, School of Medicine, University College Dublin, Dublin 4, Ireland.
[Ti] Título:Flip/flop mating-type switching in the methylotrophic yeast Ogataea polymorpha is regulated by an Efg1-Rme1-Ste12 pathway.
[So] Source:PLoS Genet;13(11):e1007092, 2017 Nov.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In haploid cells of Ogataea (Hansenula) polymorpha an environmental signal, nitrogen starvation, induces a reversible change in the structure of a chromosome. This process, mating-type switching, inverts a 19-kb DNA region to place either MATa or MATα genes under centromeric repression of transcription, depending on the orientation of the region. Here, we investigated the genetic pathway that controls switching. We characterized the transcriptomes of haploid and diploid O. polymorpha by RNAseq in rich and nitrogen-deficient media, and found that there are no constitutively a-specific or α-specific genes other than the MAT genes themselves. We mapped a switching defect in a sibling species (O. parapolymorpha strain DL-1) by interspecies bulk segregant analysis to a frameshift in the transcription factor EFG1, which in Candida albicans regulates filamentous growth and white-opaque switching. Gene knockout, overexpression and ChIPseq experiments show that EFG1 regulates RME1, which in turn regulates STE12, to achieve mating-type switching. All three genes are necessary both for switching and for mating. Overexpression of RME1 or STE12 is sufficient to induce switching without a nitrogen depletion signal. The homologous recombination genes RAD51 and RAD17 are also necessary for switching. The pathway controlling switching in O. polymorpha shares no components with the regulation of HO in S. cerevisiae, which does not involve any environmental signal, but it shares some components with mating-type switching in Kluyveromyces lactis and with white-opaque phenotypic switching in C. albicans.
[Mh] Termos MeSH primário: Proteínas Fúngicas/genética
Regulação Fúngica da Expressão Gênica
Genes Fúngicos Tipo Acasalamento/genética
Saccharomycetales/genética
Transdução de Sinais/genética
[Mh] Termos MeSH secundário: Candida albicans/genética
Centrômero/genética
Diploide
Perfilação da Expressão Gênica/métodos
Técnicas de Inativação de Genes
Haploidia
Kluyveromyces/genética
Modelos Genéticos
Saccharomyces cerevisiae/genética
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171225
[Lr] Data última revisão:
171225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1007092


  5 / 4616 MEDLINE  
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[PMID]:28468909
[Au] Autor:Melchinger AE; Schopp P; Müller D; Schrag TA; Bauer E; Unterseer S; Homann L; Schipprack W; Schön CC
[Ad] Endereço:Institute of Plant Breeding, Seed Science and Population Genetics, University of Hohenheim, 70593 Stuttgart, Germany melchinger@uni-hohenheim.de chris.schoen@tum.de.
[Ti] Título:Safeguarding Our Genetic Resources with Libraries of Doubled-Haploid Lines.
[So] Source:Genetics;206(3):1611-1619, 2017 07.
[Is] ISSN:1943-2631
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thousands of landraces are stored in seed banks as "gold reserves" for future use in plant breeding. In many crops, their utilization is hampered because they represent heterogeneous populations of heterozygous genotypes, which harbor a high genetic load. We show, with high-density genotyping in five landraces of maize, that libraries of doubled-haploid (DH) lines capture the allelic diversity of genetic resources in an unbiased way. By comparing allelic differentiation between heterozygous plants from the original landraces and 266 derived DH lines, we find conclusive evidence that, in the DH production process, sampling of alleles is random across the entire allele frequency spectrum, and purging of landraces from their genetic load does not act on specific genomic regions. Based on overall process efficiency, we show that generating DH lines is feasible for genetic material that has never been selected for inbreeding tolerance. We conclude that libraries of DH lines will make genetic resources accessible to crop improvement by linking molecular inventories of seed banks with meaningful phenotypes.
[Mh] Termos MeSH primário: Haploidia
Melhoramento Vegetal/métodos
Banco de Sementes
Zea mays/genética
[Mh] Termos MeSH secundário: Alelos
Bases de Dados de Ácidos Nucleicos
Carga Genética
Heterozigoto
Desequilíbrio de Ligação
Polimorfismo Genético
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1534/genetics.115.186205


  6 / 4616 MEDLINE  
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[PMID]:28882874
[Au] Autor:Loregger A; Raaben M; Tan J; Scheij S; Moeton M; van den Berg M; Gelberg-Etel H; Stickel E; Roitelman J; Brummelkamp T; Zelcer N
[Ad] Endereço:From the Department of Medical Biochemistry, Academic Medical Center of the University of Amsterdam, The Netherlands (A.L., J.T., S.S., M.M., M.v.d.B., N.Z.); Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam (M.R., E.S., T.B.); CeMM Research Center for Molecular Medicine of the
[Ti] Título:Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.
[So] Source:Arterioscler Thromb Vasc Biol;37(11):2064-2074, 2017 Nov.
[Is] ISSN:1524-4636
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The cellular demand for cholesterol requires control of its biosynthesis by the mevalonate pathway. Regulation of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), a rate-limiting enzyme in this pathway and the target of statins, is a key control point herein. Accordingly, HMGCR is subject to negative and positive regulation. In particular, the ability of oxysterols and intermediates of the mevalonate pathway to stimulate its proteasomal degradation is an exquisite example of metabolically controlled feedback regulation. To define the genetic determinants that govern this process, we conducted an unbiased haploid mammalian genetic screen. APPROACH AND RESULTS: We generated human haploid cells with mNeon fused to endogenous HMGCR using CRISPR/Cas9 and used these cells to interrogate regulation of HMGCR abundance in live cells. This resulted in identification of known and new regulators of HMGCR, and among the latter, UBXD8 (ubiquitin regulatory X domain-containing protein 8), a gene that has not been previously implicated in this process. We demonstrate that UBXD8 is an essential determinant of metabolically stimulated degradation of HMGCR and of cholesterol biosynthesis in multiple cell types. Accordingly, UBXD8 ablation leads to aberrant cholesterol synthesis due to loss of feedback control. Mechanistically, we show that UBXD8 is necessary for sterol-stimulated dislocation of ubiquitylated HMGCR from the endoplasmic reticulum membrane en route to proteasomal degradation, a function dependent on its UBX domain. CONCLUSIONS: We establish UBXD8 as a previously unrecognized determinant that couples flux across the mevalonate pathway to control of cholesterol synthesis and demonstrate the feasibility of applying mammalian haploid genetics to study metabolic traits.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/metabolismo
Colesterol/biossíntese
Haploidia
Hidroximetilglutaril-CoA Redutases/metabolismo
Proteínas de Membrana/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas Sanguíneas/genética
Sistemas CRISPR-Cas
Retículo Endoplasmático/enzimologia
Estabilidade Enzimática
Retroalimentação Fisiológica
Regulação Enzimológica da Expressão Gênica
Células Hep G2
Hepatócitos/enzimologia
Seres Humanos
Hidroximetilglutaril-CoA Redutases/genética
Proteínas de Membrana/genética
Ácido Mevalônico/metabolismo
Microscopia Confocal
Complexo de Endopeptidases do Proteassoma/metabolismo
Transporte Proteico
Proteólise
Ratos
Proteínas Recombinantes de Fusão/metabolismo
Transfecção
Ubiquitinação
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Blood Proteins); 0 (ETEA protein, human); 0 (Membrane Proteins); 0 (Recombinant Fusion Proteins); 97C5T2UQ7J (Cholesterol); EC 1.1.1.- (HMGCR protein, human); EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases); EC 3.4.25.1 (Proteasome Endopeptidase Complex); S5UOB36OCZ (Mevalonic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1161/ATVBAHA.117.310002


  7 / 4616 MEDLINE  
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[PMID]:28682332
[Au] Autor:Nagano T; Lubling Y; Várnai C; Dudley C; Leung W; Baran Y; Mendelson Cohen N; Wingett S; Fraser P; Tanay A
[Ad] Endereço:Nuclear Dynamics Programme, The Babraham Insitute, Cambridge CB22 3AT, UK.
[Ti] Título:Cell-cycle dynamics of chromosomal organization at single-cell resolution.
[So] Source:Nature;547(7661):61-67, 2017 07 05.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chromosomes in proliferating metazoan cells undergo marked structural metamorphoses every cell cycle, alternating between highly condensed mitotic structures that facilitate chromosome segregation, and decondensed interphase structures that accommodate transcription, gene silencing and DNA replication. Here we use single-cell Hi-C (high-resolution chromosome conformation capture) analysis to study chromosome conformations in thousands of individual cells, and discover a continuum of cis-interaction profiles that finely position individual cells along the cell cycle. We show that chromosomal compartments, topological-associated domains (TADs), contact insulation and long-range loops, all defined by bulk Hi-C maps, are governed by distinct cell-cycle dynamics. In particular, DNA replication correlates with a build-up of compartments and a reduction in TAD insulation, while loops are generally stable from G1 to S and G2 phase. Whole-genome three-dimensional structural models reveal a radial architecture of chromosomal compartments with distinct epigenomic signatures. Our single-cell data therefore allow re-interpretation of chromosome conformation maps through the prism of the cell cycle.
[Mh] Termos MeSH primário: Ciclo Celular/fisiologia
Cromossomos de Mamíferos/química
Cromossomos de Mamíferos/metabolismo
Epigênese Genética
Análise de Célula Única/métodos
[Mh] Termos MeSH secundário: Animais
Compartimento Celular
Ciclo Celular/genética
Cromossomos de Mamíferos/genética
Haploidia
Imagem Tridimensional
Camundongos
Células-Tronco Embrionárias Murinas/citologia
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1038/nature23001


  8 / 4616 MEDLINE  
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[PMID]:28655762
[Au] Autor:Yadav PK; Rajasekharan R
[Ad] Endereço:From the Lipidomic Centre, Department of Lipid Science, and.
[Ti] Título:The m A methyltransferase Ime4 epitranscriptionally regulates triacylglycerol metabolism and vacuolar morphology in haploid yeast cells.
[So] Source:J Biol Chem;292(33):13727-13744, 2017 Aug 18.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:-Methyladenosine (m A) is among the most common modifications in eukaryotic mRNA. The role of yeast m A methyltransferase, Ime4, in meiosis and sporulation in diploid strains is very well studied, but its role in haploid strains has remained unknown. Here, with the help of an immunoblotting strategy and Ime4-GFP protein localization studies, we establish the physiological role of Ime4 in haploid cells. Our data showed that Ime4 epitranscriptionally regulates triacylglycerol metabolism and vacuolar morphology through the long-chain fatty acyl-CoA synthetase Faa1, independently of the RNA methylation complex (MIS complex). The MIS complex consists of the Ime4, Mum2, and Slz1 proteins. Our affinity enrichment strategy (methylated RNA immunoprecipitation assays) using m A polyclonal antibodies coupled with mRNA isolation, quantitative real-time PCR, and standard PCR analyses confirmed the presence of m A-modified transcripts in haploid yeast cells. The term "epitranscriptional regulation" encompasses the RNA modification-mediated regulation of genes. Moreover, we demonstrate that the Aft2 transcription factor up-regulates expression. Because the m A methylation machinery is fundamentally conserved throughout eukaryotes, our findings will help advance the rapidly emerging field of RNA epitranscriptomics. The metabolic link identified here between m A methylation and triacylglycerol metabolism via the Ime4 protein provides new insights into lipid metabolism and the pathophysiology of lipid-related metabolic disorders, such as obesity. Because the yeast vacuole is an analogue of the mammalian lysosome, our findings pave the way to better understand the role of m A methylation in lysosome-related functions and diseases.
[Mh] Termos MeSH primário: Fator 2 Ativador da Transcrição/metabolismo
Coenzima A Ligases/metabolismo
Metiltransferases/metabolismo
Processamento Pós-Transcricional do RNA
Proteínas de Saccharomyces cerevisiae/metabolismo
Saccharomyces cerevisiae/fisiologia
Vacúolos/metabolismo
[Mh] Termos MeSH secundário: Fator 2 Ativador da Transcrição/genética
Substituição de Aminoácidos
Proteínas de Ciclo Celular/química
Proteínas de Ciclo Celular/genética
Proteínas de Ciclo Celular/metabolismo
Coenzima A Ligases/genética
Diploide
Epigênese Genética
Deleção de Genes
Regulação Fúngica da Expressão Gênica
Haploidia
Proteínas Luminescentes/genética
Proteínas Luminescentes/metabolismo
Metilação
Metiltransferases/química
Metiltransferases/genética
Microscopia Eletrônica de Varredura
Mutagênese Sítio-Dirigida
Mutação
Tamanho das Organelas
Proteínas Recombinantes de Fusão/metabolismo
Saccharomyces cerevisiae/genética
Saccharomyces cerevisiae/ultraestrutura
Proteínas de Saccharomyces cerevisiae/química
Proteínas de Saccharomyces cerevisiae/genética
Triglicerídeos/metabolismo
Vacúolos/ultraestrutura
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Activating Transcription Factor 2); 0 (Cell Cycle Proteins); 0 (Luminescent Proteins); 0 (Mum2 protein, S cerevisiae); 0 (Recombinant Fusion Proteins); 0 (Saccharomyces cerevisiae Proteins); 0 (Slz1 protein, S cerevisiae); 0 (Triglycerides); EC 2.1.1.- (Methyltransferases); EC 2.1.1.- (mRNA(adenine-N6)-methyltransferase); EC 6.2.1.- (Coenzyme A Ligases); EC 6.2.1.- (Faa1 protein, S cerevisiae)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.783761


  9 / 4616 MEDLINE  
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[PMID]:28640858
[Au] Autor:Angessa TT; Zhang XQ; Zhou G; Broughton S; Zhang W; Li C
[Ad] Endereço:Western Barley Genetics Alliance, School of Veterinary and Life Sciences (VLS), Murdoch University, Murdoch, WA, Australia.
[Ti] Título:Early growth stages salinity stress tolerance in CM72 x Gairdner doubled haploid barley population.
[So] Source:PLoS One;12(6):e0179715, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A doubled haploid (DH) population of barley (Hordeum vulgare L.) generated from salinity tolerant genotype CM72 and salinity sensitive variety Gairdner was studied for salinity stress tolerance at germination, seedling emergence and first leaf full expansion growth stages. Germination study was conducted with deionized water, 150 mM and 300 mM NaCl treatments. Seedling stage salinity tolerance was conducted with three treatments: control, 150 mM NaCl added at seedling emergence and first leaf full expansion growth stages. Results from this study revealed transgressive phenotypic segregations for germination percentage and biomass at seedling stage. Twelve QTL were identified on chromosomes 2H-6H each explaining 10-25% of the phenotypic variations. A QTL located at 176.5 cM on chromosome 3H was linked with fresh weight per plant and dry weight per plant in salinity stress induced at first leaf full expansion growth stage, and dry weight per plant in salinity stress induced at seedling emergence. A stable QTL for germination at both 150 and 300 mM salinity stress was mapped on chromosome 2H but distantly located from a QTL linked with seedling stage salinity stress tolerance. QTL, associated markers and genotypes identified in this study play important roles in developing salinity stress tolerant barley varieties.
[Mh] Termos MeSH primário: Haploidia
Hordeum/crescimento & desenvolvimento
Hordeum/genética
Hibridização Genética
Tolerância a Sal/genética
Estresse Fisiológico/genética
[Mh] Termos MeSH secundário: Germinação/efeitos dos fármacos
Hordeum/efeitos dos fármacos
Hordeum/fisiologia
Locos de Características Quantitativas/genética
Tolerância a Sal/efeitos dos fármacos
Plântulas/efeitos dos fármacos
Plântulas/crescimento & desenvolvimento
Cloreto de Sódio/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179715


  10 / 4616 MEDLINE  
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[PMID]:28633015
[Au] Autor:Sagi I; Benvenisty N
[Ad] Endereço:The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.
[Ti] Título:Haploidy in Humans: An Evolutionary and Developmental Perspective.
[So] Source:Dev Cell;41(6):581-589, 2017 Jun 19.
[Is] ISSN:1878-1551
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although haploidy has not been observed in vertebrates, its natural occurrence in various eukaryotic species that had diverged from diploid ancestors suggests that there is an innate capacity for an organism to regain haploidy and that haploidy may confer evolutionary benefits. Haploid embryonic stem cells have been experimentally generated from mouse, rat, monkey, and humans. Haploidy results in major differences in cell size and gene expression levels while also affecting parental imprinting, X chromosome inactivation, and mitochondrial metabolism genes. We discuss here haploidy in evolution and the barriers to haploidy, in particular in the human context.
[Mh] Termos MeSH primário: Diploide
Células-Tronco Embrionárias/citologia
Impressão Genômica/genética
Haploidia
Células-Tronco Pluripotentes/citologia
Inativação do Cromossomo X/genética
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE



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