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[PMID]:29267659
[Au] Autor:Jana A; Thomas J; Ghosh P
[Ad] Endereço:PMS College of Dental Science & Research, Department of Physiology, Kerala, India.
[Ti] Título:P-glycoprotein expression in oral lichen planus.
[So] Source:Braz Oral Res;31:e95, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Oral lichen planus (OLP) is a stress induced inflammatory condition with malignant potency. The mdr1 (multidrug resistance) is a stress gene overexpressed in cancerous conditions and its translated form, the p-glycoprotein efflux transporter is usually overexpressed with chemotherapy, leading to chemoresistance. OLP, a lesion with carcinogenic potency, is broadly classified into the asymptomatic reticular form and the aggressive erosive form. The objective of the study was to verify the expression level of p-glycoprotein in antifungal-treated and untreated reticular OLP, in untreated erosive OLP and erosive OLP patients treated with corticosteroid. Semi-quantitative reverse transcriptase polymerase chain reaction (SQ-RTPCR) and ELISA were performed on biopsy tissue samples to evaluate the mdr1 mRNA and protein expression of p-glycoprotein, respectively. The present study shows for the first time that mdr1 mRNA as well as its translated form p-glycoprotein are overexpressed in OLP subjects compared to healthy individuals. This overexpression is significantly higher in erosive than in reticular OLP patients, further confirming that the erosive form has higher risk for multidrug resistance. A higher expression is also observed in corticosteroid-treated erosive cases than similar untreated ones. The gradation of expression is in conformity with severity of the disease.
[Mh] Termos MeSH primário: Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo
Corticosteroides/uso terapêutico
Antifúngicos/uso terapêutico
Líquen Plano Bucal/tratamento farmacológico
Líquen Plano Bucal/metabolismo
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Biópsia
Farmacorresistência Fúngica Múltipla
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Líquen Plano Bucal/patologia
Masculino
Meia-Idade
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Índice de Gravidade de Doença
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ATP Binding Cassette Transporter, Sub-Family B); 0 (Adrenal Cortex Hormones); 0 (Antifungal Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  2 / 403 MEDLINE  
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[PMID]:28919635
[Au] Autor:van de Veerdonk FL; Gresnigt MS; Romani L; Netea MG; Latgé JP
[Ad] Endereço:Department of Internal Medicine, Radboud University Medical Center.
[Ti] Título:Aspergillus fumigatus morphology and dynamic host interactions.
[So] Source:Nat Rev Microbiol;15(11):661-674, 2017 Nov.
[Is] ISSN:1740-1534
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening disease in immunocompromised individuals. The interactions between A. fumigatus and the host environment are dynamic and complex. The host immune system needs to recognize the distinct morphological forms of A. fumigatus to control fungal growth and prevent tissue invasion, whereas the fungus requires nutrients and needs to adapt to the hostile environment by escaping immune recognition and counteracting host responses. Understanding these highly dynamic interactions is necessary to fully understand the pathogenesis of aspergillosis and to facilitate the design of new therapeutics to overcome the morbidity and mortality caused by A. fumigatus. In this Review, we describe how A. fumigatus adapts to environmental change, the mechanisms of host defence, and our current knowledge of the interplay between the host immune response and the fungus.
[Mh] Termos MeSH primário: Aspergilose/imunologia
Aspergillus fumigatus/citologia
Interações Hospedeiro-Patógeno
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Aspergillus fumigatus/patogenicidade
Parede Celular/química
Parede Celular/microbiologia
Farmacorresistência Fúngica Múltipla
Seres Humanos
Imunidade Inata
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1038/nrmicro.2017.90


  3 / 403 MEDLINE  
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[PMID]:28911046
[Au] Autor:Lewis RE; Verweij PE
[Ad] Endereço:Infectious Diseases Unit, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences, University of Bologna, Italy.
[Ti] Título:Animal Models for Studying Triazole Resistance in Aspergillus fumigatus.
[So] Source:J Infect Dis;216(suppl_3):S466-S473, 2017 Aug 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Infections caused by triazole-resistant Aspergillus fumigatus are associated with a higher probability of treatment failure and mortality. Because clinical experience in managing these infections is still limited, mouse models of invasive aspergillosis fulfill a critical void for studying treatment regimens designed to overcome resistance. The type of immunosuppression, the route of infection, the timing of antifungal administration, and the end points used to assess antifungal activity affect the interpretation of data from these models. Nevertheless, these models provide important insights that help guide treatment decisions in patients with triazole-resistant invasive aspergillosis. Animal models confirmed that a high triazole minimal inhibitory concentration corresponded with triazole treatment failure and that the efficacy of other classes of drugs, such as the polyenes and echinocandins, was not affected by the presence of triazole resistance mutations. Furthermore, the feasibility of triazole dose escalation, combination therapy, and prophylaxis were explored as strategies to overcome resistance.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Aspergillus fumigatus/efeitos dos fármacos
Farmacorresistência Fúngica Múltipla
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Aspergilose/tratamento farmacológico
Modelos Animais de Doenças
Equinocandinas/farmacologia
Seres Humanos
Camundongos
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Echinocandins); 0 (Triazoles)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix222


  4 / 403 MEDLINE  
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[PMID]:28911043
[Au] Autor:Arendrup MC; Patterson TF
[Ad] Endereço:Unit of Mycology, Statens Serum Institut.
[Ti] Título:Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment.
[So] Source:J Infect Dis;216(suppl_3):S445-S451, 2017 Aug 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Invasive Candida infections remain an important cause of morbidity and mortality, especially in hospitalized and immunocompromised or critically ill patients. A limited number of antifungal agents from only a few drug classes are available to treat patients with these serious infections. Resistance can be either intrinsic or acquired. Resistance mechanisms are not exchanged between Candida; thus, acquired resistance either emerges in response to an antifungal selection pressure in the individual patient or, more rarely, occur due to horizontal transmission of resistant strains between patients. Although multidrug resistance is uncommon, increasing reports of multidrug resistance to the azoles, echinocandins, and polyenes have occurred in several Candida species, most notably Candida glabrata and more recently Candida auris. Drivers are overall antifungal use, subtherapeutic drug levels at sites of infection/colonization, drug sequestration in the biofilm matrix, and, in the setting of outbreaks, suboptimal infection control. Moreover, recent research suggests that DNA mismatch repair gene mutations may facilitate acquisition of resistance mutations in C. glabrata specifically. Diagnosis of antifungal-resistant Candida infections is critical to the successful management of patients with these infections. Reduction of unnecessary use of antifungals via antifungal stewardship is critical to limit multidrug resistance emergence.
[Mh] Termos MeSH primário: Candida glabrata/efeitos dos fármacos
Candida/efeitos dos fármacos
Candidíase Invasiva/tratamento farmacológico
Farmacorresistência Fúngica Múltipla
[Mh] Termos MeSH secundário: Animais
Antifúngicos/farmacologia
Azóis/farmacologia
Candida/classificação
Candidíase Invasiva/epidemiologia
Estado Terminal/epidemiologia
Estado Terminal/terapia
Modelos Animais de Doenças
Equinocandinas/farmacologia
Seres Humanos
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Azoles); 0 (Echinocandins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix131


  5 / 403 MEDLINE  
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[PMID]:28911042
[Au] Autor:McCarthy MW; Kontoyiannis DP; Cornely OA; Perfect JR; Walsh TJ
[Ad] Endereço:Division of General Internal Medicine, Weill Cornell Medicine, New York, New York.
[Ti] Título:Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.
[So] Source:J Infect Dis;216(suppl_3):S474-S483, 2017 Aug 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The emergence of drug-resistant fungi poses a major threat to human health. Despite advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections continue to cause significant morbidity and mortality in patients with compromised immunity, underscoring the urgent need for new antifungal agents. In this article, we review the challenges associated with identifying broad-spectrum antifungal drugs and highlight novel targets that could enhance the armamentarium of agents available to treat drug-resistant invasive fungal infections.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Farmacorresistência Fúngica Múltipla
Fungos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Fungos/genética
Seres Humanos
Infecções Fúngicas Invasivas/tratamento farmacológico
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antifungal Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix130


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[PMID]:28911041
[Au] Autor:Perlin DS; Wiederhold NP
[Ad] Endereço:Public Health Research Institute, Rutgers Biomedical and Health Sciences, Newark, New Jersey.
[Ti] Título:Culture-Independent Molecular Methods for Detection of Antifungal Resistance Mechanisms and Fungal Identification.
[So] Source:J Infect Dis;216(suppl_3):S458-S465, 2017 Aug 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Resistance to azoles and echinocandins has emerged as a significant factor affecting the clinical management of patients with invasive fungal infections. Immunosuppressed patients at high risk for invasive fungal infections often have prolonged or repeated exposure to antifungals resulting in either the well-documented selection of naturally occurring, less susceptible fungal species, or the in situ development of specific resistance mechanisms. Nucleic acid-based molecular diagnostics are particularly well suited for the rapid detection of low-abundance fungal pathogens and identification of the infecting pathogen to the genus and species levels, as well as assessment of resistance mechanisms. A wide range of molecular probing technologies involving real-time polymerase chain reaction (PCR) assays that facilitate direct analysis of a single infecting genome in a sterile blood specimen are available and have recently been commercialized (eg, Roche LightCycler SeptiFast and T2 Biosystems T2Candida). One of the exciting applications of molecular technology is the direct detection of specific resistance mechanisms that evolve during therapy. In principle, the detection of resistance mechanisms that have been independently validated to cause resistance provides a culture-independent biomarker for potential therapeutic failure. The emergence of real-time PCR assays utilizing allele-specific molecular detection technology that is highly sensitive, robust, and high-throughput has the potential to improve patient care by providing faster detection of drug-resistant infecting strains and to help inform therapeutic management.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Farmacorresistência Fúngica Múltipla
Fungos/efeitos dos fármacos
Técnicas de Diagnóstico Molecular
[Mh] Termos MeSH secundário: Azóis/farmacologia
Equinocandinas/farmacologia
Fungos/classificação
Proteômica
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Azoles); 0 (Echinocandins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix121


  7 / 403 MEDLINE  
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[PMID]:28911040
[Au] Autor:McCarthy MW; Denning DW; Walsh TJ
[Ad] Endereço:Division of General Internal Medicine.
[Ti] Título:Future Research Priorities in Fungal Resistance.
[So] Source:J Infect Dis;216(suppl_3):S484-S492, 2017 Aug 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Improved understanding of basic mycological, pharmacological, and immunological processes has led to important advances in the diagnosis and treatment of invasive fungal infections. However, the rise of fungi that are resistant to existing antifungal agents poses a substantial threat to human health. Addressing this expanding problem is an urgent priority for the international research community. In this article, we highlight important diagnostic and therapeutic advances that address the rise of resistant fungi as well as new public health initiatives that warrant further investigation to help curb the spread of these potentially lethal organisms.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Pesquisa Biomédica/tendências
Farmacorresistência Fúngica Múltipla
Fungos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Seres Humanos
Micoses/diagnóstico
Micoses/tratamento farmacológico
Reação em Cadeia da Polimerase
Saúde Pública
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix103


  8 / 403 MEDLINE  
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[PMID]:28361556
[Au] Autor:Somboon P; Poonsawad A; Wattanachaisaereekul S; Jensen LT; Niimi M; Cheevadhanarak S; Soontorngun N
[Ad] Endereço:Division of Biochemical Technology, School of Bioresources & Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
[Ti] Título:Fungicide Xylaria sp. BCC 1067 extract induces reactive oxygen species and activates multidrug resistance system in Saccharomyces cerevisiae.
[So] Source:Future Microbiol;12:417-440, 2017 Apr.
[Is] ISSN:1746-0921
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: To investigate antifungal potential of Xylaria sp. BIOTEC culture collection (BCC) 1067 extract against the model yeast Saccharomyces cerevisiae. MATERIALS & METHODS: Antifungal property of extract, reactive oxygen species levels and cell survival were determined, using selected deletion strains. RESULTS: Extract showed promising antifungal effect with minimal inhibitory concentration and minimal fungicidal concentration of 500 and 1000 mg/l, respectively. Strong synergy was observed with fractional inhibitory concentration index value of 0.185 for the combination of 60.0 and 0.5 mg/l of extract and ketoconazole, respectively. Extract-induced intracellular reactive oxygen species levels in some oxidant-prone strains and mediated plasma membrane rupture. Antioxidant regulator Yap1, efflux transporter Pdr5 and ascorbate were pivotal to protect S. cerevisiae from extract cytotoxicity. CONCLUSION: Xylaria sp. BCC 1067 extract is a potentially valuable source of novel antifungals.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Produtos Biológicos/farmacologia
Misturas Complexas/farmacologia
Farmacorresistência Fúngica Múltipla
Estresse Oxidativo
Saccharomyces cerevisiae/efeitos dos fármacos
Xylariales/química
[Mh] Termos MeSH secundário: Antifúngicos/isolamento & purificação
Produtos Biológicos/isolamento & purificação
Misturas Complexas/isolamento & purificação
Viabilidade Microbiana/efeitos dos fármacos
Espécies Reativas de Oxigênio/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Biological Products); 0 (Complex Mixtures); 0 (Reactive Oxygen Species)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.2217/fmb-2016-0151


  9 / 403 MEDLINE  
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[PMID]:28333744
[Au] Autor:Todd B
[Ad] Endereço:AJN Clinical Editor.
[Ti] Título:Clinical Alert: Candida Auris.
[So] Source:Am J Nurs;117(4):53-55, 2017 Apr.
[Is] ISSN:1538-7488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new pathogen is making its presence known.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Candida/efeitos dos fármacos
Candidíase/diagnóstico
Candidíase/tratamento farmacológico
[Mh] Termos MeSH secundário: Doenças Transmissíveis Emergentes
Farmacorresistência Fúngica Múltipla
Seres Humanos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:AIM; IM; N
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1097/01.NAJ.0000515233.51795.b3


  10 / 403 MEDLINE  
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[PMID]:28235878
[Au] Autor:Rupp S; Plesken C; Rumsey S; Dowling M; Schnabel G; Weber RWS; Hahn M
[Ad] Endereço:Department of Biology, University of Kaiserslautern, Kaiserslautern, Germany.
[Ti] Título:Botrytis fragariae, a New Species Causing Gray Mold on Strawberries, Shows High Frequencies of Specific and Efflux-Based Fungicide Resistance.
[So] Source:Appl Environ Microbiol;83(9), 2017 May 01.
[Is] ISSN:1098-5336
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:causes pre- and postharvest decay of many fruit and vegetable crops. A survey of German strawberry fields revealed strains that differed from in diagnostic PCR markers and growth appearance. Phylogenetic analyses showed that these strains belong to an undescribed species in clade 2, named sp. nov. Isolates of were detected in strawberry fields throughout Germany, sometimes at frequencies similar to those of , and in the southeastern United States. was isolated from overwintering strawberry tissue but not from freshly infected fruit. invaded strawberry tissues with an efficiency similar to or lower than that of but showed poor colonization of inoculated nonhost plant tissues. These data and the exclusive occurrence of this fungus on strawberry plants indicate that is host specific and has a tissue preference different from that of Various fungicide resistance patterns were observed in populations. Many strains showed resistance to one or several chemical classes of fungicides and an efflux-based multidrug resistance (MDR1) phenotype previously described in Resistance-related mutations in were identical or similar to those of for carbendazim (E198A mutation in ), azoxystrobin (G143A in ), iprodione (G367A+V368F in ), and MDR1 (gain-of-function mutations in the transcription factor gene and overexpression of the drug efflux transporter gene ). The widespread occurrence of indicates that this species is adapted to fungicide-treated strawberry fields and may be of local importance as a gray mold pathogen alongside Gray mold is the most important fruit rot on strawberries worldwide and requires fungicide treatments for control. For a long time, it was believed to be caused only by , a ubiquitous pathogen with a broad host range that quickly develops fungicide resistance. We report the discovery and description of a new species, named , that is widely distributed in commercial strawberry fields in Germany and the southeastern United States. It was observed on overwintering tissue but not on freshly infected fruit and seems host specific on the basis of its occurrence and artificial infection tests. has also developed resistance to several fungicides that is caused by mutations similar to those known in , including an efflux-based multidrug resistance. Our data indicate that could be of practical importance as a strawberry pathogen in some regions where its abundance is similar to that of .
[Mh] Termos MeSH primário: Botrytis/classificação
Botrytis/efeitos dos fármacos
Farmacorresistência Fúngica Múltipla
Fragaria/microbiologia
Fungicidas Industriais/metabolismo
Fungicidas Industriais/farmacologia
[Mh] Termos MeSH secundário: Transporte Biológico Ativo
Botrytis/isolamento & purificação
Botrytis/metabolismo
DNA Fúngico/química
DNA Fúngico/genética
Proteínas Fúngicas/genética
Alemanha
Filogenia
Doenças das Plantas/microbiologia
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
Homologia de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Fungal); 0 (Fungal Proteins); 0 (Fungicides, Industrial)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE



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