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Pesquisa : G06.591.375 [Categoria DeCS]
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  1 / 4043 MEDLINE  
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[PMID]:29311119
[Au] Autor:Clemente JC; Manasson J; Scher JU
[Ad] Endereço:Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[Ti] Título:The role of the gut microbiome in systemic inflammatory disease.
[So] Source:BMJ;360:j5145, 2018 01 08.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The role of the gut microbiome in models of inflammatory and autoimmune disease is now well characterized. Renewed interest in the human microbiome and its metabolites, as well as notable advances in host mucosal immunology, has opened multiple avenues of research to potentially modulate inflammatory responses. The complexity and interdependence of these diet-microbe-metabolite-host interactions are rapidly being unraveled. Importantly, most of the progress in the field comes from new knowledge about the functional properties of these microorganisms in physiology and their effect in mucosal immunity and distal inflammation. This review summarizes the preclinical and clinical evidence on how dietary, probiotic, prebiotic, and microbiome based therapeutics affect our understanding of wellness and disease, particularly in autoimmunity.
[Mh] Termos MeSH primário: Doenças Autoimunes/microbiologia
Comportamento Alimentar/fisiologia
Microbioma Gastrointestinal/imunologia
Inflamação/microbiologia
Doenças Inflamatórias Intestinais/microbiologia
Membrana Mucosa/microbiologia
[Mh] Termos MeSH secundário: Doenças Autoimunes/imunologia
Transplante de Microbiota Fecal/métodos
Microbioma Gastrointestinal/fisiologia
Seres Humanos
Inflamação/imunologia
Doenças Inflamatórias Intestinais/imunologia
Doenças Inflamatórias Intestinais/patologia
Microbiota
Membrana Mucosa/imunologia
Prebióticos
Probióticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Prebiotics)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5145


  2 / 4043 MEDLINE  
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[PMID]:28461690
[Au] Autor:Mirzaei MK; Maurice CF
[Ad] Endereço:Department of Microbiology and Immunology, Microbiome Disease and Tolerance Centre, McGill University, 3775 University Street, Montreal, Quebec H3H 2B4, Canada.
[Ti] Título:Ménage à trois in the human gut: interactions between host, bacteria and phages.
[So] Source:Nat Rev Microbiol;15(7):397-408, 2017 07.
[Is] ISSN:1740-1534
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The human gut is host to one of the densest microbial communities known, the gut microbiota, which contains bacteria, archaea, viruses, fungi and other microbial eukaryotes. Bacteriophages in the gut are largely unexplored, despite their potential to regulate bacterial communities and thus human health. In addition to helping us understand gut homeostasis, applying an ecological perspective to the study of bacterial and phage communities in the gut will help us to understand how this microbial system functions. For example, temporal studies of bacteria, phages and host immune cells in the gut during health and disease could provide key information about disease development and inform therapeutic treatments, whereas understanding the regulation of the replication cycles of phages could help harness the gut microbiota to improve disease outcomes. As the most abundant biological entities in our gut, we must consider bacteriophages in our pursuit of personalized medicine.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Bacteriófagos/fisiologia
Microbioma Gastrointestinal
Interações Microbianas
[Mh] Termos MeSH secundário: Bactérias/classificação
Bactérias/virologia
Infecções Bacterianas/terapia
Seres Humanos
Medicina de Precisão/métodos
Vírus/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1038/nrmicro.2017.30


  3 / 4043 MEDLINE  
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[PMID]:29276981
[Au] Autor:Tao JH; Zhao M; Jiang S; Pu XL; Wei XY
[Ad] Endereço:School of Pharmacy, Nantong University, Nantong 226001, PR China.
[Ti] Título:Comparative metabolism of two major compounds in Fructus Corni extracts by gut microflora from normal and chronic nephropathy rats in vitro by UPLC-Q-TOF/MS.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1073:170-176, 2018 Jan 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Herbal medicines are widely used as therapeutic products in many countries. Fructus Corni, a traditional herb medicine, has been clinically used to cure chronic nephropathy for thousands of years. It could be converted by gut microflora in vivo to shape its pharmacological profiles. Thus, metabolic profiles of major active constituents in Fructus Corni extracts by gut microflora from rats in healthy and nephropathy state were firstly investigated in vitro by ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) in this study. According to the features of protonated ions, five metabolites (M1, M2, M3, M5 and M6) were found and preliminarily authenticated. Intestinal bacteria were capable of converting N0 (loganin) to its aglycone M1 (loganetin). The latter was further hydrogenated to the corresponding M2 (hydrogenated loganetin) and subsequently to M3 (hydrogenated and demethylated loganetin) by demethylation; While M5 (demethylated morronisid aglycone) and M6 (dehydroxylated morronisid aglycone) were identified as the two metabolites of N4 (morronisid) through demethylation and dehydroxylation. Gut microflora from healthy and nephropathy rats could degrade loganin and morronisid to the above metabolites. However, healthy rat intestinal bacteria showed more powerful degradation and much more amounts of M1 and M6 were obtained in their samples. Additionally, this work demonstrated that UPLC-Q-TOF/MS approach connected with MetaboLynx™ analysis software was rapid and reliable for screening and authentication of natural product metabolites.
[Mh] Termos MeSH primário: Cornus/química
Microbioma Gastrointestinal/fisiologia
Glicosídeos
Iridoides
Insuficiência Renal Crônica/metabolismo
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão/métodos
Glicosídeos/análise
Glicosídeos/metabolismo
Iridoides/análise
Iridoides/metabolismo
Espectrometria de Massas/métodos
Extratos Vegetais/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Iridoids); 0 (Plant Extracts); 0 (morroniside); H7WJ16Q93C (loganin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171226
[St] Status:MEDLINE


  4 / 4043 MEDLINE  
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[PMID]:29427649
[Au] Autor:Blagojevic V; Kovacevic-Jovanovic V; Curuvija I; Petrovic R; Vujnovic I; Vujic V; Stanojevic S
[Ad] Endereço:Immunology Research Centre "Branislav Jankovic", Institute of Virology, Vaccines and Sera "Torlak", Belgrade, Serbia. Electronic address: sstanojevic@torlak.rs.
[Ti] Título:Rat strain differences in peritoneal immune cell response to selected gut microbiota: A crossroad between tolerance and autoimmunity?
[So] Source:Life Sci;197:147-157, 2018 Mar 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Some gut commensals can be protective, whereas others are implicated as necessary for development of inflammatory/autoimmune diseases. Peritoneal immune cells may play an important role in promoting autoimmunity in response to gut microbiota. This study investigated the phenotype and the function of peritoneal immune cells in the autoimmunity-resistant Albino Oxford (AO), and the autoimmunity-prone Dark Agouti (DA) rat strains upon stimulation with their own colonic E. coli or Enterococcus. MAIN METHODS: Rats were intraperitoneally injected with their own E. coli or Enterococcus. Peritoneal cells isolated two days later were tested for nitric oxide (NO) and cytokine production, and for arginase and myeloperoxidase (MPO) activity. The phenotype of cells was determined using flow cytometry. KEY FINDINGS: While the Enterococcus injection did not affect the composition of peritoneal cells in AO rats, the E. coli treatment increased the percentages of activated CD11b HIS48 neutrophils, and decreased the proportion of resident (CD11b HIS48 , CD163 + CD86+) and anti-inflammatory CD68 + CD206+ macrophages. E. coli increased the production of NO and urea, but preserved their ratio in cells from AO rats. Conversely, both E. coli and Enterococcus diminished the proportion of resident and anti-inflammatory macrophages, increased the proportion of activated neutrophils, and induced inflammatory polarization of peritoneal cells in DA rats. However, injection of E. coli maintained the ratio of typical CD11b HIS48 neutrophils in DA rats, which correlated with the sustained MPO activity. SIGNIFICANCE: The rat strain differences in peritoneal cell response to own commensal microbiota may contribute to differential susceptibility to inflammatory/autoimmune diseases.
[Mh] Termos MeSH primário: Enterococcus/imunologia
Escherichia coli/imunologia
Microbioma Gastrointestinal/imunologia
Macrófagos Peritoneais/imunologia
Neutrófilos/imunologia
Peritônio/imunologia
[Mh] Termos MeSH secundário: Animais
Arginase/imunologia
Citocinas/imunologia
Feminino
Óxido Nítrico/imunologia
Peritônio/microbiologia
Peroxidase/imunologia
Ratos
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 31C4KY9ESH (Nitric Oxide); EC 1.11.1.7 (Peroxidase); EC 3.5.3.1 (Arginase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180211
[St] Status:MEDLINE


  5 / 4043 MEDLINE  
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[PMID]:27773355
[Au] Autor:Vuong HE; Hsiao EY
[Ad] Endereço:Department of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, California.
[Ti] Título:Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder.
[So] Source:Biol Psychiatry;81(5):411-423, 2017 03 01.
[Is] ISSN:1873-2402
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that affects one in 45 children in the United States, with a similarly striking prevalence in countries around the world. However, mechanisms underlying its etiology and manifestations remain poorly understood. Although ASD is diagnosed based on the presence and severity of impaired social communication and repetitive behavior, immune dysregulation and gastrointestinal issues are common comorbidities. The microbiome is an integral part of human physiology; recent studies show that changes in the gut microbiota can modulate gastrointestinal physiology, immune function, and even behavior. Links between particular bacteria from the indigenous gut microbiota and phenotypes relevant to ASD raise the important question of whether microbial dysbiosis plays a role in the development or presentation of ASD symptoms. Here we review reports of microbial dysbiosis in ASD. We further discuss potential effects of the microbiota on ASD-associated symptoms, drawing on signaling mechanisms for reciprocal interactions among the microbiota, immunity, gut function, and behavior. In addition, we discuss recent findings supporting a role for the microbiome as an interface between environmental and genetic risk factors that are associated with ASD. These studies highlight the integration of pathways across multiple body systems that together can impact brain and behavior and suggest that changes in the microbiome may contribute to symptoms of neurodevelopmental disease.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/imunologia
Transtorno do Espectro Autista/microbiologia
Microbioma Gastrointestinal
Trato Gastrointestinal/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Transtorno do Espectro Autista/genética
Transtorno do Espectro Autista/fisiopatologia
Comportamento Animal
Encéfalo/imunologia
Encéfalo/microbiologia
Criança
Pré-Escolar
Modelos Animais de Doenças
Endofenótipos
Trato Gastrointestinal/microbiologia
Trato Gastrointestinal/fisiopatologia
Seres Humanos
Camundongos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  6 / 4043 MEDLINE  
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[PMID]:29367525
[Au] Autor:Tanemoto S; Sujino T; Kanai T
[Ad] Endereço:Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine.
[Ti] Título:[Intestinal immune response is regulated by gut microbe].
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;40(6):408-415, 2017.
[Is] ISSN:1349-7413
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:  Human Intestine has a diverse population of bacteria which induces pathogens to disrupt not only the intestinal homeostasis but whole body immune systems. Dysbiosis, the abnormal proliferation and reduction of the microbiota, breaks down the homeostasis of the immunity and metabolisms in the host. The evolution of the microbiota analysis technology contributed to reveal the molecular biological complex interaction between the microbiota and its host systemically as well as locally. Because several diseases are caused by the dysbiosis, fecal transplantation would be the new therapeutic target for them. It has been investigated in some intestinal diseases such as CD infection, or inflammatory bowel disease. Here, we review these symbiotic interactions and the current state for the clinical application.
[Mh] Termos MeSH primário: Microbioma Gastrointestinal/imunologia
Microbioma Gastrointestinal/fisiologia
Intestinos/imunologia
Intestinos/microbiologia
[Mh] Termos MeSH secundário: Disbiose/imunologia
Disbiose/microbiologia
Disbiose/terapia
Transplante de Microbiota Fecal
Homeostase/imunologia
Seres Humanos
Doenças Inflamatórias Intestinais/imunologia
Doenças Inflamatórias Intestinais/microbiologia
Doenças Inflamatórias Intestinais/terapia
Simbiose
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.2177/jsci.40.408


  7 / 4043 MEDLINE  
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[PMID]:29241038
[Au] Autor:Hernández-Santos N; Klein BS
[Ad] Endereço:Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA.
[Ti] Título:Through the Scope Darkly: The Gut Mycobiome Comes into Focus.
[So] Source:Cell Host Microbe;22(6):728-729, 2017 12 13.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The gut microbiome is comprised of microbes from multiple kingdoms, including bacteria, but also fungi, viruses, and perhaps other agents. In this issue of Cell Host & Microbe, Jiang et al. (2017) reveal that fungal monocolonization after antibiotic-mediated depletion of intestinal bacteria prevents colitis and influenza, thus highlighting beneficial roles of fungi.
[Mh] Termos MeSH primário: Microbioma Gastrointestinal
Micobioma
[Mh] Termos MeSH secundário: Bactérias
Fungos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  8 / 4043 MEDLINE  
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[PMID]:29363966
[Au] Autor:Van den Abbeele P; Taminiau B; Pinheiro I; Duysburgh C; Jacobs H; Pijls L; Marzorati M
[Ad] Endereço:ProDigest bvba , Technologiepark 3, 9052 Ghent, Belgium.
[Ti] Título:Arabinoxylo-Oligosaccharides and Inulin Impact Inter-Individual Variation on Microbial Metabolism and Composition, Which Immunomodulates Human Cells.
[So] Source:J Agric Food Chem;66(5):1121-1130, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fecal batch fermentations coupled to cocultures of epithelial cells and macrophages were used to compare how arabinoxylo-oligosaccharides (AXOS) and inulin modulate gut microbial activity and composition of three different human donors and subsequently the epithelial permeability and immune response. Both inulin and AXOS decreased the pH during incubation (-1.5 pH units), leading to increased productions of acetate, propionate, and butyrate. Differences in terms of metabolites production could be linked to specific microbial alterations at genus level upon inulin/AXOS supplementation (i.e., Bifidobacterium, Bacteroides, Prevotella and unclassified Erysipelotrichaceae), as shown by 16S-targeted Illumina sequencing. Both products stimulated gut barrier and immune function with increases in TEER, NF-KB, IL-10, and IL-6. Ingredients with different structures selectively modulate the microbiota of a specific donor leading to differential changes at metabolic level. The extent of this effect is donor specific and is linked to a final specific modulation of the host's immune system.
[Mh] Termos MeSH primário: Microbioma Gastrointestinal/efeitos dos fármacos
Imunomodulação/efeitos dos fármacos
Inulina/farmacologia
Oligossacarídeos/farmacologia
Xilanos/farmacologia
[Mh] Termos MeSH secundário: Acetatos/metabolismo
Butiratos/metabolismo
Células CACO-2
Fezes/microbiologia
Fermentação
Microbioma Gastrointestinal/imunologia
Microbioma Gastrointestinal/fisiologia
Seres Humanos
Concentração de Íons de Hidrogênio
Propionatos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Butyrates); 0 (Oligosaccharides); 0 (Propionates); 0 (Xylans); 9005-80-5 (Inulin); 9040-27-1 (arabinoxylan)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04611


  9 / 4043 MEDLINE  
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[PMID]:29363955
[Au] Autor:Oh SY; Youn SY; Park MS; Baek NI; Ji GE
[Ad] Endereço:Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University , Seoul 151-742, Republic of Korea.
[Ti] Título:Synthesis of Stachyobifiose Using Bifidobacterial α-Galactosidase Purified from Recombinant Escherichia coli.
[So] Source:J Agric Food Chem;66(5):1184-1190, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The prebiotic effects of GOS (galactooligosaccharides) are known to depend on the glycosidic linkages, degree of polymerization (DP), and the monosaccharide composition. In this study, a novel form of α-GOS with a potentially improved prebiotic effect was synthesized using bifidobacterial α-galactosidase (α-Gal) purified from recombinant Escherichia coli. The carbohydrate produced was identified as α-d-galactopyranosyl-(1→6)-O-α-d-glucopyranosyl-(1→2)-[α-d-galactopyranosyl-(1→6)-O-ß-d-fructofuranoside] and was termed stachyobifiose. Among 17 nonprobiotics, 16 nonprobiotics showed lower growth on stachyobifiose than ß-GOS. In contrast, among the 16 probiotics, 6 probiotics showed higher growth on stachyobifiose than ß-GOS. When compared with raffinose, stachyobifiose was used less by nonprobiotics than raffinose. Moreover, compared with stachyose, stachyobifiose was used less by Escherichia coli, Enterobacter cloacae, and Clostridium butyricum. The average amounts of total short-chain fatty acids (SCFA) produced were in the order of stachyobifiose > stachyose > raffinose > ß-GOS. Taken together, stachyobifiose is expected to contribute to beneficial changes of gut microbiota.
[Mh] Termos MeSH primário: Bifidobacterium/enzimologia
Microbioma Gastrointestinal/fisiologia
Oligossacarídeos/biossíntese
Prebióticos
Proteínas Recombinantes/metabolismo
alfa-Galactosidase/metabolismo
[Mh] Termos MeSH secundário: Bactérias/crescimento & desenvolvimento
Escherichia coli/enzimologia
Escherichia coli/genética
Galactose/metabolismo
Oligossacarídeos/metabolismo
Probióticos
Rafinose/metabolismo
alfa-Galactosidase/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oligosaccharides); 0 (Prebiotics); 0 (Recombinant Proteins); 25VX64653N (stachyose); EC 3.2.1.22 (alpha-Galactosidase); N5O3QU595M (Raffinose); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04703


  10 / 4043 MEDLINE  
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[PMID]:29329346
[Au] Autor:Nycz BT; Dominguez SR; Friedman D; Hilden JM; Ir D; Robertson CE; Frank DN
[Ad] Endereço:Division of Adult Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
[Ti] Título:Evaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients.
[So] Source:PLoS One;13(1):e0191232, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bloodstream infections (BSI) and Clostridium difficile infections (CDI) in pediatric oncology/hematology/bone marrow transplant (BMT) populations are associated with significant morbidity and mortality. The objective of this study was to explore possible associations between altered microbiome composition and the occurrence of BSI and CDI in a cohort of pediatric oncology patients. Stool samples were collected from all patients admitted to the pediatric oncology floor from Oct.-Dec. 2012. Bacterial profiles from patient stools were determined by bacterial 16S rRNA gene profiling. Differences in overall microbiome composition were assessed by a permutation-based multivariate analysis of variance test, while differences in the relative abundances of specific taxa were assessed by Kruskal-Wallis tests. At admission, 9 of 42 patients (21%) were colonized with C. difficile, while 6 of 42 (14%) subsequently developed a CDI. Furthermore, 3 patients (7%) previously had a BSI and 6 patients (14%) subsequently developed a BSI. Differences in overall microbiome composition were significantly associated with disease type (p = 0.0086), chemotherapy treatment (p = 0.018), BSI following admission from any cause (p < 0.0001) or suspected gastrointestinal organisms (p = 0.00043). No differences in baseline microbiota were observed between individuals who did or did not subsequently develop C. difficile infection. Additionally, multiple bacterial groups varied significantly between subjects with post-admission BSI compared with no BSI. Our results suggest that differences in gut microbiota not only are associated with type of cancer and chemotherapy, but may also be predictive of subsequent bloodstream infection.
[Mh] Termos MeSH primário: Bacteriemia/complicações
Infecções por Clostridium/complicações
Microbioma Gastrointestinal
Neoplasias/complicações
Neoplasias/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Bacteriemia/microbiologia
Proteínas de Bactérias/genética
Toxinas Bacterianas/genética
Biodiversidade
Criança
Pré-Escolar
Infecções por Clostridium/microbiologia
Clostridium difficile/genética
Estudos de Coortes
Estudos Transversais
Fezes/microbiologia
Feminino
Microbioma Gastrointestinal/genética
Genes Bacterianos
Seres Humanos
Masculino
Valor Preditivo dos Testes
RNA Bacteriano/genética
RNA Ribossômico 16S/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Bacterial Toxins); 0 (RNA, Bacterial); 0 (RNA, Ribosomal, 16S); 0 (toxB protein, Clostridium difficile)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191232



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde