Base de dados : MEDLINE
Pesquisa : G06.591.875 [Categoria DeCS]
Referências encontradas : 24 [refinar]
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  1 / 24 MEDLINE  
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[PMID]:29241038
[Au] Autor:Hernández-Santos N; Klein BS
[Ad] Endereço:Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA.
[Ti] Título:Through the Scope Darkly: The Gut Mycobiome Comes into Focus.
[So] Source:Cell Host Microbe;22(6):728-729, 2017 12 13.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The gut microbiome is comprised of microbes from multiple kingdoms, including bacteria, but also fungi, viruses, and perhaps other agents. In this issue of Cell Host & Microbe, Jiang et al. (2017) reveal that fungal monocolonization after antibiotic-mediated depletion of intestinal bacteria prevents colitis and influenza, thus highlighting beneficial roles of fungi.
[Mh] Termos MeSH primário: Microbioma Gastrointestinal
Micobioma
[Mh] Termos MeSH secundário: Bactérias
Fungos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  2 / 24 MEDLINE  
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[PMID]:29326275
[Au] Autor:Leonardi I; Li X; Semon A; Li D; Doron I; Putzel G; Bar A; Prieto D; Rescigno M; McGovern DPB; Pla J; Iliev ID
[Ad] Endereço:Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
[Ti] Título:CX3CR1 mononuclear phagocytes control immunity to intestinal fungi.
[So] Source:Science;359(6372):232-236, 2018 01 12.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and inflammatory disease. Nonetheless, the mechanisms governing immunity to gut fungal communities (mycobiota) remain unknown. We identified CX3CR1 mononuclear phagocytes (MNPs) as being essential for the initiation of innate and adaptive immune responses to intestinal fungi. CX3CR1 MNPs express antifungal receptors and activate antifungal responses in a Syk-dependent manner. Genetic ablation of CX3CR1 MNPs in mice led to changes in gut fungal communities and to severe colitis that was rescued by antifungal treatment. In Crohn's disease patients, a missense mutation in the gene encoding CX3CR1 was identified and found to be associated with impaired antifungal responses. These results unravel a role of CX3CR1 MNPs in mediating interactions between intestinal mycobiota and host immunity at steady state and during inflammatory disease.
[Mh] Termos MeSH primário: Receptor 1 de Quimiocina CX3C/análise
Receptor 1 de Quimiocina CX3C/genética
Candida albicans/imunologia
Microbioma Gastrointestinal/imunologia
Intestinos/microbiologia
Micobioma/imunologia
Fagócitos/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antifúngicos/biossíntese
Anticorpos Antifúngicos/sangue
Candida albicans/crescimento & desenvolvimento
Colite/tratamento farmacológico
Colite/microbiologia
Doença de Crohn/genética
Doença de Crohn/imunologia
Células Dendríticas/imunologia
Microbioma Gastrointestinal/fisiologia
Seres Humanos
Imunidade nas Mucosas
Imunoglobulina G/biossíntese
Imunoglobulina G/sangue
Intestinos/imunologia
Camundongos
Mutação de Sentido Incorreto
Micobioma/fisiologia
Fagócitos/microbiologia
Linfócitos T Reguladores/imunologia
Células Th17/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Antibodies, Fungal); 0 (CX3C Chemokine Receptor 1); 0 (CX3CR1 protein, human); 0 (Cx3cr1 protein, mouse); 0 (Immunoglobulin G)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1126/science.aao1503


  3 / 24 MEDLINE  
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[PMID]:28732571
[Au] Autor:Stefanaki C; Peppa M; Mastorakos G; Chrousos GP
[Ad] Endereço:1st Department of Pediatrics, Choremeio Research Laboratory, Athens University Medical School, National and Kapodistrian University of Athens, Medical School, Athens, Greece. Electronic address: cstefanaki@gmail.com.
[Ti] Título:Examining the gut bacteriome, virome, and mycobiome in glucose metabolism disorders: Are we on the right track?
[So] Source:Metabolism;73:52-66, 2017 Aug.
[Is] ISSN:1532-8600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human gut microbiome is defined as the gene complement of the gut microbial community, measured via laboratory metagenomic techniques. It includes bacteriome, virome and mycobiome, which represent, respectively, the assemblages of bacteria, viruses and fungi, living in the human gut. Gut microbiota function as a living "organ" that interacts with the gastro-intestinal environment, provides nutrients and vitamins to the organism and transduces hormonal messages, essentially influencing the main metabolic pathways, including drug metabolism. A clear association between gut, and glucose metabolism disorders has recently emerged. Medications acting on glucose absorption in the gut, or enhancing gut hormone activity are already extensively employed in the therapy of diabetes. Moreover, the gut is characterized by immune, and autonomous neuronal features, which play a critical role in maintaining glucose metabolism homeostasis. Gut microbes respond to neuroendocrine, and immune biochemical messages, affecting the health, and behavior of the host. There is vast heterogeneity in the studies included in this review, hence a meta-analysis, or a systematic review were not applicable. In this article, we attempt to reveal the interplay between human gut microbiota physiology, and hyperglycemic states, synthesizing, and interpreting findings from human studies.
[Mh] Termos MeSH primário: Microbioma Gastrointestinal/fisiologia
Transtornos do Metabolismo de Glucose
Microbiota/fisiologia
Micobioma/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Hiperglicemia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE


  4 / 24 MEDLINE  
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[PMID]:28403451
[Au] Autor:Lyon J
[Ti] Título:The Lung Microbiome: Key to Respiratory Ills?
[So] Source:JAMA;317(17):1713-1714, 2017 May 02.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Pneumopatias/microbiologia
Pulmão/microbiologia
Microbiota
[Mh] Termos MeSH secundário: Amish
Asma/etnologia
Asma/microbiologia
Asma/terapia
Disbiose/etiologia
Seres Humanos
Pneumopatias/terapia
Microbiota/imunologia
Microbiota/fisiologia
Micobioma
[Pt] Tipo de publicação:INTERVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.3023


  5 / 24 MEDLINE  
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[PMID]:28222761
[Au] Autor:Strati F; Cavalieri D; Albanese D; De Felice C; Donati C; Hayek J; Jousson O; Leoncini S; Renzi D; Calabrò A; De Filippo C
[Ad] Endereço:Computational Biology Research Unit, Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38010, San Michele all' Adige, Italy.
[Ti] Título:New evidences on the altered gut microbiota in autism spectrum disorders.
[So] Source:Microbiome;5(1):24, 2017 Feb 22.
[Is] ISSN:2049-2618
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Autism spectrum disorders (ASDs) are neurodevelopmental conditions characterized by social and behavioural impairments. In addition to neurological symptoms, ASD subjects frequently suffer from gastrointestinal abnormalities, thus implying a role of the gut microbiota in ASD gastrointestinal pathophysiology. RESULTS: Here, we characterized the bacterial and fungal gut microbiota in a cohort of autistic individuals demonstrating the presence of an altered microbial community structure. A fraction of 90% of the autistic subjects were classified as severe ASDs. We found a significant increase in the Firmicutes/Bacteroidetes ratio in autistic subjects due to a reduction of the Bacteroidetes relative abundance. At the genus level, we observed a decrease in the relative abundance of Alistipes, Bilophila, Dialister, Parabacteroides, and Veillonella in the ASD cohort, while Collinsella, Corynebacterium, Dorea, and Lactobacillus were significantly increased. Constipation has been then associated with different bacterial patterns in autistic and neurotypical subjects, with constipated autistic individuals characterized by high levels of bacterial taxa belonging to Escherichia/Shigella and Clostridium cluster XVIII. We also observed that the relative abundance of the fungal genus Candida was more than double in the autistic than neurotypical subjects, yet due to a larger dispersion of values, this difference was only partially significant. CONCLUSIONS: The finding that, besides the bacterial gut microbiota, also the gut mycobiota contributes to the alteration of the intestinal microbial community structure in ASDs opens the possibility for new potential intervention strategies aimed at the relief of gastrointestinal symptoms in ASDs.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/microbiologia
Fezes/microbiologia
Microbioma Gastrointestinal
Trato Gastrointestinal/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Transtorno do Espectro Autista/diagnóstico
Transtorno do Espectro Autista/etiologia
Bactérias/classificação
Bactérias/genética
Bactérias/isolamento & purificação
Criança
Pré-Escolar
Clostridium/genética
Clostridium/isolamento & purificação
Constipação Intestinal
Feminino
Firmicutes/genética
Firmicutes/isolamento & purificação
Fungos/classificação
Fungos/genética
Fungos/isolamento & purificação
Gastroenteropatias/microbiologia
Trato Gastrointestinal/microbiologia
Seres Humanos
Lactobacillus/genética
Lactobacillus/isolamento & purificação
Masculino
Micobioma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1186/s40168-017-0242-1


  6 / 24 MEDLINE  
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[PMID]:28165395
[Au] Autor:Sam QH; Chang MW; Chai LY
[Ad] Endereço:Division of Infectious Diseases, University Medicine Cluster, National University Health System, Singapore 119228, Singapore. qi_hui_sam@nuhs.edu.sg.
[Ti] Título:The Fungal Mycobiome and Its Interaction with Gut Bacteria in the Host.
[So] Source:Int J Mol Sci;18(2), 2017 Feb 04.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The advent of sequencing technology has endowed us with the capacity to study microbes constituting the human commensal community that were previously non-culturable. Much of the initial works have concentrated on the bacterial flora constituting the gut microbiome, since specimens are readily accessible in health and disease. Less, however, is understood of the "silent population"-the fungal species, also known as the mycobiome. Living in symbiosis with bacteria as commensals in our body, it is perceivable that the mycobiome exerts an inadvertent influence on the microbiome. We review here the recent knowledge gained from study of the interaction between the mycobiome and microbiome in health and disease susceptibility, immunity, and consequences from antimicrobial treatment.
[Mh] Termos MeSH primário: Bactérias
Fungos
Microbioma Gastrointestinal
Interações Microbianas
[Mh] Termos MeSH secundário: Animais
Antibiose
Dieta
Suscetibilidade a Doenças
Interações Hospedeiro-Patógeno/imunologia
Seres Humanos
Imunidade
Micobioma
Obesidade/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE


  7 / 24 MEDLINE  
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[PMID]:28040157
[Au] Autor:De Filippis F; La Storia A; Blaiotta G
[Ad] Endereço:Department of Agricultural Sciences, Division of Microbiology, University of Naples Federico II, Via Università 100, 80055 Portici, Italy. Electronic address: francesca.defilippis@unina.it.
[Ti] Título:Monitoring the mycobiota during Greco di Tufo and Aglianico wine fermentation by 18S rRNA gene sequencing.
[So] Source:Food Microbiol;63:117-122, 2017 May.
[Is] ISSN:1095-9998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Spontaneous alcoholic fermentation of grape must is a complex process, carried out by indigenous yeast populations arising from the vineyard or the winery environment and therefore representing an autochthonous microbial terroir of the production area. Microbial diversity at species and biotype level is extremely important in order to develop the composite and typical flavour profile of DOCG (Appellation of Controlled and Guaranteed Origin) wines. In this study, we monitored fungal populations involved in spontaneous fermentations of Aglianico and Greco di Tufo grape must by high-throughput sequencing (HTS) of 18S rRNA gene amplicons. We firstly proposed an alternative/addition to ITS as target gene in HTS studies and highlighted consistency between the culture-dependent and -independent approaches. A complex mycobiota was found at the beginning of the fermentation, mainly characterized by non-Saccharomyces yeasts and several moulds, with differences between the two types of grapes. Moreover, Interdelta patterns revealed a succession of several Saccharomyces cerevisiae biotypes and a high genetic diversity within this species.
[Mh] Termos MeSH primário: Fermentação
Genes de RNAr
Variação Genética
Micobioma
RNA Ribossômico 18S/genética
Vinho/microbiologia
[Mh] Termos MeSH secundário: Microbiologia de Alimentos
Fungos/genética
Sequenciamento de Nucleotídeos em Larga Escala
Microbiologia Industrial
Micobioma/genética
Técnicas de Tipagem Micológica
Saccharomyces cerevisiae
Vitis/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 18S)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE


  8 / 24 MEDLINE  
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[PMID]:27697164
[Au] Autor:Taniwaki MH; Frisvad JC; Ferranti LS; de Souza Lopes A; Larsen TO; Fungaro MHP; Iamanaka BT
[Ad] Endereço:Instituto de Tecnologia de Alimentos - ITAL, C.P. 139, CEP 13070-178, Campinas, SP, Brazil. Electronic address: marta@ital.sp.gov.br.
[Ti] Título:Biodiversity of mycobiota throughout the Brazil nut supply chain: From rainforest to consumer.
[So] Source:Food Microbiol;61:14-22, 2017 Feb.
[Is] ISSN:1095-9998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A total of 172 Brazil nut samples (114 in shell and 58 shelled) from the Amazon rainforest region and São Paulo state, Brazil was collected at different stages of the Brazil nut production chain: rainforest, street markets, processing plants and supermarkets. The mycobiota of the Brazil nut samples were evaluated and also compared in relation to water activity. A huge diversity of Aspergillus and Penicillium species were found, besides Eurotium spp., Zygomycetes and dematiaceous fungi. A polyphasic approach using morphological and physiological characteristics, as well as molecular and extrolite profiles, were studied to distinguish species among the more important toxigenic ones in Aspergillus section Flavi and A. section Nigri. Several metabolites and toxins were found in these two sections. Ochratoxin A (OTA) was found in 3% of A. niger and 100% of A. carbonarius. Production of aflatoxins B and G were found in all isolates of A. arachidicola, A. bombycis, A. nomius, A. pseudocaelatus and A. pseudonomius, while aflatoxin B was found in 38% of A. flavus and all isolates of A. pseudotamarii. Cyclopiazonic acid (CPA) was found in A. bertholletius (94%), A. tamarii (100%), A. caelatus (54%) and A. flavus (41%). Tenuazonic acid, a toxin commonly found in Alternaria species was produced by A. bertholletius (47%), A. caelatus (77%), A. nomius (55%), A. pseudonomius (75%), A. arachidicola (50%) and A. bombycis (100%). This work shows the changes of Brazil nut mycobiota and the potential of mycotoxin production from rainforest to consumer, considering the different environments which exist until the nuts are consumed.
[Mh] Termos MeSH primário: Biodiversidade
Abastecimento de Alimentos
Fungos/isolamento & purificação
Micobioma
Nozes/microbiologia
[Mh] Termos MeSH secundário: Aflatoxinas/análise
Aspergillus/isolamento & purificação
Aspergillus/fisiologia
Aspergillus flavus/isolamento & purificação
Aspergillus flavus/fisiologia
Brasil
Segurança de Produtos ao Consumidor
Microbiologia de Alimentos
Fungos/fisiologia
Micobioma/fisiologia
Penicillium/isolamento & purificação
Penicillium/fisiologia
Floresta Úmida
Ácido Tenuazônico/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aflatoxins); 610-88-8 (Tenuazonic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


  9 / 24 MEDLINE  
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[PMID]:27687872
[Au] Autor:Malacrinò A; Schena L; Campolo O; Laudani F; Mosca S; Giunti G; Strano CP; Palmeri V
[Ad] Endereço:Dipartimento di Agraria, Università degli Studi "Mediterranea" di Reggio Calabria, Reggio Calabria, Italy.
[Ti] Título:A Metabarcoding Survey on the Fungal Microbiota Associated to the Olive Fruit Fly.
[So] Source:Microb Ecol;73(3):677-684, 2017 Apr.
[Is] ISSN:1432-184X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The occurrence of interaction between insects and fungi is interesting from an ecological point of view, particularly when these interactions involve insect pests and plant pathogens within an agroecosystem. In this study, we aimed to perform an accurate analysis on the fungal microbiota associated to Bactrocera oleae (Rossi) through a metabarcoding approach based on 454 pyrosequencing. From this analysis, we retrieved 43,549 reads that clustered into 128 operational taxonomic units (OTUs), of which 29 resulted in the "core" associate fungi of B. oleae. This fungal community was mainly represented by sooty mould fungi, such as Cladosporium spp., Alternaria spp. and Aureobasidium spp., by plant pathogens like Colletotrichum spp. and Pseudocercospora spp., along with several other less abundant taxa whose ecology is unclear in most of the cases. Our findings lead to new insights into the microbial ecology of this specific ecological niche, enabling the understanding of a complex network of interactions within the olive agroecosystem.
[Mh] Termos MeSH primário: Alternaria/classificação
Ascomicetos/classificação
Cladosporium/classificação
Colletotrichum/classificação
Código de Barras de DNA Taxonômico/métodos
Micobioma/genética
Tephritidae/microbiologia
[Mh] Termos MeSH secundário: Alternaria/genética
Alternaria/isolamento & purificação
Animais
Ascomicetos/genética
Ascomicetos/isolamento & purificação
Sequência de Bases
Cladosporium/genética
Cladosporium/isolamento & purificação
Colletotrichum/genética
Colletotrichum/isolamento & purificação
DNA Intergênico/genética
Sequenciamento de Nucleotídeos em Larga Escala
Olea
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Intergenic)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.1007/s00248-016-0864-z


  10 / 24 MEDLINE  
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[PMID]:28030619
[Au] Autor:Nguyen LD; Deschaght P; Merlin S; Loywick A; Audebert C; Van Daele S; Viscogliosi E; Vaneechoutte M; Delhaes L
[Ad] Endereço:Institut Pasteur de Lille, Center for Infection and Immunity of Lille (CIIL), INSERM U1019, CNRS UMR 8204, University of Lille, Lille, France.
[Ti] Título:Effects of Propidium Monoazide (PMA) Treatment on Mycobiome and Bacteriome Analysis of Cystic Fibrosis Airways during Exacerbation.
[So] Source:PLoS One;11(12):e0168860, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION AND PURPOSE: Propidium monoazide (PMA)-pretreatment has increasingly been applied to remove the bias from dead or damaged cell artefacts, which could impact the microbiota analysis by high-throughput sequencing. Our study aimed to determine whether a PMA-pretreatment coupled with high-throughput sequencing analysis provides a different picture of the airway mycobiome and bacteriome. RESULTS AND DISCUSSION: We compared deep-sequencing data of mycobiota and microbiota of 15 sputum samples from 5 cystic fibrosis (CF) patients with and without prior PMA-treatment of the DNA-extracts. PMA-pretreatment had no significant effect on the entire and abundant bacterial community (genera expressed as operational taxonomic units (OTUs) with a relative abundance greater than or equal to 1%), but caused a significant difference in the intermediate community (less than 1%) when analyzing the alpha biodiversity Simpson index (p = 0.03). Regarding PMA impact on the airway mycobiota evaluated for the first time here; no significant differences in alpha diversity indexes between PMA-treated and untreated samples were observed. Regarding beta diversity analysis, the intermediate communities also differed more dramatically than the total and abundant ones when studying both mycobiome and bacteriome. Our results showed that only the intermediate (or low abundance) population diversity is impacted by PMA-treatment, and therefore that abundant taxa are mostly viable during acute exacerbation in CF. Given such a cumbersome protocol (PMA-pretreatment coupled with high-throughput sequencing), we discuss its potential interest within the follow-up of CF patients. Further studies using PMA-pretreatment are warranted to improve our "omic" knowledge of the CF airways.
[Mh] Termos MeSH primário: Azidas/farmacologia
Fibrose Cística/microbiologia
Pulmão/microbiologia
Microbiota/genética
Micobioma/genética
Propídio/análogos & derivados
Sistema Respiratório/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antibacterianos/farmacologia
Biodiversidade
Fibrose Cística/tratamento farmacológico
Fibrose Cística/genética
DNA Bacteriano/genética
Progressão da Doença
Feminino
Volume Expiratório Forçado
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Pulmão/efeitos dos fármacos
Pulmão/fisiopatologia
Masculino
Metagenoma
Microbiota/efeitos dos fármacos
Meia-Idade
Micobioma/efeitos dos fármacos
Propídio/farmacologia
Estudos Prospectivos
Sistema Respiratório/efeitos dos fármacos
Sistema Respiratório/metabolismo
Escarro/microbiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Azides); 0 (DNA, Bacterial); 0 (propidium monoazide); 36015-30-2 (Propidium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0168860



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