Base de dados : MEDLINE
Pesquisa : G06.773 [Categoria DeCS]
Referências encontradas : 3 [refinar]
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[Au] Autor:Yang QE; Walsh TR
[Ad] Endereço:Division of Infection and Immunity, Heath Park Hospital, Cardiff University, Cardiff CF14 4XN, UK.
[Ti] Título:Toxin-antitoxin systems and their role in disseminating and maintaining antimicrobial resistance.
[So] Source:FEMS Microbiol Rev;41(3):343-353, 2017 05 01.
[Is] ISSN:1574-6976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Toxin-antitoxin systems (TAs) are ubiquitous among bacteria and play a crucial role in the dissemination and evolution of antibiotic resistance, such as maintaining multi-resistant plasmids and inducing persistence formation. Generally, activities of the toxins are neutralised by their conjugate antitoxins. In contrast, antitoxins are more liable to degrade under specific conditions such as stress, and free active toxins interfere with essential cellular processes including replication, translation and cell-wall synthesis. TAs have also been shown to be responsible for plasmid maintenance, stress management, bacterial persistence and biofilm formation. We discuss here the recent findings of these multifaceted TAs (type I-VI) and in particular examine the role of TAs in augmenting the dissemination and maintenance of multi-drug resistance in bacteria.
[Mh] Termos MeSH primário: Bactérias/efeitos dos fármacos
Biofilmes/crescimento & desenvolvimento
Farmacorresistência Bacteriana/fisiologia
Sistemas Toxina-Antitoxina/fisiologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Fenômenos Fisiológicos Bacterianos/genética
Toxinas Bacterianas/metabolismo
Parede Celular/metabolismo
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Toxins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1093/femsre/fux006

  2 / 3 MEDLINE  
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[Au] Autor:Bonneau M; Atyame C; Beji M; Justy F; Cohen-Gonsaud M; Sicard M; Weill M
[Ad] Endereço:Institut des Sciences de l'Evolution de Montpellier (ISEM), UMR CNRS-IRD-EPHE-Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier, France.
[Ti] Título:Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia.
[So] Source:Nat Commun;9(1):319, 2018 01 22.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Culex pipiens mosquitoes are infected with Wolbachia (wPip) that cause an important diversity of cytoplasmic incompatibilities (CIs). Functional transgenic studies have implicated the cidA-cidB operon from wPip and its homolog in wMel in CI between infected Drosophila males and uninfected females. However, the genetic basis of the CI diversity induced by different Wolbachia strains was unknown. We show here that the remarkable diversity of CI in the C. pipiens complex is due to the presence, in all tested wPip genomes, of several copies of the cidA-cidB operon, which undergoes diversification through recombination events. In 183 isofemale lines of C. pipiens collected worldwide, specific variations of the cidA-cidB gene repertoires are found to match crossing types. The diversification of cidA-cidB is consistent with the hypothesis of a toxin-antitoxin system in which the gene cidB co-diversifies with the gene cidA, particularly in putative domains of reciprocal interactions.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Drosophila melanogaster/microbiologia
Genoma Bacteriano
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Proteínas de Bactérias/metabolismo
Sequência de Bases
Cruzamentos Genéticos
Drosophila melanogaster/genética
Especificidade de Hospedeiro
Polimorfismo Genético
Alinhamento de Sequência
Homologia de Sequência de Aminoácidos
Sistemas Toxina-Antitoxina/genética
[Nm] Nome de substância:
0 (Bacterial Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02749-w

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[Au] Autor:Thakur Z; Saini V; Arya P; Kumar A; Mehta PK
[Ad] Endereço:Centre for Biotechnology, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
[Ti] Título:Computational insights into promoter architecture of toxin-antitoxin systems of Mycobacterium tuberculosis.
[So] Source:Gene;641:161-171, 2018 Jan 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Toxin-antitoxin (TA) systems are two component genetic modules widespread in many bacterial genomes, including Mycobacterium tuberculosis (Mtb). The TA systems play a significant role in biofilm formation, antibiotic tolerance and persistence of pathogen inside the host cells. Deciphering regulatory motifs of Mtb TA systems is the first essential step to understand their transcriptional regulation. In this study, in silico approaches, that is, the knowledge based motif discovery and de novo motif discovery were used to identify the regulatory motifs of 79 Mtb TA systems. The knowledge based motif discovery approach was used to design a Perl based bio-tool Mtb-sig-miner available at (, which could successfully detect sigma (σ) factor specific regulatory motifs in the promoter region of Mtb TA modules. The manual curation of Mtb-sig-miner output hits revealed that the majority of them possessed σ regulatory motif in their promoter region. On the other hand, de novo approach resulted in the identification of a novel conserved motif [(T/A)(G/T)NTA(G/C)(C/A)AT(C/A)] within the promoter region of 14 Mtb TA systems. The identified conserved motif was also validated for its activity as conserved core region of operator sequence of corresponding TA system by molecular docking studies. The strong binding of respective antitoxin/toxin with the identified novel conserved motif reflected the validation of identified motif as the core region of operator sequence of respective TA systems. These findings provide computational insight to understand the transcriptional regulation of Mtb TA systems.
[Mh] Termos MeSH primário: Antitoxinas/genética
Genoma Bacteriano/genética
Mycobacterium tuberculosis/genética
Regiões Promotoras Genéticas/genética
Sistemas Toxina-Antitoxina/genética
[Mh] Termos MeSH secundário: Toxinas Bacterianas/genética
Biofilmes/crescimento & desenvolvimento
Biologia Computacional/métodos
Simulação por Computador
Farmacorresistência Bacteriana/genética
Redes Reguladoras de Genes/genética
Simulação de Acoplamento Molecular/métodos
Regiões Operadoras Genéticas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitoxins); 0 (Bacterial Toxins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE

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