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Pesquisa : G07.110.232.693 [Categoria DeCS]
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[PMID]:28748670
[Au] Autor:Taye M; Lee W; Caetano-Anolles K; Dessie T; Hanotte O; Mwai OA; Kemp S; Cho S; Oh SJ; Lee HK; Kim H
[Ad] Endereço:Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea.
[Ti] Título:Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance.
[So] Source:Anim Sci J;88(12):1889-1901, 2017 Dec.
[Is] ISSN:1740-0929
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:As African indigenous cattle evolved in a hot tropical climate, they have developed an inherent thermotolerance; survival mechanisms include a light-colored and shiny coat, increased sweating, and cellular and molecular mechanisms to cope with high environmental temperature. Here, we report the positive selection signature of genes in African cattle breeds which contribute for their heat tolerance mechanisms. We compared the genomes of five indigenous African cattle breeds with the genomes of four commercial cattle breeds using cross-population composite likelihood ratio (XP-CLR) and cross-population extended haplotype homozygosity (XP-EHH) statistical methods. We identified 296 (XP-EHH) and 327 (XP-CLR) positively selected genes. Gene ontology analysis resulted in 41 biological process terms and six Kyoto Encyclopedia of Genes and Genomes pathways. Several genes and pathways were found to be involved in oxidative stress response, osmotic stress response, heat shock response, hair and skin properties, sweat gland development and sweating, feed intake and metabolism, and reproduction functions. The genes and pathways identified directly or indirectly contribute to the superior heat tolerance mechanisms in African cattle populations. The result will improve our understanding of the biological mechanisms of heat tolerance in African cattle breeds and opens an avenue for further study.
[Mh] Termos MeSH primário: Bovinos/genética
Bovinos/fisiologia
Estudos de Associação Genética/veterinária
Genoma/genética
Seleção Genética/genética
Termotolerância/genética
[Mh] Termos MeSH secundário: Animais
Ingestão de Alimentos/genética
Ontologia Genética
Cor de Cabelo/genética
Haplótipos/genética
Resposta ao Choque Térmico/genética
Homozigoto
Temperatura Alta
Pressão Osmótica
Estresse Oxidativo/genética
Glândulas Sudoríparas
Sudorese/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1111/asj.12851


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[PMID]:29385373
[Au] Autor:Bann M; Kaul DR; Haider MZ; Saint S; Goldberger ZD
[Ad] Endereço:From the Department of Medicine (M.B., M.Z.H., Z.D.G.) and the Divisions of General Internal Medicine (M.B., M.Z.H.) and Cardiology (Z.D.G.), University of Washington School of Medicine, Harborview Medical Center, Seattle; and the Department of Internal Medicine (D.R.K., S.S.) and Division of Infect
[Ti] Título:Home Sweet Home.
[So] Source:N Engl J Med;378(5):461-466, 2018 Feb 01.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Salmonella typhi/isolamento & purificação
Viagem
Febre Tifoide/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Feminino
Febre/etiologia
Bactérias Gram-Negativas/isolamento & purificação
Seres Humanos
Mialgia/etiologia
Sudorese
Febre Tifoide/complicações
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcps1704731


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[PMID]:28337936
[Au] Autor:Relf R; Willmott A; Mee J; Gibson O; Saunders A; Hayes M; Maxwell N
[Ad] Endereço:a Centre for Sport and Exercise Science and Medicine (SESAME), Environmental Extremes Laboratory , University of Brighton , Eastbourne , UK.
[Ti] Título:Females exposed to 24 h of sleep deprivation do not experience greater physiological strain, but do perceive heat illness symptoms more severely, during exercise-heat stress.
[So] Source:J Sports Sci;36(3):348-355, 2018 Feb.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There is limited and inconclusive evidence surrounding the physiological and perceptual responses to heat stress while sleep deprived, especially for females. This study aimed to quantify the effect of 24 h sleep deprivation on physiological strain and perceptual markers of heat-related illness in females. Nine females completed two 30-min heat stress tests (HST) separated by 48 h in 39°C, 41% relative humidity at a metabolic heat production of 10 W · kg . The non-sleep deprived HST was followed by the sleep deprivation (SDHST) trial for all participants during the follicular phase of the menstrual cycle. Physiological and perceptual measures were recorded at 5 min intervals during the HSTs. On the cessation of the HSTs, heat illness symptom index (HISI) was completed. HISI scores increased after sleep deprivation by 28 ± 16 versus 20 ± 16 (P = 0.01). Peak (39.40 ± 0.35°C vs. 39.35 ± 0.33°C) and change in rectal temperature (1.91 ± 0.21 vs. 1.93 ± 0.34°C), and whole body sweat rate (1.08 ± 0.31 vs. 1.15 ± 0.36 L · h ) did not differ (P > 0.05) between tests. No difference was observed in peak, nor rise in: heart rate, mean skin temperature, perceived exertion or thermal sensation during the HSTs. Twenty-four hours sleep deprivation increased perceptual symptoms associated with heat-related illness; however, no thermoregulatory alterations were observed.
[Mh] Termos MeSH primário: Exercício/fisiologia
Exercício/psicologia
Transtornos de Estresse por Calor/fisiopatologia
Transtornos de Estresse por Calor/psicologia
Temperatura Alta
Percepção
Privação do Sono/fisiopatologia
Privação do Sono/psicologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Esforço Físico
Sudorese/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1306652


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[PMID]:28452865
[Au] Autor:Meade RD; Kenny GP
[Ad] Endereço:Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Montpetit Hall, Ottawa, CANADA.
[Ti] Título:Are All Heat Loads Created Equal?
[So] Source:Med Sci Sports Exerc;49(9):1796-1804, 2017 Sep.
[Is] ISSN:1530-0315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: We evaluated physiological responses during exercise at a fixed evaporative requirement for heat balance (Ereq) but varying combinations of metabolic and environmental heat load. METHODS: Nine healthy, physically active males (age: 46 ± 8 yr) performed four experimental sessions consisting of 75 min of semirecumbent cycling at various ambient temperatures. Whole-body dry heat loss (direct calorimetry) was monitored continuously as was heat production (indirect calorimetry), which was adjusted to achieve an Ereq of 400 W. The resultant metabolic heat productions and ambient temperatures for the sessions were as follows: (i) 440 W and 30°C (440 [30]), (ii) 388 W and 35°C (388 [35]), (iii) 317 W and 40°C (317 [40]), and (iv) 258 W and 45°C (258 [45]). Whole-body evaporative heat loss was determined via direct calorimetry. Esophageal (Tes) and mean skin (Tsk) temperatures as well as HR were monitored continuously. Mean body temperature (Tb) was calculated from Tes and Tsk. Physiological strain index (PSI) was determined from Tes and HR. RESULTS: End-exercise evaporative heat loss and Tb were similar between conditions (both P ≥ 0.48). Tes was greater in 440 [30] (37.67°C ± 0.04°C) and 388 [35] (37.58°C ± 0.07°C) relative to both 317 [40] (37.35°C ± 0.06°C) and 258 [45] (37.20°C ± 0.07°C; all P ≤ 0.05). Further, Tsk was different between each condition (440 [30], 33.85°C ± 0.16°C; 388 [35], 34.53°C ± 0.08°C; 317 [40], 35.67°C ± 0.07°C; and 258 [45], 36.54°C ± 0.08°C; all P < 0.01). In 440 [30], HR was elevated by about 13 and 18 bpm relative to 317 [40] and 258 [45], respectively (both P < 0.01). Finally, PSI was greater in both 440 [30] and 388 [35] compared with 317 [40] and 258 [45] (all P ≤ 0.04). CONCLUSIONS: Exercise at a fixed Ereq resulted in similar evaporative heat loss and Tb. However, the Tes, Tsk, HR, and PSI responses varied depending on the relative contribution of metabolic and environmental heat load.
[Mh] Termos MeSH primário: Exercício/fisiologia
Temperatura Alta
Sudorese/fisiologia
[Mh] Termos MeSH secundário: Adulto
Temperatura Corporal/fisiologia
Calorimetria
Calorimetria Indireta
Esôfago/fisiologia
Frequência Cardíaca/fisiologia
Seres Humanos
Masculino
Meia-Idade
Temperatura Cutânea/fisiologia
Termometria/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1249/MSS.0000000000001309


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[PMID]:29061857
[Au] Autor:Maglie R; Caproni M
[Ad] Endereço:Department of Medical and Surgical Critical Care, Section of Dermatology, University of Florence, Florence, Italy maglieroberto78@gmail.com.
[Ti] Título:A case of blood sweating: hematohidrosis syndrome.
[So] Source:CMAJ;189(42):E1314, 2017 10 23.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Hemorragia/diagnóstico
Hemorragia/fisiopatologia
Sudorese
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Face
Feminino
Hemorragia/tratamento farmacológico
Seres Humanos
Propranolol/uso terapêutico
Doenças Raras
Pele/patologia
Síndrome
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
9Y8NXQ24VQ (Propranolol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.161298


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[PMID]:29045211
[Au] Autor:Palamara K; Nagarur A; Fintelmann FJ; Kohler MJ; Cortazar FB
[Ad] Endereço:From the Departments of Medicine (K.P., A.N., M.J.K., F.B.C.) and Radiology (F.J.F.), Massachusetts General Hospital, and the Departments of Medicine (K.P., A.N., M.J.K., F.B.C.) and Radiology (F.J.F.), Harvard Medical School - both in Boston.
[Ti] Título:Case 32-2017. A 64-Year-Old Man with Dyspnea, Wheezing, Headache, Cough, and Night Sweats.
[So] Source:N Engl J Med;377(16):1569-1578, 2017 10 19.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anticorpos Anticitoplasma de Neutrófilos/sangue
Granulomatose com Poliangiite/diagnóstico
Peroxidase/imunologia
[Mh] Termos MeSH secundário: Tosse/etiologia
Diagnóstico Diferencial
Dispneia/etiologia
Eosinofilia/etiologia
Fibromialgia/complicações
Granulomatose com Poliangiite/complicações
Granulomatose com Poliangiite/tratamento farmacológico
Cefaleia/etiologia
Seres Humanos
Imunossupressores/uso terapêutico
Pulmão/diagnóstico por imagem
Pulmão/patologia
Masculino
Meia-Idade
Sons Respiratórios/etiologia
Sudorese
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antineutrophil Cytoplasmic); 0 (Immunosuppressive Agents); EC 1.11.1.7 (Peroxidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcpc1703513


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[PMID]:28982960
[Au] Autor:Huguet I; Grossman A
[Ad] Endereço:Department of EndocrinologyHospital de la Princesa, Madrid, Spain ihm.huguet@gmail.com.
[Ti] Título:MANAGEMENT OF ENDOCRINE DISEASE: Flushing: current concepts.
[So] Source:Eur J Endocrinol;177(5):R219-R229, 2017 Nov.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Flushing can be defined as a sensation of warmth accompanied by erythema that most commonly is seen on the face and which occurs in episodic attacks. Such a problem can be clinically problematic, since many conditions and drugs can be related to flushing, and while often there appears to be no underlying organic disease, it is important to exclude disorders since they may be life-threatening conditions. DESIGN AND METHODS: We performed a search in MEDLINE using the terms 'flushing' in combination with 'carcinoid syndrome', 'pheochromocytoma', 'mastocytosis', 'menopausal hot flush' and 'treatment'. European and American guidelines relating to neuroendocrine tumours, mastocytosis and menopause were reviewed. RESULTS: In this review, we discuss the main causes of flushing and propose an algorithm based on pathogenesis, which can be used to guide the clinical evaluation process. We also review recent significant developments in the assessment and treatment of the carcinoid syndrome and menopausal hot flushes, which should guide the clinical practice regarding this common but sometimes confusing condition. CONCLUSIONS: When evaluating flushing, a precise systematic approach is needed to exclude potentially serious underlying causes, although despite this, the cause of the disorder is not always found. If symptoms are not progressive, the patient should be advised about its apparently benign nature in order to avoid unnecessary studies or initiating treatments of minimal benefit.
[Mh] Termos MeSH primário: Gerenciamento Clínico
Doenças do Sistema Endócrino/diagnóstico
Doenças do Sistema Endócrino/terapia
Rubor/diagnóstico
Rubor/terapia
[Mh] Termos MeSH secundário: Neoplasias das Glândulas Suprarrenais/diagnóstico
Neoplasias das Glândulas Suprarrenais/epidemiologia
Neoplasias das Glândulas Suprarrenais/terapia
Algoritmos
Doenças do Sistema Endócrino/epidemiologia
Rubor/epidemiologia
Fogachos/diagnóstico
Fogachos/epidemiologia
Fogachos/terapia
Seres Humanos
Síndrome do Carcinoide Maligno/diagnóstico
Síndrome do Carcinoide Maligno/epidemiologia
Síndrome do Carcinoide Maligno/terapia
Menopausa/fisiologia
Tumores Neuroendócrinos/diagnóstico
Tumores Neuroendócrinos/epidemiologia
Tumores Neuroendócrinos/terapia
Feocromocitoma/diagnóstico
Feocromocitoma/epidemiologia
Feocromocitoma/terapia
Sudorese/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0295


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[PMID]:28754234
[Au] Autor:He J; Wang T; Dong J
[Ad] Endereço:Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai JiaoTong University School of Medicine, PR China.
[Ti] Título:Effectiveness of botulinum toxin A injection for the treatment of secondary axillary bromhidrosis.
[So] Source:J Plast Reconstr Aesthet Surg;70(11):1641-1645, 2017 Nov.
[Is] ISSN:1878-0539
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Surgical removal of apocrine glands is a valid treatment option for axillary bromhidrosis. However, malodor may recur after the operation. The value of botulinum toxin A (BTX-A) injection in the treatment of secondary axillary bromhidrosis was investigated in the present study. From July of 2012 to May of 2016, 53 patients with secondary axillary bromhidrosis were enrolled in our clinic. Various BTX-A injection strategies were applied depending on different types of previous surgery. None of the patients reported adverse side effects after the procedure. The duration of efficacy ranged from 1 to 12 months, with the median value of 6 months. At the end of follow-up, 48 patients ranked the satisfaction with BTX-A treatment as "very good" or "good". For patients with secondary axillary bromhidrosis following various surgical modalities, the BTX-A treatment strategy we propose can achieve a lengthy duration of efficacy with a low risk of side effects and should be considered a good and reliable option.
[Mh] Termos MeSH primário: Toxinas Botulínicas Tipo A/administração & dosagem
Hiperidrose/tratamento farmacológico
Satisfação do Paciente
Sudorese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Axila
Feminino
Seguimentos
Seres Humanos
Hiperidrose/fisiopatologia
Injeções Intradérmicas
Masculino
Neurotoxinas/administração & dosagem
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurotoxins); EC 3.4.24.69 (Botulinum Toxins, Type A)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170730
[St] Status:MEDLINE


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[PMID]:28707431
[Au] Autor:Steels E; Steele ML; Harold M; Coulson S
[Ad] Endereço:Sydney Medical School, The University of Sydney, Sydney, Australia.
[Ti] Título:Efficacy of a Proprietary Trigonella foenum-graecum L. De-Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Study.
[So] Source:Phytother Res;31(9):1316-1322, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Trigonella foenum-graecum seed extract has demonstrated hormone modulatory activity, providing biological plausibility for relieving menopausal symptoms. The study aimed to assess efficacy of a standardized T. foenum-graecum de-husked seed extract in reducing menopausal symptoms in healthy aging women. The study was a double-blind, randomized, placebo-controlled trial that recruited 115 women aged 40 to 65 years of which 59 were allocated to active (n = 54 completed) and 56 to placebo (n = 50 completed). Active treatment was T. foenum-graecum de-husked seed extract, 600 mg per day for 12 weeks. Outcome measures included Menopause-Specific Quality of Life (MENQOL) questionnaire, frequency of hot flushes and night sweats and serum estradiol levels. There was a significant reduction in menopausal symptoms in the active group compared with placebo as assessed by total MENQOL score (p < 0.001); reflected by significant improvements in the vasomotor (p < 0.001), psychosocial (p < 0.001), physical (p < 0.001) and sexual symptoms (p < 0.001) domains. Vasomotor outcomes correlated with hot flushes, the active group reporting significantly less daytime hot flushes and night sweats at 12 weeks (p < 0.001). The average estradiol levels were similar in both the active group and placebo group after treatment. This study demonstrated that this proprietary T. foenum-graecum de-husked seed extract may reduce menopausal symptoms in healthy women. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Menopausa/efeitos dos fármacos
Extratos Vegetais/química
Trigonella/química
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Estradiol/sangue
Feminino
Fogachos/tratamento farmacológico
Seres Humanos
Meia-Idade
Qualidade de Vida
Inquéritos e Questionários
Sudorese/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts); 4TI98Z838E (Estradiol); 68990-15-8 (fenugreek seed meal)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5856


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[PMID]:28648603
[Au] Autor:Chee MK; Jo SK; Sohn KC; Kim CD; Lee JH; Lee YH
[Ad] Endereço:Department of Anatomy, College of Medicine, Chungnam National University, Daejeon, South Korea.
[Ti] Título:Effects of Brn2 overexpression on eccrine sweat gland development in the mouse paw.
[So] Source:Biochem Biophys Res Commun;490(3):901-905, 2017 Aug 26.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eccrine sweat glands regulate body temperature by secreting water and electrolytes. In humans, eccrine sweat glands are ubiquitous in the skin, except in the lips and external genitalia. In mice, eccrine sweat glands are present only in the paw pad. Brn2 is a protein belonging to a large family of transcription factors. A few studies have examined Brn2 in melanoma cells and epidermal keratinocytes. This study investigated changes in the skin in the K5-Brn2 transgenic mouse, which overexpresses Brn2 and contains the keratin 5 promotor. Interestingly, the volume of eccrine sweat glands was reduced markedly in the K5-Brn2 transgenic mouse compared with the wild-type, while the expression of aquaporin 5, important molecule in sweat secretion, was increased in each sweat gland cell, probably to compensate for the reduction in gland development. However, sweating response to a pilocarpine injection in the hind paw was significantly decreased in the K5-Brn2 transgenic mouse compared with the wild-type. The paw epidermis was thicker in the K5-Brn2 transgenic mouse compared with the wild-type. Taken together, eccrine sweat gland development and sweat secretion were suppressed markedly in the K5-Brn2 transgenic mouse. These results may be associated with dominant development of the epidermis by Brn2 overexpression in the paw skin.
[Mh] Termos MeSH primário: Glândulas Écrinas/crescimento & desenvolvimento
Epiderme/crescimento & desenvolvimento
Proteínas do Tecido Nervoso/genética
Fatores do Domínio POU/genética
Regulação para Cima
[Mh] Termos MeSH secundário: Animais
Glândulas Écrinas/fisiologia
Epiderme/fisiologia
Seres Humanos
Queratina-5/genética
Camundongos
Camundongos Transgênicos
Tamanho do Órgão
Regiões Promotoras Genéticas
Sudorese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Keratin-5); 0 (Nerve Tissue Proteins); 0 (POU Domain Factors); 147258-11-5 (Pou3f2 protein, mouse)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE



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