Base de dados : MEDLINE
Pesquisa : G07.180 [Categoria DeCS]
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[PMID]:27771728
[Au] Autor:Cornelissen G; Otsuka K
[Ad] Endereço:Halberg Chronobiology Center, University of Minnesota, Minneapolis, Minn., USA.
[Ti] Título:Chronobiology of Aging: A Mini-Review.
[So] Source:Gerontology;63(2):118-128, 2017.
[Is] ISSN:1423-0003
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Aging is generally associated with weakening of the circadian system. The circadian amplitude is reduced and the circadian acrophase becomes more labile, tending to occur earlier with advancing age. As originally noted by Franz Halberg, similar features are observed in the experimental laboratory after bilateral lesioning of the suprachiasmatic nuclei, suggesting the involvement of clock genes in the aging process as they are in various disease conditions. Recent work has been shedding light on underlying pathways involved in the aging process, with the promise of interventions to extend healthy life spans. Caloric restriction, which is consistently and reproducibly associated with prolonging life in different animal models, is associated with an increased circadian amplitude. These results indicate the critical importance of chronobiology in dealing with problems of aging, from the circadian clock machinery orchestrating metabolism to the development of geroprotectors. The quantitative estimation of circadian rhythm characteristics interpreted in the light of time-specified reference values helps (1) to distinguish effects of natural healthy aging from those associated with disease and predisease; (2) to detect alterations in rhythm characteristics as markers of increased risk before there is overt disease; and (3) to individually optimize by timing prophylactic and/or therapeutic interventions aimed at restoring a disturbed circadian system and/or enhancing a healthy life span. Mapping changes in amplitude and/or acrophase that may overshadow any change in average value also avoids drawing spurious conclusions resulting from data collected at a fixed clock hour. Timely risk detection combined with treatment optimization by timing (chronotherapy) is the goal of several ongoing comprehensive community-based studies focusing on the well-being of the elderly, so that longevity is not achieved at the cost of a reduced quality of life.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Fenômenos Cronobiológicos
[Mh] Termos MeSH secundário: Envelhecimento/genética
Envelhecimento/metabolismo
Animais
Restrição Calórica
Relógios Circadianos
Ritmo Circadiano/genética
Ritmo Circadiano/fisiologia
Seres Humanos
Longevidade
Redes e Vias Metabólicas
Transdução de Sinais
Núcleo Supraquiasmático/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1159/000450945


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[PMID]:28065489
[Au] Autor:Siddiqi HK; Luminais SN; Montgomery D; Bossone E; Dietz H; Evangelista A; Isselbacher E; LeMaire S; Manfredini R; Milewicz D; Nienaber CA; Roman M; Sechtem U; Silberbach M; Eagle KA; Pyeritz RE; GenTAC and IRAD investigators
[Ad] Endereço:Department of Internal Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: hasansiddiqi@gmail.com.
[Ti] Título:Chronobiology of Acute Aortic Dissection in the Marfan Syndrome (from the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions and the International Registry of Acute Aortic Dissection).
[So] Source:Am J Cardiol;119(5):785-789, 2017 Mar 01.
[Is] ISSN:1879-1913
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Marfan syndrome (MFS) is an autosomal dominant connective tissue disease associated with acute aortic dissection (AAD). We used 2 large registries that include patients with MFS to investigate possible trends in the chronobiology of AAD in MFS. We queried the International Registry of Acute Aortic Dissection (IRAD) and the Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) registry to extract data on all patients with MFS who had suffered an AAD. The group included 257 patients with MFS who suffered an AAD from 1980 to 2012. The chi-square tests were used for statistical testing. Mean subject age at time of AAD was 38 years, and 61% of subjects were men. AAD was more likely in the winter/spring season (November to April) than the other half of the year (57% vs 43%, p = 0.05). Dissections were significantly more likely to occur during the daytime hours, with 65% of dissections occurring from 6 a.m. to 6 p.m. (p = 0.001). Men were more likely to dissect during the daytime hours (6 a.m. to 6 p.m.) than women (74% vs 51%, p = 0.01). These insights offer a glimpse of the times of greatest vulnerability for patients with MFS who suffer from this catastrophic event. In conclusion, the chronobiology of AAD in MFS reflects that of AAD in the general population.
[Mh] Termos MeSH primário: Aneurisma Dissecante/fisiopatologia
Aneurisma da Aorta Torácica/fisiopatologia
Fenômenos Cronobiológicos
Síndrome de Marfan/fisiopatologia
Sistema de Registros
[Mh] Termos MeSH secundário: Adulto
Aneurisma Dissecante/etiologia
Aneurisma da Aorta Torácica/etiologia
Feminino
Seres Humanos
Masculino
Síndrome de Marfan/complicações
Meia-Idade
Estudos Prospectivos
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE


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[PMID]:27644893
[Au] Autor:Flo A; Cambras T; Díez-Noguera A; Calpena A
[Ad] Endereço:Departament de Farmàcia i Tecnologia Farmacèutica, Facultat de Farmàcia i Ciències de la Alimentació, Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain.
[Ti] Título:Melatonin pharmacokinetics after transdermal administration changes according to the time of the day.
[So] Source:Eur J Pharm Sci;96:164-170, 2017 Jan 01.
[Is] ISSN:1879-0720
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Melatonin is a neurohormone with multiple and different actions, such as chronobiotic or antioxidant. Melatonin is usually orally administered, but dermal administration is also useful in dermatological diseases or as adjuvant to certain skin treatments. Here, we studied the variability of the pharmacokinetics of melatonin and its metabolite AFMK, when melatonin is transdermally administered to Hairless rat at two different times of day (Zeitgeber Time 4 (ZT4) and ZT16). Moreover, in order to obtain the bioavailability, kinetics after intravenous administration was also studied. In addition, a permeation study was carried out, at both ZTs, to test the amount of melatonin retained in the skin after transdermal administration. Results showed that pharmacokinetic parameters of melatonin administered exogenously depended on the time of the day. When intravenous data were fitted to a compartmental model, the extrapolated plasma concentration at time 0 and the area under the curve were higher at ZT4, while clearance, volumes of central and peripheral compartments and volume of distribution at the steady state were higher at ZT16. Transdermal administration was best fitted to a one-compartment model and t , half-life of absorption and area under the curve showed higher values at ZT4, while the absorption rate and constant of absorption were higher at ZT16. AFMK was detected in all cases, but no differences between the two ZTs were observed. Transdermal administration showed better bioavailability also at ZT4. Results indicate that time of day is a variable that should be taken into account when melatonin is transdermally administered.
[Mh] Termos MeSH primário: Melatonina/administração & dosagem
Melatonina/farmacocinética
[Mh] Termos MeSH secundário: Administração Cutânea
Animais
Antioxidantes/administração & dosagem
Antioxidantes/farmacocinética
Disponibilidade Biológica
Fenômenos Cronobiológicos
Cronoterapia Farmacológica
Meia-Vida
Injeções Intravenosas
Masculino
Melatonina/sangue
Modelos Biológicos
Ratos Pelados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); JL5DK93RCL (Melatonin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE


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[PMID]:27638023
[Au] Autor:Manfredini R; Manfredini F; Fabbian F; Salmi R; Gallerani M; Bossone E; Deshmukh AJ
[Ad] Endereço:Clinica Medica Unit, School of Medicine, University of Ferrara, Via Lodovico Ariosto, 35, Ferrara 44121, Italy. Electronic address: roberto.manfredini@unife.it.
[Ti] Título:Chronobiology of Takotsubo Syndrome and Myocardial Infarction: Analogies and Differences.
[So] Source:Heart Fail Clin;12(4):531-42, 2016 Oct.
[Is] ISSN:1551-7136
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several pathophysiologic factors, not harmful if taken alone, are capable of triggering unfavorable events when presenting together within the same temporal window (chronorisk), and the occurrence of many cardiovascular events is not evenly distributed in time. Both acute myocardial infarction and takotsubo syndrome seem to exhibit a temporal preference in their onset, characterized by variations according to time of day, day of the week, and month of the year, although with both analogies and differences.
[Mh] Termos MeSH primário: Infarto do Miocárdio/fisiopatologia
Cardiomiopatia de Takotsubo/fisiopatologia
[Mh] Termos MeSH secundário: Fenômenos Cronobiológicos
Diagnóstico Diferencial
Seres Humanos
Infarto do Miocárdio/diagnóstico
Fatores de Risco
Estações do Ano
Cardiomiopatia de Takotsubo/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160918
[St] Status:MEDLINE


  5 / 1182 MEDLINE  
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[PMID]:27355332
[Au] Autor:Alagiakrishnan K
[Ad] Endereço:Division of Geriatric Medicine, Department of Medicine, University of Alberta, Edmonton T6G 2G3, Canada.
[Ti] Título:Melatonin based therapies for delirium and dementia.
[So] Source:Discov Med;21(117):363-71, 2016 May.
[Is] ISSN:1944-7930
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Melatonin levels have been shown to decline with aging. Melatonin and its analogs in addition to their effect on sleep promotion, has been shown to have multiple pleiotropic effects. It can also help with neuroprotection through different mechanisms. Evidence in animal and human studies suggests that low levels of melatonin have been linked to delirium, mild cognitive impairment, dementia, and with certain behavioral problems. Recent clinical trials have showed that both melatonin and its analogs may be useful in the prevention, treatment of delirium, and the management of dementia. These medications seem to have the advantage of less side effects and better safety profile when compared to antipsychotics and sedatives like benzodiazepines. These medications are available over the counter in North America, Europe, and Asia, and some of these medications are approved by FDA. This manuscript will discuss the promising role of these melatonergic medications alone or in combination with other medications for the management of Geriatric Psychiatric diseases like delirium and dementia.
[Mh] Termos MeSH primário: Antipsicóticos/uso terapêutico
Delírio/tratamento farmacológico
Demência/tratamento farmacológico
Melatonina/análogos & derivados
Melatonina/farmacologia
[Mh] Termos MeSH secundário: Idoso
Animais
Antipsicóticos/efeitos adversos
Benzodiazepinas/efeitos adversos
Benzodiazepinas/uso terapêutico
Fenômenos Cronobiológicos/fisiologia
Ensaios Clínicos como Assunto
Delírio/sangue
Demência/sangue
Quimioterapia Combinada
Galantamina/farmacologia
Galantamina/uso terapêutico
Seres Humanos
Indenos/farmacologia
Indenos/uso terapêutico
Melatonina/fisiologia
Memantina/farmacologia
Memantina/uso terapêutico
Neuroproteção/efeitos dos fármacos
Guias de Prática Clínica como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Indenes); 0D3Q044KCA (Galantamine); 12794-10-4 (Benzodiazepines); 901AS54I69 (ramelteon); JL5DK93RCL (Melatonin); W8O17SJF3T (Memantine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160630
[St] Status:MEDLINE


  6 / 1182 MEDLINE  
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[PMID]:27319184
[Au] Autor:Tanaka Y
[Ti] Título:[The 43rd Scientific Meeting: Perspectives of Internal Medicine; Genetic predisposition and related life-style underlying metabolic disorders; 4. Prevention and Therapeutic Treatment; 2) Practical and effective way of diet and exercise for treatment of diabetes based on chronometabolic science].
[So] Source:Nihon Naika Gakkai Zasshi;105(3):411-6, 2016 Mar 10.
[Is] ISSN:0021-5384
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Diabetes Mellitus/terapia
[Mh] Termos MeSH secundário: Glicemia/análise
Fenômenos Cronobiológicos
Diabetes Mellitus/dietoterapia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160620
[Lr] Data última revisão:
160620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE


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[PMID]:27307380
[Au] Autor:Pilcher JJ; Jennings KS; Phillips GE; McCubbin JA
[Ad] Endereço:Clemson University, South Carolina jpilche@clemson.edu.
[Ti] Título:Auditory Attention and Comprehension During a Simulated Night Shift: Effects of Task Characteristics.
[So] Source:Hum Factors;58(7):1031-1043, 2016 Nov.
[Is] ISSN:1547-8181
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The current study investigated performance on a dual auditory task during a simulated night shift. BACKGROUND: Night shifts and sleep deprivation negatively affect performance on vigilance-based tasks, but less is known about the effects on complex tasks. Because language processing is necessary for successful work performance, it is important to understand how it is affected by night work and sleep deprivation. METHOD: Sixty-two participants completed a simulated night shift resulting in 28 hr of total sleep deprivation. Performance on a vigilance task and a dual auditory language task was examined across four testing sessions. RESULTS: The results indicate that working at night negatively impacts vigilance, auditory attention, and comprehension. The effects on the auditory task varied based on the content of the auditory material. When the material was interesting and easy, the participants performed better. Night work had a greater negative effect when the auditory material was less interesting and more difficult. CONCLUSION: These findings support research that vigilance decreases during the night. The results suggest that auditory comprehension suffers when individuals are required to work at night. Maintaining attention and controlling effort especially on passages that are less interesting or more difficult could improve performance during night shifts. APPLICATION: The results from the current study apply to many work environments where decision making is necessary in response to complex auditory information. Better predicting the effects of night work on language processing is important for developing improved means of coping with shiftwork.
[Mh] Termos MeSH primário: Atenção/fisiologia
Percepção Auditiva/fisiologia
Fenômenos Cronobiológicos/fisiologia
Compreensão/fisiologia
Desempenho Psicomotor/fisiologia
Privação do Sono/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE


  8 / 1182 MEDLINE  
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[PMID]:27173486
[Au] Autor:Dahm SF; Rieger M
[Ad] Endereço:Institute of Psychology, UMIT - University for Health Sciences Medical Informatics and Technology, Hall in Tyrol, Austria. stephan.dahm@umit.at.
[Ti] Título:Is there symmetry in motor imagery? Exploring different versions of the mental chronometry paradigm.
[So] Source:Atten Percept Psychophys;78(6):1794-805, 2016 Aug.
[Is] ISSN:1943-393X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Motor imagery and motor execution share similar processes. However, only some factors that affect motor execution affect motor imagery in the same way. We investigated whether bimanual coordination constraints (parallel movements are performed slower than symmetric movements) are observed in motor imagery and whether the way of implementing the mental chronometry paradigm, which is used to investigate motor imagery, influences the results. Participants imagined and executed repetitive symmetric and parallel bimanual movements in three different tasks. Participants performed a certain number of movement repetitions (number task), repeated movements for a fixed duration (duration task), and performed movements in synchrony with pacing sounds (synchronization task). In both, imagination and execution, inter-response intervals were longer with parallel movements than with symmetric movements (number task and duration task), and the percentage of correct movements was lower with parallel than with symmetric movements (synchronization task). Performance of imagined and executed movements was correlated in all tasks. However, imagination took longer or was rated as less accurate than execution, and in the synchronization task the coordination constraint affected accuracy more in execution than in imagination. Thus, motor imagery and overt execution involve shared and unique processes. The synchronization task offers a promising alternative to investigate motor imagery, because the speed-accuracy trade-off is taken into account, different tempi can be used, and psychometric functions can be calculated.
[Mh] Termos MeSH primário: Imaginação/fisiologia
Movimento/fisiologia
Desempenho Psicomotor/fisiologia
Análise e Desempenho de Tarefas
[Mh] Termos MeSH secundário: Adulto
Fenômenos Cronobiológicos
Feminino
Seres Humanos
Masculino
Tempo de Reação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.3758/s13414-016-1112-9


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[PMID]:27075393
[Au] Autor:Na SY; Kwon OE; Lee YC; Eun YG
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, South Korea.
[Ti] Título:Optimal timing of saliva collection to detect pepsin in patients with laryngopharyngeal reflux.
[So] Source:Laryngoscope;126(12):2770-2773, 2016 Dec.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: To determine salivary pepsin levels as a function of collection time. STUDY DESIGN: A prospective, case-control study. METHODS: We selected 57 patients with clinical symptoms and signs of laryngopharyngeal reflux who underwent 24-hour multichannel intraluminal impedance-pH (24h MII-pH) monitoring tests, and 12 control subjects without clinical symptoms and signs of laryngopharyngeal reflux. All subjects were instructed to collect saliva samples upon waking, 1 hour after each meal (3 times per day), and upon any occurrence of laryngopharyngeal reflux (LPR) symptoms. The pepsin levels in saliva were measured by using enzyme-linked immunosorbent assay. The Reflux Symptom Index survey was also administered. RESULTS: A total of 50 patients in whom LPR was diagnosed based on results of 24h MII-pH monitoring test were enrolled in the study. The average pepsin level upon waking was 17.2 ng/mL, which was significantly higher than that measured in samples collected at any other time (P < .005). Pepsin levels were higher in patients with LPR than those in controls. The Reflux Symptom Index scores were statistically different between these groups of subjects. CONCLUSIONS: The levels of total pepsin in saliva collected upon waking were significantly higher in the group of patients presenting with LPR symptoms and who demonstrated at least one episode of proximal esophageal reflux during 24h MII-pH monitoring. Furthermore, the average pepsin level upon waking was higher than that measured at any other time. Measuring pepsin levels in the saliva upon waking may be a useful method in the diagnosis of LPR. LEVEL OF EVIDENCE: 3b Laryngoscope, 126:2770-2773, 2016.
[Mh] Termos MeSH primário: Refluxo Laringofaríngeo/diagnóstico
Pepsina A/análise
Saliva/química
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Fenômenos Cronobiológicos
Relógios Circadianos
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.23.1 (Pepsin A)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160415
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26018


  10 / 1182 MEDLINE  
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[PMID]:27053223
[Au] Autor:Nordgren A
[Ad] Endereço:Centre for Applied Ethics, Linköping University, 581 83, Linköping, Sweden. anders.nordgren@liu.se.
[Ti] Título:Genes, body clocks and prevention of sleep problems.
[So] Source:Med Health Care Philos;19(4):569-579, 2016 Dec.
[Is] ISSN:1572-8633
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chronobiologists argue that their scientific findings have implications for prevention of sleep problems. They claim that some sleep problems are caused by the fact that people live against their individual body clock rather than adjusted to it. They also claim that by taking the findings of chronobiology seriously in policy-making some sleep problems can be prevented. I investigate applications of chronobiology in two social areas-school schedules and shift work-and show that in order for these applications to be justified certain implicit presumptions have to be justified. The first presumption is explanatory, namely that a chronobiological explanation is an adequate explanation of the sleep problems at hand. In addition I analyse three ethical presumptions. The first ethical presumption is that sleep is of vital value. The second is that sleep is not an exclusively private issue. The third ethical presumption is that the preventive measures to be undertaken are ethically acceptable. My main point is that it is not possible to simply "read off" policy measures from the empirical findings of chronobiology.
[Mh] Termos MeSH primário: Relógios Biológicos/genética
Genes/fisiologia
Transtornos do Sono-Vigília/genética
[Mh] Termos MeSH secundário: Fenômenos Cronobiológicos/genética
Política de Saúde
Seres Humanos
Transtornos do Sono-Vigília/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:E; IM
[Da] Data de entrada para processamento:160408
[St] Status:MEDLINE



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