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Pesquisa : G07.180.562.797.500 [Categoria DeCS]
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[PMID]:28489896
[Au] Autor:Richardson TO; Liechti JI; Stroeymeyt N; Bonhoeffer S; Keller L
[Ad] Endereço:Department of Ecology and Evolution, University of Lausanne, Switzerland.
[Ti] Título:Short-term activity cycles impede information transmission in ant colonies.
[So] Source:PLoS Comput Biol;13(5):e1005527, 2017 May.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rhythmical activity patterns are ubiquitous in nature. We study an oscillatory biological system: collective activity cycles in ant colonies. Ant colonies have become model systems for research on biological networks because the interactions between the component parts are visible to the naked eye, and because the time-ordered contact network formed by these interactions serves as the substrate for the distribution of information and other resources throughout the colony. To understand how the collective activity cycles influence the contact network transport properties, we used an automated tracking system to record the movement of all the individuals within nine different ant colonies. From these trajectories we extracted over two million ant-to-ant interactions. Time-series analysis of the temporal fluctuations of the overall colony interaction and movement rates revealed that both the period and amplitude of the activity cycles exhibit a diurnal cycle, in which daytime cycles are faster and of greater amplitude than night cycles. Using epidemiology-derived models of transmission over networks, we compared the transmission properties of the observed periodic contact networks with those of synthetic aperiodic networks. These simulations revealed that contrary to some predictions, regularly-oscillating contact networks should impede information transmission. Further, we provide a mechanistic explanation for this effect, and present evidence in support of it.
[Mh] Termos MeSH primário: Ciclos de Atividade/fisiologia
Comunicação Animal
Formigas/fisiologia
Modelos Biológicos
Periodicidade
[Mh] Termos MeSH secundário: Animais
Biologia Computacional
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005527


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[PMID]:27977438
[Au] Autor:Bruyneel M; Sersté T; Libert W; van den Broecke S; Ameye L; Dachy B; Mulkay JP; Moreno C; Gustot T
[Ad] Endereço:aSleep Unit, Department of Pneumology bDepartment of Hepatogastroenterology, Saint-Pierre University Hospital cDepartment of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital dData Centre, Jules Bordet Institute eDepartment of Neurology, UMC Brugmann fLaboratory of Experimental Gastroenterolgy, Université Libre de Bruxelles, Brussels, Belgium gInserm Unité 1149, Center for Research on Inflammation (CRI) hUMR S_1149, Paris Diderot University, Paris, France.
[Ti] Título:Improvement of sleep architecture parameters in cirrhotic patients with recurrent hepatic encephalopathy with the use of rifaximin.
[So] Source:Eur J Gastroenterol Hepatol;29(3):302-308, 2017 Mar.
[Is] ISSN:1473-5687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIM: Sleep disorders are frequently reported in patients with cirrhosis and hepatic encephalopathy (HE). This study assessed the effect of rifaximin on sleep architecture parameters in patients with recurrent HE. PATIENTS AND METHODS: This sequential, prospective, and exploratory study involved all patients with cirrhosis and recurrent HE admitted between June 2014 and September 2015. HE was assessed according to the West-Haven Classification. Patients underwent 24-h polysomnography (PSG) and 7-day actigraphy. Rapid eye movement (REM) sleep was considered to be an indicator of good sleep quality. Patients completed questionnaires assessing the quality of sleep and sleepiness. After a 28-day course of rifaximin, the same assessment was repeated. RESULTS: Fifteen patients were included (nine men, mean age: 57±11 years). Child-Pugh scores ranged from B7 to C15. Before rifaximin, the mean HE score was 2.7±0.7. Data from PSG analysis indicated long total sleep time (TST): 571±288 min, and limited REM sleep: 2.5% TST (0-19). Seven-day actigraphy showed an impaired number of steps: 1690/24 h (176-6945). Questionnaires indicated that patients experienced impaired sleep quality and excessive daytime sleepiness. After rifaximin, HE scores decreased to 1.7±0.6 (P<0.001). REM sleep increased to 8.5% TST (0-25) (P=0.003). No changes were observed for TST, number of steps, and on questionnaires. CONCLUSION: Patients with recurrent HE suffer from poor sleep quality and excessive daytime sleepiness. On 24-h PSG, rifaximin improves objective sleep architecture parameters with no changes in the subjective quality of sleep and sleepiness.
[Mh] Termos MeSH primário: Encefalopatia Hepática/tratamento farmacológico
Cirrose Hepática/complicações
Rifamicinas/uso terapêutico
Medicamentos Indutores do Sono/uso terapêutico
Transtornos do Sono-Vigília/tratamento farmacológico
Sono REM/efeitos dos fármacos
[Mh] Termos MeSH secundário: Actigrafia
Ciclos de Atividade/efeitos dos fármacos
Afeto/efeitos dos fármacos
Idoso
Bélgica
Feminino
Encefalopatia Hepática/diagnóstico
Encefalopatia Hepática/etiologia
Encefalopatia Hepática/fisiopatologia
Seres Humanos
Cirrose Hepática/diagnóstico
Masculino
Meia-Idade
Polissonografia
Estudos Prospectivos
Qualidade de Vida
Recidiva
Rifamicinas/efeitos adversos
Medicamentos Indutores do Sono/efeitos adversos
Transtornos do Sono-Vigília/diagnóstico
Transtornos do Sono-Vigília/etiologia
Transtornos do Sono-Vigília/fisiopatologia
Inquéritos e Questionários
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Rifamycins); 0 (Sleep Aids, Pharmaceutical); L36O5T016N (rifaximin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1097/MEG.0000000000000786


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[PMID]:27869819
[Au] Autor:Katz ZB; Novotná L; Blount A; Lillemeier BF
[Ad] Endereço:Nomis Center for Immunobiology and Microbial Pathogenesis &Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, California, USA.
[Ti] Título:A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli.
[So] Source:Nat Immunol;18(1):86-95, 2017 Jan.
[Is] ISSN:1529-2916
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cell-surface-receptor pathways amplify weak, rare and local stimuli to induce cellular responses. This task is accomplished despite signaling components that segregate into nanometer-scale membrane domains. Here we describe a 'catch-and-release' mechanism that amplified and dispersed stimuli by releasing activated kinases from receptors lacking intrinsic catalytic activity. Specifically, we discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T cell antigen receptors (TCRs). This turned the TCR into a 'catalytic unit' that amplified antigenic stimuli. Zap70 released from the TCR remained at the membrane, translocated, and phosphorylated spatially distinct substrates. The mechanisms described here are based on widely used protein domains and post-translational modifications; therefore, many membrane-associated pathways might employ similar mechanisms for signal amplification and dispersion.
[Mh] Termos MeSH primário: Ciclos de Atividade
Receptores de Antígenos de Linfócitos T/metabolismo
Transdução de Sinais/imunologia
Linfócitos T/imunologia
Proteína-Tirosina Quinase ZAP-70/metabolismo
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Animais
Antígenos/imunologia
Células HEK293
Seres Humanos
Células Jurkat
Ativação Linfocitária
Proteínas de Membrana/metabolismo
Camundongos
Camundongos Transgênicos
Fosfoproteínas/metabolismo
Receptor Cross-Talk
Receptores de Antígenos de Linfócitos T/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (Antigens); 0 (Lat protein, mouse); 0 (Membrane Proteins); 0 (Phosphoproteins); 0 (Receptors, Antigen, T-Cell); EC 2.7.10.2 (ZAP-70 Protein-Tyrosine Kinase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE
[do] DOI:10.1038/ni.3631


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[PMID]:27782944
[Au] Autor:Whitehead RA; Lam NL; Sun MS; Sanchez J; Noor S; Vanderwall AG; Petersen TR; Martin HB; Milligan ED
[Ad] Endereço:From the Departments of *Neurosciences and †Anesthesiology, University of New Mexico, Albuquerque, New Mexico.
[Ti] Título:Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia.
[So] Source:Anesth Analg;124(1):346-355, 2017 Jan.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Animal models of peripheral neuropathy produced by a number of manipulations are assessed for the presence of pathologic pain states such as allodynia. Although stimulus-induced behavioral assays are frequently used and important to examine allodynia (ie, sensitivity to light mechanical touch; von Frey fiber test), other measures of behavior that reflect overall function are not only complementary to stimulus-induced responsive measures, but are also critical to gain a complete understanding of the effects of the pain model on quality of life, a clinically relevant aspect of pain on general function. Voluntary wheel-running activity in rodent models of inflammatory and muscle pain is emerging as a reliable index of general function that extends beyond stimulus-induced behavioral assays. Clinically, reports of increased pain intensity occur at night, a period typically characterized with reduced activity during the diurnal cycle. We therefore examined in rats whether alterations in wheel-running activity were more robust during the inactive phase compared with the active phase of their diurnal cycle in a widely used rodent model of chronic peripheral neuropathic pain, the sciatic nerve chronic constriction injury (CCI) model. METHODS: In adult male Sprague Dawley rats, baseline (BL) hindpaw threshold responses to light mechanical touch were assessed using the von Frey test before measuring BL activity levels using freely accessible running wheels (1 hour/day for 7 sequential days) to quantify the distance traveled. Running wheel activity BL values are expressed as total distance traveled (m). The overall experimental design was after BL measures, rats underwent either sham or CCI surgery followed by repeated behavioral reassessment of hindpaw thresholds and wheel-running activity levels for up to 18 days after surgery. Specifically, separate groups of rats were assessed for wheel-running activity levels (1 hour total/trial) during the onset (within first 2 hours) of either the (1) inactive (n = 8/group) or (2) active (n = 8/group) phase of the diurnal cycle. An additional group of CCI-treated rats (n = 8/group) was exposed to a locked running wheel to control for the potential effects of wheel-running exercise on allodynia. The 1-hour running wheel trial period was further examined at discrete 20-minute intervals to identify possible pattern differences in activity during the first, middle, and last portions of the 1-hour trial. The effect of neuropathy on activity levels was assessed by measuring the change from their respective BLs to distance traveled in the running wheels. RESULTS: Although wheel-running distances between groups were not different at BL from rats examined during either the inactive phase of the diurnal cycle or active phase of the diurnal cycle, sciatic nerve CCI reduced running wheel activity levels compared with sham-operated controls during the inactive phase. In addition, compared with sham controls, bilateral low-threshold mechanical allodynia was observed at all time points after surgical induction of neuropathy in rats with free-wheel and locked-wheel access. Allodynia in CCI compared with shams was replicated in rats whose running wheel activity was examined during the active phase of the diurnal cycle. Conversely, no significant reduction in wheel-running activity was observed in CCI-treated rats compared with sham controls at any time point when activity levels were examined during the active diurnal phase. Finally, running wheel activity patterns within the 1-hour trial period during the inactive phase of the diurnal cycle were relatively consistent throughout each 20-minute phase. CONCLUSIONS: Compared with nonneuropathic sham controls, a profound and stable reduction of running wheel activity was observed in CCI rats during the inactive phase of the diurnal cycle. A concurrent robust allodynia persisted in all rats regardless of when wheel-running activity was examined or whether they ran on wheels, suggesting that acute wheel-running activity does not alter chronic low-intensity mechanical allodynia as measured using the von Frey fiber test. Overall, these data support that acute wheel-running exercise with limited repeated exposures does not itself alter allodynia and offers a behavioral assay complementary to stimulus-induced measures of neuropathic pain.
[Mh] Termos MeSH primário: Comportamento Animal
Hiperalgesia/etiologia
Atividade Motora
Limiar da Dor
Neuropatia Ciática/complicações
Volição
[Mh] Termos MeSH secundário: Ciclos de Atividade
Animais
Doença Crônica
Modelos Animais de Doenças
Habituação Psicofisiológica
Hiperalgesia/fisiopatologia
Hiperalgesia/psicologia
Masculino
Medição da Dor
Ratos Sprague-Dawley
Tempo de Reação
Corrida
Neuropatia Ciática/fisiopatologia
Neuropatia Ciática/psicologia
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161027
[St] Status:MEDLINE


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[PMID]:27341473
[Au] Autor:Martin T; Moussay S; Bulla I; Bulla J; Toupet M; Etard O; Denise P; Davenne D; Coquerel A; Quarck G
[Ad] Endereço:UNICAEN, COMETE, 14032 Caen, France.
[Ti] Título:Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss.
[So] Source:PLoS One;11(6):e0155067, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: New insights have expanded the influence of the vestibular system to the regulation of circadian rhythmicity. Indeed, hypergravity or bilateral vestibular loss (BVL) in rodents causes a disruption in their daily rhythmicity for several days. The vestibular system thus influences hypothalamic regulation of circadian rhythms on Earth, which raises the question of whether daily rhythms might be altered due to vestibular pathology in humans. The aim of this study was to evaluate human circadian rhythmicity in people presenting a total bilateral vestibular loss (BVL) in comparison with control participants. METHODOLOGY AND PRINCIPAL FINDINGS: Nine patients presenting a total idiopathic BVL and 8 healthy participants were compared. Their rest-activity cycle was recorded by actigraphy at home over 2 weeks. The daily rhythm of temperature was continuously recorded using a telemetric device and salivary cortisol was recorded every 3 hours from 6:00AM to 9:00PM over 24 hours. BVL patients displayed a similar rest activity cycle during the day to control participants but had higher nocturnal actigraphy, mainly during weekdays. Sleep efficiency was reduced in patients compared to control participants. Patients had a marked temperature rhythm but with a significant phase advance (73 min) and a higher variability of the acrophase (from 2:24 PM to 9:25 PM) with no correlation to rest-activity cycle, contrary to healthy participants. Salivary cortisol levels were higher in patients compared to healthy people at any time of day. CONCLUSION: We observed a marked circadian rhythmicity of temperature in patients with BVL, probably due to the influence of the light dark cycle. However, the lack of synchronization between the temperature and rest-activity cycle supports the hypothesis that the vestibular inputs are salient input to the circadian clock that enhance the stabilization and precision of both external and internal entrainment.
[Mh] Termos MeSH primário: Vestibulopatia Bilateral/fisiopatologia
Ritmo Circadiano
[Mh] Termos MeSH secundário: Ciclos de Atividade
Adulto
Idoso
Vestibulopatia Bilateral/metabolismo
Temperatura Corporal
Estudos de Casos e Controles
Feminino
Seres Humanos
Hidrocortisona/metabolismo
Masculino
Meia-Idade
Fotoperíodo
Saliva/metabolismo
Sono
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0155067


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[PMID]:27266014
[Au] Autor:Gumz ML
[Ti] Título:How to Find More Hours in the Day.
[So] Source:Physiologist;59(3):127-9, 2016 May.
[Is] ISSN:0031-9376
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtornos Cronobiológicos/fisiopatologia
Ritmo Circadiano
Admissão e Escalonamento de Pessoal
[Mh] Termos MeSH secundário: Ciclos de Atividade
Animais
Eficiência
Seres Humanos
Refeições
Fotoperíodo
Sono
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160607
[Lr] Data última revisão:
160607
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE


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[PMID]:26953619
[Au] Autor:Shawa N; Roden LC
[Ad] Endereço:a Department of Molecular and Cell Biology , University of Cape Town , Cape Town , South Africa.
[Ti] Título:Chronotype of South African adults is affected by solar entrainment.
[So] Source:Chronobiol Int;33(3):315-23, 2016.
[Is] ISSN:1525-6073
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Our daily lives are influenced by three different daily timers: the solar clock, our endogenous circadian clock and the societal clock. The way an individual's endogenous clock synchronises to the solar clock, through either advances or delays relative to sunrise and sunset, results in a phenomenon known as diurnal preference or chronotype. South Africa uses just one time zone, but in the most easterly regions of the country, the sun rises and sets up to an hour earlier than in the most westerly regions throughout the year. It was hypothesised first that South Africans living in the east of the country may have a greater preference for mornings (more morning chronotypes) than those living in the west; and second, that this difference would not be due to genetic differences in the populations, particularly a genetic polymorphism previously shown to influence chronotype. Here, we describe and compare the distribution of chorotype and PERIOD3 variable number tandem repeat (VNTR) polymorphism frequency in eastern (n = 129) and western (n = 175) sample populations. Using the Horne-Östberg Morningness, Eveningness Questionnaire we found that there was a significantly higher proportion of morning-types in the eastern population (56.6%) than in the western population (39.4%), and there were higher proportions of neither-types and evening-types in the western population (51.4% and 9.1%, respectively) than in the eastern population (37.2% and 6.2%, respectively) (p = 0.009). There were no significant differences in distribution of the PER3 genotype (p = 0.895) and allele (p = 0.636) frequencies. Although previous studies have shown associations between chronotype and PER3 VNTR genotypes, no significant associations were observed in either the eastern (p = 0.695) or the western (p = 0.630) populations. These findings indicate that, in South African populations, longitude influences chronotype independently of PER3 genotype. The impacts of the differences in chronotype whilst maintaining the same societal temporal organisation in the eastern and western regions were not assessed.
[Mh] Termos MeSH primário: Atividades Cotidianas
Relógios Circadianos/efeitos da radiação
Ritmo Circadiano/efeitos da radiação
Fotoperíodo
Estações do Ano
Atividade Solar
Luz Solar
[Mh] Termos MeSH secundário: Ciclos de Atividade/efeitos da radiação
Adulto
Relógios Circadianos/genética
Ritmo Circadiano/genética
Feminino
Frequência do Gene
Genótipo
Seres Humanos
Masculino
Meia-Idade
Repetições Minissatélites
Proteínas Circadianas Period/genética
Fenótipo
Polimorfismo Genético
África do Sul
Inquéritos e Questionários
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (PER3 protein, human); 0 (Period Circadian Proteins)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE
[do] DOI:10.3109/07420528.2016.1144608


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[PMID]:26945080
[Au] Autor:Yap FC; Weber DS; Taylor MS; Townsley MI; Comer BS; Maylie J; Adelman JP; Lin MT
[Ad] Endereço:Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama;
[Ti] Título:Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure.
[So] Source:Am J Physiol Heart Circ Physiol;310(9):H1151-63, 2016 May 01.
[Is] ISSN:1522-1539
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Activation of vascular endothelial small- (KCa2.3, SK3) or intermediate- (KCa3.1, IK1) conductance Ca(2+)-activated potassium channels induces vasorelaxation via an endothelium-derived hyperpolarization (EDH) pathway. Although the activation of SK3 and IK1 channels converges on EDH, their subcellular effects on signal transduction are different and not completely clear. In this study, a novel endothelium-specific SK3 knockout (SK3(-/-)) mouse model was utilized to specifically examine the contribution of SK3 channels to mesenteric artery vasorelaxation, endothelial Ca(2+) dynamics, and blood pressure. The absence of SK3 expression was confirmed using real-time quantitative PCR and Western blot analysis. Functional studies showed impaired EDH-mediated vasorelaxation in SK3(-/-) small mesenteric arteries. Immunostaining results from SK3(-/-) vessels confirmed the absence of SK3 and further showed altered distribution of transient receptor potential channels, type 4 (TRPV4). Electrophysiological recordings showed a lack of SK3 channel activity, while TRPV4-IK1 channel coupling remained intact in SK3(-/-) endothelial cells. Moreover, Ca(2+) imaging studies in SK3(-/-) endothelium showed increased Ca(2+) transients with reduced amplitude and duration under basal conditions. Importantly, SK3(-/-) endothelium lacked a distinct type of Ca(2+) dynamic that is sensitive to TRPV4 activation. Blood pressure measurements showed that the SK3(-/-) mice were hypertensive, and the blood pressure increase was further enhanced during the 12-h dark cycle when animals are most active. Taken together, our results reveal a previously unappreciated SK3 signaling microdomain that modulates endothelial Ca(2+) dynamics, vascular tone, and blood pressure.
[Mh] Termos MeSH primário: Pressão Sanguínea
Sinalização do Cálcio
Cálcio/metabolismo
Células Endoteliais/metabolismo
Hipertensão/metabolismo
Microdomínios da Membrana/metabolismo
Artérias Mesentéricas/metabolismo
Canais de Potássio Ativados por Cálcio de Condutância Baixa/metabolismo
Vasodilatação
[Mh] Termos MeSH secundário: Ciclos de Atividade
Animais
Predisposição Genética para Doença
Hipertensão/genética
Hipertensão/fisiopatologia
Canais de Potássio Ativados por Cálcio de Condutância Intermediária/metabolismo
Potenciais da Membrana
Camundongos Endogâmicos C57BL
Camundongos Knockout
Fenótipo
Canais de Potássio Ativados por Cálcio de Condutância Baixa/deficiência
Canais de Potássio Ativados por Cálcio de Condutância Baixa/genética
Canais de Cátion TRPV/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Intermediate-Conductance Calcium-Activated Potassium Channels); 0 (Kcnn3 protein, mouse); 0 (Small-Conductance Calcium-Activated Potassium Channels); 0 (TRPV Cation Channels); 0 (Trpv4 protein, mouse); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160306
[St] Status:MEDLINE
[do] DOI:10.1152/ajpheart.00787.2015


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[PMID]:26930172
[Au] Autor:Zimmermann LK
[Ad] Endereço:a Department of Psychology , Shenandoah University , Virginia , USA.
[Ti] Título:The influence of chronotype in the daily lives of young children.
[So] Source:Chronobiol Int;33(3):268-79, 2016.
[Is] ISSN:1525-6073
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Research on chronotypic differences has been conducted for many years, however, until recently, little attention has been paid to young children. The current study examined the influence of morningness-eveningness in the daily lives of 2 to 4 year olds (291 females, 230 males, 8 gender not given) via an online survey completed by 529 mothers from across the United States. The results replicated previous findings on chronotypic differences in sleep-wake patterns and the development of morningness-eveningness in early childhood. The influence of chronotype on sleep habits, daily routines and schedules was also explored. At both bed and wake times, mothers of evening type (E-type) children were more likely to report challenges. For a while, morning type (M-type) children tended to fall asleep easily and wake themselves up in the morning, E-types were more likely to show bedtime resistance, wake in a negative mood and have conflicts with their parents. In the morning, mothers of M-type children often stuck to their normal routine on days when the child had to be somewhere at 7:00 am, whereas mothers of E-type children employed different strategies to get their child up and out the door. Bedtime routines and daily schedules also differed by chronotype. Individual differences in morningness-eveningness and their impact on sleep-wake patterns and social interactions are evident early on. A greater understanding of how they affect the lives of young children and their future development is needed.
[Mh] Termos MeSH primário: Atividades Cotidianas
Ciclos de Atividade
Comportamento Infantil
Ritmo Circadiano
[Mh] Termos MeSH secundário: Afeto
Fatores Etários
Pré-Escolar
Conflito (Psicologia)
Feminino
Hábitos
Seres Humanos
Masculino
Relações Pais-Filho
Sono
Inquéritos e Questionários
Fatores de Tempo
Vigília
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.3109/07420528.2016.1138120


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[PMID]:26780151
[Au] Autor:Lewis R; Curtis JT
[Ad] Endereço:Department of Pharmacology and Physiology, Oklahoma State University Center for Health Sciences, 1111 W. 17th St., Tulsa, OK 74107, United States. Electronic address: robert.lewis11@okstate.edu.
[Ti] Título:Male prairie voles display cardiovascular dipping associated with an ultradian activity cycle.
[So] Source:Physiol Behav;156:106-16, 2016 Mar 15.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mammals typically display alternating active and resting phases and, in most species, these rhythms follow a circadian pattern. The active and resting phases often are accompanied by corresponding physiological changes. In humans, blood pressure decreases during the resting phase of the activity cycle, and the magnitude of that "nocturnal dipping" has been used to stratify patients according to the risk for cardiovascular disease. However, in contrast to most mammals, prairie voles (Microtus ochrogaster) have periods of activity and rest that follow an ultradian rhythm with period lengths significantly <24h. While rhythmic changes in blood pressure across a circadian activity cycle have been well-documented, blood pressure patterns in species that display ultradian rhythms in activity are less well-studied. In the current study, we implanted pressure-sensitive radiotelemetry devices in male prairie voles and recorded activity, mean arterial pressure (MAP), and heart rate (HR) continuously for 3days. Visualization of the ultradian rhythms was enhanced using a 1h running average to filter the dataset. Positive correlations were found between activity and MAP and between activity and HR. During the inactive period of the ultradian cycle, blood pressure decreased by about 15%, which parallels the nocturnal dipping pattern seen in healthy humans. Further, the duration of inactivity did not affect any of the cardiovascular measures, so the differences in blood pressure values between the active and inactive periods are likely driven by ultradian oscillations in hormones and autonomic function. Finally, specific behavioral patterns also were examined. Both the instrumented animal and his non-instrumented cagemate appeared to show synchronized activity patterns, with both animals displaying sleep-like behavior for more than 90% of the inactive period. We propose that the prairie vole ultradian rhythm in blood pressure is an analogue for circadian blood pressure variability and can be used to study the long-term effects of commonly prescribed drugs on blood pressure dipping.
[Mh] Termos MeSH primário: Ciclos de Atividade/fisiologia
Arvicolinae/fisiologia
Pressão Sanguínea/fisiologia
Frequência Cardíaca/fisiologia
Modelos Animais
[Mh] Termos MeSH secundário: Animais
Anti-Hipertensivos/farmacologia
Ritmo Circadiano
Masculino
Atividade Motora/fisiologia
Telemetria/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Antihypertensive Agents)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170315
[Lr] Data última revisão:
170315
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE



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